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1. 发明申请

WO2007027545A2 ANTI-MICROBIAL CATHETER 审中-公开
标题翻译：抗微生物导管
公开(公告)号：WO2007027545A2
公开(公告)日：2007-03-08
申请号：PCT/US2006033375
申请日：2006-08-28
申请人： I FLOW CORP , RAKE LOIS , PORTO JAMES DAL , DENIEGA JOSE CASTILLO , MASSENGALE ROGER , FORREST KEVIN , SIMINUK MARK
发明人： PORTO JAMES DAL , DENIEGA JOSE CASTILLO , MASSENGALE ROGER , FORREST KEVIN , SIMINUK MARK , RAKE KENNETH W
IPC分类号： A61M25/00 , A61L29/02 , A61L29/10
CPC分类号： A61L27/54 , A61L29/16 , A61L2300/104 , A61L2300/404 , A61M25/0045 , A61M25/0069 , A61M25/007 , A61M25/0071 , A61M2025/0056 , A61M2025/0057
摘要： A catheter having features configured to provide a substantially uniform flow rate of a fluid exiting the catheter and also exhibits anti-microbial properties. The uniform flow rate features may include one or more of a flow restricting membrane or flow restricting component within an infusion section of the catheter. In other arrangements, exit holes defining the infusion section of the catheter may be configured to provide the desired uniform flow rate over the length of the infusion section. Furthermore, the catheter also includes anti-microbial properties to inhibit the growth of microbes on or within the catheter and, preferably, to inhibit microbe growth in an anatomical region surrounding the catheter. The desired anti-microbial properties may be provided by an anti-microbial layer, anti-microbial materials dispersed within the material from which components of the catheters are constructed, or a combination of anti-microbial layers and embedded anti-microbial materials. In some arrangements, one or more portions of the catheter may be bio-absorbable.
摘要翻译：具有被配置为提供离开导管的流体的基本均匀流速并且还具有抗微生物性质的特征的导管。均匀的流速特征可以包括在导管的输注部分内的流动限制膜或流量限制部件中的一个或多个。在其他布置中，限定导管的输注部分的出口孔可以被配置为在输注部分的长度上提供期望的均匀流速。此外，导管还包括抗微生物性质以抑制导管上或导管内的微生物的生长，并且优选地抑制在导管周围的解剖区域中的微生物生长。期望的抗微生物性质可以通过抗微生物层，分散在构成导管的组分的材料中的抗微生物材料，或抗微生物层和嵌入的抗微生物材料的组合来提供。在一些布置中，导管的一个或多个部分可以是生物可吸收的。

2. 发明申请

WO2007027545A3 ANTI-MICROBIAL CATHETER 审中-公开
公开(公告)号：WO2007027545A3
公开(公告)日：2007-03-08
申请号：PCT/US2006/033375
申请日：2006-08-28
申请人： I-FLOW CORPORATION , RAKE, Lois , PORTO, James, Dal , DENIEGA, Jose, Castillo , MASSENGALE, Roger , FORREST, Kevin , SIMINUK, Mark
发明人： PORTO, James, Dal , DENIEGA, Jose, Castillo , MASSENGALE, Roger , FORREST, Kevin , SIMINUK, Mark
IPC分类号： A61M25/00 , A61L29/02 , A61L29/10
摘要： A catheter (300) having features configured to provide a substantially uniform flow rate of a fluid exiting the catheter and also exhibits anti -microbial properties;. The uniform flow rate features may include one or more of a flow restricting membrane or flow restricting component (306) within an infusion section of the catheter (302). In other arrangements, exit holes (304) defining the infusion section of the catheter may be configured to provide the desired uniform flow rate over the length of the infusion section. Furthermore, the catheter also includes anti -microbial properties to inhibit the growth of microbes on or within the catheter and, preferably, to inhibit microbe growth in an anatomical region surrounding the catheter. The desired anti -microbial properties may be provided by an anti -microbial layer (310), anti -microbial materials dispersed within the material from which components of the catheters are constructed, or a combination of anti -microbial layers and embedded anti -microbial materials. In some arrangements, one or more portions of the catheter may be bio -absorbable.

3. 发明申请

WO2004101052A3 CATHETER FOR UNIFORM DELIVERY OF MEDICATION 审中-公开
公开(公告)号：WO2004101052A3
公开(公告)日：2004-11-25
申请号：PCT/US2004/014664
申请日：2004-05-11
申请人： I-FLOW CORPORATION , DENIEGA, Jose, Castillo , MASSENGALE, Roger , RAKE, Kenneth, W. , DAL PORTO, James
发明人： DENIEGA, Jose, Castillo , MASSENGALE, Roger , RAKE, Kenneth, W. , DAL PORTO, James
IPC分类号： A61M25/00
摘要： A catheter (250, 272) is provided for uniform distribution of fluid medication within an anatomical region. One embodiment of the catheter (272) is comprised of an elongated, proximal tube (282) defining a lumen (283) and an elongated, distal tube (280) having a closed end (284). The distal tube (280) is constructed from a bio-absorbable material and also defines a lumen (281), which communicates with the lumen (283) of the proximal tube (282). Another embodiment of the catheter (250) is comprised of an elongate tubular catheter body (254) defining a lumen (268). A distal end (262) of the lumen is closed and a portion of the catheter body (254) includes a plurality of openings (266) thereby defining an infusion section of the catheter (250). A tubular sheath (252) is constructed from a porous material and is positioned over the infusion section. The tubular sheath (252) extends at least a length of the infusion section. The tubular sheath (252) and the catheter body (254) are configured such that fluid within the lumen (268) must pass through the tubular sheath (252) to exit the catheter (250).

