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1. 发明申请

US20120142047A1 Purification and Separation Treatment Assembly (PASTA) for Biological Products 有权
标题翻译：生物制品的净化和分离处理组件（PASTA）
公开(公告)号：US20120142047A1
公开(公告)日：2012-06-07
申请号：US13286193
申请日：2011-11-29
申请人： Sarfaraz K. Niazi
发明人： Sarfaraz K. Niazi
IPC分类号： C12P31/00 , B01D15/08 , B65B1/04 , C12P1/00 , C12P1/04 , C12P15/00 , C12N9/92 , C12N9/26 , C12N9/42 , C12N9/74 , C12P21/00 , B01D15/22 , C12P1/02
CPC分类号： B01D15/22 , C07K1/16 , C07K1/22
摘要： An assembly capable of capturing and purifying expressed biological products during or at the end of a bioreaction cycle is disclosed wherein a binding resin is kept separated from the contents of the bioreactor allowing capturing, harvesting and purification of biological products in a bioreactor; the invention additionally provides means of removing undesirable metabolic products as well as provides for efficient loading of chromatography columns.
摘要翻译：公开了一种能够在生物反应循环期间或结束时捕获和纯化表达的生物产物的组合物，其中将粘合树脂与生物反应器的内容物保持分离，从而允许在生物反应器中捕获，收获和纯化生物产物; 本发明另外提供了去除不需要的代谢产物以及提供色谱柱的有效负载的方法。

2. 发明授权

US4372973A 16-Amino-postaglandin derivatives, their acid addition salts, and a process for the preparation thereof 失效
标题翻译： 16-氨基 - Postaglandin衍生物及其酸加成盐及其制备方法
公开(公告)号：US4372973A
公开(公告)日：1983-02-08
申请号：US332840
申请日：1981-12-21
申请人： Gabor Ambrus , Eva Toth-Sarudy , Gyorgy Cseh , Istvan Barta , Gyula Horvath
发明人： Gabor Ambrus , Eva Toth-Sarudy , Gyorgy Cseh , Istvan Barta , Gyula Horvath
IPC分类号： A61K31/557 , A61K31/5575 , A61P43/00 , C07C67/00 , C07C401/00 , C07C405/00 , C12P31/00 , C07C177/00
CPC分类号： C12P31/00 , C07C405/0041 , Y02P20/55
摘要： The invention relates to new 16-amino-prostaglandin derivatives of general formula I, ##STR1## wherein C-15 and C-16 may have either S or R configuration, Z stands for a hydrogen atom or a lower alkyl group, and their acid addition salts. These compounds can be prepared by removing the ester group and the p-nitrocarbobenzyloxy protective group of a 9.alpha., 11.alpha., 15-trihydroxy-16-p-nitrobenzyloxycarbonylamido-5-cis,13-trans-prostadienoic acid derivative of general formula XII--wherein C-15 and C-16 may have either S or R configuration and Z stands for a lower alkyl group--in an optional sequence with the limitation that in those compounds of general formula I where Z stands for a lower alkyl group solely the p-nitrocarbobenzyloxy group is removed, and the resulting product of general formula I is optionally converted with an organic or inorganic acid into a salt.The new prostaglandin derivatives of the invention have valuable therapeutical properties, and can be applied as abortive or oxytocic agents.
摘要翻译：本发明涉及通式I的新的16-氨基前列腺素衍生物，其中C-15和C-16可以具有S或R构型，Z代表氢原子或低级烷基，它们的酸加成盐。这些化合物可以通过除去通式9的9α，11α，15-三羟基-16-对硝基苄氧基羰基酰胺基-5-顺式，13-反式 - 前列腺烯酸衍生物的酯基和对硝基苄氧基保护基来制备 XII-其中C-15和C-16可以具有S或R构型，Z表示低级烷基 - 在任选的序列中，限制在通式I的那些化合物中，其中Z仅代表低级烷基除去对硝基羰基苄氧基，将所得的通式I的产物任选地用有机或无机酸转化成盐。本发明的新型前列腺素衍生物具有有价值的治疗性质，可用作流产或催产素。

