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1. 发明授权

US11918994B2 Safety cabinet 有权
公开(公告)号：US11918994B2
公开(公告)日：2024-03-05
申请号：US17595592
申请日：2020-04-27
申请人： Hitachi Industrial Equipment Systems Co., Ltd.
发明人： Takeshi Matsumura , Takeshi Kaneko
IPC分类号： B01L1/02 , B01L1/04 , B08B15/02 , F21S4/28 , F21Y103/10 , F21Y115/10
CPC分类号： B01L1/02 , B01L1/04 , B08B15/023 , F21S4/28 , B01L2200/082 , B01L2200/141 , B01L2300/0681 , F21Y2103/10 , F21Y2115/10
摘要： Sample contamination is suppressed by strengthening the air barrier of a work opening portion. A safety cabinet includes: a work room; a front surface door covering a part of a front opening portion of the work room; and a work opening portion on a lower side of the front surface door allowing a worker to work with his or her hand in. An intake port suctions air in the work room and outside air through the work opening portion on a front surface side of a workbench in a lower portion of the work room. A straightening plate drawing an air flow and a linear light source are provided on the work room side of the front surface door and above a front portion of the work room.

2. 发明申请

US20220387988A1 PURGEABLE PHARMACEUTICAL FILL NEEDLE 有权
公开(公告)号：US20220387988A1
公开(公告)日：2022-12-08
申请号：US17887667
申请日：2022-08-15
申请人： VANRX PHARMASYSTEMS INC.
发明人： Marcin CICHY , Juvenal NAING , Carlos Alberto DIAZ GUERRERO
IPC分类号： B01L1/02 , A61L2/07 , A61L2/16 , A61L2/24 , B25J21/00 , C12M1/00 , C12M1/12 , A61J1/12 , A61J1/14 , A61J1/20 , B01L1/04 , B01L3/02 , B65B3/00 , B65B3/04 , B65B55/12 , G01N35/00 , G01N35/10
摘要： The present invention involves a fill needle system for aseptically dispensing a pharmaceutical fluid in an aseptic chamber comprises a fill needle tubing in fluid communication with a pharmaceutical fluid source via flexible tubing and extending through a fill needle hub; a fill needle dispensing tip disposed at a dispensing end of the fill needle tubing; a fill needle sheath shaped and arranged to removably mate with and seal aseptically to the fill needle hub to form an aseptically sealed volume enclosing the dispensing tip; and a fluid pressure pulse induction system disposed and configured to compress the flexible tubing in order to dislodge droplets of pharmaceutical fluid retained on the dispensing tip after halting dispensing of the pharmaceutical fluid. An associated method of dispensing pharmaceutical fluid comprises operating the fluid pressure pulse induction system to dislodge the droplets. The system may comprise a controller for automatically controlling the dispensing and droplet dislodging.

3. 发明申请

US20220324123A1 Arrangement for Protecting Against Unauthorized Intervention in a Containment Using a Work Glove 有权
公开(公告)号：US20220324123A1
公开(公告)日：2022-10-13
申请号：US17631370
申请日：2020-07-23
申请人： Skan AG
发明人： Christoph Joschi Geiser , Frank Martin Lehmann
IPC分类号： B25J21/02 , B01L1/04 , B25J21/00
摘要： A work glove is installed at the port flange, with the result that the operator can enter the working chamber of the containment in a protected manner. A multiplicity of port flanges are usually mounted on the containment and a work glove is fastened in each case to the respective port flange. Machinery for processing material to be treated is often set up in the working chamber. In order to temporarily block the access, a shut-off part which can be moved into a blocking position and an open position is provided. In order to record personal data relating to the operator, the arrangement has a capture unit which has a connection to a microcontroller.