4. 发明申请

WO2004101052A2 CATHETER FOR UNIFORM DELIVERY OF MEDICATION 审中-公开
标题翻译：用于统一药物递送的导管
公开(公告)号：WO2004101052A2
公开(公告)日：2004-11-25
申请号：PCT/US2004014664
申请日：2004-05-11
申请人： I FLOW CORP , DENIEGA JOSE CASTILLO , MASSENGALE ROGER , RAKE KENNETH W , DAL PORTO JAMES
发明人： DENIEGA JOSE CASTILLO , MASSENGALE ROGER , RAKE KENNETH W , DAL PORTO JAMES
IPC分类号： A61F2/958 , A61M25/00 , A61M29/00
CPC分类号： A61M25/003 , A61M25/0032 , A61M25/007 , A61M25/10 , A61M29/00 , A61M2025/0036 , A61M2025/0057 , A61M2025/105
摘要： A catheter (250, 272) is provided for uniform distribution of fluid medication within an anatomical region. One embodiment of the catheter (272) is comprised of an elongated, proximal tube (282) defining a lumen (283) and an elongated, distal tube (280) having a closed end (284). The distal tube (280) is constructed from a bio-absorbable material and also defines a lumen (281), which communicates with the lumen (283) of the proximal tube (282). Another embodiment of the catheter (250) is comprised of an elongate tubular catheter body (254) defining a lumen (268). A distal end (262) of the lumen is closed and a portion of the catheter body (254) includes a plurality of openings (266) thereby defining an infusion section of the catheter (250). A tubular sheath (252) is constructed from a porous material and is positioned over the infusion section. The tubular sheath (252) extends at least a length of the infusion section. The tubular sheath (252) and the catheter body (254) are configured such that fluid within the lumen (268) must pass through the tubular sheath (252) to exit the catheter (250).
摘要翻译：提供导管（250,272），用于在解剖区域内均匀分布流体药物。导管（272）的一个实施例包括限定内腔（283）的细长近端管（282）和具有闭合端（284）的细长远侧管（280）。远端管（280）由生物可吸收材料构成，并且还限定与近端管（282）的内腔（283）连通的管腔（281）。导管（250）的另一实施例由限定内腔（268）的细长管状导管主体（254）组成。管腔的远端（262）是封闭的并且导管主体（254）的一部分包括多个开口（266），由此限定了导管（250）的输注部分。管状护套（252）由多孔材料制成并位于输注部分上方。管状护套（252）延伸至少一段输注部分。管状护套（252）和导管主体（254）被构造成使得腔（268）内的流体必须通过管状护套（252）以离开导管（250）。

5. 发明申请

WO0105210A3 CATHETER FOR UNIFORM DELIVERY OF MEDICATION 审中-公开
标题翻译：统一送达药物的导管
公开(公告)号：WO0105210A3
公开(公告)日：2001-07-19
申请号：PCT/US0019746
申请日：2000-07-19
申请人： I FLOW CORP , DENIEGA JOSE CASTILLO , MASSENGALE ROGER , RAKE KENNETH W
发明人： DENIEGA JOSE CASTILLO , MASSENGALE ROGER , RAKE KENNETH W
IPC分类号： A61M25/00 , A61M25/16
CPC分类号： A61M25/0074 , A61M25/00 , A61M25/0023 , A61M25/0043 , A61M25/0068 , A61M25/0069 , A61M25/007 , A61M2025/0037 , A61M2025/0039 , A61M2025/0057 , A61M2025/0073
摘要： The present invention provides a catheter for the delivery of fluid medication across an anatomical region. In accordance with one embodiment, the catheter comprises an elongated tube with a plurality of exit holes along an infusion section of the catheter, and an elongated flexible porous member residing within the tube and forming an annular space between the tube and the member. In accordance with other embodiments, the catheter includes a tube having a plurality of exit holes in a side wall of the tube. The exit holes may combine to form a flow-restricting orifice of the catheter. Advantageously, fluid within the catheter flows through all of the exit holes, resulting in uniform distribution of fluid within an anatomical region. In one particular embodiment, the catheter comprises a tube having elongated exit slots therein. In accordance with other embodiments, the catheter includes an elongated tubular member made of a porous membrane. The porous membrane is configured so that a fluid introduced into an open end of the tubular member will flow through side walls of the tubular member at a substantially uniform rate along a length of the tubular member. In accordance with other embodiments, the catheter includes an elongated "weeping" tubular coil spring attached to an end of, or enclosed within, a tube. Fluid within the spring and greater than or equal to a threshold pressure advantageously flows radially outward between the spring coils. Advantageously, the fluid is dispensed substantially uniformly throughout a length of the spring.
摘要翻译：本发明提供了用于输送流体药物穿过解剖区域的导管。根据一个实施例，所述导管包括细长管，所述细长管具有沿所述导管的输注部分的多个出口孔以及位于所述管内并在所述管和所述构件之间形成环形空间的细长柔性多孔构件。根据其他实施例，导管包括在管的侧壁中具有多个出口孔的管。出口孔可以结合以形成导管的流量限制孔口。有利地，导管内的流体流过所有的出口孔，导致在解剖区域内流体的均匀分布。在一个特定实施例中，导管包括其中具有细长出口槽的管。根据其他实施例，导管包括由多孔膜制成的细长管状构件。多孔膜构造成使得引入管状构件的开口端的流体将沿管状构件的长度以基本均匀的速率流过管状构件的侧壁。根据其他实施例，导管包括附接到管的一端或封闭在管内的细长的“哭泣”管状螺旋弹簧。弹簧内的流体并且大于或等于阈值压力有利地在弹簧圈之间径向向外流动。有利的是，流体在弹簧的整个长度上基本均匀地分配。

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