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1. 发明申请

US20210355510A1 ENZYMATIC PROCESS FOR PRODUCTION OF MODIFIED HOP PRODUCTS 有权
公开(公告)号：US20210355510A1
公开(公告)日：2021-11-18
申请号：US17362070
申请日：2021-06-29
申请人： KALAMAZOO HOLDINGS, INC.
发明人： Katie WHALEN , Donald Richard BERDAHL , Brian Patrick BUFFIN , Matthew Blake JONES , Katrina WILLIAMS
IPC分类号： C12P7/38 , C12C3/12 , C12N11/16
摘要： The present invention relates to a process for producing a beer tittering agent via enzyme catalyzed bioconversion of hop-derived isoalpha acids to dihydro-(rho)-isoalpha acids and to the novel enzyme catalysts which may be employed in such a process.

2. 发明申请

US20210164000A1 ENZYMATIC PROCESS FOR PRODUCTION OF MODIFIED HOP PRODUCTS 有权
公开(公告)号：US20210164000A1
公开(公告)日：2021-06-03
申请号：US17147579
申请日：2021-01-13
申请人： KALAMAZOO HOLDINGS, INC.
发明人： Katie WHALEN , Donald Richard BERDAHL , Brian Patrick BUFFIN , Matthew Blake JONES , Katrina WILLIAMS
IPC分类号： C12P7/38
摘要： The present invention relates to a process for producing a beer littering agent via enzyme catalyzed bioconversion of hop-derived isoalpha acids to dihydro-(rho)-isoalpha acids.

3. 发明授权

US5260447A Polyhydroxycyclopentane derivatives, their preparation and their therapeutic use 失效
标题翻译：多羟基环戊烷衍生物，其制备及其治疗用途
公开(公告)号：US5260447A
公开(公告)日：1993-11-09
申请号：US835185
申请日：1992-02-13
申请人： Mutsuo Nakajima , Osamu Ando , Kiyoshi Hamano , Shuji Takahashi , Takeshi Kinoshita , Hideyuki Haruyama , Akira Sato , Yasuyuki Takamatsu , Ryuzo Enokita
发明人： Mutsuo Nakajima , Osamu Ando , Kiyoshi Hamano , Shuji Takahashi , Takeshi Kinoshita , Hideyuki Haruyama , Akira Sato , Yasuyuki Takamatsu , Ryuzo Enokita
IPC分类号： C07C215/42 , A61K20060101 , A61K31/13 , C07C20060101 , C07C215/44 , C07D263/52 , C07D413/12 , C12P7/38 , C12P17/14 , C07D261/20 , C07C211/00
CPC分类号： C07D263/52 , C07C215/44 , C07D413/10 , C12P17/14 , C07C2101/06
摘要： 5-Amino-1-(hydroxymethyl)cyclopentane-1,2,3,4-tetraol and 2-amino-4-(hydroxymethyl)-3a,5,6,6a-tetrahydro-4H-cyclopent[d]oxazole-4,5,6-triol, which have the ability to inhibit the activity of sugar hydrolases, especially .beta.-glucosidase and sucrase and can thus be used for the treatment and prophylaxis of tumorous conditions, AIDS, diabetes and obesity, can be prepared by hydrolysis of trehazolin. 2-Amino-4-(hydroxymethyl)-3a,5,6,6a-tetrahydro-4H-cyclopent[d]oxazole-4,5,6-triol can also be prepared by fermentation using newly isolated strains Micromonospora sp. SANK 62390, FERM BP-3521 and Amycolatopsis sp. SANK 60791, FERM BP-3513.
摘要翻译： 5-氨基-1-（羟甲基）环戊烷-1,2,3,4-四醇和2-氨基-4-（羟甲基）-3a，5,6,6a-四氢-4H-环戊二烯并[d]恶唑-4 具有抑制糖水解酶，特别是β-葡糖苷酶和蔗糖酶的活性，因此可用于治疗和预防肿瘤病症，AIDS，糖尿病和肥胖症的能力的5,6-三醇可以通过水解制备的trehazolin。 2-氨基-4-（羟甲基）-3a，5,6,6a-四氢-4H-环戊[d]恶唑-4,5,6-三醇也可以通过使用新分离的小单孢菌属 SANK 62390，FERM BP-3521和Amycolatopsis sp。 SANK 60791，FERM BP-3513。

