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1. 发明授权

US3984681A Ion and electron detector for use in an ICR spectrometer 失效
标题翻译：用于ICR光谱仪的离子和电子检测器
公开(公告)号：US3984681A
公开(公告)日：1976-10-05
申请号：US500981
申请日：1974-08-27
申请人： James C. Administrator of the National Aeronautics and Space Administration, with respect to an invention of Fletcher , Wesley T. Huntress
发明人： James C. Administrator of the National Aeronautics and Space Administration, with respect to an invention of Fletcher , Wesley T. Huntress
IPC分类号： G01N24/14 , H01J49/02 , H01J49/38 , H01J39/46
CPC分类号： H01J49/38 , G01N24/14 , H01J49/025
摘要： A detector for detecting ions and/or electrons present in a resonance cell of an ICR spectrometer is disclosed. The detector which operates on the Q-meter principle is driven by an external rf oscillator capable of providing rf frequencies up to about 15MHz at an adjustable low rf signal level, e.g., below 20mV. The detector is connected across the resonance of the cell to detect ions by detecting their cyclotron frequency. Electrons are detectable by connecting the detector across the cell's trapping plates and thereby detect the electrons' trapping motion, the frequency of which is in the megahertz range.
摘要翻译：公开了一种用于检测存在于ICR光谱仪的谐振腔中的离子和/或电子的检测器。以Q-meter原理工作的检测器由外部rf振荡器驱动，该外部rf振荡器能够以可调节的低rf信号电平（例如低于20mV）提供高达约15MHz的频率。检测器跨越电池的谐振连接，通过检测其回旋加速器频率来检测离子。通过将检测器连接在电池的捕获板上，从而检测电子捕获运动，其频率在兆赫兹范围内，可以检测电子。

2. 发明授权

US10646722B2 Magnets for magnetic resonance applications 有权
公开(公告)号：US10646722B2
公开(公告)日：2020-05-12
申请号：US15990662
申请日：2018-05-27
申请人： Olena Ibragimova , Ilgiz Ibragimov
发明人： Olena Ibragimova , Ilgiz Ibragimov
IPC分类号： H01F1/047 , A61N2/00 , A61B34/30 , A61N2/06 , A61B5/055 , A61F2/82 , A61F7/00 , A61K33/24 , A61K31/714 , A61B18/06 , G01R33/36 , G01R33/38 , A61N7/02 , G01R33/28 , G01R33/32 , G01N24/10 , G01N24/12 , G01N24/14 , A61B90/00 , G01R33/383 , G01R33/3873 , G01R33/48 , H01F1/055 , H03F3/54 , G01R33/30 , G01R33/563 , G01R33/60 , G01R33/465 , A61B18/18 , A61B17/32 , A61B18/00 , H01F41/02
摘要： The invention pertains to advances in constructing predetermined magnets from appropriate magnetic material that allows for focusing the magnetic field in a target region.

3. 发明申请

US20180164292A1 METABOLIC PATHWAY AND METABOLITE IDENTIFICATION 审中-公开
公开(公告)号：US20180164292A1
公开(公告)日：2018-06-14
申请号：US15577695
申请日：2016-05-26
申请人： Waters Technologies Corporation
发明人： Giuseppe Astarita
IPC分类号： G01N33/50 , B01D15/08 , G06F19/00 , G06F19/12 , G01N24/14 , G01N30/86 , G01N30/72 , G06F19/24 , G06F19/18
CPC分类号： G01N33/5038 , B01D15/08 , G01N24/14 , G01N30/72 , G01N30/8617 , G01N30/8675 , G01N2570/00 , G16B5/00 , G16B20/00 , G16B40/00 , G16C20/20
摘要： The present disclosure relates to methods and apparatus for identifying metabolic pathways and metabolites in complex biological samples. In particular, the present disclosure relates to a method and apparatus to increase the confidence of metabolite identification in metabolomics, such as in untargeted metabolomics data, using various statistical tools, such as over representation and enrichment analysis.

4. 发明授权

US10773092B2 Real-time methods for magnetic resonance spectra acquisition 有权
公开(公告)号：US10773092B2
公开(公告)日：2020-09-15
申请号：US15990666
申请日：2018-05-27
申请人： Olena Ibragimova , Ilgiz Ibragimov
发明人： Olena Ibragimova , Ilgiz Ibragimov
IPC分类号： G01R33/60 , A61N2/00 , A61B34/30 , A61N2/06 , A61B5/055 , A61F2/82 , A61F7/00 , A61K33/24 , A61K31/714 , A61B18/06 , G01R33/36 , G01R33/38 , A61N7/02 , G01R33/28 , G01R33/32 , G01N24/10 , G01N24/12 , G01N24/14 , H01F1/047 , A61B90/00 , G01R33/383 , G01R33/3873 , G01R33/48 , H01F1/055 , H03F3/54 , G01R33/30 , G01R33/563 , G01R33/465 , A61B18/18 , A61B17/32 , A61B18/00 , H01F41/02
摘要： The invention pertains to advances in real-time methods in nuclear magnetic resonance by offering: a new real-time processing method for nuclear magnetic resonance (NMR) spectrum acquisition without external resonator(s), which remains stable despite magnetic field fluctuations, a new processing method for nuclear magnetic resonance spectrum acquisition, which remains stable despite magnetic field fluctuations and resonator stability, a new method of constructing predetermined magnets from appropriate magnetic material that allows for focusing the magnetic field in a target region, a new dual frequency dynamic nuclear polarization (DNP) generator that polarizes the spin of electrons and acts as an NMR transmitter.

