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1. 发明申请

WO2009117467A3 THERAPEUTIC COMPOUNDS 审中-公开
标题翻译：治疗化合物
公开(公告)号：WO2009117467A3
公开(公告)日：2009-11-12
申请号：PCT/US2009037477
申请日：2009-03-18
申请人： ALLERGAN INC , HOLOBOSKI MARK , BURK ROBERT M , POSNER MARI F
发明人： HOLOBOSKI MARK , BURK ROBERT M , POSNER MARI F
IPC分类号： C07C255/46 , A61K31/557 , A61P17/14 , A61P27/06 , C07C405/00 , C07D265/30 , C07D333/36 , C07D413/12
CPC分类号： C07C255/46 , C07C405/00 , C07C2601/04 , C07C2601/08 , C07D295/088 , C07D333/24 , C07D333/28 , C07D333/38
摘要： Compounds comprising or a pharmaceutically acceptable salt thereof, are disclosed, wherein Y, A, R1, R2, Z and G as described in claims 1-12. Methods, compositions and medicaments related thereto are also disclosed, for treating gloucoma, ocular hypertension, badness, stimulation of hair growth and inflammatory bowel diseases.
摘要翻译：公开了包含其药学上可接受的盐的化合物，其中如权利要求1-12所述的Y，A，R 1，R 2，Z和G。还公开了与其相关的方法，组合物和药物，用于治疗眼球炎，高眼压症，不良，刺激毛发生长和炎性肠病。

2. 发明申请

WO2002089813A3 3, 7 OR 3 AND 7 THIA OR OXA PROSTANOIC ACID DERIVATIVES AS AGENTS FOR LOWERING INTRAOCULAR PRESSURE 审中-公开
公开(公告)号：WO2002089813A3
公开(公告)日：2002-11-14
申请号：PCT/US2002/014331
申请日：2002-05-06
申请人： ALLERGAN, INC. , BURK, Robert, M. , HOLOBOSKI, Mark , POSNER, Mari, F.
发明人： BURK, Robert, M. , HOLOBOSKI, Mark , POSNER, Mari, F.
IPC分类号： A61K31/5575
摘要： The present invention provides a method of treating ocular hypertension or glaucoma which comprises administering to an animal having ocular hypertension or glaucoma therapeutically effective amount of a compound represented by the general formula (I), wherein hatched lines represent the α configuration, a triangle represents the β configuration and a dotted line represents the presence or absence of a double bond; A and B are independently selected from the group consisting of O, S and CH 2 provided that at least one of A or B is S; D represents a covalent bond or CH 2 , O, S or NH; X is CO 2 R, CONR 2 , CH 2 OR, P(O)(OR) 2 , CONRSO 2 R SONR 2 or Y is O, OH, OCOR 2 , halogen or cyano; Z is CH 2 or a covalent bond; R is H or R 2 ; R 1 is H, R 2 , phenyl, or COR 2 ; R 2 is C 1 -C 5 lower alkyl and R 3 is C 1 -C 5 n-alkyl, C 3 -C 7 cycloalkyl, phenyl, furanyl, thienyl, or substituted derivatives thereof, wherein the substituents may be selected from the group consisting of C 1 -C 5 alkyl, halogen, CF 3 , CN, NO 2 , CO 2 R and OR.

3. 发明申请

WO2008073752A3 CYCLOBUTYL DERIVATIVES FOR THE TREATMENT OF GLAUCOMA 审中-公开
标题翻译：用于治疗GLAUCOMA的CYCLOBUTYL衍生物
公开(公告)号：WO2008073752A3
公开(公告)日：2008-10-02
申请号：PCT/US2007086326
申请日：2007-12-04
申请人： ALLERGAN INC , HOLOBOSKI MARK , BURK ROBERT M , POSNER MARI F
发明人： HOLOBOSKI MARK , BURK ROBERT M , POSNER MARI F
IPC分类号： C07C255/46 , A61K31/277 , A61K31/381 , A61P27/06 , C07D333/16 , C07D333/24 , C07D333/28 , C07D333/38
CPC分类号： C07D333/38 , C07C255/46 , C07C2601/04 , C07C2601/08 , C07D333/16 , C07D333/24 , C07D333/28
摘要： Compound having the formula below are disclosed herein:formula (I).Therapeutic methods, compositions, and medicaments related thereto are also disclosed.
摘要翻译：具有下式的化合物在本文中公开：式（I）。还公开了与其相关的治疗方法，组合物和药物。