4. 发明授权

US4729953A Optically active 4-hydroxy-2-cyclopentenones, and their production 失效
标题翻译：光学活性的4-羟基-2-环戊烯酮及其制备
公开(公告)号：US4729953A
公开(公告)日：1988-03-08
申请号：US680533
申请日：1984-12-11
申请人： Masayoshi Minai , Tadashi Katsura
发明人： Masayoshi Minai , Tadashi Katsura
IPC分类号： C07C45/67 , C07C49/707 , C07C49/743 , C12P7/26 , C12P41/00 , C12P7/38 , C12R1/38
CPC分类号： C07C45/67 , C07C49/707 , C07C49/743 , C12P41/004 , C12P7/26 , Y10S435/874
摘要： A process for preparing an optically active 4-hydroxy-2-cyclopentenone of the formula: ##STR1## wherein R.sub.1 is a hydrogen atom or a methyl group, R.sub.2 is an alkyl group, an alkenyl group or an alkynyl group and the asterisk (*) indicates an asymmetric configuration, which comprises subjecting an optically active 4-cyclopentenone-alcohol of the formula: ##STR2## wherein R.sub.1 and R.sub.2 are each as defined above, the asterisk (*) indicates an asymmetric configuration and the substituents R.sub.1 and R.sub.2 take a cis-configuration to rearrangement while maintaining the original steric configuration.
摘要翻译：一种制备下式的光学活性4-羟基-2-环戊烯酮的方法：其中R1是氢原子或甲基，R2是烷基，烯基或炔基，和星号（*）表示不对称构型，其包括使下式的光学活性4-环戊烯酮 - 醇（II）：其中R1和R2各自如上所定义，星号（*）表示不对称构型，取代基R 1和R 2采取顺式配置重新排列，同时保持原始的立体构型。

5. 发明授权

US4607013A Biochemical process for optical resolution of cyclopentenolone derivatives 失效
标题翻译：环戊烯醇衍生物的光学拆分生化工艺
公开(公告)号：US4607013A
公开(公告)日：1986-08-19
申请号：US646809
申请日：1984-09-07
申请人： Satoshi Mitsuda , Hideo Hirohara
发明人： Satoshi Mitsuda , Hideo Hirohara
IPC分类号： C12P7/26 , C12P41/00 , C12P7/38
CPC分类号： C12P41/004 , C12P7/26
摘要： A biochemical process for optical resolution of 4-hydroxy-3-methyl-2-2'-propynyl-2-cyclopentenone, which comprises asymmetrically hydrolyzing organic carboxylic acid (saturated or unsaturated carboxylic acids having 1 to 18 carbon atoms) esters of (.+-.)-4-hydroxy-3-methyl-2-2'-propynyl-2-cyclopentenone by the action of an esterase originated from a microorganism or an animal pancreas to give optically active 4-hydroxy-3-methyl-2-2'-propynyl-2-cyclopentenone and esters of its antipode with high optical purity is disclosed. This resolution process is simple in steps as compared with the conventionally known organic chemical methods of optical resolution, and is quite advantageous industrially because it does not require expensive optically active reagents.
摘要翻译： PCT No.PCT / JP83 / 00086 Sec。 371日期：1984年9月7日 102（e）日期1984年9月7日PCT提交1983年3月18日PCT公布。出版物WO84 / 03714 日期：1984年9月27日。用于光学拆分4-羟基-3-甲基-2,2'-丙炔基-2-环戊烯酮的生物化学方法，其包括不对称水解有机羧酸（具有1至18个碳原子的饱和或不饱和羧酸碳原子）（+/-） - 4-羟基-3-甲基-2,2'-丙炔-2-环戊烯酮的酯通过起源于微生物或动物胰腺的酯酶的作用，得到光学活性的4-羟基公开了3-甲基-2,2'-丙炔基-2-环戊烯酮及其具有高光学纯度的对映体的酯。与常规已知的光学拆分的有机化学方法相比，该拆分方法的步骤简单，并且在工业上相当有利，因为它不需要昂贵的光学活性试剂。

6. 发明授权

US4528272A Fermentation of bile 失效
标题翻译：发酵胆汁
公开(公告)号：US4528272A
公开(公告)日：1985-07-09
申请号：US597813
申请日：1984-04-09
申请人： Robert J. Park , Raymond A. Leppik
发明人： Robert J. Park , Raymond A. Leppik
IPC分类号： C12P7/38 , C07C45/00 , C07C49/747 , C07C67/00 , C07J1/00 , C07J9/00 , C12P7/26 , C12P33/00 , C12P33/12 , C12P33/16 , C12P33/18 , C12R1/365 , C12R1/38
CPC分类号： C12R1/365 , C07J1/0011 , C07J1/0022 , C07J9/005 , C12P33/005 , C12P7/26 , C12R1/38 , Y10S435/872 , Y10S435/874
摘要： This invention relates to a process for the fermentation of bile which includes the step of cultivating one or more aerobic microorganisms which have the ability to selectively degrate bile acids or bile acid conjugates contained in bile. The fermentation is carried out in a cultivation medium containing or consisting of unfractionated bile under aerobic conditions to prepare a compound of the formula ##STR1## wherein .about. is a bond chosen from one which is alpha or beta to the ring, X is chosen from hydrogen, hydroxyl or oxo, may be either a double or single bond, and R is selected from oxo, hydroxy or a propionic acid residue, attached at the 2-position ##STR2## The invention also includes within its scope certain compounds as described herein prepared by the process of the invention.
摘要翻译： PCT No.PCT / AU81 / 00017 Sec。 371日期1981年10月22日 102（e）1981年10月22日日期PCT提交1981年2月13日PCT公布。出版物WO81 / 02427 日本1981年9月3日。本发明涉及一种发酵胆汁的方法，其包括培养一种或多种有选择性降低胆汁中所含胆汁酸或胆汁酸结合物的能力的好氧微生物的步骤。发酵在含有或未经分级的胆汁的培养基中进行，在需氧条件下制备下式化合物，其中DIFFERENCE是选自与环的α或β的键， X选自氢，羟基或氧代，可以是双键或单键，并且R选自在2-位连接的氧代，羟基或丙酸残基。本发明还在其范围内包括某些通过本发明的方法制备的本文所述的化合物。

