专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2005021734A2 GENERATION OF HEMATOPOIETIC CHIMERISM AND INDUCTION OF CENTRAL TOLERANCE 审中-公开
标题翻译：造血干细胞的产生与中枢神经的诱发
公开(公告)号：WO2005021734A2
公开(公告)日：2005-03-10
申请号：PCT/US2004/028965
申请日：2004-09-02
申请人： UNIVERSITY OF MASSACHUSSETS , GREINER, Dale, L. , MORDES, John, P. , ROSSINI, Aldo , SEUNG, Edward
发明人： GREINER, Dale, L. , MORDES, John, P. , ROSSINI, Aldo , SEUNG, Edward
IPC分类号： C12N
CPC分类号： C07K16/2866 , A01K67/0271 , A61K39/001 , A61K39/39541 , A61K2035/122 , A61K2039/507 , C07K16/2875 , C07K2317/73 , A61K2300/00
摘要： The invention relates to methods for producing hematopoietic chimerism and central tolerance by peripheral tolerance induction without myeloablative conditioning.
摘要翻译：本发明涉及通过外周耐受性诱导产生造血嵌合体和中心耐受而不进行清髓性调理的方法。

2. 发明申请

WO0100679A2 METHODS FOR INDUCING T CELL NON-RESPONSIVENESS TO A TISSUE OR ORGAN GRAFT 审中-公开
标题翻译：诱导T细胞对组织或组织细胞无反应的方法
公开(公告)号：WO0100679A2
公开(公告)日：2001-01-04
申请号：PCT/US0017730
申请日：2000-06-27
申请人： UNIV MASSACHUSETTS , ROSSINI ALDO A , IWAKOSHI NEAL , MORDES JOHN P , GREINER DALE L
发明人： ROSSINI ALDO A , IWAKOSHI NEAL , MORDES JOHN P , GREINER DALE L
IPC分类号： A61K38/11 , C07K16/28 , C07K16/00
CPC分类号： C07K16/2875 , A61K38/00 , A61K2039/505 , C07K16/2815
摘要： Methods for inducing T cell tolerance to a tissue or organ graft in a transplant recipient are disclosed. The methods involve administering to a subject antagonists of the receptor which inhibit interaction of the ligand with the receptor, and CD8 T cell depleting agents. In a preferred embodiment, the molecules on the surface of the T cell which mediate contact-dependent helper effector function are CD154. Preferred CD154 antagonists and CD8 T cell depleting agents are anti-CD154 and CD8 antibodies. The CD154 antagonists and CD8 T cell depleting agents are typically administered to a transplant recipient following transplantation of the tissue or organ. The methods of the invention can be used to induce T cell tolerance to transplants such as pancreas, pituitary, liver, kidney, heart, lung, skin, muscle, brain tissue, nerve tissue, stomach, intestines, Adenosine Deaminase-expressing cells, and leptin-expressing cells. A method for treating a skin disorder comprising administering to a subject allogeneic or xenogeneic tissues, organs, or cells expressing donor antigens, CD154 antagonists and CD8 T cell depleting agents and allogeneic skin graft cells is also disclosed.
摘要翻译：公开了在移植受体中诱导T细胞对组织或器官移植物的耐受性的方法。所述方法包括向受试者施用抑制配体与受体相互作用的受体拮抗剂和CD8 + T细胞消耗剂。在优选的实施方案中，介导接触依赖性辅助效应子功能的T细胞表面上的分子是CD154。优选的CD154拮抗剂和CD8 + T细胞消耗剂是抗CD154和CD8抗体。 CD154拮抗剂和CD8 + T细胞消耗剂通常在移植组织或器官后给予移植受体。本发明的方法可用于诱导移植物如胰腺，垂体，肝，肾，心脏，肺，皮肤，肌肉，脑组织，神经组织，胃，肠，腺嘌呤脱氨酶表达细胞的T细胞耐受性和瘦素表达细胞。还公开了一种治疗皮肤病症的方法，包括给予受试者同种异体或异种组织，器官或表达供体抗原的细胞，CD154拮抗剂和CD8 + T细胞消耗剂和同种异体皮肤移植细胞。

