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1. 发明申请

WO2010075101A2 TREATING PICORNAVIRUS INFECTION BY TARGETING MICRORNA MIR-141 审中-公开
标题翻译：用靶向MICRORNA MIR-141治疗PICORNAVIRUS感染
公开(公告)号：WO2010075101A2
公开(公告)日：2010-07-01
申请号：PCT/US2009/068095
申请日：2009-12-15
申请人： DCB-USA, LLC , LEE, Chun-Nan , HO, Bing-Ching , YU, Sung-Liang , YANG, Pan-Chyr
发明人： LEE, Chun-Nan , HO, Bing-Ching , YU, Sung-Liang , YANG, Pan-Chyr
IPC分类号： C12N15/113 , A61K31/7105 , A61P31/12
CPC分类号： A61K31/7088 , C12N15/113 , C12N2310/113 , C12N2310/14 , C12N2320/31 , Y02A50/465
摘要： Treatment of picornavirus infection by inhibiting miR-141 activity. Also disclosed herein are a method for identify miR-141 inhibitory compounds and a method for identifying a target viral infection to be treated by anti-miR-141 therapy.
摘要翻译：通过抑制miR-141活性来治疗小核糖核酸病毒感染。本文还公开了鉴定miR-141抑制性化合物的方法和用于鉴定待通过抗miR-141疗法治疗的靶病毒感染的方法。

2. 发明申请

WO2010075101A3 TREATING PICORNAVIRUS INFECTION BY TARGETING MICRORNA MIR-141 审中-公开
标题翻译：通过靶向MICRORNA MIR-141治疗PICORNVIRUS感染
公开(公告)号：WO2010075101A3
公开(公告)日：2010-11-04
申请号：PCT/US2009068095
申请日：2009-12-15
申请人： DCB USA LLC , LEE CHUN-NAN , HO BING-CHING , YU SUNG-LIANG , YANG PAN-CHYR
发明人： LEE CHUN-NAN , HO BING-CHING , YU SUNG-LIANG , YANG PAN-CHYR
IPC分类号： C12N15/113 , A61K31/7105 , A61P31/12
CPC分类号： A61K31/7088 , C12N15/113 , C12N2310/113 , C12N2310/14 , C12N2320/31
摘要： Treatment of picornavirus infection by inhibiting miR-141 activity. Also disclosed herein are a method for identify miR-141 inhibitory compounds and a method for identifying a target viral infection to be treated by anti-miR-141 therapy.
摘要翻译：通过抑制miR-141活性来治疗小RNA病毒感染。本文还公开了鉴定miR-141抑制化合物的方法和用于鉴定通过抗miR-141治疗来治疗的靶病毒感染的方法。

3. 发明申请

WO2010027424A3 9-SUBSTITUTED PHENANTHRENE BASED TYLOPHORINE DERIVATIVES 审中-公开
公开(公告)号：WO2010027424A3
公开(公告)日：2010-03-11
申请号：PCT/US2009/004828
申请日：2009-08-25
申请人： THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL , LEE, Kuo-Hsiung , SHI, Qian , YANG, Xiaoming , BASTOW, Kenneth F. , LIN, Jau-Chen , YANG, Pan-Chyr
发明人： LEE, Kuo-Hsiung , SHI, Qian , YANG, Xiaoming , BASTOW, Kenneth F. , LIN, Jau-Chen , YANG, Pan-Chyr
IPC分类号： C07D317/46 , C07D471/00 , A61K31/495 , A61P35/00
摘要： The present invention provides compounds of Formula I: compositions containing the same, and methods of use thereof such as for the treatment of cancer.

4. 发明申请

WO2011049704A1 ANTOFINE AND CRYPTOPLEURINE DERIVATIVES AS ANTICANCER AGENTS 审中-公开
标题翻译： ANTOFINE和CRYPTOPLEURINE衍生物作为反应剂代理
公开(公告)号：WO2011049704A1
公开(公告)日：2011-04-28
申请号：PCT/US2010/049780
申请日：2010-09-22
申请人： THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL , LEE, Kuo-Hsiung , YANG, Xiaoming , SHI, Qian , BASTOW, Kenneth, F. , TENG, Che-Ming , HONG, Tse-Ming , YANG, Pan-Chyr , YANG, Shuenn-Chen
发明人： LEE, Kuo-Hsiung , YANG, Xiaoming , SHI, Qian , BASTOW, Kenneth, F. , TENG, Che-Ming , HONG, Tse-Ming , YANG, Pan-Chyr , YANG, Shuenn-Chen
IPC分类号： A61K31/50 , A61K31/501
CPC分类号： C07D471/04 , C07D491/04
摘要： The present invention provides compounds of Formula (I-IV): compositions containing the same, and methods of use thereof such as for the treatment of cancer.
摘要翻译：本发明提供式（I-IV）化合物：含有该化合物的组合物及其使用方法，例如用于治疗癌症。

