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1. 发明授权

US12005100B2 Combination, therapeutic uses and prophylactic uses 有权
公开(公告)号：US12005100B2
公开(公告)日：2024-06-11
申请号：US16094058
申请日：2017-04-21
申请人： Quantec Limited
发明人： Judith Mary Bragger , Rodney Wayne Claycomb , Colin Roger Ogle
IPC分类号： A61K38/54 , A61K35/20 , A61K38/18 , A61K38/44 , A61K39/00 , A61K45/06 , A61P31/04 , C07K16/04
CPC分类号： A61K38/54 , A61K35/20 , A61K38/18 , A61K38/1808 , A61K38/44 , A61K45/06 , A61P31/04 , C07K16/04 , A61K2039/505
摘要： This invention relates to the therapeutic and prophylactic use of a combination including lactoperoxidase and at least one other component, with an isoelectric point of, or substantially above 6.8, and which are extracted from milk, to modulate the microbiome of an animal by selectively against at least one pathogenic microoganism.

2. 发明授权

US10174110B2 Highly galactosylated anti-TNF-α antibodies and uses thereof 有权
公开(公告)号：US10174110B2
公开(公告)日：2019-01-08
申请号：US14767117
申请日：2014-02-13
申请人： Laboratoire Français du Fractionnement et des Biotechnologies
发明人： Harry M. Meade , Li-How Chen
IPC分类号： C07K16/24 , C07K16/04 , A61K39/395 , C07K16/28
摘要： In one aspect, the disclosure relates to highly galactosylated anti-TNF-alpha antibodies and compositions thereof. In one aspect, the disclosure relates to populations of anti-TNF-alpha antibodies with a high level of galactosylation, and compositions thereof. In one aspect, the disclosure relates to methods of production and use of highly galactosylated anti-TNF-alpha antibodies and populations of anti-TNF-alpha antibodies with a high level of galactosylation. In some embodiments, the anti-TNF-alpha antibody is adalimumab.

3. 发明申请

US20170129966A1 PRODUCTION OF FC FRAGMENTS 审中-公开
公开(公告)号：US20170129966A1
公开(公告)日：2017-05-11
申请号：US15315809
申请日：2015-06-02
申请人： Laboratoire Français du Fractionnement et des Biotechnologies
发明人： Nicholas C. Masiello
IPC分类号： C07K16/32 , A01K67/027 , B01D15/42 , B01D15/30 , B01D61/14 , B01D15/38 , C07K16/04 , C12P21/02
CPC分类号： C07K16/32 , A01K67/0278 , A01K2207/15 , A01K2217/072 , A01K2227/10 , A01K2267/01 , B01D15/30 , B01D15/3809 , B01D15/426 , B01D61/145 , B01D2311/2626 , C07K16/04 , C07K2317/12 , C07K2317/14 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/52 , C07K2317/55 , C07K2317/76 , C07K2317/92 , C12P21/02 , C12Y204/99 , C12Y304/22002
摘要： In one aspect, the disclosure provides cells and transgenic non-human mammals for the production of Fc fragments, as well as compositions and uses thereof.

4. 发明申请

US20160083457A1 METHODS AND COMPOSITIONS FOR THE TREATMENT AND/OR PROPHYLAXIS OF CLOSTRIDIUM DIFFICILE ASSOCIATED DISEASE 审中-公开
标题翻译：治疗和/或预防性关节炎相关疾病的方法和组合物
公开(公告)号：US20160083457A1
公开(公告)日：2016-03-24
申请号：US14785527
申请日：2014-04-17
申请人： IMMURON LIMITED
发明人： Dena LYRAS , Melanie HUTTON , Bliss CUNNINGHAM , Lucy LI , Glen CARTER , Julian ROOD
IPC分类号： C07K16/12 , A61K39/40 , A61K9/00 , C07K16/04
CPC分类号： C07K16/1282 , A61K9/0053 , A61K39/40 , A61K2039/505 , A61K2039/522 , C07K16/04 , C07K2317/12 , C07K2317/76
摘要： The present invention relates to methods and compositions for the treatment and/or prophylaxis of Clostridium difficile associated disease (CD AD). In particular, the invention relates to antibodies that bind to C. difficile antigens and are capable of inhibiting C. difficile infection, at least one symptom of C. difficile associated disease, shedding of C. difficile, and C. difficile associated mortality. The compositions of the present application comprise: mammalian or avian antibodies which bind to a C. difficile Toxin B; and mammalian or avian antibodies that bind to a C. difficile vegetative cell antigen and/or a C. difficile endospore antigen.
摘要翻译：本发明涉及用于治疗和/或预防艰难梭菌相关疾病（CD AD）的方法和组合物。特别地，本发明涉及结合艰难梭菌抗原并能够抑制艰难梭菌感染，艰难梭菌相关疾病的至少一种症状，艰难梭菌切除和艰难梭菌相关死亡率的抗体。本申请的组合物包含：与艰难梭菌毒素B结合的哺乳动物或禽类抗体; 以及结合艰难梭菌营养细胞抗原和/或艰难梭菌内孢子抗原的哺乳动物或禽抗体。

