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1. 发明授权

US06204058B1 Treatment of autoimmune diseases 失效
标题翻译：自身免疫性疾病的治疗
公开(公告)号：US06204058B1
公开(公告)日：2001-03-20
申请号：US09465009
申请日：1999-12-16
申请人： Anthony E. Bolton
发明人： Anthony E. Bolton
IPC分类号： C12N1501
CPC分类号： A61K35/14 , A61K41/0023 , A61M1/32 , A61M1/3681 , A61M1/3683 , A61M2202/0216 , A61M2202/0275 , A61M2205/053
摘要： An autoimmune vaccine is provided for administration to human patients to alleviate the symptoms of autoimmune diseases such as rheumatoid arthritis. The vaccine comprises an aliquot of the patient's blood, containing, inter alia, leukocytes having upregulated expression of various cell surface markers and lymphocytes containing decreased amounts of certain stress proteins. It is produced by subjecting the blood aliquot extracorporeally to certain stressors, namely oxidizing agents, UV radiation and elevated temperature.
摘要翻译：提供了一种自身免疫性疫苗用于给予人类患者以减轻自身免疫疾病如类风湿性关节炎的症状。疫苗包含患者血液的等分试样，其中尤其含有具有上调表达各种细胞表面标志物的白细胞和含有降低量某些应激蛋白的淋巴细胞。它是通过将血液等分试样经受某些压力源，即氧化剂，紫外线辐射和升高的温度而产生的。

2. 发明授权

US06759569B1 Method for large scale mutagenesis in tomato plants 失效
标题翻译：番茄植物大规模诱变的方法
公开(公告)号：US06759569B1
公开(公告)日：2004-07-06
申请号：US09508379
申请日：2000-06-08
申请人： Avraham A. Levy , Rafael Meissner , Yonatan Elkind
发明人： Avraham A. Levy , Rafael Meissner , Yonatan Elkind
IPC分类号： C12N1501
CPC分类号： C12N15/8203 , A01H1/04 , C12N15/01 , C12N15/8201 , C12N15/8216 , C12N15/8241
摘要： The present invention relates to a rapid and large-scale production of tomato mutants by utilizing miniature tomato plants which can be crossed with tomato commercial plants. Mutations are induced in the miniature tomato cultivars and desired mutants are subsequently identified in the resulting mutant tomato population.
摘要翻译：本发明涉及通过利用可与番茄商业植物杂交的微型番茄植物快速大规模生产番茄突变体。在微型番茄品种中诱导突变，随后在所得的突变番茄种群中鉴定出所需的突变体。

3. 发明授权

US06783985B1 Gene disruption methodologies for drug target discovery 失效
标题翻译：药物靶点发现的基因破坏方法
公开(公告)号：US06783985B1
公开(公告)日：2004-08-31
申请号：US09792024
申请日：2001-02-20
申请人： Terry Roemer , Bo Jiang , Charles Boone , Howard Bussey
发明人： Terry Roemer , Bo Jiang , Charles Boone , Howard Bussey
IPC分类号： C12N1501
CPC分类号： C12R1/645 , A61K39/00 , C07K14/37 , C07K14/40 , C07K2319/00 , C12N15/1034 , C12N15/65 , C12N15/80 , C12N15/90 , C12R1/725
摘要： The present invention provides methods and compositions that enable the experimental determination as to whether any gene in the genome of a diploid pathogenic organism is essential, and whether it is required for virulence or pathogenicity. The methods involve the construction of genetic mutants in which one allele of a specific gene is inactivated while the other allele of the gene is placed under conditional expression. The identification of essential genes and those genes critical to the development of virulent infections, provides a basis for the development of screens for new drugs against such pathogenic organisms. The present invention further provides Candida albicans genes that are demonstrated to be essential and are potential targets for drug screening. The nucleotide sequence of the target genes can be used for various drug discovery purposes, such as expression of the recombinant protein, hybridization assay and construction of nucleic acid arrays. The uses of proteins encoded by the essential genes, and genetically engineered cells comprising modified alleles of essential genes in various screening methods are also encompassed by the invention.
摘要翻译：本发明提供了能够对二倍体致病生物体的基因组中的任何基因是否必需的实验测定以及是否需要毒力或致病性的方法和组合物。该方法包括构建遗传突变体，其中特定基因的一个等位基因被灭活而基因的其他等位基因置于条件表达下。识别必需基因和对致病性感染发展至关重要的那些基因，为开发针对这种致病生物的新药筛选提供了基础。本发明进一步提供了被证实是必需的白念珠菌基因，并且是药物筛选的潜在靶标。靶基因的核苷酸序列可以用于各种药物发现目的，例如重组蛋白的表达，杂交测定和核酸阵列的构建。在各种筛选方法中，由必需基因编码的蛋白质的使用以及包含必需基因的修饰的等位基因的遗传工程改造的细胞也包括在本发明中。

4. 发明授权

US06537795B1 Method and means for the production of hyaluronic acid 有权
标题翻译：用于生产透明质酸的方法和方法
公开(公告)号：US06537795B1
公开(公告)日：2003-03-25
申请号：US09496149
申请日：2000-02-01
申请人： Sten Ståhl
发明人： Sten Ståhl
IPC分类号： C12N1501
CPC分类号： C12R1/46 , C12P19/26 , Y10S435/885
摘要： A method for selecting streptococcus strains capable of producing hyaluronic acid with molecular weight exceeding six million includes the steps of cultivating strains of streptococci individually in culture medium which is free of metal ions which promote degradation of hyaluronic acid and which does not release from the reactor metal ions which promote the degradation of hyaluronic acid; and selecting a supercapsulated strain of a streptococcus, supercapsulated members thereof having a mucoid morphology and being capable of forming capsules having a diameter of greater than 4 &mgr;m.
摘要翻译：选择能够产生分子量超过600万的透明质酸的链球菌菌株的方法包括以下步骤：培养不含金属离子的培养基中的链球菌菌株，所述金属离子促进透明质酸的降解并且不从反应器金属中释放促进透明质酸降解的离子; 选择链球菌的超胶囊菌株，其具有粘液样形态的超胶囊成分，并且能够形成直径大于4μm的胶囊。