5. 发明申请

WO2007075924A3 METHODS AND APPLICATIONS OF MOLECULAR BEACON IMAGING FOR INFECTIOUS DISEASE AND CANCER DETECTION 审中-公开
标题翻译：用于感染性疾病和癌症检测的分子信标图像的方法和应用
公开(公告)号：WO2007075924A3
公开(公告)日：2008-08-14
申请号：PCT/US2006048853
申请日：2006-12-22
申请人： ALVITAE PHARMACEUTICALS , LIN AUGUSTINE , YANG PAN-CHYR , CHOU CHENG-CHUNG
发明人： LIN AUGUSTINE , YANG PAN-CHYR , CHOU CHENG-CHUNG
IPC分类号： C12Q1/68 , C12Q1/70
CPC分类号： C12Q1/6886 , C12Q1/701 , C12Q2600/106 , C12Q2600/156 , C12Q2600/158
摘要： Molecular beacon for detecting an infection and/or expression or a mutation of a disease marker for diagnostics and pharmacogenomics. The molecular beacon is capable of hybridizing a disease-related RNA or DNA of a disease marker in a specimen obtained from a living subject, thereby emitting a signal detectable without a need for signal amplification. The disease marker includes a genetic sequence specific to a pathogen including a flu virus, a cancer cell marker, and a drug resistance-related genetic mutation marker for a drug resistant cancer and infectious pathogen. To detect a disease cell, a specimen containing one or more cells is obtained from a living subject, and fixed by an organic solvent. A molecular beacon is then added to the specimen, followed by staining nuclei of the cells in the specimen. The signal is detectable with a microscope, FACS scan, ELISA plate reader, Scanner, or any combinations thereof.
摘要翻译：用于检测用于诊断和药物基因组学的疾病标记物的感染和/或表达或突变的分子信标。分子信标能够与从活体受试者获得的样本中的疾病标记物的疾病相关的RNA或DNA杂交，从而发出可检测的信号，而不需要信号放大。疾病标记物包括对包括流感病毒，癌细胞标记物和用于耐药性癌症和感染性病原体的药物抗性相关基因突变标记的病原体特异性的遗传序列。为了检测疾病细胞，从活体受试者获得含有一种或多种细胞的样品，并通过有机溶剂固定。然后将分子信标添加到样品中，随后在样品中染色细胞核。该信号可用显微镜，FACS扫描，ELISA板读数器，扫描仪或其任何组合检测。

6. 发明申请

WO2007075924A2 METHODS AND APPLICATIONS OF MOLECULAR BEACON IMAGING FOR INFECTIOUS DISEASE AND CANCER DETECTION 审中-公开
标题翻译：用于感染性疾病和癌症检测的分子信标图像的方法和应用
公开(公告)号：WO2007075924A2
公开(公告)日：2007-07-05
申请号：PCT/US2006/048853
申请日：2006-12-22
申请人： ALVITAE PHARMACEUTICALS , LIN, Augustine , YANG, Pan-Chyr , CHOU, Cheng-chung
发明人： LIN, Augustine , YANG, Pan-Chyr , CHOU, Cheng-chung
IPC分类号： C12Q1/70
CPC分类号： C12Q1/6886 , C12Q1/701 , C12Q2600/106 , C12Q2600/156 , C12Q2600/158
摘要： Molecular beacon for detecting an infection and/or expression or a mutation of a disease marker for diagnostics and pharmacogenomics. The molecular beacon is capable of hybridizing a disease-related RNA or DNA of a disease marker in a specimen obtained from a living subject, thereby emitting a signal detectable without a need for signal amplification. The disease marker includes a genetic sequence specific to a pathogen including a flu virus, a cancer cell marker, and a drug resistance-related genetic mutation marker for a drug resistant cancer and infectious pathogen. To detect a disease cell, a specimen containing one or more cells is obtained from a living subject, and fixed by an organic solvent. A molecular beacon is then added to the specimen, followed by staining nuclei of the cells in the specimen. The signal is detectable with a microscope, FACS scan, ELISA plate reader, Scanner, or any combinations thereof.
摘要翻译：用于检测用于诊断和药物基因组学的疾病标记物的感染和/或表达或突变的分子信标。分子信标能够与从活体受试者获得的样本中的疾病标记物的疾病相关的RNA或DNA杂交，从而发出可检测的信号，而不需要信号放大。疾病标记物包括对包括流感病毒，癌细胞标记物和用于耐药性癌症和感染性病原体的药物抗性相关基因突变标记的病原体特异性的遗传序列。为了检测疾病细胞，从活体受试者获得含有一种或多种细胞的样品，并通过有机溶剂固定。然后将分子信标添加到样品中，随后在样品中染色细胞核。该信号可用显微镜，FACS扫描，ELISA板读数器，扫描仪或其任何组合检测。