4. 发明授权

US11300581B2 Method for protecting and unprotecting the fluid path in a controlled environment enclosure 有权
公开(公告)号：US11300581B2
公开(公告)日：2022-04-12
申请号：US16901123
申请日：2020-06-15
申请人： VANRX PHARMASYSTEMS INC.
发明人： Christopher Procyshyn , Marcin Cichy
IPC分类号： G01N1/00 , G01N35/10 , A61J1/14 , A61J1/20 , B65B55/12 , B65B3/04 , B65B3/00 , A61J1/12 , B01L1/04 , A61L2/07 , A61L2/16 , A61L2/24 , B01L1/02 , B25J21/00 , C12M1/00 , C12M1/12 , B01L3/02 , G01N35/00
摘要： A controlled environment enclosure comprises a robotic arm manipulation system used to protect and unprotect a fluid path and a swab within the controlled environment enclosure. The apparatus allows the fluid path to be protected against dangerous decontamination vapors and chemicals before the controlled environment enclosure is decontaminated. The apparatus allows the fluid path to be unprotected without the use of gloves or other means that degrade the integrity of the controlled environment enclosure when decontamination is completed. The apparatus and method allow for the protecting, unprotecting and decontaminating sequences to be automated. In some embodiments the fluid path comprises a fill needle that can removably and aseptically be sealed with a disposable monolithic injection moulded polymeric fill needle sheath. The apparatus and method further allow for the use of a swab disposed in a swab holder that is aseptically and removably sealable to a swab cap to protect the swab against decontamination vapors.

5. 发明申请

US20220003796A1 AUTOMATED CELL PROCESSING SYSTEMS AND METHODS 有权
公开(公告)号：US20220003796A1
公开(公告)日：2022-01-06
申请号：US17448011
申请日：2021-09-17
申请人： Genesis Technologies Limited
发明人： Jan-Eric Ahlfors
IPC分类号： G01N35/10 , B01L1/02 , B01L1/04 , G01N35/00
摘要： A system for automated processing of a plurality of batches, each batch being derived from one biological sample, the system comprising an enclosure which can be closed and sterilized, each batch of the plurality of batches comprising one or more cell processing container; a plurality of reagent containers for holding reagents within the enclosure; at least one reagent dispenser within the enclosure for dispensing reagents during said automated processing; a quality control system within the enclosure for analyzing at least one characteristic of a batch during said automated processing; a harvester within the enclosure for harvesting batches; a robotic system within the enclosure, configured for transporting cell processing containers, decapping or otherwise opening cell processing containers, pipetting reagents or liquids from cell processing containers, and aspirating liquids from cell processing containers, during said automated processing; a tracker for electronically tracking the plurality of batches after its introduction to the enclosure; and a control unit (CU) communicatively coupled to the at least one reagent dispenser, the quality control system, the harvester, the robotic system and the tracker for controlling said automatic processing of said batches.

6. 发明授权

US11156627B2 Automated cell processing systems and methods 有权
公开(公告)号：US11156627B2
公开(公告)日：2021-10-26
申请号：US16311345
申请日：2017-06-20
申请人： Genesis Technologies Limited
发明人： Jan-Eric Ahlfors
IPC分类号： G01N35/10 , B01L1/02 , B01L1/04 , G01N35/00
摘要： Systems and methods for automated cell processing of biological samples, such as cells for use in cell therapy and regenerative medicine. Systems for automated processing of batches derived from biological samples comprise: a closed and sterile enclosure; a plurality of reagent containers; at least one reagent dispenser; a quality control module for analyzing at least one characteristic of a batch; a harvesting module; a robotic module; and a control unit (CU) communicatively coupled to the at least one reagent dispenser, the quality control module, the harvesting module and the robotic module for controlling the automatic processing of batches. The automatic processing may be executable without handling by a human operator. The system may be configured to automatically process the plurality of batches without cross-contamination between batches, e.g., under GMP conditions.

7. 发明授权

US10843239B2 Weighing fume cupboard with a work surface that is vibrationaly isolated from the rest of the housing 有权
公开(公告)号：US10843239B2
公开(公告)日：2020-11-24
申请号：US15558975
申请日：2016-02-15
申请人： Waldner AG
发明人： Jürgen Liebsch
IPC分类号： G01G21/30 , B25H1/20 , B08B15/02 , B01L1/04 , G01G21/28 , B01L1/00
CPC分类号： B08B15/023 , B01L1/00 , B01L1/04 , B25H1/20 , G01G21/286 , B01L2200/082 , B01L2200/087 , B01L2200/141 , G01G21/30
摘要： A weighing fume cupboard (1) for weighing pharmaceutically active or toxic substances in a laboratory, comprising a housing (10) which defines a working space (19), wherein a front side of the housing (10) has a working opening (11) which is open at all times during intended use of the weighing fume cupboard (1), a working plate (20) which delimits the working space (19) at the bottom side, an armrest (40) in the region of the working opening (11), and a support (30) which bears the weight of the housing (10), of the working plate (20) and of the armrest (40), wherein, during intended use of the weighing fume cupboard, the working plate (20) is decoupled in terms of shocks and vibrations from the housing (10), from the armrest (40) and from the support (30).