5. 发明授权

US06521818B1 Development of novel highly chemoprotectant crucifer germplasm 有权
标题翻译：开发新型高度化学保护剂十字花科植物种质
公开(公告)号：US06521818B1
公开(公告)日：2003-02-18
申请号：US09348874
申请日：1999-06-30
申请人： Jed W. Fahey
发明人： Jed W. Fahey
IPC分类号： C12N1501
CPC分类号： A01H5/10 , A01H1/04
摘要： A method for producing crucifer germplasm, in particular broccoli and cauliflower germplasm, with high levels of cancer chemoprotectant agents is provided which comprises screening a population of plants for glucosinolate profiles and selecting an individual plant with an enhanced alkyl/indole glucosinolate ratio. Subsequent breeding with a selected plant results in varieties, lines, and plants with desirable glucosinolate profiles. A method of growing crucifer sprouts to enhance chemoprotectant activity of the sprouts by germinating the seeds in a limited water volume is also provided. A method for producing crucifer germplasm which produces seeds with reduced leakage of seed material is provided which comprises screening a population of plants for production of seeds with reduced leakage and selecting an individual plant which produces such seeds.
摘要翻译：提供了一种用于生产具有高水平的癌症化学保护剂的十字花科植物种质，特别是西兰花和花椰菜种质的方法，其包括筛选一组植物的硫代葡萄糖苷类型并选择具有增强的烷基/吲哚硫代葡萄糖苷比的单个植物。随后用选择的植物进行育种，产生具有所需芥子油苷特征的品种，品系和植物。还提供了生长十字花科植物芽的方法，以通过在有限的水体积中发芽种子来增强芽苗的化学保护作用。提供了一种生产具有减少种子材料泄漏的种子的十字花科植物种质的方法，其包括筛选一群植物以生产具有减少的渗漏的种子并选择产生这种种子的个体植物。

6. 发明授权

US06500669B1 Programmable genotoxic agents and uses therefor 失效
标题翻译：可编程的遗传毒理剂及其用途
公开(公告)号：US06500669B1
公开(公告)日：2002-12-31
申请号：US09103671
申请日：1998-06-23
申请人： John M. Essigmann , Robert G. Croy , Kevin J. Yarema , Marshall Morningstar
发明人： John M. Essigmann , Robert G. Croy , Kevin J. Yarema , Marshall Morningstar
IPC分类号： C12N1501
CPC分类号： A61K47/64 , A61K47/55 , A61K47/554 , A61K47/557
摘要： The compositions and methods disclosed herein provide heterobifunctional programmable genotoxic compounds that can be designed to kill selected cells present in a heterogenous cell population. The present compounds comprise a first agent that inflicts damage on cellular DNA, and a second agent that attracts a macromolecular cell component such as a protein, which in turn shields genomic lesions from repair. Unrepaired lesions therefore persist in the cellular genome and contribute to the death of selected cells. In contrast, lesions formed in nonselected cells, which lack the cell component, are unshielded and thus are repaired. As a result, compounds described herein are less toxic to nonselected cells. Compounds of this invention can be designed to cause the selective killing of transformed cells, viral-infected cells and the like.
摘要翻译：本文公开的组合物和方法提供异源双功能可编程遗传毒性化合物，其可被设计为杀死异源细胞群体中存在的所选细胞。本发明化合物包括对细胞DNA造成损害的第一药剂和吸引诸如蛋白质的大分子细胞成分的第二药剂，其继而对基因组病变进行修复。因此，未修复的病变在细胞基因组中持续存在，并有助于所选细胞的死亡。相比之下，缺乏细胞成分的非选择细胞中形成的病变是非屏蔽的，因此被修复。结果，本文所述的化合物对非选择性细胞的毒性较小。本发明的化合物可被设计成引起转化细胞，病毒感染细胞等的选择性杀伤。

7. 发明授权

US06312955B1 Streptococcus gordonii strains resistant to fluorodeoxyuridine 失效
标题翻译：对氟脱氧尿苷耐药的链球菌gordonii菌株
公开(公告)号：US06312955B1
公开(公告)日：2001-11-06
申请号：US09301456
申请日：1999-04-29
申请人： Dennis E. Hruby , Christine A. Franke
发明人： Dennis E. Hruby , Christine A. Franke
IPC分类号： C12N1501
CPC分类号： C12N1/20
摘要： The present invention features gram-positive bacteria resistant to 5-fluorodeoxyuridine (FUdR). Such bacteria will preferably be commensal, and will not be resistant to antibiotics. Bacteria according to the present invention may also be transformed with DNA encoding an antigenic protein. Such transformed bacteria may be used to formulate a vaccine, in order to stimulate an immune response to the antigenic protein in a patient. The present invention further provides a method for isolating gram-positive bacteria resistant to FUdR.
摘要翻译：本发明具有抗5-氟脱氧尿苷（FUdR）抗性的革兰氏阳性菌。这种细菌优选是共生的，并且不会对抗生素产生抗性。根据本发明的细菌也可以用编码抗原蛋白的DNA转化。这种转化的细菌可以用于配制疫苗，以便刺激患者中抗原蛋白的免疫应答。本发明还提供了分离对FUdR有抗性的革兰氏阳性菌的方法。

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