7. 发明申请

WO2016036676A1 PHARMACEUTICAL COMPOSITION FOR TREATMENT OF CANCER USING PHENOTHIAZINE 审中-公开
标题翻译：用于治疗癌症的药物组合物使用苯并噻唑
公开(公告)号：WO2016036676A1
公开(公告)日：2016-03-10
申请号：PCT/US2015/047840
申请日：2015-09-01
申请人： HSIAO, Jane , YANG, Pan-chyr , HUANG, Chi-Ying , LEE, Meng-Hua
发明人： HSIAO, Jane , YANG, Pan-chyr , HUANG, Chi-Ying , LEE, Meng-Hua
IPC分类号： A61K31/549
CPC分类号： A61K31/5415 , A61K31/519 , A61K31/5377 , A61K31/555 , A61K31/7068 , A61K33/24 , A61K2300/00
摘要： The present invention relates to use of antipsychotic phenothiazine derivative for treatment of cancer. The invention also provides a use for manufacture a medicament, a pharmaceutical composition and a method for treating a cancer, and /or preventing or delaying cancer recurrence based on trifluoperazine. The invention further provides a use for manufacture a medicament, a pharmaceutical composition and a method for treating cancer based on thioridazine and its enantiomers. Additionally, the invention provides a use for manufacture a medicament, a pharmaceutical composition and a method for treating KRAS mutant NSCLC comprising thioridazine.
摘要翻译：本发明涉及抗精神病药吩噻嗪衍生物用于治疗癌症的用途。本发明还提供了用于制备药物，药物组合物和治疗癌症的方法，和/或预防或延迟基于三氟拉嗪的癌症复发的用途。本发明还提供了制备用于治疗基于硫利达嗪及其对映异构体的癌症的药物，药物组合物和方法的用途。另外，本发明提供了用于制备药物，药物组合物和用于治疗包含硫利达嗪的KRAS突变NSCLC的方法的用途。

8. 发明申请

WO2013005107A3 METHOD FOR PREDICTING RESPONSE OR PROGNOSIS OF LUNG ADENOCARCINOMA WITH EGFR-ACTIVATING MUTATIONS 审中-公开
标题翻译：用EGFR激活突变体预测肺腺癌的反应或预防方法
公开(公告)号：WO2013005107A3
公开(公告)日：2013-05-23
申请号：PCT/IB2012001595
申请日：2012-07-05
申请人： UNIV NAT TAIWAN , YU SUNG-LIANG , YANG PAN-CHYR , YUAN SHINSHENG , CHANG GEE-CHEN , CHEN HSUAN-YU , LI KER-CHAU
发明人： YU SUNG-LIANG , YANG PAN-CHYR , YUAN SHINSHENG , CHANG GEE-CHEN , CHEN HSUAN-YU , LI KER-CHAU
IPC分类号： C12Q1/68
CPC分类号： C12Q1/68 , C12Q1/6827 , C12Q1/6886 , C12Q2539/10 , C12Q2600/106 , C12Q2537/16
摘要： The invention provides a method for predicting the response of an EGFR-activating mutant subject suffering from a lung adenocarcinoma and receiving treatment with epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) and a method for predicting prognosis in an EGFR-activating mutant subject suffering from a lung adenocarcinoma and receiving treatment with EGFR-TKI. In the methods of the invention, clustered genomic alterations in specific chromosomes (in particular chromosomes 5p, 7p, 8q or 14q) are determined as a tool for predicting the response or prognosis.
摘要翻译：本发明提供一种用于预测患有肺腺癌并接受用表皮生长因子受体酪氨酸激酶抑制剂（EGFR-TKI）治疗的EGFR-活化突变体受试者的反应的方法和用于预测EGFR活化突变体受试者的预后的方法患有肺腺癌并接受EGFR-TKI治疗。在本发明的方法中，确定特定染色体（特别是5p，7p，8q或14q）染色体上的聚类基因组改变作为预测反应或预后的工具。