3. 发明申请

WO2005001052A3 MODULATION OF APOPTOSIS 审中-公开
标题翻译：疫苗调节
公开(公告)号：WO2005001052A3
公开(公告)日：2006-11-23
申请号：PCT/US2004018142
申请日：2004-06-07
申请人： UNIV MASSACHUSETTS , ROSSINI ALDO A , BORTELL RITA , GREINER DALE L , MORDES JOHN P , CORVERA SILVIA , WILSON-FRITCH LEANNE , PANDARPURKAR MALINI , MARKHOLST HELLE , HORNUM LARS
发明人： ROSSINI ALDO A , BORTELL RITA , GREINER DALE L , MORDES JOHN P , CORVERA SILVIA , WILSON-FRITCH LEANNE , PANDARPURKAR MALINI , MARKHOLST HELLE , HORNUM LARS
IPC分类号： C12Q1/00 , A61K39/00 , C07H21/04 , C07K14/47 , C12N20060101 , C12N9/64 , C12Q1/68 , G01N33/48 , G01N33/50 , G01N33/53 , G01N33/564 , G01N33/574
CPC分类号： G01N33/574 , C07K14/4747 , G01N33/5079 , G01N33/564 , G01N2510/00
摘要： The present invention relates, at least in part, to methods of modulating apoptosis in cells, comprising contacting the cell with a compound that modulates the expression, post-translational modification, or activity of Ian4, leucine-rich protein of l30kD, GRP78, GRP94, or hsp60. The subject methods can be used to treat a variety of different disorders, for example, autoimmune disease and neoplasia. The invention also pertains to methods for identifying compounds that modulates the activity of Ian-4, leucine-rich protein of 130kD, GRP78, GRP94, or hsp60.
摘要翻译：本发明至少部分地涉及调节细胞凋亡的方法，包括使细胞与调节Ik4，富含亮氨酸的富马酸的蛋白质，GRP78，GRP94的表达，翻译后修饰或活性的化合物接触，或hsp60。本发明方法可用于治疗各种不同的疾病，例如自身免疫性疾病和瘤形成。本发明还涉及用于鉴定调节Ik-4富含130kD的富含亮氨酸的蛋白质，GRP78，GRP94或hsp60的活性的化合物的方法。

4. 发明申请

WO9528957A3 METHODS FOR INDUCING T CELL TOLERANCE TO A TISSUE OR ORGAN GRAFT 审中-公开
标题翻译：用于诱导T细胞对组织或组织细胞耐受性的方法
公开(公告)号：WO9528957A3
公开(公告)日：1995-11-23
申请号：PCT/US9504832
申请日：1995-04-25
申请人： DARTMOUTH COLLEGE , UNIV MASSACHUSETTS MEDICAL , NOELLE RANDOLPH J , DURIE FIONA H , PARKER DAVID C , APPEL MICHAEL C , PHILIPS NANCY E , MORDES JOHN P , GRENIER DALE L , ROSSINI ALDO A
发明人： NOELLE RANDOLPH J , DURIE FIONA H , PARKER DAVID C , APPEL MICHAEL C , PHILIPS NANCY E , MORDES JOHN P , GRENIER DALE L , ROSSINI ALDO A
IPC分类号： C12N15/02 , A61K31/00 , A61K35/14 , A61K35/38 , A61K38/00 , A61K38/17 , A61K39/00 , A61K39/395 , A61P3/00 , A61P3/10 , A61P37/00 , A61P37/06 , C07K14/705 , C07K16/28 , C12P21/08 , C12R1/91
CPC分类号： A61K39/001 , A61K35/17 , A61K35/39 , A61K38/00 , A61K2039/505 , C07K14/705 , C07K16/2875 , C07K2317/73 , Y10S514/885 , A61K2300/00
摘要： Methods for inducing T cell tolerance to a tissue or organ graft in a transplant recipient are disclosed. The methods involve administering to a subject: 1) an allogeneic or xenogeneic cell which expresses donor antigens and which has a ligand on the cell surface which interacts with a receptor on the surface of a recipient T cell which mediates contact-dependent helper effector function; and 2) an antagonist of the receptor which inhibits interaction of the ligand with the receptor. In a preferred embodiment, the allogeneic or xenogeneic cell is a B cell, preferably a resting B cell, and the molecule on the surface of the T cell which mediates contact-dependent helper effector function is gp39. A preferred gp39 antagonist is an anti-gp39 antibody. The allogeneic or xenogeneic cell and the gp39 antagonist are typically administered to a transplant recipient prior to transplantation of the tissue or organ. The methods of the invention can be used to induce T cell tolerance to transplants such as liver, kidney, heart, lung, skin, muscle, neuronal tissue, stomach and intestine. A method for treating diabetes comprising administering to a subject allogeneic or xenogeneic cells expressing donor antigens, a gp39 antagonist and pancreatic islets is also disclosed.

