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1. 发明申请

WO2005087367A8 MAGNETIC COMPOSITE PARTICLE AND PROCESS FOR PRODUCING THE SAME 审中-公开
标题翻译：磁性复合颗粒及其制造方法
公开(公告)号：WO2005087367A8
公开(公告)日：2006-07-06
申请号：PCT/JP2005004441
申请日：2005-03-14
申请人： HITACHI MAXELL , KOHNO KENJI , KISHIMOTO MIKIO , NISHIYA YOSHIAKI , KUSUMOTO MASAHIRO , NISHIMURA SHIN-ICHIRO
发明人： KOHNO KENJI , KISHIMOTO MIKIO , NISHIYA YOSHIAKI , KUSUMOTO MASAHIRO , NISHIMURA SHIN-ICHIRO
IPC分类号： A61K49/00 , B01J20/24 , C12N11/14
CPC分类号： A61K49/00 , B01J20/24 , C12N11/14
摘要： Magnetic composite particles of 0.01 to 4 µm average size comprising magnetic particles and, superimposed on surfaces thereof, chitosan layers. In particular, there are provided magnetic composite particles of core shell structure comprising magnetic particles as cores and chitosan layers as shells, which magnetic composite particles are capable of immobilizing physiologically active substances with high yield and after the immobilization, exhibit high collectability by magnetism. Further, there is provided a process for producing magnetic composite particle composed of magnetic particles and, superimposed on surfaces thereof, chitosan layers, which process comprises the steps of (a) dissolving chitosan in water by acidification; (b) dispersing magnetic particles in the chitosan solution and (c) slowly neutralizing the dispersion with a weak alkali base.
摘要翻译： 0.01〜4μm平均粒度的磁性复合颗粒包含磁性颗粒，并在其表面上叠加壳聚糖层。特别是提供了包含作为核的磁性粒子和壳聚糖层作为壳的核心壳结构的磁性复合颗粒，该磁性复合颗粒能够以高产率固定生理活性物质，并且在固定之后，通过磁性表现出高收集性。另外，提供了由磁性粒子构成的磁性复合粒子的制造方法，并且在其表面上叠加壳聚糖层，该方法包括以下步骤：（a）通过酸化将壳聚糖溶解在水中; （b）将磁性颗粒分散在壳聚糖溶液中，（c）用弱碱碱缓慢中和该分散液。

2. 发明申请

WO2005008209A3 DEVICE FOR SEPARATING BIOLOGICAL COMPONENT AND METHOD OF SEPARATING BIOLOGICAL COMPONENT WITH THE USE THEREOF 审中-公开
标题翻译：用于分离生物组分的装置和用于分离生物组分的方法
公开(公告)号：WO2005008209A3
公开(公告)日：2005-03-24
申请号：PCT/JP2004010258
申请日：2004-07-13
申请人： TOYO BOSEKI , HITACHI MAXELL , KUSUMOTO MASAHIRO , NISHIYA YOSHIAKI , KISHIMOTO MIKIO , UMEBAYASHI NOBUHIRO
发明人： KUSUMOTO MASAHIRO , NISHIYA YOSHIAKI , KISHIMOTO MIKIO , UMEBAYASHI NOBUHIRO
IPC分类号： B03C1/01 , B03C1/00 , B01D11/02 , B01J19/00 , B03C1/02 , B03C1/30 , C12M1/00 , G01N33/553
CPC分类号： B03C1/01
摘要： It is intended to provide a device relating to the separation (extraction or purification) of a biological component such as a nucleic acid or a protein from a liquid sample containing the biological component; a device for separating a biological component provided with, as means of separating, a chip constructed by bonding a pair of substrates, in which one or more channels are formed on the surface of at least one of the substrates, with the channel(s) facing inward and magnet-responsive grains; and a method of separating a biological component from a liquid sample with the use of the above-described device which comprises: (a) the step of holding the device in such a manner that the bonding faces of a pair of the substrates are almost vertical to the horizontal direction; (b) the step of bringing the magnet-responsive grains into contact with the liquid sample containing the biological component and thus allowing the magnet-responsive grains to adsorb the biological component; (c) the step of separating the magnet-responsive grains having the biological component adsorbed thereby from the liquid sample; and (d) the step of separating the biological component from the magnet-responsive grains.
摘要翻译：旨在提供与从含有生物成分的液体样品中分离（提取或纯化）核酸或蛋白质等生物成分有关的装置; 一种用于分离生物组分的装置，所述生物组分用作分离装置，所述生物组分通过将其中在至少一个基底的表面上形成有一个或多个通道的一对基底与所述一个或多个通道连接而构成，面向内部和磁响应晶粒; 以及使用上述装置从液体试样中分离生物成分的方法，该方法包括：（a）以一对基板的接合面大致垂直的方式保持该装置的步骤到水平方向; （b）使磁响应颗粒与含有生物成分的液体样品接触，从而使磁响应颗粒吸附生物成分的步骤; （c）从液体试样中分离出吸附生物成分的磁响应粒子的工序; 和（d）从磁响应颗粒中分离生物成分的步骤。

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