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1. 发明申请

WO2009127715A1 COMPOUNDS COMPRISING PARAMAGNETIC CHELATES ARRANGED AROUND A CENTRAL CORE AND THEIR USE IN MAGNETO RESONANCE IMAGING AND SPECTROSCOPY 审中-公开
标题翻译：包含在中心核心附近的参考粒子的化合物及其在磁共振成像和光谱中的使用
公开(公告)号：WO2009127715A1
公开(公告)日：2009-10-22
申请号：PCT/EP2009/054579
申请日：2009-04-17
申请人： GE HEALTHCARE AS , MEIJER, Andreas , AXELSSON, Oskar , BRÅTHE, Anders , OLSSON, Andreas , JOHANSEN, John, Henrik , WYNN, Duncan, George
发明人： MEIJER, Andreas , AXELSSON, Oskar , BRÅTHE, Anders , OLSSON, Andreas , JOHANSEN, John, Henrik , WYNN, Duncan, George
IPC分类号： C07F5/00 , C07D257/02 , A61K51/04
CPC分类号： C07D257/02 , A61K49/124
摘要： The present invention relates to novel compounds of formula (I) and (II), compositions comprising compounds of formula (II) and their use as contrast agents in magnetic resonance (MR) imaging (MRI) and MR spectroscopy (MRS).
摘要翻译：本发明涉及式（I）和（II）的新型化合物，包含式（II）化合物的组合物及其作为磁共振（MR）成像（MRI）和MR光谱学（MRS）中的造影剂的用途。

2. 发明申请

WO2009047318A1 CONTRAST AGENTS 审中-公开
标题翻译：对比剂
公开(公告)号：WO2009047318A1
公开(公告)日：2009-04-16
申请号：PCT/EP2008/063588
申请日：2008-10-10
申请人： GE HEALTHCARE AS , WYNN, Duncan, George , WISTRAND, Lars-Göran
发明人： WYNN, Duncan, George , WISTRAND, Lars-Göran
IPC分类号： A61K49/04 , C07C237/46
CPC分类号： A61K49/0438 , C07C237/46
摘要： The present invention relates to a class of compounds and to diagnostic compositions containing such compounds where the compounds are iodine containing compounds. More specifically the iodine containing compounds are chemical compounds containing two linked iodinated phenyl groups of the general formula and salts or optical active isomers thereof, wherein each of R 1 , R 2 and R 3 independently are the same or different and denote a hydrogen atom or a C 1 to C 4 straight of branched alkyl group; each R 4 independently are the same or different and denote C 1 to C 6 straight of branched alkyl moieties substituted by up to 6 -OH groups; and each R 5 independently are the same or different and denote C 1 to C 6 straight or branched alkyl moieties substituted by up to 6 -OH groups. The invention also relates to the use of such diagnostic compositions as contrast agents in diagnostic imaging and in particular in X-ray imaging, and to contrast media containing such compounds.
摘要翻译：本发明涉及一类化合物和含有这些化合物的诊断组合物，其中化合物是含碘化合物。更具体地说，含碘化合物是含有通式的两个连接的碘化苯基和其盐或光学活性异构体的化合物，其中R1，R2和R3各自独立地相同或不同，表示氢原子或C1至C4 直链支链烷基; 每个R 4独立地相同或不同，并且表示被至多6个-OH基团取代的支链烷基部分的C1至C6直链; 并且每个R 5独立地相同或不同，并且表示被至多6个-OH基团取代的C 1至C 6直链或支链烷基部分。本发明还涉及这种诊断组合物作为造影剂在诊断成像中，特别是在X射线成像中的用途，以及含有这些化合物的造影剂。

3. 发明申请

WO2009047315A1 CONTRAST AGENTS 审中-公开
标题翻译：对比剂
公开(公告)号：WO2009047315A1
公开(公告)日：2009-04-16
申请号：PCT/EP2008/063584
申请日：2008-10-10
申请人： GE HEALTHCARE AS , WYNN, Duncan, George , NEWINGTON, Ian, Martin , PRIEBE, Hanno
发明人： WYNN, Duncan, George , NEWINGTON, Ian, Martin , PRIEBE, Hanno
IPC分类号： A61K49/04 , C07C237/46
CPC分类号： A61K49/0438 , C07C237/46
摘要： The present invention relates to a class of compounds and to diagnostic compositions containing such compounds where the compounds are iodine containing compounds. More specifically the iodine containing compounds are chemical compounds containing two linked iodinated phenyl groups of the general formula wherein each R 1 independently are the same or different and denotes a hydrogen atom or a C 1 to C 4 straight of branched alkyl group; each R 2 independently are the same or different and denotes a hydrogen atom or a C 1 to C 4 straight of branched alkyl group; and each R 3 , R 4 and R 5 independently are the same or different and denote C 1 to C 6 straight of branched alkyl moieties substituted by 1 to 6 -OH groups. The invention also relates to the use of such diagnostic compositions as contrast agents in diagnostic imaging and in particular in X-ray imaging, and to contrast media containing such compounds.
摘要翻译：本发明涉及一类化合物和含有这些化合物的诊断组合物，其中化合物是含碘化合物。更具体地说，含碘化合物是含有两个具有通式的连接的碘化苯基的化合物，其中每个R 1独立地相同或不同，表示氢原子或支链烷基的C1至C4直链; 每个R 2独立地相同或不同，表示氢原子或支链烷基的C1〜C4直链; 并且每个R 3，R 4和R 5独立地相同或不同，并且表示被1至6个-OH基团取代的支链烷基部分的C1至C6直链。本发明还涉及这种诊断组合物作为造影剂在诊断成像中，特别是在X射线成像中的用途，以及含有这些化合物的造影剂。