5. 发明申请

WO2005001052A2 MODULATION OF APOPTOSIS 审中-公开
标题翻译：疫苗调节
公开(公告)号：WO2005001052A2
公开(公告)日：2005-01-06
申请号：PCT/US2004/018142
申请日：2004-06-07
申请人： UNIVERSITY OF MASSACHUSETTS , ROSSINI, Aldo, A. , BORTELL, Rita , GREINER, Dale, L. , MORDES, John, P. , CORVERA, Silvia , WILSON-FRITCH, Leanne , PANDARPURKAR, Malini , MARKHOLST, Helle , HORNUM, Lars
发明人： ROSSINI, Aldo, A. , BORTELL, Rita , GREINER, Dale, L. , MORDES, John, P. , CORVERA, Silvia , WILSON-FRITCH, Leanne , PANDARPURKAR, Malini , MARKHOLST, Helle , HORNUM, Lars
IPC分类号： C12N
CPC分类号： G01N33/574 , C07K14/4747 , G01N33/5079 , G01N33/564 , G01N2510/00
摘要： The present invention relates, at least in part, to methods of modulating apoptosis in cells, comprising contacting the cell with a compound that modulates the expression, post-translational modification, or activity of Ian4, leucine-rich protein of l30kD, GRP78, GRP94, or hsp60. The subject methods can be used to treat a variety of different disorders, for example, autoimmune disease and neoplasia. The invention also pertains to methods for identifying compounds that modulates the activity of Ian-4, leucine-rich protein of 130kD, GRP78, GRP94, or hsp60.
摘要翻译：本发明至少部分地涉及调节细胞凋亡的方法，包括使细胞与调节Ik4，富含亮氨酸的富马酸的蛋白质，GRP78，GRP94的表达，翻译后修饰或活性的化合物接触，或hsp60。本发明方法可用于治疗各种不同的疾病，例如自身免疫性疾病和瘤形成。本发明还涉及用于鉴定调节Ik-4富含130kD的富含亮氨酸的蛋白质，GRP78，GRP94或hsp60的活性的化合物的方法。

6. 发明申请

WO1995028957A2 METHODS FOR INDUCING T CELL TOLERANCE TO A TISSUE OR ORGAN GRAFT 审中-公开
标题翻译：用于诱导T细胞对组织或组织细胞耐受性的方法
公开(公告)号：WO1995028957A2
公开(公告)日：1995-11-02
申请号：PCT/US1995004832
申请日：1995-04-25
申请人： TRUSTEES OF DARTMOUTH COLLEGE , UNIVERSITY OF MASSACHUSETTS MEDICAL CENTER , NOELLE, Randolph, J. , DURIE, Fiona, H. , PARKER, David, C. , APPEL, Michael, C. , PHILIPS, Nancy, E. , MORDES, John, P. , GRENIER, Dale, L. , ROSSINI, Aldo, A.
发明人： TRUSTEES OF DARTMOUTH COLLEGE , UNIVERSITY OF MASSACHUSETTS MEDICAL CENTER
IPC分类号： A61K39/00
CPC分类号： A61K39/001 , A61K35/17 , A61K35/39 , A61K38/00 , A61K2039/505 , C07K14/705 , C07K16/2875 , C07K2317/73 , Y10S514/885 , A61K2300/00
摘要： Methods for inducing T cell tolerance to a tissue or organ graft in a transplant recipient are disclosed. The methods involve administering to a subject: 1) an allogeneic or xenogeneic cell which expresses donor antigens and which has a ligand on the cell surface which interacts with a receptor on the surface of a recipient T cell which mediates contact-dependent helper effector function; and 2) an antagonist of the receptor which inhibits interaction of the ligand with the receptor. In a preferred embodiment, the allogeneic or xenogeneic cell is a B cell, preferably a resting B cell, and the molecule on the surface of the T cell which mediates contact-dependent helper effector function is gp39. A preferred gp39 antagonist is an anti-gp39 antibody. The allogeneic or xenogeneic cell and the gp39 antagonist are typically administered to a transplant recipient prior to transplantation of the tissue or organ. The methods of the invention can be used to induce T cell tolerance to transplants such as liver, kidney, heart, lung, skin, muscle, neuronal tissue, stomach and intestine. A method for treating diabetes comprising administering to a subject allogeneic or xenogeneic cells expressing donor antigens, a gp39 antagonist and pancreatic islets is also disclosed.
摘要翻译：公开了在移植受体中诱导T细胞对组织或器官移植物的耐受性的方法。所述方法包括对受试者施用：1）同种异体或异种细胞，其表达供体抗原，并且其在细胞表面上具有与介导接触依赖性辅助效应子功能的受体T细胞表面上的受体相互作用的配体; 和2）抑制配体与受体相互作用的受体拮抗剂。在一个优选的实施方案中，同种异体或异种细胞是B细胞，优选静止的B细胞，并且介导接触依赖性辅助效应子功能的T细胞表面上的分子是gp39。优选的gp39拮抗剂是抗gp39抗体。同种异体或异种细胞和gp39拮抗剂通常在移植组织或器官之前给予移植受体。本发明的方法可用于诱导移植物如肝，肾，心脏，肺，皮肤，肌肉，神经元组织，胃和肠的T细胞耐受性。还公开了一种用于治疗糖尿病的方法，其包括向受试者施用表达供体抗原的同种异体或异种细胞，gp39拮抗剂和胰岛。

