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1. 发明申请

WO2007004072A2 FORMULATIONS AND METHODS FOR TREATING AMYLOIDOSIS 审中-公开
标题翻译：用于治疗淀粉样变性的制剂和方法
公开(公告)号：WO2007004072A2
公开(公告)日：2007-01-11
申请号：PCT/IB2006002540
申请日：2006-04-17
申请人： NEUROCHEM INT LTD , GARCEAU DENIS , HAUCK WENDY , BRIAND RICHARD
发明人： GARCEAU DENIS , HAUCK WENDY , BRIAND RICHARD
CPC分类号： A61K31/185 , A61K31/16 , A61K31/255 , A61K31/525 , A61K45/06
摘要： Methods, formulations, and compositions for the treatment of amyloidosis are described.
摘要翻译：描述了用于治疗淀粉样变性的方法，制剂和组合物。

2. 发明申请

WO2007125385A3 TREATMENT OF RENAL DISORDERS, DIABETIC NEPHOPATHY AND DYSLIPIDEMIAS 审中-公开
标题翻译：治疗肾功能异常，糖尿病，糖尿病
公开(公告)号：WO2007125385A3
公开(公告)日：2008-03-20
申请号：PCT/IB2006004262
申请日：2006-12-22
申请人： NEUROCHEM INT LTD , HAUCK WENDY
发明人： HAUCK WENDY
IPC分类号： A61K31/10 , A61P3/04 , A61P3/06 , A61P9/10 , A61P9/12 , A61P13/10
CPC分类号： A61K31/10 , A61K31/185
摘要： Disclosed herein are methods, compounds and compositions for preventing or treating a renal disorder or chronic kidney diseases, including nephropathies such as diabetic nephropathy. The invention generally includes administering to a subject 1,3-propanedisulfonic acid or a pharmaceutically acceptable salt thereof, e.g., 1,3- propanedisulfonic acid sodium salt. The invention also relates to methods, compounds and compositions for the prevention and/or treatment of for preventing or treating a renal disorder complication. The invention further relates to methods, compounds and compositions for the prevention and/or treatment of dyslipidemia, and more particularly for reducing levels of harmful serum lipid levels, especially cholesterol and triglycerides in diabetic patients.
摘要翻译：本文公开了用于预防或治疗肾病或慢性肾脏疾病（包括肾病如糖尿病肾病）的方法，化合物和组合物。本发明通常包括向受试者施用1,3-丙二磺酸或其药学上可接受的盐，例如1,3-丙二磺酸钠盐。本发明还涉及用于预防和/或治疗预防或治疗肾病并发症的方法，化合物和组合物。本发明还涉及用于预防和/或治疗血脂异常的方法，化合物和组合物，更具体地涉及降低糖尿病患者中有害血清脂质水平，特别是胆固醇和甘油三酯的水平。

3. 发明申请

WO2007004072B1 FORMULATIONS AND METHODS FOR TREATING AMYLOIDOSIS 审中-公开
标题翻译：用于治疗淀粉样变性的制剂和方法
公开(公告)号：WO2007004072B1
公开(公告)日：2007-12-27
申请号：PCT/IB2006002540
申请日：2006-04-17
申请人： NEUROCHEM INT LTD , GARCEAU DENIS , HAUCK WENDY , BRIAND RICHARD
发明人： GARCEAU DENIS , HAUCK WENDY , BRIAND RICHARD
IPC分类号： A61K31/185
CPC分类号： A61K31/185 , A61K31/16 , A61K31/255 , A61K31/525 , A61K45/06
摘要： Methods, formulations, and compositions for the treatment of amyloidosis are described, whereby a therapeutically effective amount of a compound having the formula (I) wherein Y is SO 3 X or OSO 3 X independently chosen for each occurrence; X is cationic group independently chosen for each occurrence; n is 1, 2, 3 or 4; and m is 1 or 2, is applied.
摘要翻译：描述了用于治疗淀粉样变性的方法，制剂和组合物，其中治疗有效量的具有式（I）的化合物，其中Y是SO 3 X或OSO 3 X为每次出现独立选择; X是每次发生时独立选择的阳离子基团; n为1,2,3或4; 并且m为1或2。

4. 发明申请

WO2008078176A9 METHODS, COMPOUNDS, AND COMPOSITIONS FOR TREATING METABOLIC DISORDERS AND DIABETES 审中-公开
标题翻译：用于治疗代谢障碍和糖尿病的方法，化合物和组合物
公开(公告)号：WO2008078176A9
公开(公告)日：2009-03-19
申请号：PCT/IB2007004088
申请日：2007-12-21
申请人： BELLUS HEALTH INT LTD , HAUCK WENDY , HAMET PAVEL
发明人： HAUCK WENDY , HAMET PAVEL
IPC分类号： A61K31/10 , A61P3/08 , A61P3/10
CPC分类号： A61K31/10
摘要： Disclosed herein are methods, compounds and compositions for preventing or treating a pancreatic disorder, including diabetes mellitus (e.g. type 1 and/or type 2 diabetes). The invention generally includes administering to a subject 1,3-propanedisulfonic acid or a pharmaceutically acceptable salt thereof, e.g., 1,3-propanedisulfonic acid sodium salt. The invention also relates to methods, compounds and compositions for improving or at least stabilizing pancreatic function(s) and for the prevention and/or treatment of metabolic syndrome and its components. The invention further relates to methods, compounds and compositions for the prevention and/or treatment of dyslipidemia, and more particularly for reducing levels of harmful serum lipid levels, especially cholesterol and triglycerides in patients in need thereof, including diabetic patients.
摘要翻译：本文公开了用于预防或治疗胰腺疾病，包括糖尿病（例如1型和/或2型糖尿病）的方法，化合物和组合物。本发明通常包括向受试者施用1,3-丙二磺酸或其药学上可接受的盐，例如1,3-丙二磺酸钠盐。本发明还涉及用于改善或至少稳定胰腺功能以及预防和/或治疗代谢综合征及其组分的方法，化合物和组合物。本发明进一步涉及用于预防和/或治疗血脂异常的方法，化合物和组合物，更具体地涉及在需要的患者（包括糖尿病患者）中降低有害血清脂质水平，特别是胆固醇和甘油三酸酯的水平。

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