9. 发明申请

WO2010027424A2 9-SUBSTITUTED PHENANTHRENE BASED TYLOPHORINE DERIVATIVES 审中-公开
标题翻译： 9-取代的基于苯基的衍生物衍生物
公开(公告)号：WO2010027424A2
公开(公告)日：2010-03-11
申请号：PCT/US2009004828
申请日：2009-08-25
申请人： UNIV NORTH CAROLINA , LEE KUO-HSIUNG , SHI QIAN , YANG XIAOMING , BASTOW KENNETH F , LIN JAU-CHEN , YANG PAN-CHYR
发明人： LEE KUO-HSIUNG , SHI QIAN , YANG XIAOMING , BASTOW KENNETH F , LIN JAU-CHEN , YANG PAN-CHYR
IPC分类号： C07D317/46 , A61K31/495 , A61P35/00 , C07D471/00
CPC分类号： C07D405/06
摘要： The present invention provides compounds of Formula I: compositions containing the same, and methods of use thereof such as for the treatment of cancer.
摘要翻译：本发明提供式I化合物：含有该化合物的组合物及其使用方法，例如治疗癌症。

10. 发明申请

WO2007139598A2 METASTASIS-ASSOCIATED GENE PROFILING FOR IDENTIFICATION OF TUMOR TISSUE, SUBTYPING, AND PREDICTION OF PROGNOSIS OF PATIENTS 审中-公开
标题翻译： METASTASIS相关基因分型用于鉴定肿瘤组织，分型和预测患者预后
公开(公告)号：WO2007139598A2
公开(公告)日：2007-12-06
申请号：PCT/US2007/003516
申请日：2007-02-09
申请人： AdvPharma, Inc. , STASON PHARMACEUTICALS, INC. , CHOU, Yeh-Tze , TERNG, Harn-Jing , CHEN, Hsuan-Yu , YU, Sung-Liang , CHEN, Jeremy, J.W. , YANG, Pan-Chyr
发明人： CHOU, Yeh-Tze , TERNG, Harn-Jing , CHEN, Hsuan-Yu , YU, Sung-Liang , CHEN, Jeremy, J.W. , YANG, Pan-Chyr
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/118
摘要： The present invention provides methods using a gene expression profiling analysis (1) to determine whether a human sample is a tumor using a gene set containing nucleic acid sequences of SEQ ID NOS: 1-7, 8-17 or 1-17; (2) to identify whether a tumor tissue is an adenocarcinoma (using a gene set containing nucleic acid sequences of SEQ ID NOS: 15, 18- 21) or a squamous cell carcinoma (using a gene set containing nucleic acid sequences of SEQ ID NOS: 22-27); and (3) to predict the prognosis of survival and metastasis in humans with cancer (using a gene set containing nucleic acid sequences of SEQ ID NOS: 19, 28-42 or SEQ ID NOS: 19, 29, 31, 40, and 42), particularly for those humans who are at the early stage of lung cancer. The gene expression profiling is preferably performed by cDNA microarray- based techniques and/or Real-Time Reverse Transcription-Polymerase Chain Reaction (Real- Time RT-PCR), and analyzed by statistical means.
摘要翻译：本发明提供了使用基因表达谱分析（1）来确定人样品是否是使用含有SEQ ID NO：1-7,8-17或1-17的核酸序列的基因组的肿瘤的方法; （2）鉴定肿瘤组织是否是腺癌（使用含有SEQ ID NO：15,18-21的核酸序列的基因组）或鳞状细胞癌（使用含有SEQ ID NOS的核酸序列的基因组：22-27）; （3）预测患有癌症的人的存活和转移的预后（使用含有SEQ ID NO：19,28-42或SEQ ID NO：19,29,31,40和42的核酸序列的基因组），特别是那些处于肺癌早期阶段的人。基因表达谱优选通过基于cDNA微阵列的技术和/或实时逆转录聚合酶链反应（Real-Time Reverse-PCR）进行，并通过统计学方法进行分析。

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