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1. 发明申请

WO2009059041A1 CLOSED-LOOP FEEDBACK FOR STEERING STIMULATION ENERGY WITHIN TISSUE 审中-公开
标题翻译：闭合反馈在组织中转向刺激能量
公开(公告)号：WO2009059041A1
公开(公告)日：2009-05-07
申请号：PCT/US2008/081848
申请日：2008-10-30
申请人： BOSTON SCIENTIFIC NEUROMODULATION CORPORATION , MOFFITT, Michael Adam , PETERSON, David K.L. , MEADOWS, Paul Milton
发明人： MOFFITT, Michael Adam , PETERSON, David K.L. , MEADOWS, Paul Milton
IPC分类号： A61N1/36 , A61N1/372 , A61B5/04 , A61B5/0476
CPC分类号： A61N1/36139 , A61N1/0531 , A61N1/0534 , A61N1/0553 , A61N1/36067 , A61N1/36082 , A61N1/36185 , A61N1/36189 , A61N1/37235
摘要： Systems and external programmers provide therapy to a patient having a dysfunction. In one aspect, electrical energy is conveyed between electrodes to create a stimulation region in tissue adjacent the electrodes. Physiological information from the patient is acquired and analyzed, and a locus of the stimulation region is electronically displaced relative to the tissue based on the analysis of the acquired physiological information. In another aspect, electrical energy is delivered to tissue of the patient in accordance with one or more stimulation parameters. A cognitive brain signals is sensed and analyzed, and the stimulation parameter(s) are modified based on the analysis of the cognitive brain signal.
摘要翻译：系统和外部程序员为具有功能障碍的患者提供治疗。在一个方面，电能在电极之间传送以在邻近电极的组织中产生刺激区域。获取和分析来自患者的生理信息，并且基于所获取的生理信息的分析，刺激区域的位置相对于组织电子移位。在另一方面，根据一个或多个刺激参数将电能输送到患者的组织。感知和分析认知脑信号，并且基于对认知脑信号的分析来修改刺激参数。

2. 发明申请

WO2010028084A3 MULTIPLE TUNABLE CENTRAL CATHODES ON A PADDLE FOR INCREASED MEDIAL-LATERAL AND ROSTRAL-CAUDAL FLEXIBILITY VIA CURRENT STEERING 审中-公开
公开(公告)号：WO2010028084A3
公开(公告)日：2010-03-11
申请号：PCT/US2009/055781
申请日：2009-09-02
申请人： BOSTON SCIENTIFIC NEUROMODULATION CORPORATION , MOFFITT, Michael , LEE, Dongchul , BRADLEY, Kerry , PETERSON, David K.L.
发明人： MOFFITT, Michael , LEE, Dongchul , BRADLEY, Kerry , PETERSON, David K.L.
IPC分类号： A61N1/05 , A61N1/34
摘要： A neurostimulation paddle lead, method of neurostimulation, and neurostimulation system are provided. The neurostimulation paddle lead carries a plurality of electrodes comprising at least four columns of electrodes having a spacing between two inner electrode columns less than a spacing between the inner electrode columns and adjacent outer electrode columns. The inner electrode columns may also be longitudinally offset from the outer electrode columns. The methods and neurostimulation systems steer current between the electrodes to modify a medial-lateral electrical field created adjacent spinal cord tissue.