4. 发明申请

WO2005107819A2 PURIFICATION METHODS 审中-公开
标题翻译：净化方法
公开(公告)号：WO2005107819A2
公开(公告)日：2005-11-17
申请号：PCT/GB2005001796
申请日：2005-05-11
申请人： HAMMERSMITH IMANET LTD , GE HEALTHCARE LTD , AMERSHAM HEALTH AS , LUTHRA SAJINDER KAUR , BRADY FRANK , JEFFERY NICHOLAS TOBY , ARSTAD ERIK , GIBSON ALEXANDER MARK , WYNN DUNCAN , CUTHBERTSTON ALAN , SOLBAKKEN MAGNE
发明人： LUTHRA SAJINDER KAUR , BRADY FRANK , JEFFERY NICHOLAS TOBY , ARSTAD ERIK , GIBSON ALEXANDER MARK , WYNN DUNCAN , CUTHBERTSTON ALAN , SOLBAKKEN MAGNE
IPC分类号： C07B59/00 , A61K51/00
CPC分类号： C07B59/00 , C07B63/00 , C07B2200/11
摘要： The invention relates to novel processes for the purification of radiolabelled tracers, using a solid-support bound scavenger group. The general concept being illustrated by the scheme :
摘要翻译：本发明涉及使用固体支持结合清除剂组来纯化放射性标记的示踪剂的新方法。计划说明的一般概念：

5. 发明申请

WO2012067863A1 HETEROCYCLIC COMPOUNDS AS IMAGING PROBES OF TAU PATHOLOGY 审中-公开
标题翻译：杂环化合物作为TAU病理学的成像探针
公开(公告)号：WO2012067863A1
公开(公告)日：2012-05-24
申请号：PCT/US2011/059495
申请日：2011-11-07
申请人： GE HEALTHCARE LIMITED , MEDI-PHYSICS, INC. , JONES, Clare , EWAN, Amanda , WYNN, Duncan , GAETA, Alessandra , NAIRNE, James
发明人： JONES, Clare , EWAN, Amanda , WYNN, Duncan , GAETA, Alessandra , NAIRNE, James
IPC分类号： C07D215/12 , C07D215/14 , C07D215/18 , C07D215/36 , C07D401/04 , C07D401/12 , C07D295/067 , A61K31/47 , A61P25/00
CPC分类号： A61K51/0455 , C07D215/12 , C07D215/14 , C07D215/18 , C07D215/36 , C07D295/067 , C07D401/04 , C07D401/12
摘要： Heterocyclic compounds of formula (I) useful as imaging probes of Tau pathology in Alzheimer's disease are described. Compositions and methods of making such compounds are also described.
摘要翻译：描述了用作阿尔茨海默氏病Tau病理学成像探针的式（I）的杂环化合物。还描述了制备这种化合物的组合物和方法。

