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1. 发明授权

US06951717B1 Methods and compositions for inhibition of membrane fusion-associated events, including HIV transmission 失效
标题翻译：用于抑制膜融合相关事件（包括HIV传播）的方法和组合物
公开(公告)号：US06951717B1
公开(公告)日：2005-10-04
申请号：US08484741
申请日：1995-06-07
申请人： Shawn O'Lin Barney , Dennis Michael Lambert , Stephen Robert Petteway
发明人： Shawn O'Lin Barney , Dennis Michael Lambert , Stephen Robert Petteway
IPC分类号： C12N15/09 , A61K38/00 , A61K39/00 , A61K39/12 , A61K39/145 , A61K39/155 , A61K39/215 , A61K39/245 , A61K39/29 , A61P31/12 , A61P31/16 , A61P31/18 , C07K5/083 , C07K5/087 , C07K5/09 , C07K5/093 , C07K5/103 , C07K5/107 , C07K5/113 , C07K5/117 , C07K7/04 , C07K14/005 , C07K14/02 , C07K14/025 , C07K14/05 , C07K14/11 , C07K14/115 , C07K14/12 , C07K14/125 , C07K14/13 , C07K14/135 , C07K14/15 , C07K14/155 , C07K14/16 , C07K14/21 , C07K14/22 , C07K14/245 , C07K14/285 , C07K14/31 , C12N9/94 , C12N9/96 , C12N9/98 , C12N9/99 , G01N33/50 , C12Q1/70
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , A61K2039/525 , A61K2039/555 , A61K2039/60 , A61K2039/6031 , C07K5/0806 , C07K5/0808 , C07K5/0812 , C07K5/0817 , C07K5/0819 , C07K5/1008 , C07K5/101 , C07K5/1013 , C07K5/1016 , C07K5/1021 , C07K5/1024 , C07K14/21 , C07K14/22 , C07K14/245 , C07K14/285 , C07K14/31 , C07K2319/00 , C12N7/00 , C12N2710/16222 , C12N2730/10122 , C12N2740/13022 , C12N2740/14022 , C12N2740/15022 , C12N2740/16122 , C12N2740/16222 , C12N2740/17022 , C12N2760/16122 , C12N2760/18022 , C12N2760/18122 , C12N2760/18422 , C12N2760/18522 , C12N2760/18622 , C12N2760/18722 , G01N33/5008 , G01N33/502 , G01N33/505 , G01N33/5091 , Y10S530/826
摘要： Parainfluenza virus types 1 to 4 (PIV1 to PIV4) are important human pathogens that cause upper and lower respiratory tract infections, particularly in infants and children. The claimed invention is directed toward novel methods for the inhibition of parainfluenza virus transmission to a cell involving the administration of synthetic peptide fusion inhibitors. These inhibitors are derived from the parainfluenza virus and vary in length between 16 to 39 amino acids. The peptides were identified by screening for the presence of fusion inhibitory motifs (e.g., ALLMOTI5, 107x178x4, and PLZIP) within the parainfluenza virus genome. A number of peptides were identified and their fusion inhibitory activities ascertained. These peptides should provide useful antiviral agents.
摘要翻译： 1型至4型副流感病毒（PIV1至PIV4）是导致上呼吸道感染和下呼吸道感染的重要人类病原体，特别是婴儿和儿童。要求保护的发明涉及用于抑制副流感病毒向涉及施用合成肽融合抑制剂的细胞传播的新方法。这些抑制剂衍生自副流感病毒，长度在16至39个氨基酸之间变化。通过筛选副流感病毒基因组内的融合抑制基序（例如ALLMOTI5,107x178x4和PLZIP）来鉴定肽。鉴定出许多肽，并确定其融合抑制活性。这些肽应提供有用的抗病毒剂。

