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1. 发明申请

WO2010119257A2 INTERNAL RIBOSOME ENTRY SITE 审中-公开
标题翻译：内部入口网站
公开(公告)号：WO2010119257A2
公开(公告)日：2010-10-21
申请号：PCT/GB2010/000763
申请日：2010-04-15
申请人： INSTITUTE FOR ANIMAL HEALTH , THE SCRIPPS RESEARCH INSTITUTE , TAHIRI-ALAOUI, Abdou , MAURO, Vincent , NAIR, Venugopal
发明人： TAHIRI-ALAOUI, Abdou , MAURO, Vincent , NAIR, Venugopal
IPC分类号： C12N15/09 , C12N15/85
CPC分类号： C12N15/85 , C12N2710/16322 , C12N2840/203 , C12N2840/206 , C12N2840/60
摘要： The present invention provides an internal ribosome entry site (IRES) sequence derivable from the IRES located in the 5' untranslated region (UTR) of the p14 lytic protein from Marek's disease virus (MDV-1). The IRES may comprise the sequence shown as SEQ ID No 1 or a part or variant thereof. The present invention also provides a construct comprising such an IRES and a cistron; a nucleotide sequence comprising or capable of encoding such an IRES or construct and a vector comprising such a nucleotide sequence. The vector may be used as a pharmaceutical composition.
摘要翻译：本发明提供了可从位于马立克氏病病毒（MDV-1）的p14溶解蛋白的5'非翻译区（UTR）的IRES得到的内部核糖体进入位点（IRES）序列。 IRES可以包含SEQ ID No 1所示的序列或其部分或变体。本发明还提供包含这种IRES和顺反子的构建体; 包含或能够编码这种IRES或构建体的核苷酸序列和包含这种核苷酸序列的载体。载体可以用作药物组合物。

2. 发明申请

WO2009150431A1 VECTOR 审中-公开
标题翻译：向量
公开(公告)号：WO2009150431A1
公开(公告)日：2009-12-17
申请号：PCT/GB2009/001471
申请日：2009-06-11
申请人： INSTITUTE FOR ANIMAL HEALTH , NAIR, Venugopal , LAMBETH, Luke
发明人： NAIR, Venugopal , LAMBETH, Luke
IPC分类号： A61K48/00 , C12N15/11
CPC分类号： C12N15/111 , C12N2310/111 , C12N2310/14 , C12N2310/141 , C12N2320/50 , C12N2710/16043
摘要： The present invention relates to a herpes virus vector which comprises a modified genomic sequence encoding a microRNA (miRNA) against a target sequence. The herpes virus vector may be used as or in a vaccine to prevent and/or treat a disease.
摘要翻译：本发明涉及一种疱疹病毒载体，其包含编码针对靶序列的微小RNA（miRNA）的修饰基因组序列。疱疹病毒载体可以用作疫苗或在疫苗中用于预防和/或治疗疾病。

3. 发明申请

WO2009150430A2 VACCINE 审中-公开
标题翻译：疫苗
公开(公告)号：WO2009150430A2
公开(公告)日：2009-12-17
申请号：PCT/GB2009/001470
申请日：2009-06-11
申请人： INSTITUTE FOR ANIMAL HEALTH , LAMBETH, Luke , NAIR, Venugopal
发明人： LAMBETH, Luke , NAIR, Venugopal
IPC分类号： C12N15/11 , C12N15/63 , C12N5/10 , C07H21/04 , A61K31/7088
CPC分类号： C12N15/111 , A61K39/12 , A61K39/255 , A61K2039/5254 , C12N15/1133 , C12N2310/111 , C12N2310/14 , C12N2320/50 , C12N2710/16334 , C12N2710/16343 , C12N2740/11043
摘要： The present invention provides a live replicating virus vaccine comprising a heterologous nucleotide sequence capable of expressing an inhibitory RNA against a target sequence.
摘要翻译：本发明提供一种活复制病毒疫苗，其包含能够表达针对靶序列的抑制性RNA的异源核苷酸序列。

4. 发明申请

WO2004035821A1 ASSAY METHODS FOR DETECTION OF A VIRUS IN AN AVIAN TISSUE SAMPLE 审中-公开
标题翻译：用于检测AVIAN TISSUE样品中的病毒的测定方法
公开(公告)号：WO2004035821A1
公开(公告)日：2004-04-29
申请号：PCT/EP2003/011360
申请日：2003-10-14
申请人： WYETH , NAIR, Venugopal, K. , BAIGENT, Susan, Jean , CURRIE, Richard, John, William
发明人： NAIR, Venugopal, K. , BAIGENT, Susan, Jean , CURRIE, Richard, John, William
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6806 , C12Q1/701
摘要： The invention relates to methods of detecting a virus in an avian tissue sample wherein genetic material derived from feathers is tested for the presence of genetic material from the virus.
摘要翻译：本发明涉及在鸟类组织样品中检测病毒的方法，其中来自羽毛的遗传物质被测试来自病毒的遗传物质的存在。

