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1. 发明授权

US10239850B2 14-hydroxy-docosahexaenoic acid compounds 有权
公开(公告)号：US10239850B2
公开(公告)日：2019-03-26
申请号：US15437206
申请日：2017-02-20
申请人： The Brigham And Women's Hospital, Inc.
发明人： Charles N. Serhan , Rong Yang
IPC分类号： A61K31/22 , A61K31/20 , C07D303/38 , C07C59/42 , C07D303/12 , A61K8/365 , A61K8/49 , A61Q5/00 , A61Q19/08 , A61K8/37 , C07C69/732 , A61K31/202 , A23K20/158 , A61Q19/00 , C07C59/58
摘要： The invention describes novel 14-hydroxy docosahexaenoic acid (DHA) analogs, their preparation, isolation, identification, purification and uses thereof.

2. 发明申请

US20170183442A1 POLYESTER POLYOL HAVING ALICYCLIC SKELETON 审中-公开
公开(公告)号：US20170183442A1
公开(公告)日：2017-06-29
申请号：US15300104
申请日：2015-03-26
申请人： KURARAY CO., LTD.
发明人： Takuo TSURUTA , Shigeru OKANO , Takahiro HOSONO
IPC分类号： C08G18/42 , C07C31/20 , C07C59/58 , C08G63/199
CPC分类号： C08G18/423 , C07C31/20 , C07C59/58 , C08G18/7671 , C08G63/199
摘要： To provide a polyester polyol which can prevent gelation during the urethane formation reaction in the production of a polyurethane and from which a polyurethane having stable quality can be produced.A polyester polyol containing 1,3-propanediol having an alicyclic skeleton in a side chain and a dibasic acid component as constituent components, which has an alkali metal content of 20 ppm by mass or less.

3. 发明申请

US20160168408A1 SILVER INK 有权
标题翻译：银色墨水
公开(公告)号：US20160168408A1
公开(公告)日：2016-06-16
申请号：US14787031
申请日：2014-08-05
申请人： PESOLVE CO., LTD.
发明人： Hyun Nam CHO , Hyun Ju KIM
IPC分类号： C09D11/52 , C07C55/24 , C07C57/13 , C07C55/22 , C07C251/08 , C07C59/285 , C07C59/347 , C07C59/58 , C07C323/54 , C07C55/02 , C07C57/18
CPC分类号： C09D11/52 , C07C55/02 , C07C55/22 , C07C55/24 , C07C57/13 , C07C57/18 , C07C59/285 , C07C59/347 , C07C59/58 , C07C251/08 , C07C251/72 , C07C323/54 , H01B1/02
摘要： Provided is a silver ink including, as a major component, a silver malonate precursor represented by Formula 1 or Formula 2.
摘要翻译：提供一种银墨水，其包含作为主要成分的由式1或式2表示的丙烯酸银前体。

4. 发明授权

US06884820B2 5,6,7,8-tetrahydronaphthalen-2-yl-7-fluoroalkyl-heptatrienoic acid derivatives having serum glucose reducing activity 失效
标题翻译：具有血清葡萄糖还原活性的5,6,7,8-四氢萘-2-基-7-氟烷基 - 七三烯酸衍生物
公开(公告)号：US06884820B2
公开(公告)日：2005-04-26
申请号：US10406170
申请日：2003-04-03
申请人： Richard L. Beard , Haiqing Yuan , Roshantha A. Chandratratna
发明人： Richard L. Beard , Haiqing Yuan , Roshantha A. Chandratratna
IPC分类号： C07C59/58 , C07C69/734 , A01N37/10 , A61K31/235 , C07C62/06 , C07C62/12 , C07C69/76
CPC分类号： C07C59/58 , C07C69/734 , C07C2602/10
摘要： Compounds of the formula where the variables have the meaning defined in the specification are capable of reducing serum glucose levels in diabetic mammals without the undesirable side effect of reducing serum thyroxine levels.
摘要翻译：变量具有本说明书中定义的含义的式的化合物能够降低糖尿病哺乳动物中的血清葡萄糖水平，而不会降低血清甲状腺素水平的不良副作用。