4. 发明申请

WO2007001671A1 USE OF 3- OR 7-THIA- OR 3 , 7-DITΗIAPR0STEN0IC ACID DERIVATIVES FOR THE TREATMENT OF INFLAMMATORY BOWEL DISEASE 审中-公开
标题翻译：用于治疗炎症性皮肤病的3-或7-三唑或3,7-二硫代吗啉酸衍生物的用途
公开(公告)号：WO2007001671A1
公开(公告)日：2007-01-04
申请号：PCT/US2006/019137
申请日：2006-05-17
申请人： ALLERGAN, INC. , BURK, Robert, M. , HOLOBOSKI, Mark , POSNER, Mari, F. , KEDZIE, Karen, M. , GIL, Daniel, W.
发明人： BURK, Robert, M. , HOLOBOSKI, Mark , POSNER, Mari, F. , KEDZIE, Karen, M. , GIL, Daniel, W.
IPC分类号： A61K31/5575 , A61K31/559 , A61P1/04 , A61P1/06
CPC分类号： A61K31/557 , A61K31/5575 , A61K31/559 , A61K31/675 , A61K45/06 , A61K2300/00
摘要： Disclosed herein is the use of a compound represented by the general formula (I) for the treatment of a mammal suffering from an inflammatory bowel disease; wherein A, B, D, X, Y, Z, R 1 , R 3 , and R 4 are as defined in the specification.
摘要翻译：本文公开了由通式（I）表示的化合物用于治疗患有炎症性肠病的哺乳动物的用途; 其中A，B，D，X，Y，Z，R 1，R 3和R 4如说明书中所定义。

5. 发明申请

WO2006058063A1 2,3,4-SUBSTITUTED-CYCLOPENTANONES AS THERAPEUTIC AGENTS 审中-公开
标题翻译：作为治疗药物的2,3,4-取代的环戊二烯
公开(公告)号：WO2006058063A1
公开(公告)日：2006-06-01
申请号：PCT/US2005/042428
申请日：2005-11-21
申请人： ALLERGAN, INC. , DONDE, Yariv , HOLOBISKI, Mark , POSNER, Mari, F. , BURK, Robert, M. , GARST, Michael, E.
发明人： DONDE, Yariv , HOLOBISKI, Mark , POSNER, Mari, F. , BURK, Robert, M. , GARST, Michael, E.
IPC分类号： C07C405/00 , C07D333/16 , C07D333/62 , A61K31/5575 , A61P27/06
CPC分类号： C07D333/62 , C07C323/52 , C07C405/0033 , C07C2601/08 , C07D333/56
摘要： Disclosed herein are compounds comprising Formula (I), or a pharmaceutically acceptable salt or a prodrug thereof; wherein Y, A, B, J, and E are further described. Methods, compositions, and medicaments related thereto are also disclosed.
摘要翻译：本文公开了包含式（I）的化合物或其药学上可接受的盐或前药; 其中进一步描述Y，A，B，J和E。还公开了与之相关的方法，组合物和药物。

6. 发明申请

WO2009117467A2 THERAPEUTIC COMPOUNDS 审中-公开
标题翻译：治疗化合物
公开(公告)号：WO2009117467A2
公开(公告)日：2009-09-24
申请号：PCT/US2009/037477
申请日：2009-03-18
申请人： ALLERGAN, INC. , HOLOBOSKI, Mark , BURK, Robert, M. , POSNER, Mari, F.
发明人： HOLOBOSKI, Mark , BURK, Robert, M. , POSNER, Mari, F.
IPC分类号： C07C405/00 , C07D265/30 , C07C255/46
CPC分类号： C07C255/46 , C07C405/00 , C07C2601/04 , C07C2601/08 , C07D295/088 , C07D333/24 , C07D333/28 , C07D333/38
摘要： Compounds comprising or a pharmaceutically acceptable salt or a prodrug thereof, are disclosed, wherein Y, A, R 1, R 2, Z, and G are as described. Methods, compositions, and medicaments related thereto are also disclosed.
摘要翻译：公开了包含其药学上可接受的盐或其前药的化合物，其中Y，A，R 1，R 2，Z和G如上所述。还公开了与之相关的方法，组合物和药物。