2. 发明授权

US5178862A Canine distemper virus vaccine and method of preparation 失效
标题翻译：犬瘟热病毒疫苗及其制备方法
公开(公告)号：US5178862A
公开(公告)日：1993-01-12
申请号：US444525
申请日：1989-12-01
申请人： Richard G. Olsen
发明人： Richard G. Olsen
IPC分类号： A61K39/00 , C07K14/13
CPC分类号： C07K14/005 , A61K39/00 , C12N2760/18422 , Y10S424/818
摘要： Disclosed is a vaccine for the prevention of disease caused by canine distemper virus (CDV). The vaccine is prepared from CDV immunogens derived from CDV persistently-infected cells cultured in vitro. CCL-64 mink lung cells are the preferred cell line. CDV persistently-infected cells are cultured in serum-containing growth medium, the cells transferred and maintained in serum-free medium under conditions and for a time adequate to accumulate in said serum-free medium said CDV immunogens, and the cells separated from said CDV immunogen-containing supernatant. The CDV vaccine is made by diluting said supernatent and blending with a pharmaceutically-acceptable adjuvant.
摘要翻译：公开了一种用于预防犬瘟热病毒（CDV）引起的疾病的疫苗。该疫苗由来自体外培养的CDV持续感染的细胞的CDV免疫原制备。 CCL-64貂肺细胞是优选的细胞系。将CDV持续感染的细胞在含血清的生长培养基中培养，将细胞转移并保持在无血清培养基中，条件和时间足以在所述无血清培养基中积累所述CDV免疫原，并将从所述CDV分离的细胞含免疫原的上清液。通过稀释所述上清液并与药学上可接受的佐剂混合来制备CDV疫苗。

3. 发明申请

US20200206338A1 METHOD OF TREATING MAMMALS DISPLAYING SEVERE NEUROLOGICAL SYMPTOMS OF ADVANCED CANINE DISTEMPER VIRUS INFECTION USING NDV-INDUCED SERUM 审中-公开
公开(公告)号：US20200206338A1
公开(公告)日：2020-07-02
申请号：US16236258
申请日：2018-12-28
申请人： DANCLAY Properties, LLC
发明人： Anupama Y. FIELDS
IPC分类号： A61K39/12 , A61K35/16 , C07K14/13 , A61P25/08 , A61P31/14 , C07K16/06
摘要： This application discloses methods, compositions, and articles of manufacture for using NDV-induced serum to treat non-human mammals, including dogs, displaying severe neurological symptoms of advanced canine distemper virus (CDV) infection. An off-the-shelf chicken vaccine is injected into two or-more healthy mammals, of the same species as the sick animal, to provoke an immune response. After allowing several hours for the immune response to develop, blood is drawn from the healthy mammals and centrifuged to obtain serum. This “NDV-induced serum” can be injected into a mammal of the same species displaying severe neurological symptoms of advanced CDV infection on a prescribed schedule to bolster the sick animal's immune responses, preferably leading to clearance of the virus without the need for a spinal tap, which is the standard treatment for advanced CDV infection in mammals.