3. 发明授权

US4054595A 18 OR 19 Hydroxy prostaglandins 失效
公开(公告)号：US4054595A
公开(公告)日：1977-10-18
申请号：US561895
申请日：1975-03-25
申请人： Arthur Friedrich Marx , Jean Doodewaard
发明人： Arthur Friedrich Marx , Jean Doodewaard
IPC分类号： C07C29/143 , C07C67/00 , C07C401/00 , C07C405/00 , C07F1/00 , C07F1/08 , C12P31/00 , C07C177/00
CPC分类号： C12P31/00 , C07C405/00 , C07F1/00 , C07F1/08 , C12C11/02 , Y10S435/886 , Y10S435/911 , Y10S435/915 , Y10S435/929 , Y10S435/939
摘要： Novel 18 -, 19 - and 20 -hydroxy-prostaglandin derivatives of the formula I ##STR1## wherein the dotted line in the position 8-12 indicates the optional presence of a double bond, the waved lines in position 15 indicate that the hydroxyl group and the group R.sub.4 are either in .alpha.- or .beta.-position and Z represents a -- CH.sub.2 CH.sub.2 -- or a cis -- CH=CH -- group, and wherein R represents one of the groups: ##STR2## (wherein the waved lines indicate that the hydroxyl groups are either in .alpha.- or .beta.-position and R.sub.1 represents a hydrogen atom, a methyl or ethyl group), R.sub.2 represents either an oxygen atom or a hydrogen atom and an .alpha.- or .beta.-hydroxyl group, R.sub.3 represents a hydrogen atom or a hydroxyl group and R.sub.4 represents a hydrogen atom or a methyl group, with the proviso that when simultaneously, R.sub.1, R.sub.3 and R.sub.4 each represents a hydrogen atom, R.sub.2 represents an oxygen atom, a double bond is in 8-12 position and the 15-hydroxyl group is in position .alpha., R does not represent the group (b), but that when in addition to these conditions, Z represents a cis -- CH=CH -- group and the 8-12 position is saturated, R either represents the groups (b) or (c); and the pharmaceutically acceptable salts and esters thereof, novel process for their preparation by selective microbiological hydroxylation of compounds of formula II ##STR3## wherein the dotted line in the position 10-11 indicates the optional presence of a double bond in case the 8-12 position is saturated and the other symbols are as defined hereinabove, by means of microorganisms of the Division of Eumycota or, as far as the introduction of a hydroxyl group in the 18- or 19-position is concerned, of the Family of Streptomycetaceae, and, if desired, conversion of the 18 -, 19 - and 20 -hydroxy-prostaglandin derivatives thus obtained into pharmaceutically acceptable salts and esters thereof, and pharmaceutical compositions containing at least one of the novel hydroxy-prostaglandin derivatives of formula I.

4. 发明授权

US4036876A 18- AND 19-Hydroxylated prostaglandins 失效
标题翻译： 18-和19-羟基化前列腺素
公开(公告)号：US4036876A
公开(公告)日：1977-07-19
申请号：US379128
申请日：1973-07-13
申请人： Raymond P. Lanzilotta
发明人： Raymond P. Lanzilotta
IPC分类号： C07C405/00 , C12P31/00 , C07C177/00
CPC分类号： C07C405/00 , C12P31/00 , Y10S435/911
摘要： Novel 18.xi.-hydroxylated and 19.xi.-hydroxylated prostaglandins and novel microbiological process for the production thereof.
摘要翻译：新型18个羟基化和19个x-羟基化的前列腺素和用于其生产的新的微生物过程。