3. 发明申请

WO2010006304A2 SYSTEM AND METHOD FOR CONVERTING TISSUE STIMULATION PROGRAMS IN A FORMAT USABLE BY AN ELECTRICAL CURRENT STEERING NAVIGATOR 审中-公开
标题翻译：用于电流转向导管可用的格式转换组织刺激方案的系统和方法
公开(公告)号：WO2010006304A2
公开(公告)日：2010-01-14
申请号：PCT/US2009/050309
申请日：2009-07-10
申请人： BOSTON SCIENTIFIC NEUROMODULATION CORPORATION , THACKER, James, R. , MOFFITT, Michael , BRADLEY, Kerry , PETERSON, David, K.l.
发明人： THACKER, James, R. , MOFFITT, Michael , BRADLEY, Kerry , PETERSON, David, K.l.
IPC分类号： A61N1/08 , A61N1/34
CPC分类号： A61N1/37264 , A61N1/36071 , A61N1/36146 , A61N1/3615 , A61N1/36167 , A61N1/36185 , A61N1/37247 , G06F19/00 , G16H40/63
摘要： A method, computer medium, and system for programming a controller is provided. The controller controls electrical stimulation energy output to electrodes, and stores a set of programmed stimulation parameters associated with the electrodes. The programmed stimulation parameter set is compared with sets of reference stimulation parameters, each of the reference sets of stimulation parameters being associated with the electrodes. If an identical match is determined between the programmed stimulation parameter set and any one of the reference stimulation parameter sets exists based on the comparison, the identically matched stimulation parameter set is selected as an initial stimulation parameter set. If an identical match does not exist, a best between the programmed stimulation parameter set and the reference stimulation parameter sets is determined and selected as the initial stimulation parameter set. The controller is then programmed with a new set of programmable stimulation parameters based on the initial stimulation parameter set.
摘要翻译：提供了一种用于编程控制器的方法，计算机介质和系统。控制器控制对电极的电刺激能量输出，并且存储与电极相关联的一组编程的刺激参数。将编程的刺激参数集与参考刺激参数的集合进行比较，每个参考组的刺激参数与电极相关联。如果在编程的刺激参数集之间确定相同的匹配，并且基于比较存在参考刺激参数集中的任一个，则选择相同匹配的刺激参数集作为初始刺激参数集。如果不存在相同的匹配，则确定编程的刺激参数集和参考刺激参数集之间的最佳值，并将其选为初始刺激参数集。然后基于初始刺激参数集，控制器用一组新的可编程刺激参数进行编程。

4. 发明申请

WO2008150348A1 SHORT DURATION PRE-PULSING TO REDUCE STIMULATION-EVOKED SIDE-EFFECTS 审中-公开
标题翻译：短暂的预处理可以减少刺激反应的副作用
公开(公告)号：WO2008150348A1
公开(公告)日：2008-12-11
申请号：PCT/US2008/006125
申请日：2008-05-14
申请人： BOSTON SCIENTIFIC NEUROMODULATION CORPORATION , MOFFITT, Michael Adam , PETERSON, David K.L.
发明人： MOFFITT, Michael Adam , PETERSON, David K.L.
IPC分类号： A61N1/34 , A61N1/36
CPC分类号： A61N1/36128 , A61N1/0553 , A61N1/36017 , A61N1/36071 , A61N1/36164 , A61N1/36167
摘要： A neurostimulation system of providing therapy to a patient is provided. At least one electrode is place in contact with tissue of a patient. A sub-threshold, hyperpolarizing, conditioning pre-pulse (e.g., an anodic pulse) is conveyed from the electrode(s) to render a first region of the tissue (e.g., dorsal root fibers) less excitable to stimulation, and a depolarizing stimulation pulse (e.g., a cathodic pulse) is conveyed from the electrode(s) to stimulate a second different region of the tissue (e.g., dorsal column fibers). The conditioning pre-pulse has a relatively short duration (e.g., less than 200μs).
摘要翻译：提供了向患者提供治疗的神经刺激系统。至少一个电极与患者的组织接触放置。从电极传送亚阈值超极化调节预脉冲（例如阳极脉冲），以使得组织的第一区域（例如，背根根纤维）对刺激不太兴奋，并且去极化刺激脉冲（例如，阴极脉冲）从电极传送以刺激组织的第二不同区域（例如，背部柱状纤维）。调节预脉冲具有相对短的持续时间（例如，小于200μs）。

