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1. 发明申请

WO2005000288A3 TREATMENT OF PROTEIN AGGREGATION DISORDERS 审中-公开
标题翻译：治疗蛋白质聚集障碍
公开(公告)号：WO2005000288A3
公开(公告)日：2005-05-06
申请号：PCT/IB2004002405
申请日：2004-06-21
申请人： NEUROCHEM INT LTD , TREMBLAY PATRICK , MCLAUGHLIN RICHARD
发明人： TREMBLAY PATRICK , MCLAUGHLIN RICHARD
IPC分类号： A61K31/185 , A61K31/445 , A61K31/495 , A61P25/00 , A61P25/16 , A61P25/28
CPC分类号： A61K31/445 , A61K31/185 , A61K31/495
摘要： The present invention is based, at least in part on the discovery of therapeutic agents capable of preventing, inhibiting or modulating abnormal processing, misfolding or aggregation of protein. The therapeutic agents of the invention may prevent, inhibit or modulate the formation of inclusions. The therapeutic agents of the invention may also be capable of facilitating clearance and/or blocking the cellular toxicity of inclusions to treat or ameliorate disorders characterized by protein aggregation. Compounds which bind to structural motifs commonly found in protein aggregates, such as ß-sheets, would represent strong candidates for such compounds and are therefore desirable.
摘要翻译：本发明至少部分地基于能够预防，抑制或调节异常加工，蛋白质错误折叠或聚集的治疗剂的发现。本发明的治疗剂可以预防，抑制或调节夹杂物的形成。本发明的治疗剂还可以有助于清除和/或阻断内含物的细胞毒性，以治疗或改善以蛋白质聚集为特征的病症。通常在蛋白质聚集体中发现的结构基序结合的化合物，如β片，将代表这些化合物的强候选物，因此是理想的。

2. 发明申请

WO2007004072B1 FORMULATIONS AND METHODS FOR TREATING AMYLOIDOSIS 审中-公开
标题翻译：用于治疗淀粉样变性的制剂和方法
公开(公告)号：WO2007004072B1
公开(公告)日：2007-12-27
申请号：PCT/IB2006002540
申请日：2006-04-17
申请人： NEUROCHEM INT LTD , GARCEAU DENIS , HAUCK WENDY , BRIAND RICHARD
发明人： GARCEAU DENIS , HAUCK WENDY , BRIAND RICHARD
IPC分类号： A61K31/185
CPC分类号： A61K31/185 , A61K31/16 , A61K31/255 , A61K31/525 , A61K45/06
摘要： Methods, formulations, and compositions for the treatment of amyloidosis are described, whereby a therapeutically effective amount of a compound having the formula (I) wherein Y is SO 3 X or OSO 3 X independently chosen for each occurrence; X is cationic group independently chosen for each occurrence; n is 1, 2, 3 or 4; and m is 1 or 2, is applied.
摘要翻译：描述了用于治疗淀粉样变性的方法，制剂和组合物，其中治疗有效量的具有式（I）的化合物，其中Y是SO 3 X或OSO 3 X为每次出现独立选择; X是每次发生时独立选择的阳离子基团; n为1,2,3或4; 并且m为1或2。

3. 发明申请

WO2007023389B1 POLYMORPHIC FORMS OF 3-AMINO-1-PROPANESULFONIC ACID 审中-公开
标题翻译： 3-氨基-1-丙酮酸的多晶型
公开(公告)号：WO2007023389B1
公开(公告)日：2007-11-29
申请号：PCT/IB2006003013
申请日：2006-07-14
申请人： NEUROCHEM INT LTD , GUAY FRANCE
发明人： GUAY FRANCE
IPC分类号： C07C309/14 , A61K31/185 , A61P25/28
CPC分类号： C07C309/14
摘要： The invention relates to two polymorphic forms of 3 -ammo- 1 -propane sulfonic acid (homotaurme) and the use of the same for the treatment of amyloidosis The two polymorphic forms are characterized by their unique XRPD peaks and FT-IR spectra The invention also discloses processes of producing the two forms and the mixtures thereof by recrystalizmg amorphous homotaurme from various organic solvents
摘要翻译：本发明涉及3-氨基-1-丙磺酸（同型牛磺酸）的两种多晶型形式及其用于治疗淀粉样变性的用途。两种多态性的特征在于其独特的XRPD峰和FT-IR光谱本发明还公开了通过从各种有机溶剂重结晶无定形同醇异构体来生产两种形式及其混合物的方法