7. 发明申请

WO2007115020A2 THERAPEUTIC COMPOUNDS 审中-公开
标题翻译：治疗化合物
公开(公告)号：WO2007115020A2
公开(公告)日：2007-10-11
申请号：PCT/US2007065010
申请日：2007-03-27
申请人： ALLERGAN INC , DONDE YARIV , NGUYEN JEREMIAH H , HOLOBOSKI MARK , POSNER MARI F , BURK ROBERT M
发明人： DONDE YARIV , NGUYEN JEREMIAH H , HOLOBOSKI MARK , POSNER MARI F , BURK ROBERT M
IPC分类号： C07C59/56 , A61K31/5575 , A61P27/06 , C07C59/86 , C07C59/90 , C07C69/732 , C07C69/738 , C07D333/40
CPC分类号： C07C59/90 , C07C59/56 , C07C59/86 , C07C69/732 , C07C69/738 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07D333/22 , C07D333/38
摘要： Compounds having a structure are disclosed herein (Formula I). Compositions, methods, and medicaments related to the therapeutic use of these compounds are also disclosed.
摘要翻译：具有结构的化合物在本文中公开（式I）。还公开了与这些化合物的治疗用途有关的组合物，方法和药物。

8. 发明申请

WO02089813A2 3, 7 OR 3 AND 7 THIA OR OXA PROSTANOIC ACID DERIVATIVES AS AGENTS FOR LOWERING INTRAOCULAR PRESSURE 审中-公开
标题翻译： 3，7 OR 3和7 THIA或OXA PROSTANOIC酸性衍生物作为降低室内压力的代理
公开(公告)号：WO02089813A2
公开(公告)日：2002-11-14
申请号：PCT/US0214331
申请日：2002-05-06
申请人： ALLERGAN INC , BURK ROBERT M , HOLOBOSKI MARK , POSNER MARI F
发明人： BURK ROBERT M , HOLOBOSKI MARK , POSNER MARI F
IPC分类号： A61K31/5575 , A61P27/02 , A61P27/06 , C07C405/00 , A61K31/19 , A61K31/192 , A61K31/215 , A61K31/216
CPC分类号： C07C405/0033 , A61K31/5575
摘要： The present invention provides a method of treating ocular hypertension or glaucoma which comprises administering to an animal having ocular hypertension or glaucoma therapeutically effective amount of a compound represented by the general formula I, wherein hatched lines represent the alpha configuration, a triangle represents the beta configuration and a dotted line represents the presence or absence of a double bond; A and B are independently selected from the group consisting of O, S and CH2 provided that at least one of A or B is S; D represents a covalent bond or CH2, O, S or NH; X is CO2R, CONR2, CH2OR, P(O)(OR)2, CONRSO2R SONR2 or Y is O, OH, OCOR , halogen or cyano; Z is CH2 or a covalent bond; R is H or R ; R is H, R , phenyl, or COR ; R is C1-C5 lower alkyl and R3 is C1-C5 n-alkyl, C3-C7 cycloalkyl, phenyl, furanyl, thienyl, or substituted derivatives thereof, wherein the substituents may be selected from the group consisting of C1-C5 alkyl, halogen, CF3, CN, NO2, CO2R and OR.
摘要翻译：本发明提供一种治疗眼高血压或青光眼的方法，其包括向具有高眼压症或青光眼的动物施用治疗有效量的由通式I表示的化合物，其中阴影线表示α构型，三角形表示β构型虚线表示双键的存在或不存在; A和B独立地选自O，S和CH 2，条件是A或B中的至少一个为S; D表示共价键或CH 2，O，S或NH; X是CO 2 R，CONR 2，CH 2 OR，P（O）（OR）2，CONRSO 2 R SONR2或Y是O，OH，OCOR 2，卤素或氰基; Z是CH 2或共价键; R是H或R 2; R 1是H，R 2，苯基或COR 2; R 2是C 1 -C 5低级烷基，R 3是C 1 -C 5正烷基，C 3 -C 7环烷基，苯基，呋喃基，噻吩基或取代的衍生物，其中取代基可以选自C1-C5 烷基，卤素，CF 3，CN，NO 2，CO 2 R和OR。

