专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US3852287A Preparation of thionamides 失效
标题翻译：硫胺的制备
公开(公告)号：US3852287A
公开(公告)日：1974-12-03
申请号：US28717372
申请日：1972-09-07
申请人： UNIROYAL LTD
发明人： GIRGIS M
IPC分类号： C07D213/83 , C07D295/20 , C07D295/215 , C07D87/46
CPC分类号： C07D295/215 , C07D213/83 , C07D295/20
摘要： Thionamides are formed in high yield by reacting alkyl, aryl, heterocyclic nitriles, or phenylacetonitriles and hydrogen sulfide under pressure in the presence of a minimal amount of basic catalyst. The use of a minimal amount of catalyst prevents the reverse decomposition of the thionamide to nitrile and hydrogen sulfide.
摘要翻译：通过烷基，芳基，杂环腈或苯基乙腈和硫化氢在极少量的碱性催化剂的存在下在压力下反应高收率地形成硫酰胺。使用最少量的催化剂可防止硫酰胺与腈和硫化氢的反向分解。

2. 发明授权

US3839325A Synthesis of 4-sulfonamidophenyl hydrazines 失效
标题翻译：合成4-磺基亚氨基乙酰胺
公开(公告)号：US3839325A
公开(公告)日：1974-10-01
申请号：US34434073
申请日：1973-03-23
申请人： GAF CORP
发明人： HOFFSTADT W
IPC分类号： G03C7/384 , C07D87/46
CPC分类号： G03C7/384
摘要： A synthesis is disclosed utilizing p-chlorobenzene-sulfonamide compounds of the following formula:

IN WHICH R and R1 independently represent hydrogen, alkyl, hydroxyalkyl, cycloalkyl, alkaryl, aralkyl or aryl, which may or may not be further substituted, or together with the nitrogen atom form a heterocyclic ring. These compounds are dissolved in dimethyl sulfoxide (DMSO), mixed with aqueous hydrazine hydrate and heated until completely reacted to form 4 - sulfonamidophenyl hydrazines that can be readily separated from the reaction media by precipitation with water. The precipitate can be readily washed and dried to provide a pure, substituted sulfonamido hydrazine. The product is obtained in high yields frequently of about 80 - 90 percent and is sufficiently pure for subsequent use in the preparation of substituted phenyl pyrazolones which in turn are useful as magenta color formers in color photography. For example, p-chloro-benzene-sulfonyl morpholine is dissolved in DMSO and reacted under reflux conditions with aqueous hydrazine hydrate to form 4 - morpholino - sulfonamido-phenyl hydrazine having a melting point of 162*- 164*C after purification.
摘要翻译：公开了使用下式的对氯苯磺酰胺化合物的合成：

3. 发明授权

US3781284A Process for making 4-(3-amino-2-hydroxy-propoxy)-1,2,5-thiadiazoles 失效
标题翻译：制备4-（3-氨基-2-羟基 - 羟基）-1,2,5-三唑的方法
公开(公告)号：US3781284A
公开(公告)日：1973-12-25
申请号：US3781284D
申请日：1971-08-16
申请人： FROSST & CO
发明人： MULVEY D , WEINSTOCK L , TULL R
IPC分类号： C07C309/63 , C07D263/06 , C07D285/10 , C07D87/46
CPC分类号： C07D285/10 , C07C309/63 , C07D263/06
摘要： PREPARATION OF S-3-X-4-(3-SUBSTITUTED AMINO-2-HYDROXYPROPOXY)-1,2,5-THIADIAZOLE BETA ADRENERGFIC BLOCKING AGENTS USING AS STARTING MATERIAL AN OPTICALLY ACTIVE ALKAMINE IN THE SINISTER CONFIGURATION, OR A DERIVATIVE OF SAID ALKAMINE, WHICH IS REACTED WITH AN 3-X-4-CHLORO-1,2,5-THIADIAZOLE. NOVEL 3-MORPHOLINO-4-CHLORO-1,2,5-THIADIAZOLES AND NOVEL ALKAMINES AND THEIR PREPARATION ALSO ARE DESCRIBED.

4. 发明授权

US3763156A 2-heterocyclic amino-4-morpholinothieno(3,2-d)pyrimidines 失效
标题翻译： 2-杂环氨基-4-异恶唑烷酮（3,2-D）吡啶
公开(公告)号：US3763156A
公开(公告)日：1973-10-02
申请号：US10898871
申请日：1971-01-22
申请人： BOEHRINGER SOHN INGELHEIM
发明人： WOITUN E , OHNACKER G , NARR B , HORCH U , KADATZ R
IPC分类号： C07D495/04 , C07D87/46
CPC分类号： C07D495/04 , Y10S514/822
摘要： COMPOUNDS OF THE FORMULA

2-((-CH(-R1)-(CH2)N-NH-CH(-R2)-CH2-)>N-),4-(2-R4,6-R3-

MORPHOLIN-4-YL)-THIENO(3,2-D)PYRIMIDINE

WHEREIN R1, R2, R3, R4 AND R6, WHICH MAY BE IDENTICAL TO OR DIFFERENT FROM EACH OTHER, ARE EACH HYDROGEN OR METHYL, R5 IS HYDROGEN, METHYL OR PHENYL, AND N IS 1 OR 2, AND NON-TOXIC, PHARMACOLOGICALLY ACCEPTABLE ACID ADDITION SALTS THEREOF; THE COMPOUNDS AS WELL AS THEIR SALTS ARE USEFUL AS INHIBITORS OF THROMBOCYTE AGGREGATION IN BLOOD.