5. 发明授权

US4855593A Method for recording ICR mass spectra and ICR mass spectrometer designed for carrying out the said method 失效
标题翻译：用于记录设计用于执行所述方法的ICR质谱和ICR质谱仪的方法
公开(公告)号：US4855593A
公开(公告)日：1989-08-08
申请号：US198975
申请日：1988-05-26
申请人： Geoffrey Bodenhausen , Peter E. Pfandler , Jacques Rapin , Tino Gaumann , Raymond Houriet
发明人： Geoffrey Bodenhausen , Peter E. Pfandler , Jacques Rapin , Tino Gaumann , Raymond Houriet
IPC分类号： G01R33/64 , G01N24/14 , G01N27/62 , H01J49/38 , H01J49/44
CPC分类号： H01J49/38
摘要： Ion cyclotron resonance is an important method used in mass spectroscopy. Examinations for determining the reactions between substances by means of the two-dimensional ICR method are carried out using the following measuring sequence:P.sub.1 -t.sub.1 -P.sub.2 -T.sub.m -P.sub.3 -t.sub.2,wherein P.sub.1, P.sub.2 and P.sub.3 are rf pulses, with the rf pulses P.sub.1 and P.sub.2 having the same frequency, t.sub.1 and T.sub.m are time intervals between the pulses and t.sub.2 is the observation time following the last pulse. This measuring sequence is repeated several times while varying t.sub.1. In this manner, a plurality of induction signals recorded during the time t.sub.2 is obtained, from which then a two-dimensional spectrum is derived by transformation from the time domain into the frequency domain. The transformation from the time domain to the frequency domain can be effected by two-dimensional Fourier transformation, or with the aid of the method of maximum entropy.
摘要翻译：离子回旋共振是质谱中使用的重要方法。通过二维ICR方法测定物质之间的反应的检查使用以下测量顺序进行：P1-t1-P2-Tm-P3-t2，其中P1，P2和P3是rf脉冲，其中rf 具有相同频率的脉冲P1和P2，t1和Tm是脉冲之间的时间间隔，t2是最后脉冲之后的观察时间。在测量t1时，重复该测量序列数次。以这种方式，获得在时间t2期间记录的多个感应信号，然后通过从时域到频域的变换导出二维频谱。从时域到频域的变换可以通过二维傅里叶变换，或借助于最大熵的方法来实现。

6. 发明授权

US4563579A Procedure for recording ion-cyclotron-resonance spectra and apparatus for carrying out the procedure 失效
标题翻译：用于记录离子回旋共振谱的方法和用于进行该方法的装置
公开(公告)号：US4563579A
公开(公告)日：1986-01-07
申请号：US645051
申请日：1984-08-28
申请人： Hanspeter Kellerhals , Martin Allemann
发明人： Hanspeter Kellerhals , Martin Allemann
IPC分类号： H01J49/10 , G01N27/62 , G01R33/64 , H01J49/14 , H01J49/38 , G01N24/14
CPC分类号： G01R33/64 , H01J49/38 , Y10S505/842
摘要： In a procedure for recording ion-cyclotron resonance spectra or an apparatus for carrying out the procedure, gaseous ions of a sample substance in an ultrahigh vacuum are simultaneously exposed to a constant magnetic field B.sub.O and to a high frequency field which is perpendicular to it, with resonances being excited when the frequency of the alternating field corresponds to the rotational frequency of the ions which move on circular paths in the constant magnetic field. To produce gaseous ions of the sample substance, the latter is bombarded with additional gaseous, high-energy ions of a primary substance. The primary ions are produced in the measuring cell by means of an electron beam and excited to a high energy level by means of ion-cyclotron resonance (FIG. 2).
摘要翻译：在用于记录离子回旋共振光谱的过程或用于执行该过程的装置中，超高真空中的样品物质的气态离子同时暴露于恒定磁场BO和垂直于其的高频场，当交变场的频率对应于在恒定磁场中在圆形路径上移动的离子的旋转频率时，谐振被激发。为了产生样品物质的气态离子，后者用主要物质的附加气态高能离子轰击。初级离子通过电子束在测量池中产生，并通过离子回旋共振（图2）激发到高能级。

