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1. 发明申请

WO2011055944A3 METHODS FOR TREATING FIBROMYALGIA SYNDROME 审中-公开
标题翻译：治疗纤维瘤综合征的方法
公开(公告)号：WO2011055944A3
公开(公告)日：2011-11-03
申请号：PCT/KR2010007603
申请日：2010-11-01
申请人： SK HOLDINGS CO LTD , LEE SUNG JAMES , MELNICK SUSAN MARIE
发明人： LEE SUNG JAMES , MELNICK SUSAN MARIE
IPC分类号： A61K31/137 , A61K31/195 , A61K31/223 , A61P21/00 , A61P25/00 , A61P25/02
CPC分类号： C07C271/08 , A61K31/137 , A61K31/223 , A61K31/27
摘要： The invention is directed to a method of treating fibromyalgia syndrome in a subject, comprising administering a therapeutically effective amount of a carbamoyl compound, or pharmaceutically acceptable salt thereof.
摘要翻译：本发明涉及在受试者中治疗纤维肌痛综合征的方法，其包括施用治疗有效量的氨基甲酰基化合物或其药学上可接受的盐。

2. 发明申请

WO2009148291A2 3- OR 4-SUBSTITUTED PIPERIDINE COMPOUNDS 审中-公开
标题翻译： 3-或4-取代的哌啶化合物
公开(公告)号：WO2009148291A2
公开(公告)日：2009-12-10
申请号：PCT/KR2009003042
申请日：2009-06-05
申请人： SK HOLDINGS CO LTD , LEE KI-HO , PARK CHUN-EUNG , MIN KYUNG-HYUN , SHIN YONG-JE , SHIN YU-JIN , YOON HAE-JEONG , KIM WON , RYU EUN-JU
发明人： LEE KI-HO , PARK CHUN-EUNG , MIN KYUNG-HYUN , SHIN YONG-JE , SHIN YU-JIN , YOON HAE-JEONG , KIM WON , RYU EUN-JU
IPC分类号： C07D257/04 , A61K31/445 , C07D257/02
CPC分类号： C07D401/06 , C07D409/14
摘要： There are disclosed racemic or enantiomerically enriched 3- or 4-substituted piperidine compounds represented by the following structural formula (I) or any of their isomers, or pharmaceutically acceptable salts thereof. Also disclosed are pharmaceutical compositions containing the subject compounds. The subject compounds are useful for the treatment of diseases of the central nervous system, particularly depression, anxiety and pain disorder.
摘要翻译：公开了由以下结构式（I）表示的外消旋或对映体富集的3-或4-取代的哌啶化合物或其任何异构体或其药学上可接受的盐。还公开了含有本发明化合物的药物组合物。本发明化合物可用于治疗中枢神经系统疾病，特别是抑郁症，焦虑和疼痛障碍。

3. 发明申请

WO2009145590A2 PHENYL PIPERAZINE COMPOUNDS, PHARMACEUTICAL COMPOSITION COMPRISING THE SAME, AND USE THEREOF 审中-公开
标题翻译：苯基哌嗪化合物，包含其的药物组合物及其用途
公开(公告)号：WO2009145590A2
公开(公告)日：2009-12-03
申请号：PCT/KR2009002880
申请日：2009-05-29
申请人： SK HOLDINGS CO LTD , KIM YONGGIL , LEE KIHO , CHO NAHMRYUNE , YOO JIN UK , HEO JOON , RYU CHOONHO , DONG SEONMIN , CHA MAN-YOUNG , CHOI JONG GIL , KIM YUNHEE , JI MI KYUNG
发明人： KIM YONGGIL , LEE KIHO , CHO NAHMRYUNE , YOO JIN UK , HEO JOON , RYU CHOONHO , DONG SEONMIN , CHA MAN-YOUNG , CHOI JONG GIL , KIM YUNHEE , JI MI KYUNG
IPC分类号： C07D241/12 , A61K31/496 , A61P21/00 , C07D241/04
CPC分类号： C07D295/088 , C07D295/096
摘要： The present invention relates to a novel piperazine derivative or pharmaceutically acceptable salt thereof, a process for preparing the same, a pharmaceutical composition for treating central nervous system diseases comprising an effective amount of the piperazine compound and a method of treating central nervous system (CNS) disorder such as psychosis in a mammal.
摘要翻译：本发明涉及一种新的哌嗪衍生物或其药学上可接受的盐，其制备方法，用于治疗中枢神经系统疾病的药物组合物，其包含有效量的哌嗪化合物和治疗中枢神经系统（CNS）的方法，疾病如精神病在哺乳动物中。