8. 发明授权

US10583431B2 Portable containment device for manipulating organic and/or chemical substances, and removable containment enclosure for such a device 有权
公开(公告)号：US10583431B2
公开(公告)日：2020-03-10
申请号：US15514262
申请日：2015-09-26
申请人： K-Plan
发明人： Dominique Parzy , Sébastien Parzy , Cyril Desmoort
IPC分类号： B01D50/00 , B01D59/50 , B01L1/02 , B08B15/02 , B25J21/02 , G21F7/04 , B01L1/04
摘要： The invention relates to a portable containment device for manipulating organic and/or chemical substances, which includes: a transporting case including two half-cases (2, 3) connected by a hinged structure (4) such as to be movable between a closed position (F), in which the half-cases (2, 3) are against one another and define a stowing space for at least the hinged structure (4), and an open position (O), in which the half-cases (2, 3) are spaced apart from one another by being maintained vertical by the hinged structure (4) and in which the half-cases (2, 3) and the hinged structure (4) form a supporting structure for a flexible containment enclosure (20); and a plastic, removable and flexible containment enclosure (20) that is at least partially transparent, for forming a generally parallelepiped foldable isolation chamber provided with means (31, 32) for accessing the inside of the enclosure and with means (21) for attachment to the supporting structure. The containment enclosure (20) is collapsible inside the transporting case in the closed position (F). The invention also relates to a removable, flexible enclosure for such a device.

9. 发明申请

US20190310177A1 Isolation Device with Built-In Particle Counter 审中-公开
公开(公告)号：US20190310177A1
公开(公告)日：2019-10-10
申请号：US16309337
申请日：2017-05-12
申请人： Hitachi Industrial Equipment Systems Co., Ltd.
发明人： Keiichi ONO , Tomoyuki SUZUKI
IPC分类号： G01N15/06 , G01N33/00 , B01L1/02 , B01L1/04
摘要： The present invention accurately manages the number of fine particles in a workspace and prevents fine particles from mixing with an experimental material. An isolation device for supplying a workspace with clean air resulting from dust filtration by an air cleaning means, said isolation device being provided with: a measurement probe that is for air intake and is disposed in the workspace; a particle counter for measuring the fine-particle counts for a plurality of particle sizes in the workspace air taken in by the measurement probe and outputting the measurements; a storage unit for storing, for each of the plurality of particle sizes and for work times and non-work times, management fine-particle counts at which the number of fine particles per unit volume is determined to be large; a cleanliness determination unit for determining cleanliness by comparing the fine particle counts for the plurality of particle sizes measured by the particle counter and the management fine-particle counts for the plurality of particle sizes stored by the storage unit; and an output unit for outputting an alarm if the cleanliness determination unit determines that the work-time/non-work time fine particle count for a particle size in the workspace during operation exceeds the corresponding management fine-particle count.

10. 发明授权

US10376807B2 Methods and apparatuses for water purification 有权
公开(公告)号：US10376807B2
公开(公告)日：2019-08-13
申请号：US16159639
申请日：2018-10-13
申请人： Huei Meng Chang , Yee Chun Lee , Narayan D. Raju
发明人： Huei Meng Chang , Yee Chun Lee , Narayan D. Raju
IPC分类号： B01D1/04 , B01D5/00 , B01D1/28 , C02F1/04 , B01D1/00 , B01D1/30 , B01D21/00 , B03C3/017 , B01L1/04
摘要： An apparatus for generating purified liquid from an input liquid, comprises, an evaporation chamber flooded with the input liquid and wherein the evaporation chamber generates saturated gases and comprises a shared wall with the condensation chamber and wherein the evaporation chamber is configured to generate evaporation cavities and condensation cavities on respective sides of the shared wall for a 2-phase counter flow of a liquid phase component and a gaseous phase component in composite flows for a 2-phase to 2-phase direct latent heat exchange. A condensation chamber has channels disposed in the input liquid, wherein liquid-saturated gases are generated therefrom in the evaporation chamber. The apparatus is operated as a four-port counter-flow heat exchanger where two different fluids are exchanging heat based on the inlet ports of both fluids being on opposite sides and the outlet ports of both fluids are also on opposite sides of the evaporator and condenser.

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