7. 发明授权

US08193490B2 High mass resolution with ICR measuring cells 有权
标题翻译：高质量分辨率与ICR测量单元
公开(公告)号：US08193490B2
公开(公告)日：2012-06-05
申请号：US12637184
申请日：2009-12-14
申请人： Roland Jertz , Gökhan Baykut
发明人： Roland Jertz , Gökhan Baykut
IPC分类号： G01N27/62 , G01N24/14
CPC分类号： H01J49/38
摘要： The compensation potentials on the compensation electrodes of an ICR measuring cell are sequentially adjusted so that an ICR measurement with the longest possible usable image current transient is produced. Then, subsequent ICR measurements are made using the ICR cell with the optimally adjusted compensation potentials. Depending on the kind of ion mixture involved, measurements with image current transients from 10 to more than 20 seconds long can be performed, from which mass spectra with a maximum mass resolution without peak coalescence can be obtained.
摘要翻译：依次调整ICR测量单元的补偿电极上的补偿电位，使得产生具有尽可能长的可用图像电流瞬变的ICR测量。然后，使用具有最佳调整的补偿电位的ICR单元进行随后的ICR测量。根据所涉及的离子混合物的种类，可以进行从10秒到20秒以上的图像电流瞬变的测量，从而可以获得具有最大质量分辨率而不具有峰值聚结的质谱。

8. 发明授权

US4746802A Ion cyclotron resonance spectrometer 失效
标题翻译：离子回旋共振光谱仪
公开(公告)号：US4746802A
公开(公告)日：1988-05-24
申请号：US924854
申请日：1986-10-28
申请人： Hanspeter Kellerhals
发明人： Hanspeter Kellerhals
IPC分类号： G01N24/14 , G01R33/64 , H01J49/38 , B01D59/44
CPC分类号： G01R33/64 , H01J49/38
摘要： An Ion cyclotron resonance spectrometer comprises a first cell (8) which can be evacuated to a normal high vacuum and which is coupled with means (17, 18) for ionizing a sample substance. The first cell (8) is connected with a second cell (11) via a partition wall (15) provided with a small opening (14), which second cell (11) comprises an ion trap (27, 31) located in the homogenous area of the magnet arrangement (1, 2) and adapted for determining ion cyclotron resonances. The second cell (11) can be evacuated to a superhigh vacuum. The first cell (8) comprises an area located outside the magnet arrangement (1, 2) which lies still within the stray field of the magnet arrangement and which may be provided with an additional magnet (35) so that any desired substance can be ionized therein by any suitably adapted equipment. The ions thus produced can be displaced by means of potential grids (22, 23, 24) located within the first chamber (8), which may be caused to form ion traps by applying suitable potentials, towards the end of the first cell (8) located inside the magnet arrangement (1, 2) and transferred substantially completely to the ion trap (27, 31) arranged in the second cell (11).
摘要翻译：离子回旋共振光谱仪包括可被排空至正常高真空的第一电池（8），并与用于电离样品物质的装置（17,18）耦合。第一电池单元（8）经由设置有小开口（14）的隔壁（15）与第二电池单元（11）连接，该第二电池单元（11）包括位于同质的离子阱（27,31）磁体布置（1,2）的面积，并适于确定离子回旋共振。可以将第二电池（11）抽真空至超高真空。第一电池（8）包括位于磁体布置（1,2）外部的区域，该区域仍然位于磁体布置的杂散磁场内，并且可以设置有额外的磁体（35），使得任何所需物质可被电离通过任何适当调整的设备。这样产生的离子可以通过位于第一室（8）内的电位栅极（22,23,24）来移动，这可以通过向第一电池（8）的端部施加合适的电势而形成离子阱），并且基本上完全转移到布置在第二电池（11）中的离子阱（27,31）。

9. 发明授权

USB500981I5 失效
公开(公告)号：USB500981I5
公开(公告)日：1976-01-27
申请号：US50098174
申请日：1974-08-27
IPC分类号： G01N24/14 , H01J49/02 , H01J49/38
CPC分类号： H01J49/38 , G01N24/14 , H01J49/025

10. 发明授权

US11237154B2 Metabolic pathway and metabolite identification 有权
公开(公告)号：US11237154B2
公开(公告)日：2022-02-01
申请号：US15577695
申请日：2016-05-26
申请人： Waters Technologies Corporation
发明人： Giuseppe Astarita
IPC分类号： G01N33/50 , B01D15/08 , G16B5/00 , G16B20/00 , G16B40/00 , G16C20/20 , G16B40/10 , G16B20/20 , G01N24/14 , G01N30/72 , G01N30/86
摘要： The present disclosure relates to methods and apparatus for identifying metabolic pathways and metabolites in complex biological samples. In particular, the present disclosure relates to a method and apparatus to increase the confidence of metabolite identification in metabolomics, such as in untargeted metabolomics data, using various statistical tools, such as over representation and enrichment analysis.

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