5. 发明授权

US5698711A Compounds containing phenyl linked to aryl or heteroaryl by an aliphatic- or heteroatom-containing linking group 失效
标题翻译：含有通过含脂肪族或含杂原子的连接基与芳基或杂芳基连接的苯基的化合物
公开(公告)号：US5698711A
公开(公告)日：1997-12-16
申请号：US487377
申请日：1995-06-07
申请人： Malcolm Norman Palfreyman
发明人： Malcolm Norman Palfreyman
IPC分类号： C07C43/225 , C07C45/00 , C07C45/29 , C07C45/71 , C07C47/575 , C07C49/84 , C07C59/58 , C07C59/60 , C07C59/62 , C07C65/21 , C07C65/24 , C07C65/26 , C07C65/42 , C07C69/76 , C07C69/92 , C07C205/59 , C07C217/88 , C07C235/56 , C07C255/57 , C07C255/60 , C07C275/34 , C07C311/29 , C07C311/46 , C07C317/40 , C07C323/42 , C07C327/48 , C07D213/50 , C07D213/75 , C07D213/89 , C07D239/42 , C07D241/20 , C07D261/14 , C07D275/02 , C07D275/03 , C07D409/12 , C07D333/02 , C07C13/10 , C07C3/20
CPC分类号： C07C43/225 , C07C205/59 , C07C217/88 , C07C235/56 , C07C255/57 , C07C255/60 , C07C275/34 , C07C311/29 , C07C311/46 , C07C317/40 , C07C323/42 , C07C327/48 , C07C45/004 , C07C45/292 , C07C45/71 , C07C47/575 , C07C49/84 , C07C59/58 , C07C59/60 , C07C59/62 , C07C65/21 , C07C65/24 , C07C65/26 , C07C65/42 , C07C69/76 , C07C69/92 , C07D213/50 , C07D213/75 , C07D213/89 , C07D239/42 , C07D241/20 , C07D261/14 , C07D275/03 , C07D409/12 , C07C2101/08 , C07C2101/14 , C07C2102/42
摘要： This invention is directed to the pharmaceutical use of phenyl compounds, which are linked to an aryl moiety by various linkages, for inhibiting tumor necrosis factor. The invention is also directed to the compounds, their preparation and pharmaceutical compositions containing these compounds. Furthermore, this invention is directed to the pharmaceutical use of the compounds for inhibiting cyclic AMP phosphodiesterase.
摘要翻译：本发明涉及通过各种连接与芳基部分连接的用于抑制肿瘤坏死因子的苯基化合物的药物用途。本发明还涉及含有这些化合物的化合物及其制备方法和药物组合物。此外，本发明涉及化合物抑制环AMP磷酸二酯酶的药物用途。

6. 发明授权

US5484935A Pharmaceutical compounds 失效
标题翻译：药物化合物
公开(公告)号：US5484935A
公开(公告)日：1996-01-16
申请号：US289045
申请日：1994-08-11
申请人： Peter T. Gallagher , Terence A. Hicks , William M. Owton
发明人： Peter T. Gallagher , Terence A. Hicks , William M. Owton
IPC分类号： A61K31/18 , A61K31/19 , A61K31/215 , A61K31/41 , A61P29/00 , A61P35/00 , C07C59/58 , C07C65/40 , C07C66/02 , C07C311/12 , C07D257/04 , A61K31/22 , C07C69/017
CPC分类号： C07D257/04 , C07C66/02
摘要： Pharmaceutical compounds of the formula ##STR1## in which R.sup.1 and R.sup.3 are each C.sub.1-4 alkyl or C.sub.1-4 alkyl-carbonyl, and R.sup.2 is carboxy, tetrazolyl, C.sub.1-4 alkyl-sulphonamido or --CR.sup.4 R.sup.5 CO.sub.2 H where R.sup.4 and R.sup.5 are each hydrogen or C.sub.1-4 alkyl; provided that when R.sup.1 and R.sup.3 are both methyl and when R.sup.1 and R.sup.3 are both methylcarbonyl, R.sup.2 is not carboxy; and salts and esters thereof.
摘要翻译：式IMAMA 1-4烷基羰基的药物化合物，R 2为羧基，四唑基，C 1-4烷基磺酰胺基或-CR 4 R 5 CO 2 H，其中R 4和R 5各自为氢或C 1-4烷基; 条件是当R 1和R 3都是甲基，并且当R 1和R 3都是甲基羰基时，R 2不是羧基; 及其盐和酯。