4. 发明申请

WO2007049098A3 THERAPEUTIC FORMULATIONS FOR THE TREATMENT OF BETA-AMYLOID RELATED DISEASES 审中-公开
标题翻译：用于治疗β-淀粉样相关疾病的治疗剂型
公开(公告)号：WO2007049098A3
公开(公告)日：2007-10-04
申请号：PCT/IB2005004199
申请日：2005-06-17
申请人： NEUROCHEM INT LTD , GERVAIS FRANCINE , BELLINI FRANCESCO
发明人： GERVAIS FRANCINE , BELLINI FRANCESCO
IPC分类号： A61K31/185 , A61K31/27 , A61K31/445 , A61K45/06 , A61P25/28
CPC分类号： A61K45/06 , A61K31/185 , A61K31/27 , A61K31/445 , A61K2300/00
摘要： This invention relates to methods and pharmaceutical compositions for treating amyloid-ß related diseases, including Alzheimer's disease. The invention, for example, includes a method of concomitant therapeutic treatment of a subject, comprising administering an effective amount of a first agent and a second agent, wherein said first agent treats an amyloid-ß disease, neurodegeneration, or cellular toxicity; and said second agent is a therapeutic drug or nutritive supplement.
摘要翻译：本发明涉及用于治疗淀粉样蛋白ß相关疾病（包括阿尔茨海默氏病）的方法和药物组合物。本发明例如包括对受试者进行伴随治疗性治疗的方法，包括施用有效量的第一药剂和第二药剂，其中所述第一药物治疗淀粉样蛋白β疾病，神经变性或细胞毒性; 并且所述第二药剂是治疗药物或营养补充剂。

5. 发明申请

WO2005000406A3 TREATMENT OF AMYLOID- AND EPILEPTOGENESIS-ASSOCIATED DISEASES 审中-公开
标题翻译：治疗淀粉样变性和纤维蛋白原相关性疾病
公开(公告)号：WO2005000406A3
公开(公告)日：2005-06-23
申请号：PCT/US2004019839
申请日：2004-06-21
申请人： NEUROCHEM INT LTD , KONG XIANQI , LU WENSHUO , WU XINFU
发明人： KONG XIANQI , LU WENSHUO , WU XINFU
IPC分类号： A61K31/185 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/22 , A61P25/28 , A61P27/00 , A61P29/00 , C07C309/14 , C07C309/26 , C07D209/14 , C07D213/38 , C07D233/24 , C07D233/28 , C07D239/06 , C07D263/10 , C07D263/16 , C07D265/08 , C07D277/10 , C07D277/12 , C07D279/06 , C07D317/58 , C07D333/20 , C07D333/58
CPC分类号： C07D239/06 , A61K31/185 , C07C309/14 , C07C309/26 , C07C2601/14 , C07C2602/10 , C07D209/14 , C07D213/38 , C07D233/24 , C07D233/28 , C07D263/10 , C07D263/16 , C07D265/08 , C07D277/10 , C07D277/12 , C07D279/06 , C07D317/58 , C07D333/20 , C07D333/58
摘要： Methods of treating or preventing an amyloid-related disease in a subject by administering to a subject a therapeutic amount of a compound of the invention are described. Also included are methods for inhibiting epileptogenesis in a subject, by administering to a subject an effective amount of an anti-epileptogenic agent. Methods for treating a subject suffering from an epileptogenesis-associated condition, by administering to the subject an effective amount of an anti-epileptogenic agent are also included. Methods for treating convulsions in a subject by administering to the subject an effective amount of a therapeutic amount of a compound of the invention are also described.
摘要翻译：描述了通过向受试者施用治疗量的本发明化合物来治疗或预防受试者中淀粉样蛋白相关疾病的方法。还包括通过向受试者施用有效量的抗癫痫发生剂来抑制受试者中癫痫发生的方法。还包括通过向受试者施用有效量的抗癫痫发生剂来治疗患有癫痫发生相关病症的受试者的方法。还描述了通过向受试者施用有效量的治疗量的本发明化合物来治疗受试者的抽搐的方法。