5. 发明授权

US4008263A Racemic fluoro-substituted PGF.sub.2 .sub..alpha. analogs 失效
标题翻译：外消旋氟取代的PGF {HD 2 {B {301 {0类似物
公开(公告)号：US4008263A
公开(公告)日：1977-02-15
申请号：US530413
申请日：1974-12-06
申请人： William P. Schneider
发明人： William P. Schneider
IPC分类号： C07C35/27 , C07C405/00 , C07D309/12 , C07D317/26 , C07D317/30 , C12P31/00 , C07C177/00
CPC分类号： C07C35/27 , C07C405/00 , C07D309/12 , C07D317/26 , C07D317/30 , C12P31/00
摘要： This invention is racemic PGE.sub.2, racemic PGF.sub.2.sub..alpha., racemic PGF.sub.2.sub..beta., racemic PGA.sub.2, racemic PGB.sub.2, analogs of those, and processes for making them. These compounds are useful for a variety of pharmacological purposes, including anti-ulcer, inhibiton of platelet aggregation, increase of nasal patency, abortion, and wound healing.
摘要翻译：本发明是外消旋PGE2，外消旋PGF2α，外消旋PGF2β，外消旋PGA2，外消旋PGB2，其类似物及其制备方法。这些化合物可用于各种药理学目的，包括抗溃疡，抑制血小板聚集，增加鼻通气，流产和伤口愈合。

6. 发明授权

US3880712A Reduction process 失效
标题翻译：还原过程
公开(公告)号：US3880712A
公开(公告)日：1975-04-29
申请号：US42831373
申请日：1973-12-26
申请人： ICI LTD
发明人： MOORE RONALD HAYWOOD
IPC分类号： C12P7/18 , C07C67/00 , C07C401/00 , C07C405/00 , C07D307/935 , C12P31/00 , C12D13/00
CPC分类号： C07D307/935 , C07C405/00 , C12P31/00
摘要： The disclosure relates to a steroselective microbiological reduction, for example using Trechispora brinkmannii (Bresadola) of optically active hydroxy-enone prostaglandin intermediates, for example (3aR,4R,5R,6aS)-4-(4-(3-chlorophenoxy)-3-oxobut-1trans-enyl)-2,3,3a,6a -tetrahydro-5-hydroxy-2oxocyclopenteno(b)furan, to give the optically active form of a known hydroxy-enol prostaglandin intermediate, for example (3aR, 4R,5R,6aS)-4-((3R)-4-(3-chlorophenoxy)-3-hydroxybut-1-transenvl)-2,3,3a,6a -tetrahydro-5-hydroxy-2-oxocyclopenteno(b)furan.
摘要翻译：本公开涉及例如使用光学活性羟基 - 酮前列腺素中间体的紫花苜蓿（Bresadola）的例如（3aR，4R，5R，6aS）-4- [4-（3-氯苯氧基）-3 - 氧代异丁-1-异戊烯基] -2,3,3a，6a-四氢-5-羟基-2-氧代环戊烯并[b]呋喃，得到已知的羟基 - 烯醇前列腺素中间体的旋光形式，例如（3aR，4R，5R，6aS）-4 - [（3R）-4-（3-氯苯氧基）-3-羟基丁-1-基] -2,3,3a，6a-四氢-5-羟基 - 2-氧代环戊烯并[b]呋喃。

7. 发明授权

US3796740A Dihydro-pgf1beta 失效
标题翻译： DIHYDRO-PGF1BETA
公开(公告)号：US3796740A
公开(公告)日：1974-03-12
申请号：US3796740D
申请日：1972-07-03
申请人： BERGSTROM S , SJOVALL J
发明人： BERGSTROM S , SJOVALL J
IPC分类号： B01J23/42 , C07C405/00 , C12P31/00 , C07C61/32 , C07C69/74
CPC分类号： C12P31/00 , B01J23/42 , C07C405/00 , C07C405/0016
摘要： THE PROSTAGLANDIN DIHYDRO-PGF1B, AND ITS SATLS, ESTERS, AND ALKONATES ARE DISCLOSED. THESE NOVEL COMPOUNDS ARE USEFUL FOR A VARIETY OF PHARMACOLOGICAL PURPOSES, INCLUDING USE AS SMOOTH MUSCLE STIMULTANTS AND AS CARDIOVASCULAR AGENTS.

