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1. 发明申请

WO2007131012A1 12-ARYL OR HETEROARYL PROSTAGLANDIN ANALOGS 审中-公开
公开(公告)号：WO2007131012A1
公开(公告)日：2007-11-15
申请号：PCT/US2007/067985
申请日：2007-05-02
申请人： ALLERGAN, INC. , DONDE, Yariv , NGUYEN, Jeremiah, H.
发明人： DONDE, Yariv , NGUYEN, Jeremiah, H.
IPC分类号： C07C59/90 , C07C59/56 , C07C59/54 , C07D333/40 , A61K31/5575 , A61K31/559 , A61P27/06
CPC分类号： C07C59/90 , C07C59/56 , C07C65/17 , C07D277/56 , C07D307/68 , C07D333/38 , C07D333/40 , C07D409/12 , C07D417/12
摘要： A compound having structure (I) is disclosed herein. Compositions, medicaments, and therapeutic methods related thereto are also disclosed.
摘要翻译：本文公开了具有结构（I）的化合物。还公开了与其有关的组合物，药物和治疗方法。

2. 发明申请

WO2007130902A2 THERAPEUTIC CYCLOPENTANE DERIVATIVES 审中-公开
标题翻译：治疗性环磷酰胺衍生物
公开(公告)号：WO2007130902A2
公开(公告)日：2007-11-15
申请号：PCT/US2007/067762
申请日：2007-04-30
申请人： ALLERGAN, INC. , DONDE, Yariv , NGUYEN, Jeremiah, H.
发明人： DONDE, Yariv , NGUYEN, Jeremiah, H.
IPC分类号： C07C23/08 , C07C69/65 , A61K31/215
CPC分类号： C07C69/732 , C07B2200/07 , C07C57/54 , C07C57/62 , C07C57/68 , C07C59/56 , C07C59/72 , C07C65/19 , C07C65/26 , C07C205/56 , C07C255/57 , C07C309/10 , C07C309/42 , C07C323/17 , C07C323/52 , C07C323/56 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2602/08 , C07D277/24 , C07D277/56 , C07D307/68 , C07D333/16 , C07D333/38 , C07D333/40 , C07D335/06 , C07D405/10 , C07D409/10 , C07F9/3834 , C07F9/3882 , C07F9/65515
摘要： Described herein are compounds having Formula (I) and therapeutic methods, compositions, and medicaments, related thereto.
摘要翻译：本文描述了具有式（I）的化合物及其相关的治疗方法，组合物和药物。

3. 发明申请

WO2007115020A2 THERAPEUTIC COMPOUNDS 审中-公开
标题翻译：治疗化合物
公开(公告)号：WO2007115020A2
公开(公告)日：2007-10-11
申请号：PCT/US2007065010
申请日：2007-03-27
申请人： ALLERGAN INC , DONDE YARIV , NGUYEN JEREMIAH H , HOLOBOSKI MARK , POSNER MARI F , BURK ROBERT M
发明人： DONDE YARIV , NGUYEN JEREMIAH H , HOLOBOSKI MARK , POSNER MARI F , BURK ROBERT M
IPC分类号： C07C59/56 , A61K31/5575 , A61P27/06 , C07C59/86 , C07C59/90 , C07C69/732 , C07C69/738 , C07D333/40
CPC分类号： C07C59/90 , C07C59/56 , C07C59/86 , C07C69/732 , C07C69/738 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07D333/22 , C07D333/38
摘要： Compounds having a structure are disclosed herein (Formula I). Compositions, methods, and medicaments related to the therapeutic use of these compounds are also disclosed.
摘要翻译：具有结构的化合物在本文中公开（式I）。还公开了与这些化合物的治疗用途有关的组合物，方法和药物。

4. 发明申请

WO2006113571A2 THERAPEUTIC SUBSTITUTED CYCLOPENTANONES 审中-公开
标题翻译：治疗性替代性CYPOPENTANONES
公开(公告)号：WO2006113571A2
公开(公告)日：2006-10-26
申请号：PCT/US2006014319
申请日：2006-04-17
申请人： ALLERGAN INC , DONDE YARIV
发明人： DONDE YARIV
IPC分类号： A61K31/5575 , A61P1/00
CPC分类号： C07C405/00 , A61K31/5575 , C07C59/90
摘要： Compounds are disclosed herein comprising formula (I) or a pharmaceutically acceptable salt, or a metabolite or a prodrug thereof; wherein a dashed line indicates the presence or absence of a bond; Y, A, and B are described herein Therapeutic methods, manufacturing methods, compositions, and medicaments related thereto are also disclosed.
摘要翻译：本文公开的化合物包含式（I）或其药学上可接受的盐，或其代谢物或前药; 其中虚线表示存在或不存在键; Y，A和B在本文中被描述。还公开了与之相关的治疗方法，制造方法，组合物和药物。