5. 发明授权

US06974573B2 Antibody production in farm animals 有权
公开(公告)号：US06974573B2
公开(公告)日：2005-12-13
申请号：US09845036
申请日：2001-04-27
申请人： Sang He Lee
发明人： Sang He Lee
IPC分类号： C07K16/04 , C07K16/12 , A61K39/00
CPC分类号： A61K39/08 , A61K39/107 , A61K2039/505 , A61K2039/541 , A61K2039/552 , C07K16/04 , C07K16/1282
摘要： The present invention provides means and methods for obtaining an antibody in a mammary secretion product of a farm-animal comprising administering to said animal at least two compositions, which may be the same or different, comprising an antigen to which said antibody is to be raised, the method comprising administering at least a first of said compositions such that a high mucosal and/or systemic immune response is obtained and wherein at least a second of said compositions is administered to a mammary gland and/or a supramammary lymph node of said animal.

6. 发明授权

US6153200A Vaccine compositions and methods useful in inducing immune protection against arthritogenic peptides involved in the pathogenesis of rheumatoid arthritis 失效
公开(公告)号：US6153200A
公开(公告)日：2000-11-28
申请号：US107615
申请日：1998-06-30
申请人： Dennis A. Carson , Salvatore Albani
发明人： Dennis A. Carson , Salvatore Albani
IPC分类号： A61K38/00 , A61K31/00 , A61K35/74 , A61K38/22 , A61K39/00 , A61K39/395 , A61K39/40 , A61K45/00 , A61K48/00 , A61P19/00 , A61P19/02 , A61P29/00 , A61P37/00 , C07K14/245 , C07K14/47 , C07K14/74 , C07K16/04 , C07K16/12 , C12N15/09 , C12N15/31 , G01N33/53 , G01N33/564 , A61K39/116 , A61K39/38 , A61K38/16 , A01N37/18
CPC分类号： G01N33/6854 , A61K38/1841 , A61K39/0008 , A61K39/40 , C07K14/245 , C07K14/70539 , C07K16/04 , C07K16/12 , G01N33/6893 , A61K39/00 , A61K48/00 , G01N2800/102 , G01N2800/50
摘要： Vaccine compositions useful in inducing immune protection in a host against arthritogenic peptides involved in the pathogenesis of rheumatoid arthritis are disclosed. Each vaccine composition provides antigenic dnaJp1 peptide (by including the peptide or a polynucleotide which encodes the peptide) and, optionally, other peptide fragments of the microbial dnaJ protein and/or human homologs thereof. Methods for identifying persons who are predisposed to develop rheumatoid arthritis and methods for use of the inventive vaccines are also disclosed.

7. 发明授权

US6143330A Compositions for inhibiting dental caries and/or middle ear infections and uses thereof 失效
标题翻译：用于抑制龋齿和/或中耳感染的组合物及其用途
公开(公告)号：US6143330A
公开(公告)日：2000-11-07
申请号：US68393
申请日：1998-08-24
申请人： Antti Sakari Aaltonen , Jouko Suhonen
发明人： Antti Sakari Aaltonen , Jouko Suhonen
IPC分类号： A23C9/20 , A61C19/06 , A61J7/00 , A61J17/00 , A61J17/02 , C07K16/04 , C07K16/12 , A61K35/20 , A61K35/16 , A61K39/395 , A61K45/00
CPC分类号： A61C19/06 , A23C9/20 , A61J7/0092 , C07K16/04 , C07K16/1217 , C07K16/1242 , C07K16/1275 , A61J17/001 , A61J17/006 , A61J7/0053
摘要： Compositions for treating or preventing dental caries and/or middle ear infections. These compositions comprise antibodies to dental caries and/or antibodies to bacteria causing middles ear infections and/or an agent preventing the adhesion, accumulation or reporduction of the pathogens of tooth or middle ear. The preferred agent is xylitol. Methods for using these compositions are also included.
摘要翻译： PCT No.PCT / FI96 / 00610 Sec。 371日期：1998年8月24日 102（e）1998年8月24日PCT 1996年11月11日PCT PCT。出版物WO97 / 17089 日期1997年5月15日治疗或预防龋齿和/或中耳感染的组合物。这些组合物包含抗龋齿的抗体和/或导致中耳感染的细菌的抗体和/或防止牙齿或中耳的病原体的粘附，积累或重新排斥的试剂。优选的试剂是木糖醇。还包括使用这些组合物的方法。

