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1. 发明授权

US11065759B2 Articulated arm apparatus 有权
公开(公告)号：US11065759B2
公开(公告)日：2021-07-20
申请号：US14377696
申请日：2013-02-08
申请人： VANRX PHARMASYSTEMS, INC.
发明人： Ross M. Gold , Christopher Procyshyn , Jeroen Immerzeel , Steve Sang Joon Park
IPC分类号： B25J9/04 , B25J9/00 , B25J19/00 , B25J21/00 , B25J18/04
摘要： A hermetically sealed multi-axis articulated arm apparatus for use within a sealable isolator chamber is disclosed. In one general aspect, it comprises a rotational shaft that passes through an opening in the chamber, a sealing member disposed within the chamber for sealing the shaft to an inner surface of the chamber, interconnected hermetically sealed arm segments operably attached to the linear motion shaft; an end effector operably attached to a terminal arm segment among the arm segments, and at least one fully enclosed drive system for driving and controlling the shaft and the arm segments. The rotational shaft can further be a linear motion shaft for which the sealing member is a bellows. The materials for the parts of the apparatus exposed to the atmosphere of the chamber can be compatible with an aseptic and cleanable environment and the surfaces of the arm segments can be shaped to avoid pooling of contaminants.

2. 发明授权

US10196161B2 Method for filling pharmaceutical containers 有权
公开(公告)号：US10196161B2
公开(公告)日：2019-02-05
申请号：US15719736
申请日：2017-09-29
申请人： VANRX PHARMASYSTEMS INC.
发明人： Nick Broadbent , Jeroen Immerzeel , Christopher Procyshyn , Ross M. Gold , Steve Sang Joon Park
IPC分类号： B65B3/00 , B65B7/16 , B65B7/28 , B65D1/02 , B65B55/02 , B65B55/04 , B65B55/08 , B65B55/10 , B65B63/08 , B65D51/00
摘要： In one general aspect, a method for filling multiple containers with a pharmaceutical product is disclosed, which comprises decontaminating sealed nested materials in a transfer chamber, removing from the sealed nested materials one or both of a container nest holding the multiple containers and a closure nest holding multiple closures, transferring from the transfer chamber to a controlled environment enclosure the removed nest, aseptically filling the containers with the pharmaceutical product, and closing the containers with the multiple closures. The nests are configured to allow multiple closures and containers to be simultaneously aligned concentrically, and closed simultaneously. Spring-loaded retaining structures on the closure nest allow it to releasably retain multiple closures above the corresponding multiple containers. In some embodiments the spring-loaded features are monolithically integrated with the closure nest. The product may be lyophilized in partially sealed containers while the sealing closures are releasably retained by the closure nest.

3. 发明申请

US20160200461A1 METHOD, DEVICE AND SYSTEM FOR FILLING PHARMACEUTICAL CONTAINERS 审中-公开
标题翻译：方法，用于填充药物容器的装置和系统
公开(公告)号：US20160200461A1
公开(公告)日：2016-07-14
申请号：US14912145
申请日：2014-08-15
申请人： VANRX PHARMASYSTEMS INC.
发明人： Nick Broadbent , Jeroen Immerzeel , Christopher Procyshyn , Ross M. Gold , Steve Sang Joon Park
IPC分类号： B65B3/00 , B65B55/08 , B65D51/00 , B65B55/02 , B65B63/08 , B65B7/16 , B65B55/10
摘要： In one general aspect, a method for filling multiple containers with a pharmaceutical product is disclosed, which comprises decontaminating sealed nested materials in a transfer chamber, removing from the sealed nested materials one or both of a container nest holding the multiple containers and a closure nest holding multiple closures, transferring from the transfer chamber to a controlled environment enclosure the removed nest, aseptically filling the containers with the pharmaceutical product, and closing the containers with the multiple closures. The nests are configured to allow multiple closures and containers to be simultaneously aligined concentrically, and closed simultaneously. Spring-loaded retaining structures on the closure nest allow it to releasably retain multiple closures above the corresponding multiple containers. In some embodiments the spring-loaded features are monolithically integrated with the closure nest. The product may be lyophilized in partially sealed containers while the sealing closures are releasably retained by the closure nest.
摘要翻译：在一个一般方面，公开了一种用药物产品填充多个容器的方法，其包括在传送室中对密封的嵌套材料进行去污染，从密封的嵌套材料中去除容纳多个容器的容器嵌套中的一个或两个，以及封闭嵌套保持多个封闭件，从传送室转移到包围所移除的嵌套的受控环境中，用药物产品无菌地填充容器，并且用多个封闭件封闭容器。巢被配置为允许同时密集多个闭合和容器同时闭合并同时闭合。封闭套管上的弹簧保持结构允许其可释放地将多个封闭件保持在相应的多个容器上方。在一些实施例中，弹簧加载特征与闭合套筒整体地集成。产品可以在部分密封的容器中冻干，同时密封封盖由封闭套管可释放地保持。

