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    • 2. 发明申请
    • UNILAMELLAR LIPOSOMAL PREPARATIONS WITH HIGH ACTIVE SUBSTANCE CONTENT
    • 单层脂质体具有高主动型筹备工作
    • WO1996005808A1
    • 1996-02-29
    • PCT/DE1995001162
    • 1995-08-18
    • MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZINBRANDL, MartinBACHMANN, DieterRESZKA, RegineDRECHSLER, Markus
    • MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN
    • A61K09/133
    • A61K9/1277Y10T428/2984
    • The liposomal preparation proposed is suitable for use in pharmaceutics and medicine, in particular as a carrier for drugs, vaccines, diagnostic agents and vectors. Its production and use are also disclosed. The liposomes in the preparation proposed are exclusively, or to by far the greater part, unilamellar liposomes of small to medium size, preferably 10 t0 300 nm in diameter, with a closely packed vesicular structure. A high proportion, preferably at least 20 %, of the active substance is included in the preparation in encapsulated form. The preparation can be used directly as a depot of the encapsulated substance, or after stepwise dilution by addition of an aqueous solution. The preparation is produced by mixing a lipid or lipids, water and the active substance to be incorporated, and subsequently removing the solvents by evaporation and dispersal in water, followed by single or multiple high-pressure homogenization (at the most 50 times) at a pressure between 50 and 1600 bar (5-160 MPa) and, optionally, freeze/thaw treatment. The preparation is then converted into a free-flowing dispersion which is extruded through filters with a pore size of 0.1 to 1 mu m.
    • 本发明涉及脂质体制剂,它们的制备和它们的用途来。 应用领域医药及医药,特别是作为药物,疫苗,诊断试剂和载体载波系统中使用。 本发明的脂质体制剂从到中型,优选为100〜300nm的直径,具有多孔结构的致密堆积的小的单层脂质体完全或主要组成。 它包含高比例的,优选至少20%,以包封形式的活性成分。 该制剂可以直接作为包封的物质的贮库或通过加入水性介质的逐步稀释来施加。 制剂的通过蒸发和分散在水中的一种或更多次(最大50malige)高压均质化混合脂质(一个或多个),水和einzuschliessendem活性成分,随后去除溶剂,用50和1600巴之间的压力的制备(5-160兆帕 )和随后的冷冻,必要/融处理,转化成通过具有0.1至1微米的孔尺寸的过滤器自由流动的分散体和挤出。
    • 3. 发明申请
    • METHOD AND SYSTEM FOR THE GEOREFERENCED DETERMINATION OF THE LOCATION OF CONTAINERS IN THE LOADING RANGE OF CONTAINER CRANES
    • 方法和设备货柜的地理参考厘定发生在集装箱起重机计费领域
    • WO2012069179A1
    • 2012-05-31
    • PCT/EP2011005877
    • 2011-11-22
    • IDENTEC SOLUTIONS AGSCHWIERS STEFANBACHMANN DIETER
    • SCHWIERS STEFAN
    • B66C13/46
    • B66C13/46
    • The invention relates to a method for the georeferenced determination of the location of containers, in particular in the loading range of container cranes, wherein a satellite-based determination of the location of the container crane and of the transport vehicle which picks up the containers and puts them down, characterised in that for detecting the absolute position co-ordinates of the containers located in the satellite reception shadow in a first method step a distance measurement is carried out between at least one measurement point on the transport vehicle and one or more measurement points on the container crane, that in a second method step the position co-ordinates obtained by satellite-based determination of the location of the container crane in relation to the relative co-ordinates of the transport vehicle obtained by the distance measurement are set, and that in a third method step the absolute position of the transport vehicle and/or the container located below the transport vehicle are determined from the absolute crane co-ordinates and the relative position co-ordinates of the transport vehicle.
    • 卫星接收机阴影的一种用于地理参考位置确定的容器,特别是在集装箱起重机的装载区域,其中,所述集装箱起重机的基于卫星的位置确定和容器容纳和稳定运输车辆发生,其特征在于,设置用于检测绝对位置的过程坐标 在第一工艺步骤的容器发生在运输车辆上的至少一个测量点和一个或多个测量点上,在第二处理步骤中获得的集装箱起重机之间的距离的测量,通过基于卫星的位置确定位置获得的产品的集装箱起重机相对于由距离测量坐标到 ,所述运输车辆的相对坐标被设置,并且,在从绝对起重机的第三方法步骤坐标和相对位置坐标所述运输车辆的,位置的绝对位置 运输车辆和/或位于所述运输车辆下方的容器的被确定。