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1. 发明申请

WO2011103069A1 DEVICES AND METHODS FOR LOW SHEARING LOCAL DELIVERY OF THERAPEUTIC AGENTS TO THE WALL OF A BODILY LUMEN 审中-公开
标题翻译：治疗方法低剂量局部输送给身体壁的设备和方法
公开(公告)号：WO2011103069A1
公开(公告)日：2011-08-25
申请号：PCT/US2011/024839
申请日：2011-02-15
申请人： CARDIOVASCULAR SYSTEMS, INC. , SCHOENLE, Victor Leo , WELTY, Ryan, D. , TIBESAR JENSEN, Kristina , PIIPPO SVENDSEN, Cassandra Ann , MCBROOM, Jeffrey, A.
发明人： SCHOENLE, Victor Leo , WELTY, Ryan, D. , TIBESAR JENSEN, Kristina , PIIPPO SVENDSEN, Cassandra Ann , MCBROOM, Jeffrey, A.
IPC分类号： A61M25/10
CPC分类号： A61M25/1011 , A61M25/0029 , A61M25/0662 , A61M25/104 , A61M2025/0018 , A61M2025/0681 , A61M2025/1013 , A61M2025/105
摘要： The invention relates generally to devices and methods for local delivery of therapeutic agents to the wall of a bodily lumen with minimal shearing damage to the therapeutic agents, more specifically to the wall of a blood vessel following atherectomy. A preferred delivery mechanism comprises a balloon, or double balloon, though any distal catheter design may be used to reduce shear stress and to conserve and/or isolate the therapeutic substance.
摘要翻译：本发明一般涉及用于将治疗剂局部递送到体腔壁的装置和方法，其具有对治疗剂的最小的剪切损伤，更具体地涉及粥样斑块切除术后的血管壁。优选的输送机构包括球囊或双气囊，尽管任何远端导管设计可用于降低剪切应力并保护和/或分离治疗物质。

2. 发明申请

WO2011103115A1 THERAPEUTIC AGENT DELIVERY SYSTEM, DEVICE AND METHOD FOR LOCALIZED APPLICATION OF THERAPEUTIC SUBSTANCES TO A BIOLOGICAL CONDUIT 审中-公开
标题翻译：治疗药物递送系统，用于将治疗性物质局部应用于生物系统的装置和方法
公开(公告)号：WO2011103115A1
公开(公告)日：2011-08-25
申请号：PCT/US2011/024974
申请日：2011-02-16
申请人： CARDIOVASCULAR SYSTEMS, INC. , SCHOENLE, Victor Leo , DOBROVOLNY, Walter John , SCHNABEL, Rainer
发明人： SCHOENLE, Victor Leo , DOBROVOLNY, Walter John , SCHNABEL, Rainer
IPC分类号： A61B17/22
CPC分类号： A61B17/320758 , A61B17/320725 , A61B2017/22054 , A61B2017/22061 , A61B2017/22069 , A61B2017/22082 , A61B2017/320733
摘要： The invention provides a system, device and method for localized application of therapeutic substances within a biological conduit after the lumen wall has been scored by an eccentric scoring head. One embodiment comprises radial scoring with the eccentric scoring head, with a therapeutic agent coated balloon inflated distal to the scoring and dragged proximally through the scoring. Another embodiment comprises inflation of two anchor balloons on either side of scoring with subsequent inflation of a therapeutic agent coated balloon therebetween which causes the distance between anchor balloons to increase, thus stretching the scoring crevices while applying the agent therein with subsequent closure of crevices on deflation of anchor and application balloons. Another embodiment comprises an inflated anchor balloon with a threaded scoring device wherein the scoring members are coated with agent and rotation of the threaded device enables travel in the proximal direction away from anchor balloon.
摘要翻译：本发明提供了一种在通过偏心评分头对管腔壁进行刻痕之后将生物导管内的治疗物质局部应用的系统，装置和方法。一个实施例包括具有偏心评分头的径向刻痕，治疗剂涂覆的球囊在评分的远侧膨胀并且通过评分向近侧拖动。另一个实施例包括在评分的任一侧上两个锚定气囊的膨胀，随后在其间涂覆有治疗剂的球囊随后膨胀，导致锚定气球之间的距离增加，从而拉伸评分裂缝，同时在其中施加试剂，随后在通气闭合缝隙的锚和应用气球。另一个实施例包括具有螺纹刻痕装置的充气锚定球囊，其中刻划部件被涂覆有试剂并且螺纹装置的旋转使得能够沿近端方向远离锚定气球。

