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1. 发明申请

WO2009056555A1 CONTRAST AGENTS 审中-公开
标题翻译：对比剂
公开(公告)号：WO2009056555A1
公开(公告)日：2009-05-07
申请号：PCT/EP2008/064632
申请日：2008-10-29
申请人： GE HEALTHCARE AS , WYNN, Duncan, George , NEWINGTON, Ian, Martin , WADSWORTH, Harry, John
发明人： WYNN, Duncan, George , NEWINGTON, Ian, Martin , WADSWORTH, Harry, John
IPC分类号： A61K49/04 , C07C237/46
CPC分类号： A61K49/04 , A61K49/0438 , C07C237/46
摘要： The present invention relates to a class of compounds and to diagnostic compositions containing such compounds where the compounds are iodine containing compounds of the formula R-Y-X-Z-R where each R denotes a triiodinated phenyl residue further substituted by hydrophilic moieties, Y and Z are urea and urethane groups and X is a alkylene group which may be further substituted. The invention also relates to the use of such diagnostic compositions as contrast agents in diagnostic imaging and in particular in X-ray imaging, and to contrast media containing such compounds.
摘要翻译：本发明涉及一类化合物和含有这种化合物的诊断组合物，其中化合物是含碘的式RYXZR化合物，其中每个R表示进一步被亲水部分取代的三碘代苯基，Y和Z是脲和氨基甲酸酯基团， X是可以被进一步取代的亚烷基。本发明还涉及这种诊断组合物作为造影剂在诊断成像中，特别是在X射线成像中的用途，以及含有这些化合物的造影剂。

2. 发明申请

WO2009047319A1 CONTRAST AGENTS 审中-公开
标题翻译：对比剂
公开(公告)号：WO2009047319A1
公开(公告)日：2009-04-16
申请号：PCT/EP2008/063589
申请日：2008-10-10
申请人： GE HEALTHCARE AS , NEWINGTON, Ian, Martin , WYNN, Duncan, George , MORISSON-IVESON, Véronique , PASSMORE, Joanna, Marie
发明人： NEWINGTON, Ian, Martin , WYNN, Duncan, George , MORISSON-IVESON, Véronique , PASSMORE, Joanna, Marie
IPC分类号： A61K49/04 , C07C237/46
CPC分类号： A61K49/0438 , C07C237/46 , C07C2601/14 , C07D211/58 , C07D295/108
摘要： The present invention relates to a class of compounds and to diagnostic compositions containing such compounds where the compounds are iodine containing compounds. More specifically the iodine containing compounds are chemical compounds containing two linked iodinated phenyl groups of the general formula (I) and salts or optical active isomers thereof, wherein each R 1 independently are the same or different and denotes a hydrogen atom or a C 1 to C 4 straight or branched alkyl group which is optionally substituted by 1 to 4 - OH groups; each of R 2 independently are the same or different and denote a hydrogen atom or a C 1 to C 4 straight or branched alkyl group; each R 3 independently are the same or different and denotes a hydrogen atom or a C 1 to C 4 straight or branched alkyl group which is optionally substituted by 1 to 4 - OH groups; each R 4 independently are the same or different and denote C 1 to C 6 straight or branched alkyl moieties substituted by up to 6 -OH groups; and each R 5 independently are the same or different and denote C 1 to C 6 straight or branched alkyl moieties substituted by up to 6 -OH groups; and X denotes a straight chain alkylene moiety with 3 to 10 carbon atoms, a 1,4- cyclohexylene group, or X together with the adjacent -NR 1 groups forms a 1,4- piperazine group or a 4-aminopiperidine group. The invention also relates to the use of such diagnostic compositions as contrast agents in diagnostic imaging and in particular in X-ray imaging, and to contrast media containing such compounds.
摘要翻译：本发明涉及一类化合物和含有这些化合物的诊断组合物，其中化合物是含碘化合物。更具体地说，含碘化合物是含有通式（I）的两个连接的碘化苯基和其盐或光学活性异构体的化合物，其中每个R 1独立地相同或不同，表示氢原子或C1至C4直链或任选被1至4-OH基团取代的支链烷基; R2各自相同或不同，表示氢原子或C1〜C4直链或支链烷基; 每个R 3独立地相同或不同，表示氢原子或任选被1至4-OH基团取代的C 1至C 4直链或支链烷基; 每个R 4独立地相同或不同，表示被至多6个-OH基团取代的C1至C6直链或支链烷基部分; 并且每个R 5独立地相同或不同，表示被至多6个-OH基团取代的C 1至C 6直链或支链烷基部分; X表示具有3至10个碳原子的直链亚烷基部分，1,4-亚环己基或X与相邻的-NR1基团一起形成1,4-哌嗪基团或4-氨基哌啶基团。本发明还涉及这种诊断组合物作为造影剂在诊断成像中，特别是在X射线成像中的用途，以及含有这些化合物的造影剂。