6. 发明申请

WO2009060021A1 CONTRAST AGENTS 审中-公开
标题翻译：对比剂
公开(公告)号：WO2009060021A1
公开(公告)日：2009-05-14
申请号：PCT/EP2008/065042
申请日：2008-11-06
申请人： GE HEALTHCARE AS , MORISSON-IVESON, Véronique , WYNN, Duncan, George
发明人： MORISSON-IVESON, Véronique , WYNN, Duncan, George
IPC分类号： C07C237/46 , A61K49/04
CPC分类号： C07C237/46 , A61K49/0433
摘要： Compounds of formula (I) R A -CO-N(R 2 )-(CR 1 2 ) n -N(R 5 )-R B and salts or optical active isomers thereof, wherein each R 1 independently are the same or different and denotes a hydrogen atom, a hydroxyl group, a C 1 to C 4 straight of branched alkyl group or a C 1 to C 4 straight of branched oxyalkyl group; R 2 denotes a hydrogen atom or a C 1 to C 4 straight of branched alkyl group; R 5 independently are the same or different and denotes a acyl moiety; R A and R B independently are the same or different and denote a triiodinated phenyl group, preferably a 2,4,6-triiodinated phenyl group further substituted by two groups R 3 in the 3 and 5 positions wherein each R 3 are the same or different and denote a hydrogen atom or a non-ionic hydrophilic moiety, provided that at least one R 3 group in the compound of formula (I) is a hydrophilic moiety; and n denotes a positive integer of 1 to 6. The invention also relates to the use of such diagnostic compositions as contrast agents in diagnostic imaging and in particular in X-ray imaging, and to contrast media containing such compounds.
摘要翻译：式（I）化合物RA-CO-N（R2） - （CR1 2）nN（R5）-RB及其盐或光学活性异构体，其中每个R 1各自独立地相同或不同，表示氢原子，羟基基团，支链烷基的C1至C4直链或支链烷氧基的C1至C4直链; R2表示氢原子或支链烷基的C1〜C4直链; R5独立地相同或不同，表示酰基部分; RA和RB独立地相同或不同，表示三碘代苯基，优选2,4,6-三碘代苯基，其进一步被3和5位的R3基团取代，其中每个R 3相同或不同，表示氢原子或非离子亲水部分，条件是式（I）化合物中的至少一个R 3基团是亲水部分; 并且n表示1至6的正整数。本发明还涉及这种诊断组合物作为造影剂在诊断成像中，特别是在X射线成像中的用途，以及含有这些化合物的造影剂。

7. 发明申请

WO2009056555A1 CONTRAST AGENTS 审中-公开
标题翻译：对比剂
公开(公告)号：WO2009056555A1
公开(公告)日：2009-05-07
申请号：PCT/EP2008/064632
申请日：2008-10-29
申请人： GE HEALTHCARE AS , WYNN, Duncan, George , NEWINGTON, Ian, Martin , WADSWORTH, Harry, John
发明人： WYNN, Duncan, George , NEWINGTON, Ian, Martin , WADSWORTH, Harry, John
IPC分类号： A61K49/04 , C07C237/46
CPC分类号： A61K49/04 , A61K49/0438 , C07C237/46
摘要： The present invention relates to a class of compounds and to diagnostic compositions containing such compounds where the compounds are iodine containing compounds of the formula R-Y-X-Z-R where each R denotes a triiodinated phenyl residue further substituted by hydrophilic moieties, Y and Z are urea and urethane groups and X is a alkylene group which may be further substituted. The invention also relates to the use of such diagnostic compositions as contrast agents in diagnostic imaging and in particular in X-ray imaging, and to contrast media containing such compounds.
摘要翻译：本发明涉及一类化合物和含有这种化合物的诊断组合物，其中化合物是含碘的式RYXZR化合物，其中每个R表示进一步被亲水部分取代的三碘代苯基，Y和Z是脲和氨基甲酸酯基团， X是可以被进一步取代的亚烷基。本发明还涉及这种诊断组合物作为造影剂在诊断成像中，特别是在X射线成像中的用途，以及含有这些化合物的造影剂。

8. 发明申请

WO2009047316A1 CONTRAST AGENTS 审中-公开
标题翻译：对比剂
公开(公告)号：WO2009047316A1
公开(公告)日：2009-04-16
申请号：PCT/EP2008/063585
申请日：2008-10-10
申请人： GE HEALTHCARE AS , WYNN, Duncan, George , WISTRAND, Lars-Göran
发明人： WYNN, Duncan, George , WISTRAND, Lars-Göran
IPC分类号： C07C237/46 , A61K49/04
CPC分类号： C07C237/46 , A61K49/0433
摘要： The present invention relates to a class of compounds and to diagnostic compositions containing such compounds where the compounds are iodine containing compounds. More specifically the iodine containing compounds are chemical compounds containing two linked iodinated phenyl groups of the general formula (I) and salts or optical active isomers thereof, wherein each of R 1 , R 2 and R 3 independently are the same or different and denote a hydrogen atom or a C 1 to C 4 straight of branched alkyl group; each R 4 independently are the same or different and denote C 1 to C 6 straight of branched alkyl moieties substituted by up to 6 -OH groups; and each R 5 independently are the same or different and denote C 1 to C 6 straight of branched alkyl moieties substituted by up to 6 -OH groups provided that at least one alkyl group is substituted with at least 2 hydroxy groups. The invention also relates to the use of such diagnostic compositions as contrast agents in diagnostic imaging and in particular in X-ray imaging, and to contrast media containing such compounds.
摘要翻译：本发明涉及一类化合物和含有这些化合物的诊断组合物，其中化合物是含碘化合物。更具体地说，含碘化合物是含有通式（I）的两个连接的碘化苯基及其盐或光学活性异构体的化合物，其中R1，R2和R3各自独立地相同或不同，表示氢原子或支链烷基的C1〜C4直链; 每个R 4独立地相同或不同，并且表示被至多6个-OH基团取代的支链烷基部分的C1至C6直链; 并且每个R 5独立地相同或不同，并且表示被至多6个-OH基团取代的支链烷基部分的C1至C6直链，条件是至少一个烷基被至少2个羟基取代。本发明还涉及这种诊断组合物作为造影剂在诊断成像中，特别是在X射线成像中的用途，以及含有这些化合物的造影剂。

