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1. 发明授权

US06794527B1 Hydrolyzable and polymerizable silanes 失效
标题翻译：可水解和可聚合的硅烷
公开(公告)号：US06794527B1
公开(公告)日：2004-09-21
申请号：US09936206
申请日：2001-12-13
申请人： Herbert Wolter , Siegfried Schmitzer
发明人： Herbert Wolter , Siegfried Schmitzer
IPC分类号： C07F712
CPC分类号： C07F7/12 , C07F7/10 , C07F7/1804 , C08G77/22 , C08G77/26 , C08G77/58 , C09D183/08
摘要： The invention relates to hydrolyzable and polymerizable silanes of formula (I), methods of preparing the same, and their use in the production of silica polycondensates, silica heteropolycondensates, polymers, heteropolymers, and other products. B=straight-chain or branched substituted or unsubstituted organic radical having 2 to 50 carbon atoms comprising one or more acrylate and/or methacrylate groups, the —CO—NH— group in the formula I being bonded to a carbon atom of the radical B, and B containing no norbornene, bicyclo[2.2.2]oct-2-ene or 7-oxabicyclo[2.2.1]hept-2-ene group; R=optionally substituted alkyl, alkenyl, aryl, alkylaryl or arylalkyl, each having 1 to 15 carbon atoms, it being possible for these radicals to contain oxygen and/or sulfur and/or nitrogen atoms; Ro=optionally substituted alkylene, alkenylene, arylene, alkylenearylene or arylenealkylene, each having 1 to 15 carbon atoms, it being possible for these radicals to contain oxygen and/or sulfur and/or nitrogen atoms; R′=optionally substituted alkylene, alkenylene, arylene, alkylenearylene or aryleneakylene, each having 1to 15 carbon atoms, it being possible for these radicals to contain oxygen and/or sulfur and/or nitrogen atoms; X=hydrogen, halogen, hydroxyl, alkoxy, acyloxy, alkylcarbonyl, alkoxycarbonyl or NR″2, where R″ is hydrogen, alkyl or aryl; a=1, 2 or 3; b=1, 2 or 3, and a+b=2, 3 or 4; c=0 or 1; d=1, 2, 3, 4, 5, 6, 7, 8, 9 or 10; e=1.
摘要翻译：本发明涉及式（I）的可水解和可聚合的硅烷，其制备方法及其在制备二氧化硅缩聚物，二氧化硅杂多糖缩合物，聚合物，杂聚物和其它产物中的用途.B =直链或支链取代或包含一个或多个丙烯酸酯和/或甲基丙烯酸酯基团的未取代的具有2-50个碳原子的有机基团，式I中的-CO-NH-基团键合到基团B的碳原子上，B不包含降冰片烯，双环[ 2.2.2]辛-2-烯或7-氧杂二环[2.2.1]庚-2-烯基; R =任选取代的烷基，烯基，芳基，烷基芳基或芳基烷基，各自具有1至15个碳原子，这是可能的这些基团含有氧和/或硫和/或氮原子; R 0 =任选取代的亚烷基，亚烯基，亚芳基，亚烷基亚芳基或亚芳基亚烷基，各自具有1至15个碳原子，这些基团可能含有氧和/或硫和/或氮原子 R'=任选取代的亚烷基，亚烯基，亚芳基，亚烷基亚芳基或亚芳基亚芳基，各自具有1至15个碳原子，这些基团可能含有氧和/或硫和/或氮原子; X =氢，卤素，羟基，烷氧基，酰氧基，烷基羰基，烷氧基羰基或NR'2，其中R“为氢，烷基或芳基; a = 1,2或3; b = 1,2或3，a + b = 2,3或4 ; c = 0或1; d = 1,2,3,4,5,6,7,8,9或10; e = 1。

2. 发明授权

US06169194A High surface density covalent immobilization of oligonucleotide monolayers using a 1-(thiotrifluoroacetato)-11-(trichlorososilyl)-undecane linker 失效
标题翻译：使用1-（三（三氟乙酰））-11-（三氯硅烷基） - 十一烷接头的高密度共价固定寡核苷酸单层
公开(公告)号：US06169194A
公开(公告)日：2001-01-02
申请号：US08951448
申请日：1997-10-16
申请人： Michael Thompson , Mark E. McGovern
发明人： Michael Thompson , Mark E. McGovern
IPC分类号： C07F712
CPC分类号： B82Y30/00 , B01J20/3242 , B32B17/10688 , B82Y5/00 , B82Y15/00 , C03C17/30 , C03C17/3405 , C07B2200/11 , C07H21/00 , Y10S977/702 , Y10S977/902 , Y10S977/92 , Y10S977/924 , Y10S977/958
摘要： Oligonucleotides and other biomolecules are immobilized in high density on solid substrates through covalent forces using either a permanent thioether bond, or a chemoselectively reversible disulfide bond to a surface thiol. Substrates which have hydroxyl groups on their surfaces can be first silanized with a trichlorosilane containing 2-20 carbon atoms in its hydrocarbon backbone, terminating in a protected thiol group. The oligonucleotides or other biomolecules are first connected to a tether consisting of a hydrocarbon or polyether chain of 2-20 units in length which terminates in a thiol group. This thiol may be further modified with a halobenzylic-bifunctional water soluble reagent which allows the conjugate to be immobilized onto the surface thiol group by a permanent thioether bond. Alternatively, the oligonucleotide-tether-thiol group can be converted to a pyridyldisulfide functionality which attaches to the surface thiol by a chemoselectively reversible disulfide bond. The permanently bound oligonucleotides are immobilized in high density compared to other types of thiol functionalized silane surfaces and to the avidin-biotin method.
摘要翻译：寡核苷酸和其他生物分子通过共价力使用永久硫醚键或与表面硫醇的化学选择性可逆二硫键以高密度固定在固体基质上。在其表面上具有羟基的底物可以首先在其烃骨架中用含有2-20个碳原子的三氯硅烷硅烷化，终止于受保护的硫醇基团。寡核苷酸或其他生物分子首先连接到由长度为2-20单位的烃或聚醚链组成的系链，其终止于硫醇基团。该硫醇可以用卤代苄基双功能水溶性试剂进一步改性，其允许缀合物通过永久硫醚键固定在表面硫醇基上。或者，寡核苷酸 - 系链 - 硫醇基团可以转化成通过化学选择性可逆的二硫键附着于表面硫醇的吡啶基二硫键官能团。与其他类型的硫醇官能化硅烷表面和抗生物素蛋白 - 生物素方法相比，永久结合的寡核苷酸以高密度固定。

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