9. 发明申请

WO2009006370A1 THERAPEUTIC SUBSTITUTED CYCLOPENTANES FOR REDUCING INTRAOCULAR PRESSURE 审中-公开
标题翻译：用于减少心室压力的治疗性替代疗法
公开(公告)号：WO2009006370A1
公开(公告)日：2009-01-08
申请号：PCT/US2008/068716
申请日：2008-06-30
申请人： ALLERGAN, INC. , OLD, David, W. , NGO, Vinh, X. , HOLOBOSKI, Mark , POSNER, Mari, F.
发明人： OLD, David, W. , NGO, Vinh, X. , HOLOBOSKI, Mark , POSNER, Mari, F.
IPC分类号： A61K31/5575 , A61K31/559 , C07C405/00 , A61P27/06
CPC分类号： C07D409/08 , A47G19/06 , A61K31/38 , A61K31/381 , A61K31/41 , A61K31/5575 , A61K31/559 , C07C405/00 , C07C2601/08 , C07D257/04 , C07D277/56 , C07D333/10 , C07D333/40
摘要： Disclosed herein are compounds having formula (I) wherein a dashed line represents the presence or absence of a bond; Y is an organic acid functional group, or an amide or ester thereof; or Y is hydroxymethyl or an ether thereof; or Y is a tetrazolyl functional group; A is -(CH 2 ) 6 -, cis -CH 2 CH=CH-(CH 2 ) 3 -, or -CH 2 C=C-(CH 2 ) 3 -, wherein 1 or 2 carbon atoms may be replaced by S or O; or A is -(CH 2 ) m -Ar-(CH 2 ) o - wherein Ar is interarylene or heterointerarylene, the sum of m and o is 1, 2, 3, or 4, and wherein 1 -CH 2 - may be replaced by S or O, and 1 -CH 2 -CH 2 - may be replaced by -CH=CH- or -C≡C-; U 1 and U 2 are independently selected from -H, =O, -OH, -F, -Cl, and -CN; and B is aryl or heteroaryl, for use as acular hypotensive agent.
摘要翻译：本文公开了具有式（I）的化合物，其中虚线表示键的存在或不存在; Y是有机酸官能团，或其酰胺或酯; 或Y为羟甲基或其醚; 或Y为四唑基官能团; A是 - （CH 2）6 - ，顺式-CH 2 CH = CH-（CH 2）3 - 或-CH 2 C = C-（CH 2）3 - ，其中1或2个碳原子可被S或O取代; 或A是 - （CH 2）m -Ar-（CH 2）o-，其中Ar是亚芳基或杂亚环烷基，m和o的总和是1,2,3或4，并且其中1 -CH 2可以被S 或O和1 -CH 2 -CH 2 - 可以被-CH = CH-或-C = C-取代; U1和U2独立地选自-H，= O，-OH，-F，-Cl和-CN; 和B是芳基或杂芳基，用作眼压降低剂。

10. 发明申请

WO2008073752A2 THERAPEUTIC COMPOUNDS 审中-公开
标题翻译：治疗化合物
公开(公告)号：WO2008073752A2
公开(公告)日：2008-06-19
申请号：PCT/US2007/086326
申请日：2007-12-04
申请人： ALLERGAN, INC. , HOLOBOSKI, Mark , BURK, Robert, M. , POSNER, Mari, F.
发明人： HOLOBOSKI, Mark , BURK, Robert, M. , POSNER, Mari, F.
IPC分类号： C07C255/46 , C07D333/16 , C07D333/24 , C07D333/28 , C07D333/38 , A61K31/277
CPC分类号： C07D333/38 , C07C255/46 , C07C2601/04 , C07C2601/08 , C07D333/16 , C07D333/24 , C07D333/28
摘要： Compound having the formula below are disclosed herein:formula (I).Therapeutic methods, compositions, and medicaments related thereto are also disclosed.
摘要翻译：具有下式的化合物在本文中公开：式（I）。还公开了与其相关的治疗方法，组合物和药物。

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