6. 发明申请

WO2007069073A3 PHARMACEUTICAL FORMULATIONS OF AMYLOID INHIBITING COMPOUNDS 审中-公开
标题翻译： AMYLOID抑制化合物的药物制剂
公开(公告)号：WO2007069073A3
公开(公告)日：2007-11-08
申请号：PCT/IB2006003865
申请日：2006-04-12
申请人： NEUROCHEM INT LTD , LAURIN JULIE , GARCEAU DENIS
发明人： LAURIN JULIE , GARCEAU DENIS
IPC分类号： A61K31/185 , A61P25/28
CPC分类号： A61K31/185 , A61K9/0004 , A61K9/2009 , A61K9/2018 , A61K9/2054 , A61K9/2086 , A61K9/209 , A61K9/2846 , A61K9/2886 , A61K9/485 , A61K9/5047
摘要： Therapeutic formulations and methods for inhibiting amyloid deposition in a subject, whatever its clinical setting, are described. Therapeutic formulations and methods for preventing or treating amyloidosis and/or amyloid-related disease are also described.
摘要翻译：描述了用于抑制受试者中淀粉样蛋白沉积的治疗剂型和方法，无论其临床情况如何。还描述了用于预防或治疗淀粉样变性和/或淀粉样蛋白相关疾病的治疗剂型和方法。

7. 发明申请

WO2006085149A3 METHODS AND COMPOSITIONS FOR TREATING AMYLOID-RELATED DISEASES 审中-公开
标题翻译：用于治疗淀粉样相关疾病的方法和组合物
公开(公告)号：WO2006085149A3
公开(公告)日：2007-05-10
申请号：PCT/IB2005004166
申请日：2005-12-21
申请人： NEUROCHEM INT LTD , KONG XIANQI , WU XINFU , BOUZIDE ABDERRAHIM , VALADE ISABELLE , MIGNEAULT DAVID , GERVAIS FRANCINE , DELORME DANIEL , BACHAND BENOIT , ATFANI MOHAMED , LEVESQUE SOPHIE , SAMIM BITA
发明人： KONG XIANQI , WU XINFU , BOUZIDE ABDERRAHIM , VALADE ISABELLE , MIGNEAULT DAVID , GERVAIS FRANCINE , DELORME DANIEL , BACHAND BENOIT , ATFANI MOHAMED , LEVESQUE SOPHIE , SAMIM BITA
IPC分类号： C07C309/14 , C07C309/19 , C07C309/21 , C07C309/24 , C07C309/26 , C07D211/22 , C07D211/24 , C07D211/54 , C07D235/28 , C07D307/14 , C07D307/52 , C07D317/58 , C07D333/18 , C07D333/38 , C07D333/58
CPC分类号： C07C309/19 , C07C309/14 , C07C309/21 , C07C309/24 , C07C309/26 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07C2602/08 , C07C2602/10 , C07C2602/42 , C07C2603/74 , C07D207/12 , C07D207/333 , C07D209/08 , C07D209/16 , C07D209/36 , C07D209/44 , C07D209/48 , C07D209/86 , C07D211/06 , C07D211/14 , C07D211/18 , C07D211/34 , C07D211/48 , C07D211/52 , C07D211/58 , C07D211/64 , C07D211/70 , C07D211/82 , C07D213/04 , C07D213/20 , C07D213/50 , C07D213/75 , C07D213/82 , C07D217/04 , C07D219/10 , C07D231/44 , C07D233/54 , C07D235/28 , C07D257/04 , C07D275/06 , C07D277/66 , C07D295/073 , C07D295/088 , C07D307/14 , C07D307/52 , C07D317/58 , C07D327/04 , C07D327/06 , C07D327/08 , C07D333/20 , C07D333/34 , C07D409/04 , C07D471/04 , C07D471/08 , C07K5/06
摘要： Compounds of formulae (VIII), (IX), (X), (XI), (XII) (XIII), (XIV) and (XV), in which the variables are as defined in the claims are described, as well as methods, pharmaceutical compositions and kits for treating or preventing amyloid-related disease.
摘要翻译：描述了变量如权利要求中所定义的式（VIII），（IX），（X），（XI），（XII）（XIII），（XIV）和（XV）方法，药物组合物和用于治疗或预防淀粉样蛋白相关疾病的试剂盒。

8. 发明申请

WO2007004072A2 FORMULATIONS AND METHODS FOR TREATING AMYLOIDOSIS 审中-公开
标题翻译：用于治疗淀粉样变性的制剂和方法
公开(公告)号：WO2007004072A2
公开(公告)日：2007-01-11
申请号：PCT/IB2006002540
申请日：2006-04-17
申请人： NEUROCHEM INT LTD , GARCEAU DENIS , HAUCK WENDY , BRIAND RICHARD
发明人： GARCEAU DENIS , HAUCK WENDY , BRIAND RICHARD
CPC分类号： A61K31/185 , A61K31/16 , A61K31/255 , A61K31/525 , A61K45/06
摘要： Methods, formulations, and compositions for the treatment of amyloidosis are described.
摘要翻译：描述了用于治疗淀粉样变性的方法，制剂和组合物。