4. 发明授权

US6093794A Isolated peptides derived from the Epstein-Barr virus containing fusion inhibitory domains 失效
标题翻译：衍生自含有融合抑制结构域的爱泼斯坦 - 巴尔病毒的分离的肽
公开(公告)号：US6093794A
公开(公告)日：2000-07-25
申请号：US471913
申请日：1995-06-07
申请人： Shawn O'Lin Barney , Dennis Michael Lambert , Stephen Robert Petteway
发明人： Shawn O'Lin Barney , Dennis Michael Lambert , Stephen Robert Petteway
IPC分类号： C12N15/09 , A61K38/00 , A61K39/00 , A61K39/12 , A61K39/145 , A61K39/155 , A61K39/215 , A61K39/245 , A61K39/29 , A61P31/12 , A61P31/16 , A61P31/18 , C07K5/083 , C07K5/087 , C07K5/09 , C07K5/093 , C07K5/103 , C07K5/107 , C07K5/113 , C07K5/117 , C07K7/04 , C07K14/005 , C07K14/02 , C07K14/025 , C07K14/05 , C07K14/11 , C07K14/115 , C07K14/12 , C07K14/125 , C07K14/13 , C07K14/135 , C07K14/15 , C07K14/155 , C07K14/16 , C07K14/21 , C07K14/22 , C07K14/245 , C07K14/285 , C07K14/31 , C12N9/94 , C12N9/96 , C12N9/98 , C12N9/99 , G01N33/50
CPC分类号： C07K14/005 , C07K14/21 , C07K14/22 , C07K14/245 , C07K14/285 , C07K14/31 , C07K5/0806 , C07K5/0808 , C07K5/0812 , C07K5/0817 , C07K5/0819 , C07K5/1008 , C07K5/101 , C07K5/1013 , C07K5/1016 , C07K5/1021 , C07K5/1024 , C12N7/00 , G01N33/5008 , G01N33/502 , G01N33/505 , G01N33/5091 , A61K2039/525 , A61K2039/555 , A61K2039/60 , A61K2039/6031 , A61K38/00 , A61K39/00 , C07K2319/00 , C12N2710/16222 , C12N2730/10122 , C12N2740/13022 , C12N2740/14022 , C12N2740/15022 , C12N2740/16122 , C12N2740/16222 , C12N2740/17022 , C12N2760/16122 , C12N2760/18022 , C12N2760/18122 , C12N2760/18422 , C12N2760/18522 , C12N2760/18622 , C12N2760/18722 , Y10S530/826
摘要： The present invention relates to peptides which exhibit potent anti-retroviral activity. The peptides of the invention comprise DP178 (SEQ ID:1) peptide corresponding to amino acids 638 to 673 of the HIV-1.sub.LAI gp41 protein, and fragments, analogs and homologs of DP178. The invention further relates to the uses of such peptides as inhibitory of human and non-human retroviral, especially HIV, transmission to uninfected cells.
摘要翻译：本发明涉及显示出有力的抗逆转录病毒活性的肽。本发明的肽包含对应于HIV-1LAI gp41蛋白的氨基酸638至673的DP178（SEQ ID：1）肽，以及DP178的片段，类似物和同系物。本发明还涉及这样的肽的用途，例如抑制人和非人类逆转录病毒，特别是HIV，向未感染细胞的传播。

5. 发明授权

US6017536A Simian immunodeficiency virus peptides with antifusogenic and antiviral activities 失效
标题翻译：具有抗融合和抗病毒活性的猿猴免疫缺陷病毒肽
公开(公告)号：US6017536A
公开(公告)日：2000-01-25
申请号：US360107
申请日：1994-12-20
申请人： Shawn O'Lin Barney , Dennis Michael Lambert , Stephen Robert Petteway , Alphonse J. Langlois
发明人： Shawn O'Lin Barney , Dennis Michael Lambert , Stephen Robert Petteway , Alphonse J. Langlois
IPC分类号： A61K38/00 , A61K39/00 , A61P31/18 , C07K5/083 , C07K5/087 , C07K5/09 , C07K5/093 , C07K5/103 , C07K5/107 , C07K5/113 , C07K5/117 , C07K14/02 , C07K14/05 , C07K14/11 , C07K14/115 , C07K14/12 , C07K14/125 , C07K14/13 , C07K14/135 , C07K14/15 , C07K14/155 , C07K14/16 , C07K14/21 , C07K14/22 , C07K14/285 , C07K14/31 , A61K39/21
CPC分类号： C07K5/0806 , C07K14/005 , C07K14/21 , C07K14/22 , C07K14/285 , C07K14/31 , C07K5/0808 , C07K5/0812 , C07K5/0817 , C07K5/0819 , C07K5/1008 , C07K5/101 , C07K5/1013 , C07K5/1016 , C07K5/1021 , C07K5/1024 , A61K2039/525 , A61K38/00 , A61K39/00 , C07K2319/00 , C12N2710/16222 , C12N2730/10122 , C12N2740/15022 , C12N2740/16222 , C12N2740/17022 , C12N2760/16122 , C12N2760/18022 , C12N2760/18122 , C12N2760/18422 , C12N2760/18522 , C12N2760/18622 , C12N2760/18722
摘要： The present invention relates to peptides which exhibit antifusogenic and antiviral activities. The peptides of the invention consist of a 16 to 39 amino acid region of a simian immunodeficiency virus (SIV) protein. These regions were identified through computer algorithms capable of recognizing the ALLMOTI5, 107.times.178.times.4, or PLZIP amino acid motifs. These motifs are associated with the antifusogenic and antiviral activities of the claimed peptides.
摘要翻译：本发明涉及展现抗融合和抗病毒活性的肽。本发明的肽由猿猴免疫缺陷病毒（SIV）蛋白质的16至39个氨基酸区域组成。通过能够识别ALLMOTI5,107x178x4或PLZIP氨基酸图案的计算机算法鉴定这些区域。这些基序与要求保护的肽的抗融合和抗病毒活性相关。

