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1. 发明申请

WO2009127715A1 COMPOUNDS COMPRISING PARAMAGNETIC CHELATES ARRANGED AROUND A CENTRAL CORE AND THEIR USE IN MAGNETO RESONANCE IMAGING AND SPECTROSCOPY 审中-公开
标题翻译：包含在中心核心附近的参考粒子的化合物及其在磁共振成像和光谱中的使用
公开(公告)号：WO2009127715A1
公开(公告)日：2009-10-22
申请号：PCT/EP2009/054579
申请日：2009-04-17
申请人： GE HEALTHCARE AS , MEIJER, Andreas , AXELSSON, Oskar , BRÅTHE, Anders , OLSSON, Andreas , JOHANSEN, John, Henrik , WYNN, Duncan, George
发明人： MEIJER, Andreas , AXELSSON, Oskar , BRÅTHE, Anders , OLSSON, Andreas , JOHANSEN, John, Henrik , WYNN, Duncan, George
IPC分类号： C07F5/00 , C07D257/02 , A61K51/04
CPC分类号： C07D257/02 , A61K49/124
摘要： The present invention relates to novel compounds of formula (I) and (II), compositions comprising compounds of formula (II) and their use as contrast agents in magnetic resonance (MR) imaging (MRI) and MR spectroscopy (MRS).
摘要翻译：本发明涉及式（I）和（II）的新型化合物，包含式（II）化合物的组合物及其作为磁共振（MR）成像（MRI）和MR光谱学（MRS）中的造影剂的用途。

2. 发明申请

WO2007064227A1 MULTIMERIC MAGENTIC RESONANCE CONTRAST AGENTS 审中-公开
标题翻译：多媒体磁共振对比剂
公开(公告)号：WO2007064227A1
公开(公告)日：2007-06-07
申请号：PCT/NO2006/000450
申请日：2006-12-01
申请人： GE HEALTHCARE AS , AXELSSON, Oskar , JOHANNESSON, Haukur , MEIJER, Andreas , OLSSON, Andreas , STÅHLBERG, Tim , THANING, Mikkel , WYNN, Duncan , BRÅTHE, Anders
发明人： AXELSSON, Oskar , JOHANNESSON, Haukur , MEIJER, Andreas , OLSSON, Andreas , STÅHLBERG, Tim , THANING, Mikkel , WYNN, Duncan , BRÅTHE, Anders
IPC分类号： C07D403/12 , C07D257/02 , A61K49/12
CPC分类号： C07D403/12 , C07D257/02
摘要： The present invention relates to novel compounds of formula (I) and (II), compositions comprising compounds of formula (II) and their use as contrast agents in magnetic resonance (MR) imaging (MRI) and MR spectroscopy (MRS).
摘要翻译：本发明涉及式（I）和（II）的新型化合物，包含式（II）化合物的组合物及其作为磁共振（MR）成像（MRI）和MR光谱学（MRS）中的造影剂的用途。

3. 发明申请

WO2007111514A1 CONTRAST AGENTS FOR MAGNETIC RESONANCE IMAGING AND SPECTROSCOPY CONSISTING OF A CYCLIC OLIGOAMID CORE OF 3 TO 4 IDENTICAL MONOMER UNITS WITH 3 TO 4 PARAMAGNETIC CHELATE SIDE CHAINS 审中-公开
标题翻译：具有3至4个参考火焰侧链的3至4个标识单元的环状共轭成像和光谱学的对比剂
公开(公告)号：WO2007111514A1
公开(公告)日：2007-10-04
申请号：PCT/NO2006/000448
申请日：2006-12-01
申请人： GE HEALTHCARE AS , AXELSSON, Oskar , CUTHBERTSON, Alan , MEIJER, Andreas
发明人： AXELSSON, Oskar , CUTHBERTSON, Alan , MEIJER, Andreas
IPC分类号： C07D487/22 , A61K31/555 , A61P43/00
CPC分类号： C07D487/22 , C07D471/22 , C07D498/22
摘要： The present invention relates to: Compounds of formula (I) consisting of a cyclic polymer core A and groups -L-X attached to said core A-(L-X) n (I) wherein A denotes a cyclic polymer which is comprised of 3 or 4 identical monomers which are connected by amide bonds; L may be present or not and if present is that same or different and denotes a linker moiety, X is the same or different and denotes a chelator; and n denotes an integer of 3 or 4; Compound of formula (II) consisting of a cyclic polymer core A and groups -L-X' attached to said core A-(L-X’) n (H) wherein A denotes a cyclic polymer which is comprised of 3 or 4 identical monomers which are connected by amide bonds; L may be present or not and if present is that same or different and denotes a linker moiety, X is the same or different and denotes a paramagnetic chelate consisting of a chelator X and a paramagnetic metal ion M; and n denotes an integer of 3 or 4; And compositions comprising compounds of formula (II) and their use as contrast agents in magnetic resonance (MR) imaging (MRI) and magnetic resonance spectroscopy (MRS).
摘要翻译：本发明涉及：由环状聚合物核A和与所述核A-（LX）n（I）连接的基团-LX组成的式（I）化合物，其中A表示环状聚合物，由通过酰胺键连接的3或4个相同的单体组成; L可以存在或不存在，如果存在相同或不同，并且表示连接体部分，X相同或不同，表示螯合剂; n表示3或4的整数; （II）的化合物，其由环状聚合物核心A和与所述核心部分（L-X'）n（H）连接的基团-LX'组成，其中A表示包含的环状聚合物通过酰胺键连接的3或4个相同的单体; L可以存在或不存在，如果存在相同或不同，并且表示连接体部分，X相同或不同，表示由螯合剂X和顺磁性金属离子M组成的顺磁性螯合物; n表示3或4的整数; 和包含式（II）化合物的组合物及其作为磁共振（MR）成像（MRI）和磁共振光谱（MRS）中的造影剂的用途。

4. 发明申请

WO2011073371A1 MANGANESE CHELATES AND THEIR USE AS CONTRAST AGENTS IN MAGNETIC RESONANCE IMAGING (MRI) 审中-公开
标题翻译：马来西亚辣椒及其作为磁共振成像（MRI）中的对比剂使用
公开(公告)号：WO2011073371A1
公开(公告)日：2011-06-23
申请号：PCT/EP2010/070029
申请日：2010-12-17
申请人： GE HEALTHCARE AS , MEIJER, Andreas
发明人： MEIJER, Andreas
IPC分类号： A61K49/12 , C07D471/08
CPC分类号： A61K49/106 , A61K49/10 , C07D471/04
摘要： The present invention relates to manganese(ll) chelates. The invention also relates to said mangenese(ll) chelates attached to other molecules and their use as contrast agents in magnetic resonance imaging (MRI).
摘要翻译：本发明涉及锰（II）螯合物。本发明还涉及附着于其它分子的所述人类（II）螯合物及其在磁共振成像（MRI）中作为对比剂的用途。

5. 发明申请

WO2021123383A NOVEL MANUFACTURING PROCESS FOR GADOLINIUM COMPLEXES 审中-公开
公开(公告)号：WO2021123383A
公开(公告)日：2021-06-24
申请号：PCT/EP2020/087323
申请日：2020-12-18
申请人： GE HEALTHCARE AS [NO]/[NO]
发明人： THANING, Mikkel , MEIJER, Andreas
IPC分类号： C07D257/02 , A61K49/10 , A61K49/18 , A61K49/108
摘要： The present invention provides a novel method for removal of gadolinium ions from a solution comprising gadolinium complexed with DOTA. The method of the invention is relatively straightforward and cost-efficient compared with known methods.

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