7. 发明授权

US4877887A Preparation of alkoxy maleic anhydrides 失效
标题翻译：制备烷氧基马来酸酐
公开(公告)号：US4877887A
公开(公告)日：1989-10-31
申请号：US189297
申请日：1988-05-02
申请人： Rainer Becker , Wolfgang Rohr
发明人： Rainer Becker , Wolfgang Rohr
IPC分类号： C07D307/60 , C07C59/58 , C07D207/44 , C07D207/456 , C08F283/08
CPC分类号： C07D207/456 , C07C59/58
摘要： The invention relates to novel alkoxy substituted maleimides of the formula ##STR1## where R.sup.1 is hydrogen, C.sub.1 -C.sub.8 -alkyl, C.sub.2 -C.sub.8 -alkenyl, phenyl or phenylalkyl, and the organic radicals may furthermore carry inert substituents, and R.sup.2 and R.sup.3 are each C.sub.1 -C.sub.4 -alkyl, C.sub.2 -C.sub.4 -alkenyl, C.sub.1 -C.sub.4 -haloalkyl or C.sub.2 -C.sub.4 -haloalkenyl, and alkoxy-substituted maleic anhydrides of the formula II ##STR2## where R.sup.2 is C.sub.1 -C.sub.4 -alkyl, C.sub.2 -C.sub.4 -alkenyl, C.sub.1 -C.sub.4 -haloalkyl or C.sub.2 -C.sub.4 -haloalkenyl and Z is hydrogen, halogen or a radical OR.sup.3, where R.sup.3 is C.sub.1 -C.sub.4 -alkyl, C.sub.2 -C.sub.4 -alkenyl, C.sub.1 -C.sub.4 -haloalkyl or C.sub.2 -C.sub.4 -haloalkenyl.The invention further relates to processes for preparing such maleimides I and the corresponding maleic anhydrides II and their use as graft monomers in graft polymers based on polyphenylene ethers.
摘要翻译：本发明涉及式Ⅰ的新的烷氧基取代的马来酰亚胺，其中R 1是氢，C 1 -C 8 - 烷基，C 2 -C 8 - 烯基，苯基或苯基烷基，有机基团还可带有惰性取代基，R2和R3 C 1 -C 4 - 烷基，C 2 -C 4 - 烯基，C 1 -C 4 - 卤代烷基或C 2 -C 4 - 卤代烯基，以及式II其中R 2是C 1 -C 4 - 烷基的C 2 -C 4烷氧基取代的马来酸酐 C 4 - 烯基，C 1 -C 4 - 卤代烷基或C 2 -C 4 - 卤代烯基，Z是氢，卤素或基团OR 3，其中R 3是C 1 -C 4烷基，C 2 -C 4 - 链烯基，C 1 -C 4卤代烷基或C 2 -C 4 - C4-卤代链烯基。本发明还涉及制备这种马来酰亚胺I和相应的马来酸酐II的方法及其作为基于聚苯醚的接枝聚合物中的接枝单体的用途。