8. 发明授权

US3776939A Dihydro-pgf1a 失效
标题翻译： DIHYDRO-PGF1A
公开(公告)号：US3776939A
公开(公告)日：1973-12-04
申请号：US3776939D
申请日：1972-07-03
申请人： BERGSTROM S , SJOVALL J
发明人： BERGSTROM S , SJOVALL J
IPC分类号： B01J23/42 , C07C405/00 , C12P31/00 , C07C61/36
CPC分类号： C07C405/0016 , B01J23/42 , C07C405/00 , C12P31/00 , Y10S514/843 , Y10S514/927
摘要： THE PROSTAGLANDIN DIHYDRO-PGF1A, AND ITS SALTS AND ESTERS ARE DISCLOSE. THESE NOVEL COMPOUNDS ARE USEFUL FOR A VARIETY OF PHARMACOLOGICAL PURPOSES, INCLUDING USE AS SMOOTH MUSCLE STIMULATNS AND AS CARDIOVASCULAR AGENTS.

9. 发明授权

US3776938A Dihydro-pge1 失效
标题翻译： DIHYDRO-PGE1
公开(公告)号：US3776938A
公开(公告)日：1973-12-04
申请号：US3776938D
申请日：1971-02-12
申请人： BERGSTROM S , SJOVALL J
发明人： BERGSTROM S , SJOVALL J
IPC分类号： B01J23/42 , C07C405/00 , C12P31/00 , C07C61/36
CPC分类号： C12P31/00 , B01J23/42 , C07C405/00 , C07C405/0016
摘要： THE PROSTAGLANDINS DIHYDRO-PGE1 AND DIHYDRO-PGF1A, AND THE SALTS AND ESTERS ARE DISCLOSED. THESE NOVEL COMPOUNDS ARE USEFUL FOR A VARIETY OF PHARMACOLOGICAL PURPOSES, INCLUDING USE AS SMOOTH MUSCLE STIMULATNS AND AS CARDIOVASCULAR AGENTS.

10. 发明授权

US3687811A Microbiological reduction of 15-keto prostaglandin derivatives 失效
标题翻译： 15-KETO PROSTAGLANDIN衍生物的微生物学减少
公开(公告)号：US3687811A
公开(公告)日：1972-08-29
申请号：US3687811D
申请日：1970-12-18
申请人： SEARLE & CO
发明人： COLTON FRANK B , MARSHECK WILLIAM J , MIYANO MASATERU
IPC分类号： C07C405/00 , C12P31/00 , C12D1/02
CPC分类号： C07C405/00 , C12P31/00 , Y10S435/83 , Y10S435/85 , Y10S435/866 , Y10S435/872 , Y10S435/874
摘要： SELECTIVE REDUCTION OF THE 15-KETO GROUP OF 9,15-DIKETO PROSTAGLANDIN DERIVATIVES IS ACHIEVED BY FERMENTATION WITH A BACTERIUM OF THE GENERA ARTHROBACTER, PSEUDOMONAS, NOCARDIA, CORYNEBACTERIUM, MYCOBACTERIUM OR FLAVOBACTERIUM OR WITH A YEAST BELONGING TO THE CLASS CONSISTING OF RHODOTORULA AND SACCHAROMYCES. THE RESULTING 9-KETO-15-HYDROXY COMPOUNDS DISPLAY USEFUL PHARMACOLOGICAL PROPERTIES, E.G. ANTI-ULCEROGENIC, HYPOTENSIVE AND SMOOTH MUSCLE STIMULATING PROPERTIES.

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