9. 发明申请

WO2006059245A3 COMPOUNDS FOR THE TREATMENT OF CNS AND AMYLOID ASSOCIATED DISEASES 审中-公开
标题翻译：用于治疗CNS和AMYLOID相关疾病的化合物
公开(公告)号：WO2006059245A3
公开(公告)日：2006-10-05
申请号：PCT/IB2005004115
申请日：2005-11-16
申请人： NEUROCHEM INT LTD , KONG XIANQI , WU XINFU , VALADE ISABELLE , GERVAIS FRANCINE
发明人： KONG XIANQI , WU XINFU , VALADE ISABELLE , GERVAIS FRANCINE
IPC分类号： C07D401/12 , C07D215/12 , C07D233/42 , C07D233/54 , C07D235/04 , C07D257/04 , C07D263/30 , C07D271/07 , C07D295/04 , C07D401/04 , C07D401/06 , C07D401/14 , C07D403/04 , C07D413/12 , C07D487/04
CPC分类号： C07D401/12 , C07D233/84 , C07D239/47 , C07D239/56 , C07D249/12 , C07D257/04 , C07D271/113 , C07D401/04 , C07D413/12 , C07D417/12 , C07D487/04
摘要： Methods, compounds, pharmaceutical compositions and kits are described for treating or preventing CNS and amyloid associated disease. Also described are methods, compounds, pharmaceutical compositions and kits for detecting, diagnosing, monitoring and treating or preventing CNS and amyloid associated disease Pn particular, modified blood bram barrier (BBB) vectors such as phenylalanine derivatives are described as to provide parameters to select CNS drug candidates designated to penetrate the bram using a specific active transporter.
摘要翻译：描述了治疗或预防CNS和淀粉样蛋白相关疾病的方法，化合物，药物组合物和试剂盒。还描述了用于检测，诊断，监测和治疗或预防CNS和淀粉样蛋白相关疾病的方法，化合物，药物组合物和试剂盒，特别地，修饰的血液阻遏（BBB）载体如苯丙氨酸衍生物被描述为提供选择CNS的参数候选药物使用特定的活性转运蛋白来指定用于渗透乳块。

10. 发明申请

WO2007125385A3 TREATMENT OF RENAL DISORDERS, DIABETIC NEPHOPATHY AND DYSLIPIDEMIAS 审中-公开
标题翻译：治疗肾功能异常，糖尿病，糖尿病
公开(公告)号：WO2007125385A3
公开(公告)日：2008-03-20
申请号：PCT/IB2006004262
申请日：2006-12-22
申请人： NEUROCHEM INT LTD , HAUCK WENDY
发明人： HAUCK WENDY
IPC分类号： A61K31/10 , A61P3/04 , A61P3/06 , A61P9/10 , A61P9/12 , A61P13/10
CPC分类号： A61K31/10 , A61K31/185
摘要： Disclosed herein are methods, compounds and compositions for preventing or treating a renal disorder or chronic kidney diseases, including nephropathies such as diabetic nephropathy. The invention generally includes administering to a subject 1,3-propanedisulfonic acid or a pharmaceutically acceptable salt thereof, e.g., 1,3- propanedisulfonic acid sodium salt. The invention also relates to methods, compounds and compositions for the prevention and/or treatment of for preventing or treating a renal disorder complication. The invention further relates to methods, compounds and compositions for the prevention and/or treatment of dyslipidemia, and more particularly for reducing levels of harmful serum lipid levels, especially cholesterol and triglycerides in diabetic patients.
摘要翻译：本文公开了用于预防或治疗肾病或慢性肾脏疾病（包括肾病如糖尿病肾病）的方法，化合物和组合物。本发明通常包括向受试者施用1,3-丙二磺酸或其药学上可接受的盐，例如1,3-丙二磺酸钠盐。本发明还涉及用于预防和/或治疗预防或治疗肾病并发症的方法，化合物和组合物。本发明还涉及用于预防和/或治疗血脂异常的方法，化合物和组合物，更具体地涉及降低糖尿病患者中有害血清脂质水平，特别是胆固醇和甘油三酯的水平。

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