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1. 发明申请

US20070275954A1 Novel Fused Heterocycles and Uses Thereof 审中-公开
标题翻译：新型融合杂环及其用途
公开(公告)号：US20070275954A1
公开(公告)日：2007-11-29
申请号：US11569112
申请日：2005-05-19
申请人： Gregory Basarab , Charles Eyermann , Bolin Geng , Madhusudhan Gowravaram , James Loch III , Lawrence MacPherson , Marshall Morningstar , George Mullen , Alex Staz , Andrew Kiely
发明人： Gregory Basarab , Charles Eyermann , Bolin Geng , Madhusudhan Gowravaram , James Loch III , Lawrence MacPherson , Marshall Morningstar , George Mullen , Alex Staz , Andrew Kiely
IPC分类号： A61K31/5513 , A61P1/04 , A61P31/04 , C07D243/14 , C07D491/02
CPC分类号： A61K31/551 , A61K31/5513 , C07D243/20 , C07D403/04 , C07D409/04 , C07D409/14 , C07D471/04
摘要： This invention relates to novel compounds having the Formula (I) and to their pharmaceutical compositions and to their methods of use. These novel compounds provide a treatment or prophylaxis of H. pylori infection.
摘要翻译：本发明涉及具有式（I）的新化合物及其药物组合物及其使用方法。这些新型化合物提供治疗或预防幽门螺杆菌感染。

2. 发明申请

US20060252781A1 Fused heterocycles as inhibitors of glutamate racemase(muri) 失效
标题翻译：稠合杂环作为谷氨酸消旋酶抑制剂（muri）
公开(公告)号：US20060252781A1
公开(公告)日：2006-11-09
申请号：US10567797
申请日：2004-08-12
申请人： Gregory Basarab , Charles Eyermann , Madhusudhhan Gowravaram , Oluyinka Green , Andrew Kiely , Lawrence Macpherson , Marshall Morningstar , Nguyen Thanh
发明人： Gregory Basarab , Charles Eyermann , Madhusudhhan Gowravaram , Oluyinka Green , Andrew Kiely , Lawrence Macpherson , Marshall Morningstar , Nguyen Thanh
IPC分类号： A61K31/519 , C07D487/14
CPC分类号： C07D487/14
摘要： This invention relates to novel compounds having formula: (I) or (II) and to their pharmaceutical compositions and to their methods of use. These novel compounds provide a treatment or prophylaxis of H. pylori infection.
摘要翻译：本发明涉及具有式（I）或（II）的新化合物及其药物组合物及其使用方法。这些新型化合物提供治疗或预防幽门螺杆菌感染。

3. 发明申请

US20050148602A1 Inhibitors of alphaLbeta2 mediated cell adhesion 失效
标题翻译： αLbeta2介导的细胞粘附抑制剂
公开(公告)号：US20050148602A1
公开(公告)日：2005-07-07
申请号：US11070335
申请日：2005-03-03
申请人： Ila Sircar , Paul Furth , Bradley Teegarden , Marshall Morningstar , Nicholas Smith , Ronald Griffith
发明人： Ila Sircar , Paul Furth , Bradley Teegarden , Marshall Morningstar , Nicholas Smith , Ronald Griffith
IPC分类号： C07D471/04 , C07D487/04 , C07D513/04 , A61K31/519 , A61K31/4188 , A61K31/424 , A61K31/43 , A61K31/4439 , C07D491/02 , C07D498/02
CPC分类号： C07D471/04 , C07D487/04 , C07D513/04
摘要： The present invention relates to a compound of the following formula: or a pharmaceutically acceptable salt thereof. Also disclosed are compositions containing the compound and methods of preparing and using the compounds. The compounds of the invention are useful in treating αLβ2 adhesion mediated conditions in a mammal.
摘要翻译：本发明涉及下式的化合物或其药学上可接受的盐。还公开了含有该化合物的组合物和制备和使用该化合物的方法。本发明的化合物可用于治疗哺乳动物中的α2 L 2β2/2粘附介导的病症。

4. 发明授权

US06897225B1 Inhibitors of αLβ2 mediated cell adhesion 失效
公开(公告)号：US06897225B1
公开(公告)日：2005-05-24
申请号：US10111110
申请日：2000-10-19
申请人： Ila Sircar , Marshall Morningstar , Paul Furth , Nicholas Smith , Bradley R. Teegarden , Ronald C. Griffith
发明人： Ila Sircar , Marshall Morningstar , Paul Furth , Nicholas Smith , Bradley R. Teegarden , Ronald C. Griffith
IPC分类号： C07D471/04 , C07D487/04 , C07D513/04 , A61K31/4188 , A61K31/4439 , A61P19/02
CPC分类号： C07D471/04 , C07D487/04 , C07D513/04
摘要： The present invention relates to a compound of the following formula: or a pharmaceutically acceptable salt thereof. Also disclosed are compositions containing the compound and methods of preparing and using the compounds. The compounds of the invention are useful in treating αLβ2 adhesion mediated conditions in a mammal.