9. 发明申请

WO2007133088A1 CONTRAST AGENTS 审中-公开
标题翻译：对比剂
公开(公告)号：WO2007133088A1
公开(公告)日：2007-11-22
申请号：PCT/NO2007/000168
申请日：2007-05-10
申请人： GE HEALTHCARE AS , WYNN, Duncan , WADSWORTH, Harry , NEWINGTON, Ian Martin
发明人： WYNN, Duncan , WADSWORTH, Harry , NEWINGTON, Ian Martin
IPC分类号： C07C237/46 , A61K49/04
CPC分类号： C07C275/42 , A61K49/0433 , C07C271/28
摘要： The present invention relates to a class of compounds and to diagnostic compositions containing such compounds where the compounds are iodine containing compounds. More specifically the iodine containing compounds are chemical compounds containing an aliphatic central moiety containing urea or urethane functions allowing for the arrangement of three iodinated phenyl groups bound thereto. The invention also relates to the use of such diagnostic compositions as contrast agents in diagnostic imaging and in particular in X-ray imaging and to contrast media containing such compounds.
摘要翻译：本发明涉及一类化合物和含有这些化合物的诊断组合物，其中化合物是含碘化合物。更具体地，含碘化合物是含有含有脲或氨基甲酸酯官能团的脂族中心部分的化合物，其允许与其结合的三个碘化苯基的排列。本发明还涉及这种诊断组合物作为造影剂在诊断成像中的用途，特别是在X射线成像中以及含有这种化合物的造影剂的用途。

10. 发明申请

WO2004069365A8 DIAGNOSTIC IMAGING AGENTS WITH MMP INHIBITORY ACTIVITY 审中-公开
标题翻译：具有MMP抑制活性的诊断成像剂
公开(公告)号：WO2004069365A8
公开(公告)日：2004-09-30
申请号：PCT/GB2004000524
申请日：2004-02-10
申请人： AMERSHAM PLC , STOREY ANTHONY , DAVIS JULIE , RICKETTS SALLY-ANN , MENDIZABAL MARIVI , CUTHBERTSON ALAN , ARUKWE JOSEPH , HEYWOOD KIRSTY , WILSON IAN , WYNN DUNCAN , SCHAFERS MICHAEL , LEVKAU BODU , WAGNER STEFAN , BREYHOLZ HANS-JORG , KOPKA KLAUS
发明人： STOREY ANTHONY , DAVIS JULIE , RICKETTS SALLY-ANN , MENDIZABAL MARIVI , CUTHBERTSON ALAN , ARUKWE JOSEPH , HEYWOOD KIRSTY , WILSON IAN , WYNN DUNCAN , SCHAFERS MICHAEL , LEVKAU BODU , WAGNER STEFAN , BREYHOLZ HANS-JORG , KOPKA KLAUS
IPC分类号： A61K51/04 , A65K51/04
CPC分类号： A61K51/0497
摘要： The present invention relates to the field of diagnostic imaging. Specifically, the invention relates to the diagnostic imaging of diseases where specific matrix metalloproteinases are known to be involved. One embodiment of the invention is a compound having matrix metalloproteinase inhibitory activity suitable for diagnostic imaging. Also disclosed in the present invention is a pharmaceutical composition comprising the diagnostic imaging agent of the invention in a form suitable for mammalian administration. The invention furthermore discloses intermediates in the synthesis of the diagnostic imaging agents of the invention and kits for the preparation of the pharmaceutical composition of the invention. The pharmaceutical composition of the invention may be used in the diagnosis of diseases where specific matrix metalloproteinases are known to be involved.
摘要翻译：本发明涉及诊断成像领域。具体而言，本发明涉及已知涉及特定基质金属蛋白酶的疾病的诊断成像。本发明的一个实施方案是具有适用于诊断成像的基质金属蛋白酶抑制活性的化合物。本发明还公开了包含适合于哺乳动物给药形式的本发明诊断成像剂的药物组合物。本发明还公开了合成本发明诊断显像剂的中间体和用于制备本发明药物组合物的试剂盒。本发明的药物组合物可用于已知涉及特定基质金属蛋白酶的疾病的诊断。

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