7. 发明授权

US4039381A Composition of matter and process 失效
公开(公告)号：US4039381A
公开(公告)日：1977-08-02
申请号：US632635
申请日：1975-11-17
申请人： John C. Knight , Merle G. Wovcha
发明人： John C. Knight , Merle G. Wovcha
IPC分类号： C12N1/20 , C07D311/94 , C12P7/24 , C12P7/26 , C12P7/38 , C12P17/06 , C12R1/01 , C12R1/06 , C12R1/07 , C12R1/13 , C12R1/15 , C12R1/32 , C12R1/365 , C12R1/425 , C12R1/465 , C07B29/00
CPC分类号： C12P17/06 , C07D311/94 , C12P7/26 , Y10S435/822 , Y10S435/83 , Y10S435/832 , Y10S435/84 , Y10S435/843 , Y10S435/866 , Y10S435/868 , Y10S435/869 , Y10S435/872 , Y10S435/88 , Y10S435/886
摘要： Novel compounds prepared by microbial transformation using novel mutants to selectively degrade steroids with or without 17-alkyl side chains of from 2 to 10 carbon atoms, inclusive. These compounds can be used as intermediates to make useful steroids.

8. 发明授权

US3773622A Method for preparing 2-substituted-4-hydroxy-cyclopentane-1,3-diones 失效
标题翻译：制备2-取代-4-羟基 - 环戊烷-1,3-二酮的方法
公开(公告)号：US3773622A
公开(公告)日：1973-11-20
申请号：US3773622D
申请日：1972-09-29
申请人： WISCONSIN ALUMNI RES FOUND
发明人： SIH C
IPC分类号： C12P7/38 , C07C45/00 , C07C49/493 , C07C67/00 , C07C405/00 , C12P7/00 , C12P7/62 , C12P31/00 , C12D13/00
CPC分类号： C12P31/00 , C07C405/00 , Y10S435/911 , Y10S435/912 , Y10S435/913 , Y10S435/919 , Y10S435/93 , Y10S435/931 , Y10S435/933 , Y10S435/94 , Y10S435/942 , Y10S435/944 , Y10S435/945
摘要： A method for preparing optically active 2-substituted-4-hydroxycyclopentane-1,3-diones by subjecting 2-substituted cyclopentane1,3,4-trione or 2-substituted-3-alkoxy-2-cyclopentene-1,4-dione to the fermentative enzymatic action of microorganisms of the orders Endomycetales, Mucorales, Moliliales and Eurotiales.

9. 发明授权

US11884613B2 Processes and intermediates for the preparation of carbaprostacyclin analogues 有权
公开(公告)号：US11884613B2
公开(公告)日：2024-01-30
申请号：US17737273
申请日：2022-05-05
申请人： CHIROGATE INTERNATIONAL INC.
发明人： Chun-Yu Lin , Tzyh-Mann Wei , Shih-Yi Wei
IPC分类号： C07C59/62 , C07C49/743 , C12P7/38 , C07C33/12 , C07D307/42 , C12P7/62
CPC分类号： C07C49/743 , C07C33/12 , C07C59/62 , C07D307/42 , C12P7/38 , C12P7/62
摘要： The invention relates to processes for preparing carbaprostacyclin analogues and intermediates prepared from the processes. The invention also relates to cyclopentenone intermediates in racemic or optically active form.

10. 发明申请

US20210300953A1 OPTICALLY-ACTIVE CYCLOPENTENONE DERIVATIVES 有权
公开(公告)号：US20210300953A1
公开(公告)日：2021-09-30
申请号：US17269762
申请日：2019-09-13
申请人： Tohoku University , Genesis Research Institute, Inc. , Ouchi Shinko Chemical Industrial Co., Ltd.
发明人： Hitoshi Kasai , Yoshitaka Koseki , Takaaki Kamishima , Shigenobu Aoyagi
IPC分类号： C07F7/18 , C12P7/38 , C07B51/00 , C07B63/02
摘要： The present invention provides: industrially desirable and novel optically-active cyclopentenone derivatives; and a novel industrial manufacturing method. The novel optically-active cyclopentenone derivatives and method for manufacturing the same are, respectively: an intermediate for industrially desirable and novel prostaglandin derivatives and the like; and a method for manufacturing the same. It is expected that the present invention will be commercialized and industrialized.

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