3. 发明申请

WO2011041010A3 ROTATIONAL ATHERECTOMY DEVICE WITH FRICTIONAL CLUTCH HAVING MAGNETIC NORMAL FORCE 审中-公开
标题翻译：具有磁性正常力的摩擦离合器的旋转自行车装置
公开(公告)号：WO2011041010A3
公开(公告)日：2012-04-12
申请号：PCT/US2010041787
申请日：2010-07-13
申请人： CARDIVASCULAR SYSTEMS , GRUBAC VLADIMIR , DOBROVOLNY WALTER JOHN , SCHOENLE VICTOR LEO
发明人： GRUBAC VLADIMIR , DOBROVOLNY WALTER JOHN , SCHOENLE VICTOR LEO
IPC分类号： A61B17/22
CPC分类号： A61B17/320758 , A61B17/3207 , A61B2017/00398 , A61B2017/00477 , A61B2017/00858 , A61B2017/00876 , A61B2017/320766
摘要： An atherectomy device is disclosed, with a clutch between the motor and the drive shaft. The clutch includes two plates that rely on frictional to transmit torque from one plate to the other. The clutch has an attractive magnetic normal force that holds the plates together. For relatively low torques, as is the case during normal use, a static frictional torque holds the plates together, and the plates spin together without slipping. For relatively high torques, as occurs when the distal end of the drive shaft encounters an obstacle and stops abruptly, the high torque exceeds the maximum possible static frictional torque, and the plates slip. When slipping, the plates transmit a kinetic frictional torque that is low enough to avoid damage to the patient or to the atherectomy device. In some cases, the torque levels associated with a stoppage of the drive shaft distal end are chosen to mimic those of a known atherectomy device, in which a gas-driven turbine is clutchlessly attached to the drive shaft.
摘要翻译：公开了一种粥样斑块切除装置，其中电动机和驱动轴之间具有离合器。离合器包括依靠摩擦从两个板向另一个板传递扭矩的两个板。离合器具有吸引力的法向力，将板保持在一起。对于相对较低的扭矩，如正常使用情况下，静摩擦转矩将板保持在一起，并且板旋转在一起而不滑动。对于相对较高的扭矩，当驱动轴的远端遇到障碍物而突然停止时，高扭矩超过最大可能的静摩擦转矩，并且板滑动。当滑动时，板传递足够低的动力学摩擦转矩，以避免对患者或动脉粥样硬化切除装置造成伤害。在一些情况下，与驱动轴远端的停止相关联的扭矩水平被选择为模拟已知的粥样斑块切除装置的扭矩水平，其中气体驱动涡轮机无离子地附接到驱动轴。

4. 发明申请

WO2011103384A1 SYSTEMS AND METHODS FOR MIXING THERAPEUTIC AGENTS BEFORE AND/OR DURING ADMINISTRATION 审中-公开
标题翻译：在管理和/或管理之前混合治疗药物的系统和方法
公开(公告)号：WO2011103384A1
公开(公告)日：2011-08-25
申请号：PCT/US2011/025379
申请日：2011-02-18
申请人： CARDIOVASCULAR SYSTEMS, INC. , SCHOENLE, Victor Leo , PIIPPO SVENDSEN, Cassandra Ann , TIBESAR JENSEN, Kristina , ORESCHNICK, Mark B. , BORRELL, Alyson M.
发明人： SCHOENLE, Victor Leo , PIIPPO SVENDSEN, Cassandra Ann , TIBESAR JENSEN, Kristina , ORESCHNICK, Mark B. , BORRELL, Alyson M.
IPC分类号： A61M37/00
CPC分类号： A61M5/31596 , A61M2025/0004 , B01F11/0054 , B01F13/0023 , B01F13/0818 , B01F15/0279
摘要： The invention provides systems and methods for mixing of therapeutic agents before and/or during the localized application of the therapeutic agents. Most preferably, the present invention provides systems and methods for mixing of therapeutic agents before and/or during administration of the agents within a biological lumen. Various embodiments of the present invention comprise systems and methods for inducing a mixing state in the therapeutic agents, thereby inducing and/or maintaining homogeneity of the agents before and/or during localized delivery.
摘要翻译：本发明提供了在治疗剂的局部应用之前和/或期间混合治疗剂的系统和方法。最优选地，本发明提供在药物在生物管腔内施用之前和/或期间混合治疗剂的系统和方法。本发明的各种实施方案包括用于在治疗剂中诱导混合状态的系统和方法，从而在局部递送之前和/或期间诱导和/或维持试剂的均匀性。

