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1. 发明申请

WO2007075924A9 METHODS AND APPLICATIONS OF MOLECULAR BEACON IMAGING FOR INFECTIOUS DISEASE AND CANCER DETECTION 审中-公开
标题翻译：分子信标在传染性疾病和癌症检测中的应用
公开(公告)号：WO2007075924A9
公开(公告)日：2008-06-26
申请号：PCT/US2006048853
申请日：2006-12-22
申请人： ALVITAE PHARMACEUTICALS , LIN AUGUSTINE , YANG PAN-CHYR , CHOU CHENG-CHUNG
发明人： LIN AUGUSTINE , YANG PAN-CHYR , CHOU CHENG-CHUNG
IPC分类号： C12Q1/70
CPC分类号： C12Q1/6886 , C12Q1/701 , C12Q2600/106 , C12Q2600/156 , C12Q2600/158
摘要： Molecular beacon for detecting an infection and/or expression or a mutation of a disease marker for diagnostics and pharmacogenomics. The molecular beacon is capable of hybridizing a disease-related RNA or DNA of a disease marker in a specimen obtained from a living subject, thereby emitting a signal detectable without a need for signal amplification. The disease marker includes a genetic sequence specific to a pathogen including a flu virus, a cancer cell marker, and a drug resistance-related genetic mutation marker for a drug resistant cancer and infectious pathogen. To detect a disease cell, a specimen containing one or more cells is obtained from a living subject, and fixed by an organic solvent. A molecular beacon is then added to the specimen, followed by staining nuclei of the cells in the specimen. The signal is detectable with a microscope, FACS scan, ELISA plate reader, Scanner, or any combinations thereof.
摘要翻译：用于检测诊断和药物基因组学的感染和/或表达或疾病标志物突变的分子信标。分子信标能够与从活体获得的标本中疾病相关RNA或疾病标志物的DNA杂交，从而发出可检测信号而不需要信号放大。疾病标记物包括对包括流感病毒，癌细胞标记物和耐药性相关基因突变标记物的病原体特异的遗传序列，所述遗传序列用于耐药性癌症和感染性病原体。为了检测疾病细胞，从活体获得含有一个或多个细胞的样本，并通过有机溶剂固定。然后将分子信标加入样本中，随后对样本中的细胞核进行染色。信号可用显微镜，FACS扫描，ELISA平板读数器，扫描仪或其任何组合检测。

2. 发明申请

WO2007075924A3 METHODS AND APPLICATIONS OF MOLECULAR BEACON IMAGING FOR INFECTIOUS DISEASE AND CANCER DETECTION 审中-公开
标题翻译：用于感染性疾病和癌症检测的分子信标图像的方法和应用
公开(公告)号：WO2007075924A3
公开(公告)日：2008-08-14
申请号：PCT/US2006048853
申请日：2006-12-22
申请人： ALVITAE PHARMACEUTICALS , LIN AUGUSTINE , YANG PAN-CHYR , CHOU CHENG-CHUNG
发明人： LIN AUGUSTINE , YANG PAN-CHYR , CHOU CHENG-CHUNG
IPC分类号： C12Q1/68 , C12Q1/70
CPC分类号： C12Q1/6886 , C12Q1/701 , C12Q2600/106 , C12Q2600/156 , C12Q2600/158
摘要： Molecular beacon for detecting an infection and/or expression or a mutation of a disease marker for diagnostics and pharmacogenomics. The molecular beacon is capable of hybridizing a disease-related RNA or DNA of a disease marker in a specimen obtained from a living subject, thereby emitting a signal detectable without a need for signal amplification. The disease marker includes a genetic sequence specific to a pathogen including a flu virus, a cancer cell marker, and a drug resistance-related genetic mutation marker for a drug resistant cancer and infectious pathogen. To detect a disease cell, a specimen containing one or more cells is obtained from a living subject, and fixed by an organic solvent. A molecular beacon is then added to the specimen, followed by staining nuclei of the cells in the specimen. The signal is detectable with a microscope, FACS scan, ELISA plate reader, Scanner, or any combinations thereof.
摘要翻译：用于检测用于诊断和药物基因组学的疾病标记物的感染和/或表达或突变的分子信标。分子信标能够与从活体受试者获得的样本中的疾病标记物的疾病相关的RNA或DNA杂交，从而发出可检测的信号，而不需要信号放大。疾病标记物包括对包括流感病毒，癌细胞标记物和用于耐药性癌症和感染性病原体的药物抗性相关基因突变标记的病原体特异性的遗传序列。为了检测疾病细胞，从活体受试者获得含有一种或多种细胞的样品，并通过有机溶剂固定。然后将分子信标添加到样品中，随后在样品中染色细胞核。该信号可用显微镜，FACS扫描，ELISA板读数器，扫描仪或其任何组合检测。

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