5. 发明授权

US07875715B2 Compounds for the treatment of multi-drug resistant bacterial infections 有权
标题翻译：用于治疗多重耐药细菌感染的化合物
公开(公告)号：US07875715B2
公开(公告)日：2011-01-25
申请号：US11917394
申请日：2006-06-16
申请人： Gloria Breault , Charles Joseph Eyermann , Bolin Geng , Marshall Morningstar , Folkert Reck
发明人： Gloria Breault , Charles Joseph Eyermann , Bolin Geng , Marshall Morningstar , Folkert Reck
IPC分类号： C07D498/04
CPC分类号： C07D401/06 , C07D401/14 , C07D403/06 , C07D405/06 , C07D413/06 , C07D491/04 , C07D513/04
摘要： The present invention relates to compounds that demonstrate antibacterial activity, processes for their preparation, pharmaceutical compositions containing them as the active ingredient, to their use as medicaments and to their use in the manufacture of medicaments for use in the treatment of bacterial infections in warm-blooded animals such as humans. In particular this invention relates to compounds useful for the treatment of bacterial infections in warm-blooded animals such as humans, more particularly to the use of these compounds in the manufacture of medicaments for use in the treatment of bacterial infections in warm-blooded animals such as humans.
摘要翻译：本发明涉及表现出抗菌活性的化合物，其制备方法，含有它们作为活性成分的药物组合物，它们作为药物的用途，以及它们在制备用于治疗温暖的细菌感染的药物中的用途，血液动物如人类。特别地，本发明涉及可用于治疗温血动物如人的细菌感染的化合物，更具体地涉及这些化合物在制备用于治疗温血动物细菌感染的药物中的用途，例如作为人类

6. 发明授权

US07169611B2 Programmable genotoxic agents and uses therefor 失效
标题翻译：可编程的遗传毒理剂及其用途
公开(公告)号：US07169611B2
公开(公告)日：2007-01-30
申请号：US10299029
申请日：2002-11-18
申请人： John M. Essigmann , Robert G. Croy , Kevin J. Yarema , Marshall Morningstar
发明人： John M. Essigmann , Robert G. Croy , Kevin J. Yarema , Marshall Morningstar
IPC分类号： C12N15/00 , C12N15/01 , C12Q1/00 , C12Q1/68 , C07J1/00 , C07H21/00
CPC分类号： A61K47/64 , A61K47/55 , A61K47/554 , A61K47/557
摘要： The compositions and methods disclosed herein provide heterobifunctional programmable genotoxic compounds that can be designed to kill selected cells present in a heterogenous cell population. The present compounds comprise a first agent that inflicts damage on cellular DNA, and a second agent that attracts a macromolecular cell component such as a protein, which in turn shields genomic lesions from repair. Unrepaired lesions therefore persist in the cellular genome and contribute to the death of selected cells. In contrast, lesions formed in nonselected cells, which lack the cell component, are unshielded and thus are repaired. As a result, compounds described herein are less toxic to nonselected cells. Compounds of this invention can be designed to cause the selective killing of transformed cells, viral-infected cells and the like.
摘要翻译：本文公开的组合物和方法提供异源双功能可编程遗传毒性化合物，其可被设计为杀死异源细胞群体中存在的所选细胞。本发明化合物包含对细胞DNA造成损害的第一药剂和吸引大分子细胞成分例如蛋白质的第二药剂，其又将基因组病变屏蔽修复。因此，未修复的病变在细胞基因组中持续存在，并有助于所选细胞的死亡。相比之下，缺乏细胞成分的非选择细胞中形成的病变是非屏蔽的，因此被修复。结果，本文所述的化合物对非选择性细胞的毒性较小。本发明的化合物可被设计成引起转化细胞，病毒感染细胞等的选择性杀伤。

7. 发明申请

US20090131444A1 Aminopiperidine Quinolines and Their Azaisosteric Analogues with Antibacterial Activity 审中-公开
标题翻译：氨基哌啶喹啉及其具有抗菌活性的阿片类兴奋剂类似物
公开(公告)号：US20090131444A1
公开(公告)日：2009-05-21
申请号：US11914799
申请日：2006-05-23
申请人： Folkert Reck , Marshall Morningstar , Hajnalka Hartl
发明人： Folkert Reck , Marshall Morningstar , Hajnalka Hartl
IPC分类号： A61K31/517 , A61K31/4709 , A61K31/502 , A61K31/4745 , A61K31/445 , C07D475/02 , C07D471/02 , C07D403/02 , C07D401/02 , A61K31/525
CPC分类号： C07D471/04 , C07D491/04
摘要： The present invention relates to compounds that demonstrate antibacterial activity, processes for their preparation, pharmaceutical compositions containing them as the active ingredient, to their use as medicaments and to their use in the manufacture of medicaments for use in the treatment of bacterial infections in warm blooded animals such as humans. In particular this invention relates to compounds useful for the treatment of bacterial infections in warm-blooded animals such as humans, more particularly to the use of these compounds in the manufacture of medicaments for use in the treatment of bacterial infections in warm blooded animals such as humans.
摘要翻译：本发明涉及显示抗菌活性的化合物，其制备方法，含有它们作为活性成分的药物组合物，它们作为药物的用途及其在制备用于治疗温血细菌感染的药物中的用途动物如人类。特别地，本发明涉及可用于治疗温血动物如人的细菌感染的化合物，更具体地涉及这些化合物在制备用于治疗温血动物细菌感染的药物中的用途，例如人类。