3. 发明申请

WO2009005364A1 CONTRAST AGENTS 审中-公开
标题翻译：对比剂
公开(公告)号：WO2009005364A1
公开(公告)日：2009-01-08
申请号：PCT/NO2008/000242
申请日：2008-06-27
申请人： GE HEALTHCARE AS , WISTRAND, Lars-Göran , WYNN, Duncan, George , NEWINGTON, Ian, Martin , MORISSON-IVESON, Véronique
发明人： WISTRAND, Lars-Göran , WYNN, Duncan, George , NEWINGTON, Ian, Martin , MORISSON-IVESON, Véronique
IPC分类号： A61K49/04 , C07C237/46
CPC分类号： A61K49/0433 , C07C237/42 , C07C237/46
摘要： The present invention relates to a class of compounds and to diagnostic compositions containing such compounds where the compounds are iodine containing compounds. More specifically the iodine containing compounds are chemical compounds containing a triamine alkyl central moiety allowing for the arrangement of three iodinated phenyl groups bound thereto. The invention also relates to the use of such diagnostic compositions as contrast agents in diagnostic imaging and in particular in X-ray imaging and to contrast media containing such compounds.
摘要翻译：本发明涉及一类化合物和含有这些化合物的诊断组合物，其中化合物是含碘化合物。更具体地，含碘化合物是含有三胺烷基中心部分的化合物，允许与其结合的三个碘化苯基的排列。本发明还涉及这种诊断组合物作为造影剂在诊断成像中的用途，特别是在X射线成像中以及含有这种化合物的造影剂的用途。

4. 发明申请

WO2009047315A1 CONTRAST AGENTS 审中-公开
标题翻译：对比剂
公开(公告)号：WO2009047315A1
公开(公告)日：2009-04-16
申请号：PCT/EP2008/063584
申请日：2008-10-10
申请人： GE HEALTHCARE AS , WYNN, Duncan, George , NEWINGTON, Ian, Martin , PRIEBE, Hanno
发明人： WYNN, Duncan, George , NEWINGTON, Ian, Martin , PRIEBE, Hanno
IPC分类号： A61K49/04 , C07C237/46
CPC分类号： A61K49/0438 , C07C237/46
摘要： The present invention relates to a class of compounds and to diagnostic compositions containing such compounds where the compounds are iodine containing compounds. More specifically the iodine containing compounds are chemical compounds containing two linked iodinated phenyl groups of the general formula wherein each R 1 independently are the same or different and denotes a hydrogen atom or a C 1 to C 4 straight of branched alkyl group; each R 2 independently are the same or different and denotes a hydrogen atom or a C 1 to C 4 straight of branched alkyl group; and each R 3 , R 4 and R 5 independently are the same or different and denote C 1 to C 6 straight of branched alkyl moieties substituted by 1 to 6 -OH groups. The invention also relates to the use of such diagnostic compositions as contrast agents in diagnostic imaging and in particular in X-ray imaging, and to contrast media containing such compounds.
摘要翻译：本发明涉及一类化合物和含有这些化合物的诊断组合物，其中化合物是含碘化合物。更具体地说，含碘化合物是含有两个具有通式的连接的碘化苯基的化合物，其中每个R 1独立地相同或不同，表示氢原子或支链烷基的C1至C4直链; 每个R 2独立地相同或不同，表示氢原子或支链烷基的C1〜C4直链; 并且每个R 3，R 4和R 5独立地相同或不同，并且表示被1至6个-OH基团取代的支链烷基部分的C1至C6直链。本发明还涉及这种诊断组合物作为造影剂在诊断成像中，特别是在X射线成像中的用途，以及含有这些化合物的造影剂。