5. 发明申请

WO2007067825A1 BATTERY PROTECTION AND ZERO-VOLT BATTERY RECOVERY SYSTEM FOR AN IMPLANTABLE MEDICAL DEVICE 审中-公开
标题翻译：用于可植入医疗器械的电池保护和零电压电池恢复系统
公开(公告)号：WO2007067825A1
公开(公告)日：2007-06-14
申请号：PCT/US2006/060081
申请日：2006-10-19
申请人： ADVANCED BIONICS CORPORATION , HE, Yuping , PETERSON, David, K.L.
发明人： HE, Yuping , PETERSON, David, K.L.
IPC分类号： A61N1/378 , H02J7/00
CPC分类号： A61N1/378 , A61N1/08 , A61N1/37 , A61N1/3787 , H01M10/44 , H02J7/00 , H02J7/025 , H02J7/041 , H02J50/10 , H02J2007/105
摘要： Circuitry useable to protect and reliably charge a rechargeable battery, even from a zero-volt state, is disclosed, and is particularly useful when employed in an implantable medical device. The circuit includes two charging paths, a first path for trickle charging the battery at a relatively low current when the battery voltage is below a threshold, and a second path for charging the battery at relatively higher currents that the battery voltage is above a certain threshold. A passive diode is used in the first trickle-charging path which allows trickle charging even when the battery voltage is too low for reliable gating, while a gateable switch (preferably a PMOS transistor) is used in the second higher-current charging path when the voltage is higher and the switch can therefore be gated more reliably. A second diode between the two paths ensures no leakage to the substrate through the gateable switch during trickle charging. The load couples to the battery through the switch, and preferably through a second switch specifically used for decoupling the load.
摘要翻译：公开了用于保护和可靠地对可再充电电池进行充电的电路，即使是从零伏状态，并且当用于可植入医疗装置时特别有用。该电路包括两个充电路径，当电池电压低于阈值时，第一路径用于以相对低的电流对电池进行涓流充电;以及第二路径，用于以相对较高的电流对电池充电以使得电池电压高于某一阈值。在第一涓流充电路径中使用无源二极管，即使当电池电压太低以至于可靠的选通时也允许涓流充电，而当第二高电流充电路径中使用可选择的开关（优选为PMOS晶体管）时电压较高，因此开关更可靠地选通。在两个路径之间的第二个二极管确保在滴流充电期间通过可切换开关不会泄漏到衬底。负载通过开关耦合到电池，并且优选地通过专门用于去耦负载的第二开关。

6. 发明申请

WO2010011721A1 SYSTEM AND METHOD FOR MAINTAINING A DISTRIBUTION OF CURRENTS IN AN ELECTRODE ARRAY USING INDEPENDENT VOLTAGE SOURCES 审中-公开
标题翻译：使用独立电压源在电极阵列中维持电流分配的系统和方法
公开(公告)号：WO2010011721A1
公开(公告)日：2010-01-28
申请号：PCT/US2009/051361
申请日：2009-07-22
申请人： BOSTON SCIENTIFIC NEUROMODULATION CORPORATION , MOFFITT, Michael, A. , PETERSON, David, K.l.
发明人： MOFFITT, Michael, A. , PETERSON, David, K.l.
IPC分类号： A61N1/05 , A61N1/36
CPC分类号： A61N1/36071 , A61N1/0551
摘要： In one technique, a desired electrical current distribution on at least three active electrodes is selected. An electrical energy perturbation is generated on at least one electrode. A current-to-voltage relationship at each active electrode is estimated based on the energy perturbation. The current-to-voltage relationship for each active electrode takes into account current flow through other active electrodes. The voltage distribution necessary to achieve the desired current distribution is determined based on the estimated current-to-voltage relationship. Voltage-regulated energy is conveyed between the electrodes and tissue in accordance with the determined electrical voltage distribution. In another technique, electrical energy perturbation on at least one of the electrodes is generated. Network resistances for each of at least three active electrodes are computed in response to the energy perturbation. The network resistances represent the resistances between the electrodes and common node to which the electrodes are connected.
摘要翻译：在一种技术中，选择在至少三个有效电极上的期望的电流分布。在至少一个电极上产生电能扰动。基于能量扰动来估计每个有源电极处的电流 - 电压关系。每个有源电极的电流 - 电压关系考虑到通过其他有源电极的电流。基于估计的电流 - 电压关系确定实现所需电流分布所需的电压分布。电压调节能量根据确定的电压分布在电极和组织之间传送。在另一种技术中，产生至少一个电极上的电能扰动。响应于能量扰动计算至少三个有效电极中的每一个的网络电阻。网络电阻表示电极与电极连接的公共节点之间的电阻。