5. 发明申请

WO2006050241A1 PROSTAGLANDIN EP4 ANTAGONISTS 审中-公开
公开(公告)号：WO2006050241A1
公开(公告)日：2006-05-11
申请号：PCT/US2005/039215
申请日：2005-10-25
申请人： ALLERGAN, INC. , WHEELER, Larry, A. , GARST, Michael, E. , LIANG, Yanbin , WOODWARD, David, F. , KRAUSS, Achim, H.P , BURK, Robert, M. , DONDE, Yariv , HOLOBOSKI, Mark , OLD, David, W. , CHEN, June
发明人： WHEELER, Larry, A. , GARST, Michael, E. , LIANG, Yanbin , WOODWARD, David, F. , KRAUSS, Achim, H.P , BURK, Robert, M. , DONDE, Yariv , HOLOBOSKI, Mark , OLD, David, W. , CHEN, June
IPC分类号： A61K31/473 , A61P43/00
CPC分类号： A61K31/473 , Y10S514/913
摘要： Disclosed herein are methods and compositions related to compound 1 or compound 2: or pharmaceutically acceptable salts, or prodrugs thereof, which are antagonists of a prostaglandin EP 4 receptor, or are prostaglandin EP 4 antagonists.
摘要翻译：本文公开了与化合物1或化合物2相关的方法和组合物：或其药学上可接受的盐或前药，其为前列腺素EP 4受体的拮抗剂，或为前列腺素EP 4， SUB>拮抗剂。

6. 发明申请

WO2006047476A3 THERAPEUTIC AND DELIVERY METHODS OF PROSTAGLANDIN EP4 AGONISTS 审中-公开
公开(公告)号：WO2006047476A3
公开(公告)日：2006-05-04
申请号：PCT/US2005/038303
申请日：2005-10-24
申请人： ALLERGAN, INC. , IM, Wha, Bin , DONDE, Yariv , HOLOBOSKI, Mark , OLD, David, W. , KEDZIE, Karen, M. , GIL, Daniel, W. , DONELLO, John, E. , BURK, Robert, M. , GAC, Todd, S.
发明人： IM, Wha, Bin , DONDE, Yariv , HOLOBOSKI, Mark , OLD, David, W. , KEDZIE, Karen, M. , GIL, Daniel, W. , DONELLO, John, E. , BURK, Robert, M. , GAC, Todd, S.
IPC分类号： C07C405/00 , A61K31/557 , A61K47/48
摘要： A compound comprising a prodrug of a prostaglandin EP 4 agonist, wherein said prodrug is an ester, ether, or amide of a carbohydrate; or said prodrug is an ester, ether, or amide of an amino acid is disclosed herein. Maintenance of the colonic mucosal barrier by method comprising administering a therapeutically effective amount of a prostaglandin EP 4 agonist to a colon of a mammal is also disclosed herein. Dosage forms, medicaments, and compositions, related thereto are also disclosed.

7. 发明申请

WO2006047476A2 THERAPEUTIC AND DELIVERY METHODS OF PROSTAGLANDIN EP4 AGONISTS 审中-公开
标题翻译：前列腺素EP4激动剂的治疗和给药方法
公开(公告)号：WO2006047476A2
公开(公告)日：2006-05-04
申请号：PCT/US2005038303
申请日：2005-10-24
申请人： ALLERGAN INC , IM WHA BIN , DONDE YARIV , HOLOBOSKI MARK , OLD DAVID W , KEDZIE KAREN M , GIL DANIEL W , DONELLO JOHN E , BURK ROBERT M , GAC TODD S
发明人： IM WHA BIN , DONDE YARIV , HOLOBOSKI MARK , OLD DAVID W , KEDZIE KAREN M , GIL DANIEL W , DONELLO JOHN E , BURK ROBERT M , GAC TODD S
IPC分类号： C07C405/00 , A61K31/557 , A61K47/48
CPC分类号： C07C405/00 , A61K47/549 , A61K47/64
摘要： A compound comprising a prodrug of a prostaglandin EP 4 agonist, wherein said prodrug is an ester, ether, or amide of a carbohydrate; or said prodrug is an ester, ether, or amide of an amino acid is disclosed herein. Maintenance of the colonic mucosal barrier by method comprising administering a therapeutically effective amount of a prostaglandin EP 4 agonist to a colon of a mammal is also disclosed herein. Dosage forms, medicaments, and compositions, related thereto are also disclosed.
摘要翻译：包含前列腺素EP 4激动剂的前药的化合物，其中所述前药是碳水化合物的酯，醚或酰胺; 或所述前药是本文公开的氨基酸的酯，醚或酰胺。本文还公开了通过包含给予哺乳动物结肠的治疗有效量的前列腺素EP 4激动剂的方法来维持结肠粘膜屏障。还公开了与其相关的剂型，药物和组合物。