5. 发明申请

WO2009005365A1 CONTRAST AGENTS 审中-公开
标题翻译：对比剂
公开(公告)号：WO2009005365A1
公开(公告)日：2009-01-08
申请号：PCT/NO2008/000243
申请日：2008-06-27
申请人： GE HEALTHCARE AS , WISTRAND, Lars-Göran , WYNN, Duncan, George , NEWINGTON, Ian, Martin
发明人： WISTRAND, Lars-Göran , WYNN, Duncan, George , NEWINGTON, Ian, Martin
IPC分类号： A61K49/04 , C07C237/46
CPC分类号： A61K49/0433 , C07C237/46
摘要： The present invention relates to a class of compounds and to diagnostic compositions containing such compounds where the compounds are iodine containing compounds. More specifically the iodine containing compounds are chemical compounds containing a tris(aminoalkyl)amine group allowing for the arrangement of three iodinated phenyl groups bound thereto. The invention also relates to the use of such diagnostic compositions as contrast agents in diagnostic imaging and in particular in X-ray imaging and to contrast media containing such compounds.
摘要翻译：本发明涉及一类化合物和含有这些化合物的诊断组合物，其中化合物是含碘化合物。更具体地说，含碘化合物是含有三（氨基烷基）胺基团的化合物，允许与其结合的三个碘化苯基的排列。本发明还涉及这种诊断组合物作为造影剂在诊断成像中的用途，特别是在X射线成像中以及含有这种化合物的造影剂的用途。

6. 发明申请

WO2009021948A1 CHELATORS, PARAMAGNETIC CHELATES THEREOF AND THEIR USE AS CONTRAST AGENTS IN MAGNETIC RESONANCE IMAGING (MRI) 审中-公开
标题翻译：引证文献，参考文献及其作为磁共振成像（MRI）的对比剂使用
公开(公告)号：WO2009021948A1
公开(公告)日：2009-02-19
申请号：PCT/EP2008/060572
申请日：2008-08-12
申请人： GE HEALTHCARE AS , WADSWORTH, Harry, John , NEWINGTON, Ian, Martin , O'SHEA, Dennis
发明人： WADSWORTH, Harry, John , NEWINGTON, Ian, Martin , O'SHEA, Dennis
IPC分类号： C07D401/14 , C07D403/14 , C07D407/14 , C07F5/00 , A61K49/10
CPC分类号： C07D213/69 , C07D309/40 , C07D401/14 , C07D405/14
摘要： The present invention relates to chelators, in particular to chelators which are capable of forming complexes, i.e. paramagnetic chelates, with paramagnetic metal ions. The invention also relates to said paramagnetic chelates, said paramagnetic chelates linked to other molecules and their use as contrast agents in magnetic resonance imaging (MRI).
摘要翻译：本发明涉及螯合剂，特别涉及能够与顺磁性金属离子形成络合物即顺磁性螯合物的螯合剂。本发明还涉及所述顺磁性螯合物，所述顺磁性螯合物与其它分子连接，以及它们在磁共振成像（MRI）中作为造影剂的用途。

7. 发明申请

WO2008085064A3 HYDROXYPYRIDINONE CHELATING AGENTS, THEIR METAL COMPLEXES AND THEIR USE AS MRI CONTRAST AGENTS 审中-公开
公开(公告)号：WO2008085064A3
公开(公告)日：2008-07-17
申请号：PCT/NO2008/000012
申请日：2008-01-11
申请人： GE HEALTHCARE AS , WADSWORTH, Harry, John , NEWINGTON, Ian, Martin , JONES, Clare, L. , EWAN, Amanda , O'SHEA, Dennis
发明人： WADSWORTH, Harry, John , NEWINGTON, Ian, Martin , JONES, Clare, L. , EWAN, Amanda , O'SHEA, Dennis
IPC分类号： C07D213/81 , A61K49/10
摘要： The present invention relates to chelating agents, in particular to chelating agents which are capable of forming complexes with paramagnetic metal ions such as iron (III) and gadolinium (III). The invention also relates to the complexes formed and their use as MRI contrast agents.

8. 发明申请

WO2009021947A1 CHELATORS, PARAMAGNETIC CHELATES THEREOF AND THEIR USE AS CONTRAST AGENTS IN MAGNETIC RESONANCE IMAGING (MRI) 审中-公开
标题翻译：螯合剂，顺磁性螯合物及其作为造影剂用于磁共振成像（MRI）
公开(公告)号：WO2009021947A1
公开(公告)日：2009-02-19
申请号：PCT/EP2008/060570
申请日：2008-08-12
申请人： GE HEALTHCARE AS , AXELSSON, Oskar , WADSWORTH, Harry, John , NEWINGTON, Ian, Martin , O'SHEA, Dennis
发明人： AXELSSON, Oskar , WADSWORTH, Harry, John , NEWINGTON, Ian, Martin , O'SHEA, Dennis
IPC分类号： C07D401/14 , C07D403/14 , C07D407/14 , C07F5/00 , A61K49/10
CPC分类号： C07D401/14 , C07D213/81 , C07D309/40 , C07D407/14
摘要： The present invention relates to chelators, in particular to chelators which are capable of forming complexes, i.e. paramagnetic chelates, with paramagnetic metal ions. The invention also relates to said paramagnetic chelates, said paramagnetic chelates linked to other molecules and their use as contrast agents in magnetic resonance imaging (MRI).
摘要翻译：本发明涉及螯合剂，具体涉及能够与顺磁性金属离子形成配合物即顺磁性螯合物的螯合剂。本发明还涉及所述顺磁性螯合物，所述顺磁性螯合物与其他分子连接以及它们在磁共振成像（MRI）中用作造影剂。