4. 发明申请

WO2009139589A3 TRANSNASAL ANTICONVULSIVE PHARMACEUTICAL COMPOSITION COMPRISING POORLY SOLUBLE ANTICONVULSANT 审中-公开
公开(公告)号：WO2009139589A3
公开(公告)日：2009-11-19
申请号：PCT/KR2009/002567
申请日：2009-05-14
申请人： SK HOLDINGS CO., LTD. , BAEK, Myoung-Ki , JO, Jae-Hoon , CHANG, Hye-Jin
发明人： BAEK, Myoung-Ki , JO, Jae-Hoon , CHANG, Hye-Jin
IPC分类号： A61K9/08 , A61K31/5513 , A61K31/19 , A61K31/325 , A61P25/08
摘要： There is provided a transnasal anticonvulsive pharmaceutical composition including a poorly soluble anticonvulsant. The anticonvulsive pharmaceutical composition comprising a poorly soluble anticonvulsant as an active component, which is transnasally spray- administered, comprises diethylene glycol monoethyl ether and fatty acid ester, wherein the fatty acid ester is selected from the group consisting of caprylocaproyl polyoxylglyceride, isopropyl palmitate, oleoyl polyoxylglyceride, sorbitan monolaurate 20, methyl laurate, ethyl laurate, and polysorbate 20. Also, the anticonvulsive pharmaceutical composition comprising a poorly soluble anticonvulsant as an active component, which is transnasally spray-administered, comprises diethylene glycol monoethyl ether, fatty acid ester, methylpyrrolidone, water and alcohol. Therefore, the transnasal anticonvulsive pharmaceutical composition may be useful to highly enhance the bioavailability of the poorly soluble anticonvulsant. Also, the transnasal anticonvulsive pharmaceutical composition may be useful to allow the poorly soluble anticonvulsant to show the improved viscosity and/or enhanced solubility in order to effectively deliver the poorly soluble anticonvulsant at a therapeutic dose.

5. 发明申请

WO2009139589A2 TRANSNASAL ANTICONVULSIVE PHARMACEUTICAL COMPOSITION COMPRISING POORLY SOLUBLE ANTICONVULSANT 审中-公开
标题翻译：包含不良溶解性物质的跨药物药物组合物
公开(公告)号：WO2009139589A2
公开(公告)日：2009-11-19
申请号：PCT/KR2009002567
申请日：2009-05-14
申请人： SK HOLDINGS CO LTD , BAEK MYOUNG-KI , JO JAE-HOON , CHANG HYE-JIN
发明人： BAEK MYOUNG-KI , JO JAE-HOON , CHANG HYE-JIN
IPC分类号： A61K9/08
CPC分类号： A61K31/5513 , A61K9/0043 , A61K47/26 , A61K47/44
摘要： There is provided a transnasal anticonvulsive pharmaceutical composition including a poorly soluble anticonvulsant. The anticonvulsive pharmaceutical composition comprising a poorly soluble anticonvulsant as an active component, which is transnasally spray- administered, comprises diethylene glycol monoethyl ether and fatty acid ester, wherein the fatty acid ester is selected from the group consisting of caprylocaproyl polyoxylglyceride, isopropyl palmitate, oleoyl polyoxylglyceride, sorbitan monolaurate 20, methyl laurate, ethyl laurate, and polysorbate 20. Also, the anticonvulsive pharmaceutical composition comprising a poorly soluble anticonvulsant as an active component, which is transnasally spray-administered, comprises diethylene glycol monoethyl ether, fatty acid ester, methylpyrrolidone, water and alcohol. Therefore, the transnasal anticonvulsive pharmaceutical composition may be useful to highly enhance the bioavailability of the poorly soluble anticonvulsant. Also, the transnasal anticonvulsive pharmaceutical composition may be useful to allow the poorly soluble anticonvulsant to show the improved viscosity and/or enhanced solubility in order to effectively deliver the poorly soluble anticonvulsant at a therapeutic dose.
摘要翻译：提供了包含难溶性抗惊厥药的经鼻抗惊厥药物组合物。包含作为经鼻喷雾给药的作为活性成分的难溶性抗惊厥药的抗惊厥药物组合物包含二甘醇单乙醚和脂肪酸酯，其中脂肪酸酯选自辛酰己酰基聚氧乙烯甘油酯，棕榈酸异丙酯，油酰基聚氧乙烯甘油酯，脱水山梨糖醇单月桂酸酯20，月桂酸甲酯，月桂酸乙酯和聚山梨酸酯20.此外，通过经鼻喷雾给药的包含作为活性成分的难溶性抗惊厥药的抗惊厥药物组合物包括二甘醇单乙醚，脂肪酸酯，甲基吡咯烷酮，水和酒精。因此，经鼻抗惊厥药物组合物可用于高度增强难溶性抗惊厥药的生物利用度。此外，经鼻抗惊厥药物组合物可用于使难溶性抗惊厥药显示出改善的粘度和/或增加的溶解性，以有效递送治疗剂量下的难溶性抗惊厥药。

