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1. 发明申请

WO2011103115A1 THERAPEUTIC AGENT DELIVERY SYSTEM, DEVICE AND METHOD FOR LOCALIZED APPLICATION OF THERAPEUTIC SUBSTANCES TO A BIOLOGICAL CONDUIT 审中-公开
标题翻译：治疗药物递送系统，用于将治疗性物质局部应用于生物系统的装置和方法
公开(公告)号：WO2011103115A1
公开(公告)日：2011-08-25
申请号：PCT/US2011/024974
申请日：2011-02-16
申请人： CARDIOVASCULAR SYSTEMS, INC. , SCHOENLE, Victor Leo , DOBROVOLNY, Walter John , SCHNABEL, Rainer
发明人： SCHOENLE, Victor Leo , DOBROVOLNY, Walter John , SCHNABEL, Rainer
IPC分类号： A61B17/22
CPC分类号： A61B17/320758 , A61B17/320725 , A61B2017/22054 , A61B2017/22061 , A61B2017/22069 , A61B2017/22082 , A61B2017/320733
摘要： The invention provides a system, device and method for localized application of therapeutic substances within a biological conduit after the lumen wall has been scored by an eccentric scoring head. One embodiment comprises radial scoring with the eccentric scoring head, with a therapeutic agent coated balloon inflated distal to the scoring and dragged proximally through the scoring. Another embodiment comprises inflation of two anchor balloons on either side of scoring with subsequent inflation of a therapeutic agent coated balloon therebetween which causes the distance between anchor balloons to increase, thus stretching the scoring crevices while applying the agent therein with subsequent closure of crevices on deflation of anchor and application balloons. Another embodiment comprises an inflated anchor balloon with a threaded scoring device wherein the scoring members are coated with agent and rotation of the threaded device enables travel in the proximal direction away from anchor balloon.
摘要翻译：本发明提供了一种在通过偏心评分头对管腔壁进行刻痕之后将生物导管内的治疗物质局部应用的系统，装置和方法。一个实施例包括具有偏心评分头的径向刻痕，治疗剂涂覆的球囊在评分的远侧膨胀并且通过评分向近侧拖动。另一个实施例包括在评分的任一侧上两个锚定气囊的膨胀，随后在其间涂覆有治疗剂的球囊随后膨胀，导致锚定气球之间的距离增加，从而拉伸评分裂缝，同时在其中施加试剂，随后在通气闭合缝隙的锚和应用气球。另一个实施例包括具有螺纹刻痕装置的充气锚定球囊，其中刻划部件被涂覆有试剂并且螺纹装置的旋转使得能够沿近端方向远离锚定气球。

2. 发明申请

WO2011041010A3 ROTATIONAL ATHERECTOMY DEVICE WITH FRICTIONAL CLUTCH HAVING MAGNETIC NORMAL FORCE 审中-公开
标题翻译：具有磁性正常力的摩擦离合器的旋转自行车装置
公开(公告)号：WO2011041010A3
公开(公告)日：2012-04-12
申请号：PCT/US2010041787
申请日：2010-07-13
申请人： CARDIVASCULAR SYSTEMS , GRUBAC VLADIMIR , DOBROVOLNY WALTER JOHN , SCHOENLE VICTOR LEO
发明人： GRUBAC VLADIMIR , DOBROVOLNY WALTER JOHN , SCHOENLE VICTOR LEO
IPC分类号： A61B17/22
CPC分类号： A61B17/320758 , A61B17/3207 , A61B2017/00398 , A61B2017/00477 , A61B2017/00858 , A61B2017/00876 , A61B2017/320766
摘要： An atherectomy device is disclosed, with a clutch between the motor and the drive shaft. The clutch includes two plates that rely on frictional to transmit torque from one plate to the other. The clutch has an attractive magnetic normal force that holds the plates together. For relatively low torques, as is the case during normal use, a static frictional torque holds the plates together, and the plates spin together without slipping. For relatively high torques, as occurs when the distal end of the drive shaft encounters an obstacle and stops abruptly, the high torque exceeds the maximum possible static frictional torque, and the plates slip. When slipping, the plates transmit a kinetic frictional torque that is low enough to avoid damage to the patient or to the atherectomy device. In some cases, the torque levels associated with a stoppage of the drive shaft distal end are chosen to mimic those of a known atherectomy device, in which a gas-driven turbine is clutchlessly attached to the drive shaft.
摘要翻译：公开了一种粥样斑块切除装置，其中电动机和驱动轴之间具有离合器。离合器包括依靠摩擦从两个板向另一个板传递扭矩的两个板。离合器具有吸引力的法向力，将板保持在一起。对于相对较低的扭矩，如正常使用情况下，静摩擦转矩将板保持在一起，并且板旋转在一起而不滑动。对于相对较高的扭矩，当驱动轴的远端遇到障碍物而突然停止时，高扭矩超过最大可能的静摩擦转矩，并且板滑动。当滑动时，板传递足够低的动力学摩擦转矩，以避免对患者或动脉粥样硬化切除装置造成伤害。在一些情况下，与驱动轴远端的停止相关联的扭矩水平被选择为模拟已知的粥样斑块切除装置的扭矩水平，其中气体驱动涡轮机无离子地附接到驱动轴。