8. 发明授权

US4827004A Isoprene derivatives 失效
标题翻译：异戊二烯衍生物
公开(公告)号：US4827004A
公开(公告)日：1989-05-02
申请号：US88315
申请日：1987-08-24
申请人： Albert Fischli , Max Schmid , Rudolf Schmid
发明人： Albert Fischli , Max Schmid , Rudolf Schmid
IPC分类号： A61K31/045 , A61K31/12 , A61K31/15 , A61K31/16 , A61K31/215 , A61K31/695 , A61P1/04 , C07C27/00 , C07C29/147 , C07C33/02 , C07C33/035 , C07C33/12 , C07C41/00 , C07C43/13 , C07C43/178 , C07C43/30 , C07C43/315 , C07C45/00 , C07C45/29 , C07C45/67 , C07C47/263 , C07C49/20 , C07C49/24 , C07C49/242 , C07C49/255 , C07C49/258 , C07C59/42 , C07C59/58 , C07C59/76 , C07C67/00 , C07C69/66 , C07C69/732 , C07C231/00 , C07C231/12 , C07C233/09 , C07C235/28 , C07C235/30 , C07C235/76 , C07C235/78 , C07C251/34 , C07C313/00 , C07C317/24 , C07C317/28 , C07C317/44 , C07C317/46 , C07C323/22 , C07C323/24 , C07C323/25 , C07C323/27 , C07C323/52 , C07C323/54 , C07C323/60 , C07C325/00 , C07C327/22 , C07D303/46 , C07D317/20 , C07D317/30 , C07F7/18 , C09F5/00
CPC分类号： C07F7/1852 , C07C323/00 , C07C323/24 , C07C33/02 , C07C33/035 , C07C33/12 , C07C43/178 , C07C43/315 , C07C45/298 , C07C45/673 , C07C47/263 , C07C49/24 , C07C49/242 , C07C49/255 , C07C49/258 , C07C59/42 , C07C59/76 , C07D317/20
摘要： Novel Isoprene Derivatives which have mucosa-protective and gastric acid secretion-inhibiting properties and are useful for combatting ulcers both by treating and as a prophylaxis against gastric and/or duodenal ulcers.
摘要翻译：具有粘膜保护性和胃酸分泌抑制性质的新型异戊二烯衍生物，可用于通过治疗和预防胃和/或十二指肠溃疡来对抗溃疡。

9. 发明授权

US4631287A Aryl and heteroaryl ethers as agents for the treatment of hypersensitive ailments 失效
标题翻译：芳基和杂芳基醚作为治疗过敏性疾病的药剂
公开(公告)号：US4631287A
公开(公告)日：1986-12-23
申请号：US723781
申请日：1985-04-16
申请人： Utpal R. Chakraborty , Raymond D. Youssefyeh
发明人： Utpal R. Chakraborty , Raymond D. Youssefyeh
IPC分类号： A61K31/47 , A61K31/472 , A61P29/00 , A61P37/08 , A61P43/00 , C07C41/00 , C07C43/14 , C07C43/18 , C07C43/20 , C07C43/23 , C07C43/257 , C07C45/00 , C07C47/228 , C07C47/52 , C07C49/215 , C07C49/84 , C07C51/00 , C07C59/58 , C07C59/76 , C07C65/21 , C07C67/00 , C07C69/003 , C07C69/007 , C07C201/00 , C07C205/38 , C07C209/00 , C07C213/00 , C07C215/48 , C07C215/74 , C07C217/48 , C07C231/00 , C07C235/42 , C07C237/30 , C07C313/00 , C07C323/24 , C07D215/14 , C07D215/20 , C07D217/16 , C07D257/04 , C07D257/06 , C07D307/28 , C07D307/38 , C07D309/04 , C07D309/20 , C07D309/22 , C07D333/16 , C07D333/18 , C07D401/12 , C07D405/12 , C12N9/99
CPC分类号： C07D257/04 , C07C43/23 , C07D215/14 , C07D309/22 , C07D401/12 , C07D405/12
摘要： The present invention is concerned with the therapeutic composition comprising as an active ingredient a compound of the formula:(R.sub.1)(R.sub.2)Ar--Z--M--Ar.sub.1 (R.sub.3)(R.sub.4) Iand salts thereof;whereinAr and Ar.sub.1 are independently phenyl, naphthyl or a nitrogen, oxygen, or sulfur heterocyclic ring;Z is an alkylene chain containing from 1 to 5 carbon atoms in the principal chain and up to a total of 10 carbon atoms;M is oxygen, sulfur, or NR.sub.5 ;R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are each independently H, lower alkyl, lower alkoxy, hydroxy, halo, trihalomethyl, hydroxy lower alkyl, carboxy, formyl, aryl, aryloxy, benzyloxy, lower alkanoyl, carboxy lower alkoxy, nitro, amino, lower alkylamino, dilower alkylamino, cyano, lower alkanoyloxy, carbamoyl, lower alkoxy-alkoxy, carbo-lower-alkoxy-alkoxy, or tetrahydropyranylmethyl; andR.sub.5 is hydrogen or lower alkyl.
摘要翻译：本发明涉及包含下式化合物作为活性成分的治疗组合物：（R1）（R2）Ar-Z-M-Ar1（R3）（R4）I及其盐; 其中Ar和Ar 1独立地是苯基，萘基或氮，氧或硫杂环; Z是在主链中含有1至5个碳原子并且总共10个碳原子的亚烷基链; M是氧，硫或NR5; R 1，R 2，R 3和R 4各自独立地为H，低级烷基，低级烷氧基，羟基，卤素，三卤甲基，羟基低级烷基，羧基，甲酰基，芳基，芳氧基，苄氧基，低级烷酰基，羧基低级烷氧基，硝基，烷基氨基，二元烷基氨基，氰基，低级烷酰氧基，氨基甲酰基，低级烷氧基 - 烷氧基，碳 - 低级 - 烷氧基 - 烷氧基或四氢吡喃基甲基。 R5是氢或低级烷基。

