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1. 发明申请

WO2005087367A8 MAGNETIC COMPOSITE PARTICLE AND PROCESS FOR PRODUCING THE SAME 审中-公开
标题翻译：磁性复合颗粒及其制造方法
公开(公告)号：WO2005087367A8
公开(公告)日：2006-07-06
申请号：PCT/JP2005004441
申请日：2005-03-14
申请人： HITACHI MAXELL , KOHNO KENJI , KISHIMOTO MIKIO , NISHIYA YOSHIAKI , KUSUMOTO MASAHIRO , NISHIMURA SHIN-ICHIRO
发明人： KOHNO KENJI , KISHIMOTO MIKIO , NISHIYA YOSHIAKI , KUSUMOTO MASAHIRO , NISHIMURA SHIN-ICHIRO
IPC分类号： A61K49/00 , B01J20/24 , C12N11/14
CPC分类号： A61K49/00 , B01J20/24 , C12N11/14
摘要： Magnetic composite particles of 0.01 to 4 µm average size comprising magnetic particles and, superimposed on surfaces thereof, chitosan layers. In particular, there are provided magnetic composite particles of core shell structure comprising magnetic particles as cores and chitosan layers as shells, which magnetic composite particles are capable of immobilizing physiologically active substances with high yield and after the immobilization, exhibit high collectability by magnetism. Further, there is provided a process for producing magnetic composite particle composed of magnetic particles and, superimposed on surfaces thereof, chitosan layers, which process comprises the steps of (a) dissolving chitosan in water by acidification; (b) dispersing magnetic particles in the chitosan solution and (c) slowly neutralizing the dispersion with a weak alkali base.
摘要翻译： 0.01〜4μm平均粒度的磁性复合颗粒包含磁性颗粒，并在其表面上叠加壳聚糖层。特别是提供了包含作为核的磁性粒子和壳聚糖层作为壳的核心壳结构的磁性复合颗粒，该磁性复合颗粒能够以高产率固定生理活性物质，并且在固定之后，通过磁性表现出高收集性。另外，提供了由磁性粒子构成的磁性复合粒子的制造方法，并且在其表面上叠加壳聚糖层，该方法包括以下步骤：（a）通过酸化将壳聚糖溶解在水中; （b）将磁性颗粒分散在壳聚糖溶液中，（c）用弱碱碱缓慢中和该分散液。

2. 发明申请

WO1995028718A1 MAGNETIC POWDER AND ITS MANUFACTURE AND APPLICATION 审中-公开
标题翻译：磁粉及其制造及应用
公开(公告)号：WO1995028718A1
公开(公告)日：1995-10-26
申请号：PCT/JP1995000731
申请日：1995-04-14
申请人： HITACHI MAXELL, LTD. , KISHIMOTO, Mikio , KITAHATA, Shinichi , KANZAKI, Hisao , OHTANI, Noriaki , SUEYOSHI, Toshinobu
发明人： HITACHI MAXELL, LTD.
IPC分类号： H01F01/06
CPC分类号： H01F1/047 , G06K19/02 , G11B5/70605 , G11B5/70626 , G11B5/716 , H01F1/06 , H01F1/061 , Y10S283/904 , Y10S428/90 , Y10T428/256 , Y10T428/265 , Y10T428/2991 , Y10T428/2993
摘要： A magnetic powder which contains MnBi and has a mean particle diameter of 0.1-20 mu m. The coercive force is 3,000-15,000 Oe measured at 300 K in a magnetic field of 16 KOe and 50-1,000 Oe measured at 80 K in the same magnetic field. The magnetic susceptibility is 20-60 emu/g measured at 300 K in a magnetic field of 16 KOe. The rate of decrease of the magnetic susceptibility is below 40 % and the generated amount of metallic Bi satisfies the relation, metallic Bi/(MnBi + metallic Bi)
摘要翻译：含有MnBi，平均粒径为0.1-20μm的磁性粉末。在相同磁场中在80K下测量的在1600K的磁场中测量的矫顽力为3,000-15,000Oe，在80K下测量的50-1,000Oe的矫顽力为3,000-15,000Oe。在160 KOe的磁场中，磁化率在300 K下测得为20-60 emu / g。磁化率的降低率低于40％，金属Bi的产生量满足金属Bi /（MnBi +金属Bi）<0.5（金属Bi表示X的（012）面的峰面积 Bi和MnBi的射线衍射峰表示当磁粉在60℃的温度和90℃的环境中保持7天时，MnBi的X射线衍射峰处的（101）面的峰面积％相对湿度。磁性粉末具有优异的耐腐蚀性，饱和磁化强度几乎不劣化。因此，当使用该磁性粉末制造磁记录介质时，可以防止记录的伪造。