8. 发明授权

US6054124A Immune suppressive product 失效
标题翻译：免疫抑制产品
公开(公告)号：US6054124A
公开(公告)日：2000-04-25
申请号：US815630
申请日：1991-12-30
申请人： Lee R. Beck , Ralph J. Stolle
发明人： Lee R. Beck , Ralph J. Stolle
IPC分类号： A23C9/20 , A23L15/00 , A24B15/30 , A61K35/20 , A61K35/54 , A61K38/00 , A61P37/06 , A61P37/08 , C07K2/00 , C07K14/47 , C07K16/02 , C07K16/04 , C07K16/12 , A61K39/00 , A23J1/00
CPC分类号： A61K35/20 , A23C9/20 , A23L15/00 , A24B15/30 , C07K14/47 , C07K16/02 , C07K16/04 , C07K16/1282 , C07K2/00 , C07K2317/11
摘要： An immune suppressive product prepared by injecting an allergen or a mixture of allergens into the body of milk-producing species. Said product being the milk or a polypeptide subfraction of milk obtained from the allergen treated host. The immune suppressive product(s) is milk and or the polypeptide fractions contained therein, which is ostensively free of the intact allergen or allergens used for the treatment of the host. The immune suppressive factor(s) being a subfraction of the allergen used for the treatment. A method of preparing immune suppressive polypeptides from intact allergens, which involves injection of the specific intact allergens into a milk-producing species, collecting the immune suppressive polypeptide fractions of the intact allergens from the milk of the treated host. The immune suppressive milk containing said polypeptide fractions, and/or the polypeptide fractions obtained from said milk, are nonreactive in animals and humans as allergens. Said factor(s), however, are highly effective in preventing or alleviating allergic reactions.
摘要翻译：通过将过敏原或过敏原的混合物注射到产奶物质的体内制备的免疫抑制产物。所述产品是从变应原处理的宿主获得的乳或多余的牛奶分馏。免疫抑制产物是乳和/或其中含有多肽部分，其表面上没有用于治疗宿主的完整过敏原或过敏原。免疫抑制因子是用于治疗的变应原的次级分。从完整的过敏原制备免疫抑制性多肽的方法，其涉及将特异的完整过敏原注射到产乳物种中，从处理的宿主的乳中收集完整过敏原的免疫抑制多肽部分。含有所述多肽部分的免疫抑制乳和/或从所述牛奶获得的多肽部分在动物和人中作为变应原是非反应性的。然而，所述因子在预防或减轻过敏反应方面是非常有效的。

9. 发明授权

US5871731A Oral administration of immunoglobulin preparations for treatment of chronic pain syndrome 失效
标题翻译：口服免疫球蛋白G制剂用于治疗慢性疼痛综合征
公开(公告)号：US5871731A
公开(公告)日：1999-02-16
申请号：US763582
申请日：1996-12-10
申请人： Gunter Sprotte , Helge Karch , Reinhard Lissner , Wolfgang Moller
发明人： Gunter Sprotte , Helge Karch , Reinhard Lissner , Wolfgang Moller
IPC分类号： A61K38/00 , A61K39/40 , C07K16/02 , C07K16/04 , C07K16/12 , A61K39/395 , A61K39/38 , C07K16/00
CPC分类号： C07K16/1228 , A61K39/40 , C07K16/02 , C07K16/04 , C07K16/1207 , C07K16/121 , A61K38/00 , Y10S530/833
摘要： The invention concerns the oral administration of immunoglobulins from plasma, colostral milk, milk, eggs or cell cultures for the therapy and prophylaxis of heavy therapy-refractory pain conditions in patients without typical pathological anatomical correlates.
摘要翻译：本发明涉及来自血浆，初乳，乳，卵或细胞培养物的免疫球蛋白的口服施用，用于治疗和预防无典型病理解剖学相关性患者的重度治疗难治性疼痛病症。

10. 发明授权

US5531988A Bacteria and immunoglobulin-containing composition for human gastrointestinal health 失效
标题翻译：用于人类胃肠健康的细菌和含免疫球蛋白的组合物
公开(公告)号：US5531988A
公开(公告)日：1996-07-02
申请号：US331140
申请日：1994-10-28
申请人： Stephen M. Paul
发明人： Stephen M. Paul
IPC分类号： A23L1/305 , A23L1/308 , A61K9/00 , A61K39/395 , A61K39/40 , A61K39/42 , C07K16/04 , A01N63/04 , A61K35/00 , A61K47/00
CPC分类号： C07K16/04 , A23L33/19 , A23L33/21 , A61K39/395 , A61K39/39508 , A61K39/40 , A61K39/42 , A61K9/0095 , A23V2002/00 , A23V2250/54248 , A23V2250/5425 , A23V2250/5434 , Y10S424/809 , Y10S514/867
摘要： A composition for promoting gastrointestinal health comprises an effective amount of a beneficial human intestinal microorganism and an effective amount of an immunoglobulin composition comprising concentrated immunologically active immunoglobulins. Preferred beneficial human intestinal bacteria include lactobacilli and bifidobacteria. The immunologically active immunoglobulins are preferably purified from bovine milk, milk products, or whey. Methods of use are also described.
摘要翻译：用于促进胃肠健康的组合物包含有效量的有益的人肠微生物和有效量的包含浓缩的免疫活性免疫球蛋白的免疫球蛋白组合物。优选的有益人肠细菌包括乳酸杆菌和双歧杆菌。免疫活性的免疫球蛋白优选从牛奶，乳制品或乳清中纯化。还描述了使用方法。

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