7. 发明申请

WO2008143857A1 SMART CHARGER ALIGNMENT INDICATOR 审中-公开
标题翻译： SMART CHARGER对准指示灯
公开(公告)号：WO2008143857A1
公开(公告)日：2008-11-27
申请号：PCT/US2008/006129
申请日：2008-05-14
申请人： BOSTON SCIENTIFIC NEUROMODULATION CORPORATION , PETERSON, David K.L.
发明人： PETERSON, David K.L.
IPC分类号： A61N1/378
CPC分类号： A61N1/3787
摘要： Electrical energy is transmitted to charge the implanted medical device, and an electrical parameter (e.g., a steady-state voltage) indicating a rate at which the implanted medical device is charged by the electrical energy is detected. A threshold (e.g., by modifying a stored threshold value) at which the charge strength indicator generates a user-discernible signal is adjusted based on the detected electrical parameter.
摘要翻译：传输电能以对植入的医疗装置充电，并且检测指示通过电能对植入的医疗装置充电的速率的电参数（例如，稳态电压）。基于检测到的电参数来调整充电强度指示器产生用户可识别信号的阈值（例如，通过修改存储的阈值）。

8. 发明申请

WO2012158562A3 NEUROSTIMULATION SYSTEM WITH MEANS FOR PREVENTING A STIMULATION EXCEEDING LIMIT 审中-公开
公开(公告)号：WO2012158562A3
公开(公告)日：2012-11-22
申请号：PCT/US2012/037646
申请日：2012-05-11
申请人： BOSTON SCIENTIFIC NEUROMODULATION CORPORATION , MOFFITT, Michael A. , KOTHANDARAMAN, Sridhar , PETERSON, David K.L.
发明人： MOFFITT, Michael A. , KOTHANDARAMAN, Sridhar , PETERSON, David K.L.
IPC分类号： A61N1/36 , A61N1/08
摘要： A neurostimulation system (10) for management of stimulation safety limits. The system determines a tissue charge injection metric at each electrode (26), compares the metric to a hard stop charge limit, and prevents the neurostimulator from delivering stimulation energy to the tissue region in accordance based on the comparison. The hard stop limit may be user-programmable or may be automatically modified in response to detection of electrode characteristics. The system may quantitatively notify a user of a value of the injected charge injected into the tissue. The electrodes may be organized into different sets, in which case, the system may directly control tissue charge independently at each of the electrode sets. If current steering is provided, the system may displace the electrical stimulation energy along the tissue region in one direction, while preventing the charge injection value at each of the electrodes from meeting or exceeding the hard stop charge limit.