7. 发明申请

WO2005021734A3 GENERATION OF HEMATOPOIETIC CHIMERISM AND INDUCTION OF CENTRAL TOLERANCE 审中-公开
标题翻译： HEMATOPOIETIC CHIMERISM的产生和中央容忍的诱导
公开(公告)号：WO2005021734A3
公开(公告)日：2005-09-22
申请号：PCT/US2004028965
申请日：2004-09-02
申请人： UNIV MASSACHUSSETS , GREINER DALE L , MORDES JOHN P , ROSSINI ALDO , SEUNG EDWARD
发明人： GREINER DALE L , MORDES JOHN P , ROSSINI ALDO , SEUNG EDWARD
IPC分类号： A61K35/12 , A61K39/00 , A61K39/395 , C07K16/28 , C12N20060101
CPC分类号： C07K16/2866 , A01K67/0271 , A61K39/001 , A61K39/39541 , A61K2035/122 , A61K2039/507 , C07K16/2875 , C07K2317/73 , A61K2300/00
摘要： The invention relates to methods for producing hematopoietic chimerism and central tolerance by peripheral tolerance induction without myeloablative conditioning.
摘要翻译：本发明涉及通过外周耐受诱导产生造血嵌合体和中枢耐受的方法，而不需要骨髓切除术。

8. 发明申请

WO1993000366A1 METHOD FOR TREATING IMMUNOLOGICAL DISORDERS AND DISEASES 审中-公开
标题翻译：治疗免疫缺陷病和疾病的方法
公开(公告)号：WO1993000366A1
公开(公告)日：1993-01-07
申请号：PCT/US1992005360
申请日：1992-06-24
申请人： UNIVERSITY OF MASSACHUSETTS MEDICAL CENTER , ROSSINI, Aldo, A. , MORDES, John, P. , HANDLER, Eugene, S. , GREINER, Dale, L.
发明人： UNIVERSITY OF MASSACHUSETTS MEDICAL CENTER
IPC分类号： C07K15/06
CPC分类号： C07K14/705 , A61K38/00 , A61K39/0008 , A61K2039/5158
摘要： This invention pertains to a method and apparatus for therapeutically treating insulin-dependent diabetes mellitus and other immunological disorders and disease states which are characterized by the presence of immunologically abnormal leukocytes in the body of the afflicted subject. The method involves the therapeutic administration of postthymic T lymphocytes capable of secreting soluble factors that can ameliorate disease state associated with diabetes or other autoimmune disease. Methods of screening and/or detecting insulin-dependent diabetes are also described.
摘要翻译：本发明涉及治疗性治疗胰岛素依赖性糖尿病和其他免疫学疾病和疾病状态的方法和装置，其特征在于受影响的受试者身体中存在免疫学异常的白细胞。该方法涉及能够分泌能够改善与糖尿病或其他自身免疫疾病相关的疾病状态的可溶性因子的胸腺后T淋巴细胞的治疗性给药。还描述了筛选和/或检测胰岛素依赖性糖尿病的方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式