6. 发明授权

US6159477A Canine herpesvirus based recombinant live vaccine, in particular against canine distemper, rabies or the parainfluenza 2 virus 有权
标题翻译：犬疱疹病毒基于重组活疫苗，特别是针对犬瘟热，狂犬病或副流感2病毒
公开(公告)号：US6159477A
公开(公告)日：2000-12-12
申请号：US213053
申请日：1998-12-16
申请人： Jean-Christophe Audonnet , Philippe Baudu
发明人： Jean-Christophe Audonnet , Philippe Baudu
IPC分类号： C12N15/09 , A61K31/00 , A61K39/00 , A61K39/10 , A61K39/205 , A61K39/23 , A61K39/245 , A61K39/295 , A61P31/00 , A61P31/12 , A61P31/22 , C07K14/015 , C07K14/03 , C07K14/115 , C07K14/13 , C07K14/145 , C07K14/20 , C07K14/235 , C12N15/00 , C12N15/38 , C12N15/86 , C12N15/869 , C12R1/92 , A61K39/12 , A61K39/175 , A61K39/27
CPC分类号： C12N15/86 , C07K14/005 , A61K39/00 , C12N2710/16722 , C12N2710/16743 , C12N2760/18422 , C12N2760/20122
摘要： Disclosed and claimed is a recombinant canine herepes virus (CHV). The recombinant CHV includes and expresses at least one heterologous nucleotide sequence encoding an antigen. The antigen can be canine distemper virus HA, canine distemper virus F, rabies virus G, canine parvovirus VP2, parainfluenza virus type 2 HA, parainfluenza virus type 2 F, Borrelia burgdorferi OspA, or Borrelia burgdorferi OspB. The at least one heterologous nucleotide sequence can be in at least one insertion site selected from the group consisting of ORF3 (SEQ ID NO:4), ORF5 (SEQ ID NO:5), the thymidine kinase gene, and the intergenic region corresponding to genes coding for the large subunit and the small subunit. Immunological or vaccine compositions as well as methods for inducing an immunological response are also disclosed and claimed.
摘要翻译：公开并要求保护的是重组犬类病毒（CHV）。重组CHV包括并表达至少一个编码抗原的异源核苷酸序列。抗原可以是犬瘟热病毒HA，犬瘟热病毒F，狂犬病病毒G，犬细小病毒VP2，副流感病毒2型HA，副流感病毒2型F，疏螺旋体疏螺旋体OspA或布氏疏螺旋体OspB。所述至少一个异源核苷酸序列可以在至少一个选自ORF3（SEQ ID NO：4），ORF5（SEQ ID NO：5），胸苷激酶基因和对应于编码大亚基和小亚基的基因。免疫学或疫苗组合物以及诱导免疫应答的方法也被公开并要求保护。