10. 发明授权

US4603017A Fluorosulfonate containing polyfluorocarbonyl compounds 失效
标题翻译：含氟磺酸盐的多氟羰基化合物
公开(公告)号：US4603017A
公开(公告)日：1986-07-29
申请号：US720163
申请日：1985-04-05
申请人： Hans Millauer , Gunter Siegemund , Werner Schwertfeger
发明人： Hans Millauer , Gunter Siegemund , Werner Schwertfeger
IPC分类号： C07C69/708 , C07C45/54 , C07C49/167 , C07C51/00 , C07C51/373 , C07C53/50 , C07C59/21 , C07C59/347 , C07C59/58 , C07C59/88 , C07C67/00 , C07C67/313 , C07C69/716 , C07C301/00 , C07C303/00 , C07C305/00 , C07C305/26 , C25B3/00 , C25B3/02 , C07C141/00
CPC分类号： C07C45/54 , C07C305/26 , C07C49/167 , C07C51/00 , C07C59/21
摘要： Perfluorocarbonyl compounds of the formulae IV and V ##STR1## in which R.sub.f denotes perfluoroalkyl, R'.sub.f denotes perfluoroalkylene, R denotes F, Cl, perfluoroalkyl or --OR"' (R"'=alkyl, aryl or aralkyl) and n denotes a number from 0 to 10, are prepared, starting from compounds of the formula I ##STR2## in which R.sub.f, R'.sub.f and n have the same meaning as in the formulae IV and V and R" is F, Cl or perfluoroalkyl, by electrolysis in an electrolyte consisting of fluorosulfonic acid/alkali metal fluorosulfonate and, if necessary, esterification with R"'OH, and decomposition ##STR3## in the presence of catalytic amounts of alkali metal fluorides and/or aprotic N-bases. Most of the compounds IV and V are new; the latter are, above all, valuable heat transfer fluids, lubricating oils or intermediates for the preparation of other F-organic compounds.
摘要翻译：（IV）的全氟羰基化合物其中Rf表示全氟烷基，R'f表示全氟亚烷基，R表示F，Cl，全氟烷基或-OR“（R”'） =烷基，芳基或芳烷基），n表示0至10的数，从其中R f，R'f和n与式（I）中相同含义的式I的化合物 IV和V和R“是F，Cl或全氟烷基，通过在由氟磺酸/碱金属氟代磺酸盐组成的电解质中电解并在需要时与R”OH进行酯化，并在催化剂存在下分解“IMAGE” 碱金属氟化物和/或非质子N-碱的量。大多数化合物IV和V是新的; 后者首先是有价值的传热流体，润滑油或用于制备其它F-有机化合物的中间体。

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