9. 发明申请

WO2008052085A1 METHOD OF MAINTAINING INTENSITY OUTPUT WHILE ADJUSTING PULSE WIDTH OR AMPLITUDE 审中-公开
标题翻译：在调节脉冲宽度或幅度时维持强度输出的方法
公开(公告)号：WO2008052085A1
公开(公告)日：2008-05-02
申请号：PCT/US2007/082447
申请日：2007-10-24
申请人： ADVANCED BIONICS CORPORATION , THACKER, James, R. , HAUT, Harold , NATHAN, Robert , PETERSON, David, K.L. , BRADLEY, Kerry
发明人： THACKER, James, R. , HAUT, Harold , NATHAN, Robert , PETERSON, David, K.L. , BRADLEY, Kerry
IPC分类号： A61N1/372 , A61N1/08 , A61N1/36
CPC分类号： A61N1/37247 , A61N1/36071 , A61N1/36146 , A61N1/36171 , A61N1/36175
摘要： Tissue stimulation systems generally include a pulse generating device for generating electrical stimulation pulses, at least one implanted electrode for delivering the electrical stimulation pulses generated by the pulse generating device, and a programmer capable of communicating with the pulse generating device. Stimulation pulses may be defined by several parameters, such as pulse width and amplitude. In methods of stimulating the tissue with the stimulation system, a user may adjust one of the parameters such as pulse width. The programmer may automatically adjust the pulse amplitude in response to the change in pulse width in order to maintain a substantially constant effect of the stimulation pulses.
摘要翻译：组织刺激系统通常包括用于产生电刺激脉冲的脉冲产生装置，用于传递由脉冲发生装置产生的电刺激脉冲的至少一个注入电极以及能够与脉冲发生装置通信的编程器。刺激脉冲可以由几个参数定义，例如脉冲宽度和幅度。在用刺激系统刺激组织的方法中，用户可以调整诸如脉冲宽度的参数之一。编程器可以响应于脉冲宽度的变化自动调节脉冲幅度，以便保持刺激脉冲的基本恒定的效果。

10. 发明申请

WO2008048725A1 CURRENT GENERATION ARCHITECTURE FOR AN IMPLANTABLE STIMULATOR DEVICE HAVING COARSE AND FINE CURRENT CONTROL 审中-公开
标题翻译：具有粗糙和精细电流控制的可植入刺激装置的电流生成结构
公开(公告)号：WO2008048725A1
公开(公告)日：2008-04-24
申请号：PCT/US2007/072238
申请日：2007-06-27
申请人： ADVANCED BIONICS CORPORATION , PARRAMON, Jordi , PETERSON, David, K.l. , GRIFFITH, Paul, J.
发明人： PARRAMON, Jordi , PETERSON, David, K.l. , GRIFFITH, Paul, J.
IPC分类号： A61N1/36 , H02M3/07
CPC分类号： A61N1/36125 , A61N1/0531 , A61N1/0534 , A61N1/0541 , A61N1/0543 , A61N1/0551 , A61N1/36071
摘要： Disclosed herein is a current generation architecture for an implantable stimulator device such as an Implantable Pulse Generator (IPG). Current source and sink circuitry are both divided into coarse and fine portions, which respectively can provide a coarse and fine current resolution to a specified electrode on the IPG. The coarse portion is distributed across all of the electrodes and so can source or sink current to any of the electrodes. The coarse portion is divided into a plurality of stages, each of which is capable via an associated switch bank of sourcing or sinking a coarse amount of current to or from any one of the electrodes on the device. The fine portion of the current generation circuit preferably includes source and sink circuitry dedicated to each of the electrode on the device, which can comprise digital-to-analog current converters (DACs). The DACs also receives the above-noted reference current, which is amplified by the DACs in fine increments by appropriate selection of fine current control signals. When the coarse and fine current control circuitry are used in tandem, ample current with a fine current resolution can be achieved at any electrode and in a space- and power-efficient manner.
摘要翻译：本文公开了用于植入式脉冲发生器（IPG）的植入式刺激器装置的当前一代架构。电流源和接收电路都分为粗细部分，分别可以为IPG上的指定电极提供粗细和精细的电流分辨率。粗糙部分分布在所有电极上，因此可以将电流吸收或吸收到任何电极。粗略部分被分成多个级，每个级能够经由相关联的开关组，该器件对器件中的任何一个电极产生或吸收粗略的电流。电流产生电路的优良部分优选地包括专用于器件上的每个电极的源极和漏极电路，其可以包括数模转换器（DAC）。 DAC还接收上述参考电流，其通过适当选择精细电流控制信号以细微增量由DAC放大。当粗调和精细电流控制电路串联使用时，可以在任何电极上以空间和功率有效的方式实现具有精细电流分辨率的充足电流。

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