7. 发明授权

US6090393A Recombinant canine adenoviruses, method for making and uses thereof 失效
标题翻译：重组犬腺病毒，其制备方法及用途
公开(公告)号：US6090393A
公开(公告)日：2000-07-18
申请号：US675566
申请日：1996-07-03
申请人： Laurent Fischer
发明人： Laurent Fischer
IPC分类号： A61K39/00 , C07K14/13 , C12N15/861 , C12N7/00
CPC分类号： C07K14/005 , C12N15/86 , A61K39/00 , C12N2710/10343 , C12N2760/18422 , C12N2760/18434 , C12N2810/60 , C12N2810/6018 , C12N2810/6054 , C12N2830/00 , C12N2830/60
摘要： Disclosed and claimed are recombinant adenoviruses, methods of making them, uses for them (including in immunological, immunogenic, vaccine or therapeutic compositions, or, as a vector for cloning, replicating or expressing DNA and methods of using the compositions and vector), expression products from them, and uses for the expression products. More particularly, disclosed and claimed are recombinant canine adenoviruses (CAV) and methods of making them, uses for them, expression products from them, and uses for the expression products, including recombinant CAV2 viruses. Additionally, disclosed and claimed are truncated promoters, expression cassettes containing the promoters, and recombinant viruses and plasmids containing the promoters or expression cassettes.
摘要翻译：披露并要求保护的是重组腺病毒，其制备方法，用途（包括免疫学，免疫原性，疫苗或治疗组合物，或用作克隆，复制或表达DNA的载体和使用组合物和载体的方法），表达来自他们的产品，并用于表达产品。更具体地，公开和要求保护的是重组犬腺病毒（CAV）及其制备方法，它们的用途，它们的表达产物以及用于表达产物，包括重组CAV2病毒的用途。此外，公开和要求保护的是截短的启动子，含有启动子的表达盒，以及含有启动子或表达盒的重组病毒和质粒。

8. 发明授权

US6068973A Methods for inhibition of membrane fusion-associated events, including influenza virus 失效
标题翻译：抑制膜融合相关事件的方法，包括流感病毒
公开(公告)号：US6068973A
公开(公告)日：2000-05-30
申请号：US485551
申请日：1995-06-07
申请人： Shawn O'Lin Barney , Dennis Michael Lambert , Stephen Robert Petteway
发明人： Shawn O'Lin Barney , Dennis Michael Lambert , Stephen Robert Petteway
IPC分类号： C12N15/09 , A61K38/00 , A61K39/00 , A61K39/12 , A61K39/145 , A61K39/155 , A61K39/215 , A61K39/245 , A61K39/29 , A61P31/12 , A61P31/16 , A61P31/18 , C07K5/083 , C07K5/087 , C07K5/09 , C07K5/093 , C07K5/103 , C07K5/107 , C07K5/113 , C07K5/117 , C07K7/04 , C07K14/005 , C07K14/02 , C07K14/025 , C07K14/05 , C07K14/11 , C07K14/115 , C07K14/12 , C07K14/125 , C07K14/13 , C07K14/135 , C07K14/15 , C07K14/155 , C07K14/16 , C07K14/21 , C07K14/22 , C07K14/245 , C07K14/285 , C07K14/31 , C12N9/94 , C12N9/96 , C12N9/98 , C12N9/99 , G01N33/50 , C12Q1/70 , A61K39/42 , C07K16/00
CPC分类号： C07K14/005 , C07K14/21 , C07K14/22 , C07K14/245 , C07K14/285 , C07K14/31 , C07K5/0806 , C07K5/0808 , C07K5/0812 , C07K5/0817 , C07K5/0819 , C07K5/1008 , C07K5/101 , C07K5/1013 , C07K5/1016 , C07K5/1021 , C07K5/1024 , C12N7/00 , G01N33/5008 , G01N33/502 , G01N33/505 , G01N33/5091 , A61K2039/525 , A61K2039/555 , A61K2039/60 , A61K2039/6031 , A61K38/00 , A61K39/00 , C07K2319/00 , C12N2710/16222 , C12N2730/10122 , C12N2740/13022 , C12N2740/14022 , C12N2740/15022 , C12N2740/16122 , C12N2740/16222 , C12N2740/17022 , C12N2760/16122 , C12N2760/18022 , C12N2760/18122 , C12N2760/18422 , C12N2760/18522 , C12N2760/18622 , C12N2760/18722 , Y10S530/826
摘要： The present invention relates to peptides which exhibit potent anti-retroviral activity. The peptides of the invention comprise DP178 (SEQ ID:1) peptide corresponding to amino acids 638 to 673 of the HIV-1.sub.LAI gp41 protein, and fragments, analogs and homologs of DP178. The invention further relates to the uses of such peptides as inhibitory of human and non-human retroviral, especially HIV, transmission to uninfected cells.
摘要翻译：本发明涉及显示出有力的抗逆转录病毒活性的肽。本发明的肽包含对应于HIV-1LAI gp41蛋白的氨基酸638至673的DP178（SEQ ID：1）肽，以及DP178的片段，类似物和同系物。本发明还涉及这样的肽的用途，例如抑制人和非人类逆转录病毒，特别是HIV，向未感染细胞的传播。