5. 发明申请

WO2011103112A1 THERAPEUTIC AGENT DELIVERY SYSTEM, DEVICE AND METHOD FOR LOCALIZED APPLICATION OF THERAPEUTIC SUBSTANCES TO A BIOLOGICAL CONDUIT 审中-公开
标题翻译：治疗药物递送系统，用于将治疗性物质局部应用于生物系统的装置和方法
公开(公告)号：WO2011103112A1
公开(公告)日：2011-08-25
申请号：PCT/US2011/024967
申请日：2011-02-16
申请人： CARDIOVASCULAR SYSTEMS, INC. , SCHOENLE, Victor, Leo , RIVERS, Jody, Lee , DARLEY, Jesse, C.
发明人： SCHOENLE, Victor, Leo , RIVERS, Jody, Lee , DARLEY, Jesse, C.
IPC分类号： A61B17/22
CPC分类号： A61B17/320758 , A61B2017/320004 , A61B2017/320766 , A61M11/006 , A61M2025/105 , A61M2205/103
摘要： The invention provides a system, device and method for localized application of therapeutic substances within a biological conduit. One embodiment comprises a rotational atherectomy device having a flexible, elongated, rotatable, drive shaft having a lumen and with an eccentric enlarged abrading head having at least one application hole attached therethrough and in communication with a therapeutic agent delivery sheath and an operator-controlled actuator. The therapeutic substances may then spray radially outwardly from the application hole(s) on the eccentric abrading head during and/or after high-speed rotation of the head. Another embodiment comprises compartments in the abrading head that hold therapeutic agent(s) for release during high-speed rotation. In each case, the therapeutic substance(s) is delivered with radial forces resulting from high-speed orbital rotation of the eccentric abrading head, driving the therapeutic substance(s) into the conduit wall.
摘要翻译：本发明提供了一种用于在生物导管内局部应用治疗物质的系统，装置和方法。一个实施例包括具有柔性，细长的，可旋转的驱动轴的旋转粥样斑块切除装置，所述驱动轴具有内腔和具有附接穿过其中的至少一个施加孔并与治疗剂输送护套和操作者控制致动器连通的偏心扩大研磨头。然后，治疗物质可以在头部高速旋转期间和/或之后从偏心研磨头上的施加孔径向向外喷射。另一个实施例包括在高速旋转期间保持用于释放的治疗剂的研磨头中的隔室。在每种情况下，治疗物质以由偏心研磨头的高速轨道旋转产生的径向力输送，将治疗物质驱动到导管壁中。

6. 发明申请

WO2011041010A2 ROTATIONAL ATHERECTOMY DEVICE WITH FRICTIONAL CLUTCH HAVING MAGNETIC NORMAL FORCE 审中-公开
标题翻译：具有磁性正常力的摩擦离合器的旋转式自动装置
公开(公告)号：WO2011041010A2
公开(公告)日：2011-04-07
申请号：PCT/US2010/041787
申请日：2010-07-13
申请人： CARDIOVASCULAR SYSTEMS, INC. , GRUBAC, Vladimir , DOBROVOLNY, Walter, John , SCHOENLE, Victor, Leo
发明人： GRUBAC, Vladimir , DOBROVOLNY, Walter, John , SCHOENLE, Victor, Leo
IPC分类号： A61B17/22
CPC分类号： A61B17/320758 , A61B17/3207 , A61B2017/00398 , A61B2017/00477 , A61B2017/00858 , A61B2017/00876 , A61B2017/320766
摘要： An atherectomy device is disclosed, with a clutch between the motor and the drive shaft. The clutch includes two plates that rely on frictional to transmit torque from one plate to the other. The clutch has an attractive magnetic normal force that holds the plates together. For relatively low torques, as is the case during normal use, a static frictional torque holds the plates together, and the plates spin together without slipping. For relatively high torques, as occurs when the distal end of the drive shaft encounters an obstacle and stops abruptly, the high torque exceeds the maximum possible static frictional torque, and the plates slip. When slipping, the plates transmit a kinetic frictional torque that is low enough to avoid damage to the patient or to the atherectomy device. In some cases, the torque levels associated with a stoppage of the drive shaft distal end are chosen to mimic those of a known atherectomy device, in which a gas-driven turbine is clutchlessly attached to the drive shaft.
摘要翻译：公开了一种粥样斑块切除装置，其中电动机和驱动轴之间具有离合器。离合器包括两个依靠摩擦传递扭矩从一个板到另一个板的板。离合器具有吸引力的法向力，将板保持在一起。对于相对较低的扭矩，如正常使用情况下，静摩擦转矩将板保持在一起，并且板旋转在一起而不滑动。对于相对较高的扭矩，当驱动轴的远端遇到障碍物而突然停止时，高扭矩超过最大可能的静摩擦转矩，并且板滑动。当滑动时，板传递足够低的动力学摩擦转矩，以避免对患者或粥样斑块切除装置造成伤害。在一些情况下，与驱动轴远端的停止相关联的扭矩水平被选择为模拟已知的粥样斑块切除装置的扭矩水平，其中气体驱动涡轮机无离子地附接到驱动轴。

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