9. 发明申请

WO2011150183A1 RADIOLABELED COMPOUNDS AND METHODS THEREOF 审中-公开
标题翻译：放射性化合物及其方法
公开(公告)号：WO2011150183A1
公开(公告)日：2011-12-01
申请号：PCT/US2011/038099
申请日：2011-05-26
申请人： GE HEALTHCARE LIMITED , MEDI-PHYSICS, INC. , NEWINGTON, Ian, Martin , WYNN, Duncan George , NAIRNE, Robert James Domett , GUILBERT, Benedicte , MANDAL, Subrata , JINTO, Jose , VARADARAJAN, Sunderaraman , RANGASWAMY, Chitralekha , BETTS, Helen , DAVIS, Rebecca
发明人： NEWINGTON, Ian, Martin , WYNN, Duncan George , NAIRNE, Robert James Domett , GUILBERT, Benedicte , MANDAL, Subrata , JINTO, Jose , VARADARAJAN, Sunderaraman , RANGASWAMY, Chitralekha , BETTS, Helen , DAVIS, Rebecca
IPC分类号： C07D251/30 , C07D251/52 , C07D263/58 , C07D277/74 , C07D277/82 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D413/12 , C07D417/12 , A61K31/496 , A61K51/04 , A61P25/00
CPC分类号： C07D401/04 , A61K51/0459 , A61K51/0461 , B01J19/00 , C07D209/14 , C07D211/96 , C07D213/74 , C07D213/75 , C07D217/06 , C07D233/88 , C07D239/88 , C07D249/04 , C07D253/075 , C07D263/46 , C07D263/58 , C07D277/36 , C07D277/64 , C07D277/74 , C07D295/096 , C07D295/125 , C07D327/04 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/04
摘要： The present invention relates to radiodiagnostic compounds, methods of making those compounds, and methods of use thereof as imaging agents for preferably a HA serotonin 5-HT1A receptor for use in PET or SPECT, preferably PET. Compositions comprising an imaging-effective amount of radiolabeled compounds are also disclosed. The present invention also relates to non-radiolabeled compounds, methods of making those compounds, and methods of use thereof to treat various neurological and/or psychiatric disorders.
摘要翻译：本发明涉及放射诊断化合物，制备这些化合物的方法及其用作优选用于PET或SPECT，优选PET的HA血清素5-HT1A受体的显像剂。还公开了包含成像有效量的放射性标记化合物的组合物。本发明还涉及非放射性标记的化合物，制备这些化合物的方法及其用于治疗各种神经和/或精神疾病的方法。

10. 发明申请

WO2007133090A1 CONTRAST AGENTS 审中-公开
标题翻译：对比剂
公开(公告)号：WO2007133090A1
公开(公告)日：2007-11-22
申请号：PCT/NO2007/000171
申请日：2007-05-11
申请人： GE HEALTHCARE AS , WYNN, Ducan , NEWINGTON, Ian, Martin
发明人： WYNN, Ducan , NEWINGTON, Ian, Martin
IPC分类号： C07C237/46 , A61K31/167 , A61K49/04
CPC分类号： C07C237/46 , A61K49/0438 , C07C2601/14
摘要： The present invention relates to iodine containing compounds containing a central optionally substituted cyclohexane central moiety allowing for the arrangement of three iodinated phenyl groups bound thereto. The invention also relates to the use of such diagnostic compositions as contrast agents in diagnostic imaging and in particular in X-ray imaging and to contrast media containing such compounds.
摘要翻译：本发明涉及含有中心任选取代的环己烷中心部分的含碘化合物，其允许与其结合的三个碘化苯基的排列。本发明还涉及这种诊断组合物作为造影剂在诊断成像中的用途，特别是在X射线成像中以及含有这种化合物的造影剂的用途。

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