3. 发明申请

WO2011106053A1 ROTATIONAL ATHERECTOMY DEVICE WITH ELECTRIC MOTOR 审中-公开
标题翻译：带电动马达的旋转自行车装置
公开(公告)号：WO2011106053A1
公开(公告)日：2011-09-01
申请号：PCT/US2010/058286
申请日：2010-11-30
申请人： CARDIOVASCULAR SYSTEMS, INC. , RIVERS, Jody Lee , PLOWE, Charles A. , PIIPPO SVENDSEN, Cassandra Ann , DOBROVOLNY, Walter John , ENG, Michael John , HANSON, Scott M.
发明人： RIVERS, Jody Lee , PLOWE, Charles A. , PIIPPO SVENDSEN, Cassandra Ann , DOBROVOLNY, Walter John , ENG, Michael John , HANSON, Scott M.
IPC分类号： A61B17/3207
CPC分类号： A61B17/320758 , A61B2017/00075 , A61B2017/00199 , A61B2017/320004 , A61B2017/320766 , A61B2090/066
摘要： An atherectomy device is disclosed, which is rotationally driven by an electric motor. In some designs, the device includes features unavailable on gas turbine-driven systems, such as the storing in memory of low/medium/high preset rotation speeds for particular models of handle, calculations of the amount of saline left in the IV and associated warnings when it gets sufficiently low, and automatic adjustment of the IV pump rate to a predetermined or calculated level when the rotational speed of the motor is changed. The electric motor has far more rotational inertia than a comparable gas turbine, so the system includes a control mechanism that helps prevent damage from excessive torque being applied to the distal end of the drive shaft. When an obstruction at the distal end is detected, by a drop in the motor rotational speed, the motor is released and is allowed to spin freely as a flywheel.
摘要翻译：公开了一种由电动机旋转驱动的粥样斑块切除装置。在一些设计中，该装置包括在燃气轮机驱动的系统上不可用的特征，例如存储针对特定型号的手柄的低/中/高预设转速的存储器，IV中留下的盐水量的计算和相关警告当其变得足够低时，并且当电动机的转速改变时，将IV泵速率自动调节到预定或计算的水平。电动机具有比类似的燃气轮机更大的转动惯量，因此该系统包括一个控制机构，该控制机构有助于防止施加到驱动轴远端的过大转矩的损坏。当检测到远端处的障碍物时，通过电动机转速的下降，电动机被释放并被允许作为飞轮自由旋转。

4. 发明申请

WO2011041010A2 ROTATIONAL ATHERECTOMY DEVICE WITH FRICTIONAL CLUTCH HAVING MAGNETIC NORMAL FORCE 审中-公开
标题翻译：具有磁性正常力的摩擦离合器的旋转式自动装置
公开(公告)号：WO2011041010A2
公开(公告)日：2011-04-07
申请号：PCT/US2010/041787
申请日：2010-07-13
申请人： CARDIOVASCULAR SYSTEMS, INC. , GRUBAC, Vladimir , DOBROVOLNY, Walter, John , SCHOENLE, Victor, Leo
发明人： GRUBAC, Vladimir , DOBROVOLNY, Walter, John , SCHOENLE, Victor, Leo
IPC分类号： A61B17/22
CPC分类号： A61B17/320758 , A61B17/3207 , A61B2017/00398 , A61B2017/00477 , A61B2017/00858 , A61B2017/00876 , A61B2017/320766
摘要： An atherectomy device is disclosed, with a clutch between the motor and the drive shaft. The clutch includes two plates that rely on frictional to transmit torque from one plate to the other. The clutch has an attractive magnetic normal force that holds the plates together. For relatively low torques, as is the case during normal use, a static frictional torque holds the plates together, and the plates spin together without slipping. For relatively high torques, as occurs when the distal end of the drive shaft encounters an obstacle and stops abruptly, the high torque exceeds the maximum possible static frictional torque, and the plates slip. When slipping, the plates transmit a kinetic frictional torque that is low enough to avoid damage to the patient or to the atherectomy device. In some cases, the torque levels associated with a stoppage of the drive shaft distal end are chosen to mimic those of a known atherectomy device, in which a gas-driven turbine is clutchlessly attached to the drive shaft.
摘要翻译：公开了一种粥样斑块切除装置，其中电动机和驱动轴之间具有离合器。离合器包括两个依靠摩擦传递扭矩从一个板到另一个板的板。离合器具有吸引力的法向力，将板保持在一起。对于相对较低的扭矩，如正常使用情况下，静摩擦转矩将板保持在一起，并且板旋转在一起而不滑动。对于相对较高的扭矩，当驱动轴的远端遇到障碍物而突然停止时，高扭矩超过最大可能的静摩擦转矩，并且板滑动。当滑动时，板传递足够低的动力学摩擦转矩，以避免对患者或粥样斑块切除装置造成伤害。在一些情况下，与驱动轴远端的停止相关联的扭矩水平被选择为模拟已知的粥样斑块切除装置的扭矩水平，其中气体驱动涡轮机无离子地附接到驱动轴。

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