9. 发明授权

US5180675A Recombinant fowlpox virus 失效
标题翻译：重组FOWLPOX病毒
公开(公告)号：US5180675A
公开(公告)日：1993-01-19
申请号：US264493
申请日：1988-10-28
申请人： Robert Drillien , Daniele Spehner
发明人： Robert Drillien , Daniele Spehner
IPC分类号： C12N7/00 , A61K39/00 , A61K39/155 , A61K39/275 , A61P31/12 , C07K14/065 , C07K14/115 , C07K14/12 , C07K14/125 , C07K14/13 , C07K14/165 , C12N5/10 , C12N7/01 , C12N15/09 , C12N15/39 , C12N15/863 , C12P21/00
CPC分类号： C12N15/86 , C07K14/005 , A61K39/00 , C12N2710/24022 , C12N2710/24043 , C12N2760/18122 , C12N2760/18422 , C12N2760/18622 , C12N2770/20022
摘要： Recombinant fowlpox virus, derived from an attenuated strain, which has integrated in a non-coding intergenic region of its genome a DNA sequence coding for a heterologous protein.
摘要翻译：衍生自减毒菌株的重组禽痘病毒，其整合在其基因组的非编码基因间区域中，编码异源蛋白质的DNA序列。

10. 发明申请

US20050186220A1 T helper cell epitopes 失效
标题翻译： T辅助细胞表位
公开(公告)号：US20050186220A1
公开(公告)日：2005-08-25
申请号：US10705819
申请日：2003-11-13
申请人： David Jackson , Souravi Ghosh , John Walker
发明人： David Jackson , Souravi Ghosh , John Walker
IPC分类号： A61K38/00 , A61K20060101 , A61K38/09 , A61K39/00 , A61K39/165 , A61K39/175 , A61K39/39 , A61P37/04 , C07K14/13 , C07K14/705 , C12P20060101 , C12P21/02 , C12Q1/68 , A61K39/12 , C12P21/06
CPC分类号： C07K14/005 , A61K39/00 , A61K2039/57 , C07K2319/00 , C12N2760/18422
摘要： The present invention provides T helper cell epitopes and compositions for use in inducing an immune response comprising at least one of these epitopes. The epitopes are contained within a peptide sequence selected from the group consisting of PRTSDRPVSYTMNRTRS (SEQ ID NO: 4); TRSRKQTSHRLKNIPVH (SEQ ID NO: 5); SHQYLVIKLIPNASLIE (SEQ ID NO: 6); and SPDKLLTFIASDTCPLV (SEQ ID NO: 25).
摘要翻译：本发明提供了用于诱导包含这些表位中的至少一个的免疫应答的T辅助细胞表位和组合物。表位包含在选自PRTSDRPVSYTMNRTRS（SEQ ID NO：4）的肽序列中; TRSRKQTSHRLKNIPVH（SEQ ID NO：5）; SHQYLVIKLIPNASLIE（SEQ ID NO：6）; 和SPDKLLTFI A SDTCPLV（SEQ ID NO：25）。

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