8. 发明申请

WO2005100339A1 10-HYDROXY-11-DIHYDROPROSTAGLANDIN ANALOGS AS SELECTIVE EP4 AGONISTS 审中-公开
标题翻译：作为选择性EP4激动剂的10-羟基-11-二氢吡咯烷酮类似物
公开(公告)号：WO2005100339A1
公开(公告)日：2005-10-27
申请号：PCT/US2005/010124
申请日：2005-03-25
申请人： ALLERGAN, INC. , DONDE, Yariv
发明人： DONDE, Yariv
IPC分类号： C07D333/60
CPC分类号： C07D333/62
摘要： A compound comprising formula I (I) or a pharmaceutically acceptable salt or a prodrug thereof, wherein the dashed line represents the presence or absence of a double bond; J is C=O or CHOH; A is -(CH2) 6 -, or cis -CH 2 CH=CH-(CH 2 ) 3 -, wherein 1 or 2 carbons may be substituted with S or O; B is CO 2 H, or CO 2 R, CONR 2 , CONHCH 2 CH 2 OH, CON(CH 2 CH 2 OH) 2 , CH 2 OR, P(O)(OR) 2 , CONRSO 2 R, SONR 2 , or formula II (II), R is H, C 1-6 alkyl; D is -(CH 2 ) n -, -X(CH 2 ) n , or -(CH 2 ) n X-, wherein n is from 0 to 3 and X is S or O; and E is an aromatic or heteroaromatic moiety having from 0 to 4 substituents, said substituents each comprising from 1 to 6 non-hydrogen atoms is disclosed herein. Methods, compositions, and medicaments related thereto, as well as experimental results showing prostaglandin EP4 selective agonist activity for certain compounds disclosed herein, are also disclosed.
摘要翻译：包含式I（I）或其药学上可接受的盐或前药的化合物，其中虚线表示双键的存在或不存在; J为C = O或CHOH; A是 - （CH 2）6 - 或顺式-CH 2 CH = CH-（CH 2）3 - ，其中1或2个碳可以被S或O取代; B是CO 2 H或CO 2 R，CONR 2，CONHCH 2 CH 2 OH，CON（CH 2 CH 2 OH）2，CH 2 OR，P（O）（OR）2，CONRSO 2 R，SONR 2或式II（II） D是 - （CH 2）n - ， - X（CH 2）n或 - （CH 2）n X-，其中n为0至3，X为S或O; 并且E是具有0至4个取代基的芳族或杂芳族部分，所述取代基各自包含1至6个非氢原子。还公开了与其相关的方法，组合物和药物，以及显示本文公开的某些化合物的前列腺素EP4选择性激动剂活性的实验结果。

9. 发明申请

WO2009137413A1 THERAPEUTIC CYCLOPENTANE DERIVATIVES 审中-公开
标题翻译：治疗性环孢素衍生物
公开(公告)号：WO2009137413A1
公开(公告)日：2009-11-12
申请号：PCT/US2009/042725
申请日：2009-05-04
申请人： ALLERGAN, INC. , DONDE, Yariv , NGUYEN, Jeremiah, H.
发明人： DONDE, Yariv , NGUYEN, Jeremiah, H.
IPC分类号： C07C255/46 , C07C405/00 , C07D265/30 , A61P17/14 , A61P27/06 , A61K31/557
CPC分类号： C07C255/46 , C07C405/00 , C07C2601/08 , C07C2601/10 , C07D295/088
摘要： Compounds comprising formula (I) or a pharmaceutically acceptable salt thereof, are disclosed, wherein B, Y, and A are as described in claims 1-10. Methods, compositions, and medicaments related thereto are also disclosed, for treating baldness, glaucoma or inflammatory bowel diseases.
摘要翻译：公开了包含式（I）的化合物或其药学上可接受的盐，其中B，Y和A如权利要求1-10所述。还公开了用于治疗秃发，青光眼或炎症性肠病的方法，组合物和与之相关的药物。

10. 发明申请

WO2009061811A8 SUBSTITUTED CYCLOPENTANES HAVING PROSTAGLANDING ACTIVITY 审中-公开
公开(公告)号：WO2009061811A8
公开(公告)日：2009-05-14
申请号：PCT/US2008/082469
申请日：2008-11-05
申请人： ALLERGAN, INC. , DONDE, Yariv , NGUYEN, Jeremiah, H. , BURK, Robert, M.
发明人： DONDE, Yariv , NGUYEN, Jeremiah, H. , BURK, Robert, M.
IPC分类号： C07D263/34 , C07D333/40 , A61K31/381 , A61P27/06
摘要： Disclosed herein are compounds having a formula: (I) Therapeutic methods, medicaments, and compositions related thereto are also disclosed.

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