8. 发明申请

US20070004761A1 Pyrazolo [3,4-d] pyrimidine derivatives and their use in the treatment of h.pylori infection 审中-公开
标题翻译：吡唑并[3,4-d]嘧啶衍生物及其在治疗幽门螺杆菌感染中的应用
公开(公告)号：US20070004761A1
公开(公告)日：2007-01-04
申请号：US10539936
申请日：2003-12-19
申请人： Gregory Basarab , Joseph Eyermann , Madhusudhan Gowravaram , Ohryinka Green , Lawrence MacPherson , Marshall Morningstar , Thanh Nguyen
发明人： Gregory Basarab , Joseph Eyermann , Madhusudhan Gowravaram , Ohryinka Green , Lawrence MacPherson , Marshall Morningstar , Thanh Nguyen
IPC分类号： A61K31/519 , C07D487/02
CPC分类号： C07D487/04
摘要： This invention relates to novel compounds having the structural diagram (I) and to their pharmaceutical compositions and to their methods of use. These novel compounds provide a treatment or prophylaxis of H. pylori infection.
摘要翻译：本发明涉及具有结构图（I）及其药物组合物及其使用方法的新型化合物。这些新型化合物提供治疗或预防幽门螺杆菌感染。

9. 发明申请

US20050171174A1 Inhibitors of alpha l beta 2 integrin mediated cell adhesion 失效
标题翻译： α1β2整合素介导的细胞粘附抑制剂
公开(公告)号：US20050171174A1
公开(公告)日：2005-08-04
申请号：US10503602
申请日：2003-02-06
申请人： IIa Sircar , Marshall Morningstar , Masatoshi Kakushima
发明人： IIa Sircar , Marshall Morningstar , Masatoshi Kakushima
IPC分类号： A61K31/4188 , A61P1/02 , A61P1/04 , A61P3/10 , A61P7/02 , A61P9/00 , A61P9/10 , A61P11/00 , A61P11/06 , A61P13/10 , A61P17/00 , A61P17/02 , A61P17/06 , A61P19/02 , A61P19/10 , A61P25/00 , A61P27/02 , A61P29/00 , A61P31/18 , A61P35/00 , A61P37/02 , A61P37/08 , A61P43/00 , C07D487/04
CPC分类号： C07D487/04
摘要： The present invention relates to a compound of formula (I): wherein R is hydrogen atom, hydroxyl group or carbamoyl group, and n is 1 or 2, or a pharmaceutically acceptable salt thereof.
摘要翻译：本发明涉及式（I）化合物或其药学上可接受的盐，其中R是氢原子，羟基或氨基甲酰基，n是1或2。

10. 发明授权

US06894068B2 Substituted benzimidazoles as non-nucleoside inhibitors of reverse transcriptase 失效
标题翻译：取代的苯并咪唑作为逆转录酶的非核苷抑制剂
公开(公告)号：US06894068B2
公开(公告)日：2005-05-17
申请号：US10119634
申请日：2002-04-09
申请人： Christopher J. Michejda , Marshall Morningstar , Thomas Roth
发明人： Christopher J. Michejda , Marshall Morningstar , Thomas Roth
IPC分类号： A61K31/4184 , A61K31/4439 , A61P31/18 , A61P37/04 , A61P43/00 , C07D235/06 , C07D235/08 , C07D235/12 , C07D235/18 , C07D235/22 , C07D401/04 , C07D401/06 , A61K31/415 , A61K31/47 , A61K31/495 , A61K31/70 , A61K43/42
CPC分类号： C07D235/06 , C07D235/08 , C07D235/12 , C07D235/18 , C07D401/04 , C07D401/06
摘要： The present invention provides compositions and methods for the treatment of HIV infection. In particular, the present invention provides non-nucleoside inhibitors of reverse transcriptase (RT), as well as methods to treat HIV infection using these non-nucleoside inhibitors of RT. In preferred embodiments, the present invention provides a novel class of substituted benzimidazoles, effective in the inhibition of human immunodeficiency virus (HIV) RT.
摘要翻译：本发明提供了用于治疗HIV感染的组合物和方法。特别地，本发明提供了逆转录酶（RT）的非核苷抑制剂，以及使用这些RT的非核苷抑制剂治疗HIV感染的方法。在优选的实施方案中，本发明提供了有效抑制人类免疫缺陷病毒（HIV）RT的新型取代的苯并咪唑。

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