4. 发明授权

US11518555B2 Method, device and system for filling pharmaceutical containers 有权
公开(公告)号：US11518555B2
公开(公告)日：2022-12-06
申请号：US15950480
申请日：2018-04-11
申请人： VANRX PHARMASYSTEMS INC.
发明人： Nick Broadbent , Jeroen Immerzeel , Christopher Procyshyn , Ross M. Gold , Steve Sang Joon Park
IPC分类号： B65B7/16 , B65B7/28 , B65D51/00 , B65B55/02 , B65B3/00 , B65D41/28 , B65B55/08 , B65B55/10 , B65B55/04 , B65D1/02
摘要： In one general aspect, a method for filling multiple containers with a pharmaceutical product is disclosed, which comprises decontaminating sealed nested materials in a transfer chamber, removing from the sealed nested materials one or both of a container nest holding the multiple containers and a closure nest holding multiple closures, transferring from the transfer chamber to a controlled environment enclosure the removed nest, aseptically filling the containers with the pharmaceutical product, and closing the containers with the multiple closures. The nests are configured to allow multiple closures and containers to be simultaneously aligned concentrically, and closed simultaneously. Spring-loaded retaining structures on the closure nest allow it to releasably retain multiple closures above the corresponding multiple containers. In some embodiments the spring-loaded features are monolithically integrated with the closure nest. The product may be lyophilized in partially sealed containers while the sealing closures are releasably retained by the closure nest.

5. 发明授权

US10850873B2 Apparatus and method for asepticaly filling pharmaceutical containers with a pharmaceutical fluid using rotary stage 有权
公开(公告)号：US10850873B2
公开(公告)日：2020-12-01
申请号：US15453615
申请日：2017-03-08
申请人： Vanrx Pharmasystems Inc.
发明人： Christopher Procyshyn , Juvenal Naing , John Senger , Marcin Cichy
IPC分类号： B65B3/00 , B65B55/02 , A61M5/178 , B67C3/00 , B65D41/20
摘要： Systems and methods for aseptically filling pharmaceutical containers with pharmaceutical fluid are disclosed. In one general aspect, these are based on an aseptically sealable chamber that includes a transfer wall to which pre-sealed pharmaceutical source and receiving containers are mounted aseptically. A robotic arm and a syringe store are disposed within the chamber along with a sterilizing facility for establishing in the chamber an aseptic condition. The robotic arm can grip and operate syringes to inject and/or extract pharmaceutical products from the containers by piercing their closures with the needles of the syringes.

6. 发明授权

US10901941B2 Robotic filling systems and methods 有权
公开(公告)号：US10901941B2
公开(公告)日：2021-01-26
申请号：US16356734
申请日：2019-03-18
申请人： Vanrx Pharmasystems Inc.
发明人： Christopher Procyshyn , Ross M. Gold
IPC分类号： G06F16/00 , B25J21/00 , B65B55/02 , B65B3/00 , B65B7/28 , G06F1/16 , H04M1/04 , H04M1/725 , G01N35/00 , G01N35/10
摘要： Systems and methods are disclosed, which permit filling containers with a product. A filling atm is disposed within a chamber and an optical sensor is configured to sense openings of the containers within the chamber. Locations of the sensed openings are used to guide the filling atm to fill the containers with a product.

7. 发明授权

US10781002B2 Method, device and system for filling pharmaceutical containers 有权
公开(公告)号：US10781002B2
公开(公告)日：2020-09-22
申请号：US14912145
申请日：2014-08-15
申请人： VANRX PHARMASYSTEMS INC.
发明人： Nick Broadbent , Jeroen Immerzeel , Christopher Procyshyn , Ross M. Gold , Steve Sang Joon Park
IPC分类号： B65B7/16 , B65B7/28 , B65B3/00 , B65B55/04 , B65B55/02 , B65D1/02 , B65D51/00 , B65D41/28 , B65B55/08 , B65B55/10
摘要： In one general aspect, a method for filling multiple containers with a pharmaceutical product is disclosed, which comprises decontaminating sealed nested materials in a transfer chamber, removing from the sealed nested materials one or both of a container nest holding the multiple containers and a closure nest holding multiple closures, transferring from the transfer chamber to a controlled environment enclosure the removed nest, aseptically filling the containers with the pharmaceutical product, and closing the containers with the multiple closures. The nests are configured to allow multiple closures and containers to be simultaneously aligned concentrically, and closed simultaneously. Spring-loaded retaining structures on the closure nest allow it to releasably retain multiple closures above the corresponding multiple containers. In some embodiments the spring-loaded features are monolithically integrated with the closure nest. The product may be lyophilized in partially sealed containers while the sealing closures are releasably retained by the closure nest.