5. 发明申请

WO2011023950A1 ASSAY METHODS FOR MDV-1 审中-公开
标题翻译： MDV-1的测定方法
公开(公告)号：WO2011023950A1
公开(公告)日：2011-03-03
申请号：PCT/GB2010/001602
申请日：2010-08-25
申请人： WYETH , BAIGENT, Susan , NAIR, Venugopal , LE GALLUDEC, Herve
发明人： BAIGENT, Susan , NAIR, Venugopal , LE GALLUDEC, Herve
IPC分类号： C12Q1/70
CPC分类号： C12Q1/705 , C12Q2600/156
摘要： A method for the quantification of a vaccine strain and/or a virulent strain of Wlarek's Disease Virus Serotype-1 (MDV-1) in a sample from a bird, comprising the steps of: (i) providing a biological sample from the bird and optionally isolating nucleic acid from the biological sample; (ii) subjecting the biological sample of (i) to real-time quantitative PCR (qPCR) comprising: (a) amplification of a region of the pp3B gene within the nucleic acid sample of (i), said region containing a consistent single nucleotide polymorphism (SNP) difference between vaccine and virulent strains of MDV-1; and (b) contacting the amplified nucleic acid of (a) with a detectable nucleic acid probe specific for the SNP of the vaccine strain of MDV-1 and/or a detectable nucleic aα'd probe specific for the SNP of the virulent strain of MDV-1; and (iii) Measuring changes in the detectable signal produced by the probe of (ii). Methods are also provided for the absolute quantification of vaccine and virulent viruses.
摘要翻译：一种用于定量来自鸟的样品中的Wlarek's病毒血清型-1（MDV-1）的疫苗株和/或毒性株的方法，包括以下步骤：（i）从鸟提供生物样品，任选地从生物样品中分离核酸; （ii）对（i）生物样品进行实时定量PCR（qPCR），包括：（a）在（i）的核酸样品中扩增pp3B基因的区域，所述区域含有一致的单核苷酸疫苗与MDV-1毒株之间的多态性（SNP）差异; 和（b）将（a）的扩增的核酸与特异于MDV-1的疫苗株的SNP的可检测的核酸探针和/或对于毒性毒株的SNP特异性的可检测的核酸探针接触 MDV-1; 和（iii）测量由（ii）的探针产生的可检测信号的变化。还提供了用于绝对定量疫苗和毒性病毒的方法。

6. 发明申请

WO2010119257A3 INTERNAL RIBOSOME ENTRY SITE FROM MAREK' S DISEASE VIRUS 审中-公开
标题翻译：来自MAREK的疾病病毒的内部入侵场所
公开(公告)号：WO2010119257A3
公开(公告)日：2010-12-09
申请号：PCT/GB2010000763
申请日：2010-04-15
申请人： ANIMAL HEALTH INST , SCRIPPS RESEARCH INST , TAHIRI-ALAOUI ABDOU , MAURO VINCENT , NAIR VENUGOPAL
发明人： TAHIRI-ALAOUI ABDOU , MAURO VINCENT , NAIR VENUGOPAL
IPC分类号： C12N15/09 , C12N15/85
CPC分类号： C12N15/85 , C12N2710/16322 , C12N2840/203 , C12N2840/206 , C12N2840/60
摘要： The present invention provides an internal ribosome entry site (IRES) sequence derivable from the IRES located in the 5' untranslated region (UTR) of the pl4 lytic protein from Marek's disease virus (MDV-I). The IRES may comprise the sequence shown in figure 1 or a part or variant thereof. The present invention also provides a construct comprising such an IRES and a cistron; a nucleotide sequence comprising or capable of encoding such an IRES or construct and a vector comprising such a nucleotide sequence. The vector may be used as a pharmaceutical composition.
摘要翻译：本发明提供了可从位于马立克氏病病毒（MDV-1）的pl4裂解蛋白的5'非翻译区（UTR）的IRES得到的内部核糖体进入位点（IRES）序列。 IRES可以包括图1所示的序列或其一部分或变体。本发明还提供了包含这种IRES和顺反子的构建体; 包含或能够编码这种IRES或构建体的核苷酸序列和包含这种核苷酸序列的载体。载体可以用作药物组合物。

7. 发明申请

WO2009150430A3 VACCINE 审中-公开
标题翻译：疫苗
公开(公告)号：WO2009150430A3
公开(公告)日：2010-08-12
申请号：PCT/GB2009001470
申请日：2009-06-11
申请人： ANIMAL HEALTH INST , LAMBETH LUKE , NAIR VENUGOPAL
发明人： LAMBETH LUKE , NAIR VENUGOPAL
IPC分类号： C12N15/11 , C12N15/113 , C12N15/869
CPC分类号： C12N15/111 , A61K39/12 , A61K39/255 , A61K2039/5254 , C12N15/1133 , C12N2310/111 , C12N2310/14 , C12N2320/50 , C12N2710/16334 , C12N2710/16343 , C12N2740/11043
摘要： The present invention provides a live replicating virus vaccine comprising a heterologous nucleotide sequence capable of expressing an inhibitory RNA against a target sequence.
摘要翻译：本发明提供一种活复制病毒疫苗，其包含能够表达针对靶序列的抑制性RNA的异源核苷酸序列。

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