6. 发明申请

WO2011055965A3 METHODS FOR TREATING ATTENTION-DEFICIT/HYPERACTIVITY DISORDER 审中-公开
标题翻译：治疗注意力缺陷/过度活动障碍的方法
公开(公告)号：WO2011055965A3
公开(公告)日：2011-10-20
申请号：PCT/KR2010007698
申请日：2010-11-03
申请人： SK HOLDINGS CO LTD , LEE SUNG JAMES , MELNICK SUSAN MARIE
发明人： LEE SUNG JAMES , MELNICK SUSAN MARIE
IPC分类号： A61K31/137 , A61K31/13 , A61P25/00 , A61P25/14
CPC分类号： C07C271/12 , A61K31/27
摘要： The invention is directed to a method of treating attention-deficit/hyperactivity disorder (ADHD) in a subject, comprising administering a therapeutically effective amount of a carbamoyl compound, or pharmaceutically acceptable salt thereof.
摘要翻译：本发明涉及治疗受试者的注意力不集中/多动症（ADHD）的方法，其包括施用治疗有效量的氨基甲酰基化合物或其药学上可接受的盐。

7. 发明申请

WO2011005473A9 METHODS FOR TREATING OR PREVENTING FATIGUE 审中-公开
标题翻译：治疗或预防疲劳的方法
公开(公告)号：WO2011005473A9
公开(公告)日：2011-05-12
申请号：PCT/US2010039313
申请日：2010-06-21
申请人： SK HOLDINGS CO LTD , KHAYRALLAH MOISE A , BREAM GARY , BUTTS STEPHEN E , MELNICK SUSAN MARIE , TAYLOR DUNCAN
发明人： KHAYRALLAH MOISE A , BREAM GARY , BUTTS STEPHEN E , MELNICK SUSAN MARIE , TAYLOR DUNCAN
IPC分类号： A61K31/175 , A61K31/137 , A61P35/00 , A61P43/00
CPC分类号： A61K31/27 , A61K31/137 , A61K31/175 , A61K45/06 , C07C271/20 , A61K2300/00