8. 发明授权

US10684303B2 Method for protecting and unprotecting the fluid path in a controlled environment enclosure 有权
公开(公告)号：US10684303B2
公开(公告)日：2020-06-16
申请号：US15898650
申请日：2018-02-18
申请人： VANRX PHARMASYSTEMS INC.
发明人： Christopher Procyshyn , Marcin Cichy
IPC分类号： G01N35/10 , A61J1/14 , A61J1/20 , B65B55/12 , B65B3/04 , B65B3/00 , A61J1/12 , B01L1/04 , B01L3/02 , G01N35/00
摘要： A controlled environment enclosure comprises a robotic arm manipulation system used to protect and unprotect a fluid path and a swab within the controlled environment enclosure. The apparatus allows the fluid path to be protected against dangerous decontamination vapors and chemicals before the controlled environment enclosure is decontaminated. The apparatus allows the fluid path to be unprotected without the use of gloves or other means that degrade the integrity of the controlled environment enclosure when decontamination is completed. The apparatus and method allow for the protecting, unprotecting and decontaminating sequences to be automated. In some embodiments the fluid path comprises a fill needle that can removably and aseptically be sealed with a disposable monolithic injection moulded polymeric fill needle sheath. The apparatus and method further allow for the use of a swab disposed in a swab holder that is aseptically and removably sealable to a swab cap to protect the swab against decontamination vapors.

9. 发明授权

US11300581B2 Method for protecting and unprotecting the fluid path in a controlled environment enclosure 有权
公开(公告)号：US11300581B2
公开(公告)日：2022-04-12
申请号：US16901123
申请日：2020-06-15
申请人： VANRX PHARMASYSTEMS INC.
发明人： Christopher Procyshyn , Marcin Cichy
IPC分类号： G01N1/00 , G01N35/10 , A61J1/14 , A61J1/20 , B65B55/12 , B65B3/04 , B65B3/00 , A61J1/12 , B01L1/04 , A61L2/07 , A61L2/16 , A61L2/24 , B01L1/02 , B25J21/00 , C12M1/00 , C12M1/12 , B01L3/02 , G01N35/00
摘要： A controlled environment enclosure comprises a robotic arm manipulation system used to protect and unprotect a fluid path and a swab within the controlled environment enclosure. The apparatus allows the fluid path to be protected against dangerous decontamination vapors and chemicals before the controlled environment enclosure is decontaminated. The apparatus allows the fluid path to be unprotected without the use of gloves or other means that degrade the integrity of the controlled environment enclosure when decontamination is completed. The apparatus and method allow for the protecting, unprotecting and decontaminating sequences to be automated. In some embodiments the fluid path comprises a fill needle that can removably and aseptically be sealed with a disposable monolithic injection moulded polymeric fill needle sheath. The apparatus and method further allow for the use of a swab disposed in a swab holder that is aseptically and removably sealable to a swab cap to protect the swab against decontamination vapors.

10. 发明授权

US11186390B2 Method for filling pharmaceutical containers 有权
公开(公告)号：US11186390B2
公开(公告)日：2021-11-30
申请号：US16238433
申请日：2019-01-02
申请人： VANRX PHARMASYSTEMS INC.
发明人： Nick Broadbent , Jeroen Immerzeel , Christopher Procyshyn , Ross M. Gold , Steve Sang Joon Park
IPC分类号： B65B7/16 , B65B55/02 , B65B3/00 , B65B7/28 , B65D41/28 , B65B55/08 , B65B55/10 , B65B55/04 , B65D1/02 , B65D51/00
摘要： In one general aspect, a method for filling multiple containers with a pharmaceutical product is disclosed, which comprises decontaminating sealed nested materials in a transfer chamber, removing from the sealed nested materials one or both of a container nest holding the multiple containers and a closure nest holding multiple closures, transferring from the transfer chamber to a controlled environment enclosure the removed nest, aseptically filling the containers with the pharmaceutical product, and closing the containers with the multiple closures. The nests are configured to allow multiple closures and containers to be simultaneously aligned concentrically, and closed simultaneously. Spring-loaded retaining structures on the closure nest allow it to releasably retain multiple closures above the corresponding multiple containers. In some embodiments the spring-loaded features are monolithically integrated with the closure nest. The product may be lyophilized in partially sealed containers while the sealing closures are releasably retained by the closure nest.

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