3. 发明申请

WO1991016706A1 METHOD OF PRODUCING MAGNETIC DISKS HAVING SIGNALS 审中-公开
标题翻译：生产具有信号的磁盘的方法
公开(公告)号：WO1991016706A1
公开(公告)日：1991-10-31
申请号：PCT/JP1991000507
申请日：1991-04-17
申请人： HITACHI MAXELL, LTD. , KAWAKAMI, Shinji , KUSUMOTO, Kensyu , KISHIMOTO, Mikio
发明人： HITACHI MAXELL, LTD.
IPC分类号： G11B05/86
CPC分类号： G11B5/865
摘要： A method of producing many duplicate magnetic disks from a master disk at high speed using a simple device while preventing the demagnetization of the master disk. The disk for duplication has a magnetic layer including magnetic powder such as hexagonal ferrite crystals, a majority of which has the easy axis substantially perpendicular to the disk surface rather than along the tracks. The disk is placed in a manner that its magnetic layer is in contact with the magnetic layer of the master disk in which signals are recorded with magnetization along the tracks. The alternating magnetic field is applied over the disks in nearly a vertical direction, so that the signals of the master disk are transferred to the disk for duplication.
摘要翻译：一种使用简单的装置从主盘高速生产多个重复磁盘的方法，同时防止主盘的退磁。用于复制的盘具有包括诸如六边形铁素体晶体的磁性粉末的磁性层，其大部分具有基本上垂直于盘表面的容易轴，而不是沿轨道。磁盘以其磁性层与主磁盘的磁性层接触的方式放置，其中信号沿磁道沿磁化记录。交变磁场几乎在垂直方向上被施加在磁盘上，使得主磁盘的信号被传送到磁盘以进行复制。

4. 发明申请

WO2005008209A3 DEVICE FOR SEPARATING BIOLOGICAL COMPONENT AND METHOD OF SEPARATING BIOLOGICAL COMPONENT WITH THE USE THEREOF 审中-公开
标题翻译：用于分离生物组分的装置和用于分离生物组分的方法
公开(公告)号：WO2005008209A3
公开(公告)日：2005-03-24
申请号：PCT/JP2004010258
申请日：2004-07-13
申请人： TOYO BOSEKI , HITACHI MAXELL , KUSUMOTO MASAHIRO , NISHIYA YOSHIAKI , KISHIMOTO MIKIO , UMEBAYASHI NOBUHIRO
发明人： KUSUMOTO MASAHIRO , NISHIYA YOSHIAKI , KISHIMOTO MIKIO , UMEBAYASHI NOBUHIRO
IPC分类号： B03C1/01 , B03C1/00 , B01D11/02 , B01J19/00 , B03C1/02 , B03C1/30 , C12M1/00 , G01N33/553
CPC分类号： B03C1/01
摘要： It is intended to provide a device relating to the separation (extraction or purification) of a biological component such as a nucleic acid or a protein from a liquid sample containing the biological component; a device for separating a biological component provided with, as means of separating, a chip constructed by bonding a pair of substrates, in which one or more channels are formed on the surface of at least one of the substrates, with the channel(s) facing inward and magnet-responsive grains; and a method of separating a biological component from a liquid sample with the use of the above-described device which comprises: (a) the step of holding the device in such a manner that the bonding faces of a pair of the substrates are almost vertical to the horizontal direction; (b) the step of bringing the magnet-responsive grains into contact with the liquid sample containing the biological component and thus allowing the magnet-responsive grains to adsorb the biological component; (c) the step of separating the magnet-responsive grains having the biological component adsorbed thereby from the liquid sample; and (d) the step of separating the biological component from the magnet-responsive grains.
摘要翻译：旨在提供与从含有生物成分的液体样品中分离（提取或纯化）核酸或蛋白质等生物成分有关的装置; 一种用于分离生物组分的装置，所述生物组分用作分离装置，所述生物组分通过将其中在至少一个基底的表面上形成有一个或多个通道的一对基底与所述一个或多个通道连接而构成，面向内部和磁响应晶粒; 以及使用上述装置从液体试样中分离生物成分的方法，该方法包括：（a）以一对基板的接合面大致垂直的方式保持该装置的步骤到水平方向; （b）使磁响应颗粒与含有生物成分的液体样品接触，从而使磁响应颗粒吸附生物成分的步骤; （c）从液体试样中分离出吸附生物成分的磁响应粒子的工序; 和（d）从磁响应颗粒中分离生物成分的步骤。

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