8. 发明申请

WO2010150995A3 COMPOSITIONS FOR TREATING DRUG ADDICTION AND IMPROVING ADDICTION-RELATED BEHAVIOR 审中-公开
标题翻译：用于治疗药物滥用和改善与药物相关的行为的组合物
公开(公告)号：WO2010150995A3
公开(公告)日：2011-04-28
申请号：PCT/KR2010003742
申请日：2010-06-10
申请人： SK HOLDINGS CO LTD , LEE SUNG JAMES , MELNICK SUSAN MARIE
发明人： LEE SUNG JAMES , MELNICK SUSAN MARIE
IPC分类号： A61K31/137 , A61K31/223 , A61K31/4965 , A61K31/5375 , A61P25/00 , A61P25/30
CPC分类号： A61K31/165 , A61K31/167 , A61K31/40 , A61K31/4453 , A61K31/495 , A61K31/5375
摘要： The invention is directed to a composition, a use of the composition and a method of treating addiction to drugs of abuse in a subject, wherein the composition comprises a cabamoyl compound, or pharmaceutically acceptable salt or ester thereof as an active ingredient, and the method comprises administering a therapeutically effective amount of a cabamoyl compound, or pharmaceutically acceptable salt or ester thereof.
摘要翻译：本发明涉及一种组合物，该组合物的用途和一种治疗受试者滥用药物成瘾的方法，其中所述组合物包含作为有效成分的天花酰氨基化合物或其药学上可接受的盐或酯，该方法包括施用治疗有效量的氨甲酰基化合物或其药学上可接受的盐或酯。

9. 发明申请

WO2010150995A2 COMPOSITIONS FOR TREATING DRUG ADDICTION AND IMPROVING ADDICTION-RELATED BEHAVIOR 审中-公开
标题翻译：用于治疗药物滥用和改善与药物相关的行为的组合物
公开(公告)号：WO2010150995A2
公开(公告)日：2010-12-29
申请号：PCT/KR2010/003742
申请日：2010-06-10
申请人： SK HOLDINGS CO., LTD. , LEE, Sung James , MELNICK, Susan, Marie
发明人： LEE, Sung James , MELNICK, Susan, Marie
IPC分类号： A61K31/137 , A61K31/223 , A61K31/5375 , A61K31/4965 , A61P25/30 , A61P25/00
CPC分类号： A61K31/165 , A61K31/167 , A61K31/40 , A61K31/4453 , A61K31/495 , A61K31/5375
摘要： The invention is directed to a composition, a use of the composition and a method of treating addiction to drugs of abuse in a subject, wherein the composition comprises a cabamoyl compound, or pharmaceutically acceptable salt or ester thereof as an active ingredient, and the method comprises administering a therapeutically effective amount of a cabamoyl compound, or pharmaceutically acceptable salt or ester thereof.
摘要翻译：本发明涉及一种组合物，该组合物的用途和一种治疗受试者滥用药物成瘾的方法，其中所述组合物包含作为有效成分的天花酰氨基化合物或其药学上可接受的盐或酯，该方法包括施用治疗有效量的氨甲酰基化合物或其药学上可接受的盐或酯。

10. 发明申请

WO2010044585A2 PIPERIDINE COMPOUNDS, PHARMACEUTICAL COMPOSITION COMPRISING THE SAME AND ITS USE 审中-公开
标题翻译：哌啶化合物，包含其的药物组合物及其用途
公开(公告)号：WO2010044585A2
公开(公告)日：2010-04-22
申请号：PCT/KR2009/005863
申请日：2009-10-13
申请人： SK HOLDINGS CO., LTD. , CHUNG, Coo-Min , JUN, Hyung-Jin , KIM, Jin-Sung , KIM, Hui-Ho , MIN, Hye-Kyung , KIM, Yong-Gil , CHOI, Jong-Gil , KIM, Hongwook
发明人： CHUNG, Coo-Min , JUN, Hyung-Jin , KIM, Jin-Sung , KIM, Hui-Ho , MIN, Hye-Kyung , KIM, Yong-Gil , CHOI, Jong-Gil , KIM, Hongwook
IPC分类号： C07D401/12 , C07D403/12 , C07D235/06 , C07D235/04 , A61K31/435 , A61K31/415 , A61P1/04 , A61P1/00 , A61P35/00
CPC分类号： C07D409/06 , A61K31/445 , C07D211/26 , C07D401/06 , C07D401/12
摘要： Piperidine compounds and pharmaceutically useful salts thereof, a pharmaceutical composition including an effective amount of the racemic or enantiomerically enriched piperidine compounds to treat gastrointestinal diseases, and a method of treating gastrointestinal diseases in a mammal are provided.
摘要翻译：提供哌啶化合物及其药学上有用的盐，包括有效量的外消旋或对映异构体富集的哌啶化合物以治疗胃肠道疾病的药物组合物，以及哺乳动物治疗胃肠道疾病的方法。

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