5. 发明授权

US3733322A N-(aminodialkyl)thienyl(3,2-b)thiophene2-carboxamides and methods of preparation 失效
标题翻译： N-（氨基甲基）三烯（3,2-B）噻吩-2-羧酸及其制备方法
公开(公告)号：US3733322A
公开(公告)日：1973-05-15
申请号：US3733322D
申请日：1971-06-16
申请人： AMERICAN CYANAMID CO
发明人： WRIGHT W
IPC分类号： C07D495/04 , C07D87/46
CPC分类号： C07D495/04
摘要： THE PREPARATION OF N-(AMINOALKYL)-THIENO(3,2-B)THIOPHENE-2-CARBOXAMIDES BY THE REACTION OF A THIENO(3,2-B) THIOPHENE-2-CARBONYL CHLORIDE WITH AN ALKYLENEDIAMINE DERIVATIVE IS DESCRIBED. OTHER METHODS OF PREPARING N-(AMINOALKYL) THIENO(3,2-B THIOPHENE - 2 - CARBOXAMIDES ARE DESCRIBED. THE LATTER PRODUCTS ARE USEFUL FOR THEIR ANTIDEPRESSANT, ANTI-INFLAMMATORY AND ANALGESTIC PROPERTIES.

6. 发明授权

US3729469A 4-(3-amino-2-hydroxypropoxy)-1,2,5-thiadiazole compounds 失效
标题翻译： 4-（3-氨基-2-羟基丙氧基）-1,2,5-噻二唑化合物
公开(公告)号：US3729469A
公开(公告)日：1973-04-24
申请号：US3729469D
申请日：1971-09-09
申请人： FROSST & CO CHARLES E
发明人： WASSON B
IPC分类号： C07D263/06 , C07D285/10 , C07D87/46
CPC分类号： C07D285/10 , C07D263/06
摘要： WHEREIN R IS THE 1,2,5 - THIADIAZOLE-4-YL GROUP, AND (4) REACTION OF A 3-SUBSTITUTED - 4 - (3-AMINO - 2 - HYDROXYPROPOXY) - 1,2,5 - THIADIAZOLE WITH A HALOALKYL OR OTHER DESIRED HALOGENATED COMPOUND TO PROVIDE THE 3-SUBSTITUTED - 4 - (3-SUBSTITUTED AMINO - 2 - HYDROXYPROPOXY)1,2,5-THIADIAZOLE.

CH(-OH)-CN, OR R-O-CH2-CO-CH

R-O-CH2-CO-CH2-NO2, R-O-CH2-CH(-OH)-CH2-NO2, R-O-CH2-

R-O-CH2-CO-CH-N2, R-O-CH2-CO-CN3, R-O-CH2-CO-CH=N-OH,

4-(3-(SUBSTITUTED AMINO) - 2 - HYDROXYPROPOXY)-1,2,5THIADIAZOLE COMPOUNDS, OPTIONALLY SUBSTITUTED IN THE 3POSITION OF THE THIADIAZOLE NUCLEUS WHICH EXHIBIT B-ADRENERGIC BLOCKING PROPERTIES AND THUS ARE USEFUL IN THE MANAGEMENT OF ANGINA PECTORIS ARE DESCRIBED. THE PRODUCTS ARE PREPARED BY ONE OF FOUR PRINCIPAL METHODS (1) REACTION OF A 4-HYDROXY - 1,2,5 - THIADIAZOLE WITH EPIHALOHYDRIN TO PROVIDE 4-(3-HALO - 2 - HYDROXYPROPOXY)-1,2,5THIADIAZOLE WHICH, UPON TREATMENT WITH ALKALI, FORMS THE EPOXIDE WHICH IS THEN REACTED WITH AN AMINE TO PROVIDE THE DESIRED PRODUCTS, (2) REACTION OF A 3-CHLORO(OR BROMO)4-(3 - SUBSTITUTED AMINO - 2 - HYDROXYPROPOXY) - 1,2,5THIADIAZOLE WITH AN AMINE OR AN N-CONTAINING HETEROCYCLE THAT REPLACES THE 3-CHLORO GROUP, (3) REDUCTIVE ALKYLATION OF AN

7. 发明授权

US3625969A 6-sulfamyl-4-hydroxy-3-carboxy-quinolines 失效
标题翻译： 6-磺酰基-4-羟基-3-羧氧基喹啉
公开(公告)号：US3625969A
公开(公告)日：1971-12-07
申请号：US3625969D
申请日：1967-10-10
申请人： CIBA GEIGY CORP
发明人： ROSSI ALBERTO
IPC分类号： A61K31/00 , C07D215/56 , C07D87/46
CPC分类号： A61K31/00 , C07D215/56
摘要： Compounds of the formula

IN WHICH R disubstituted amino group R3 lower aliphatic hydrocarbon radical, lower alkoxy group, lower alkenyloxy group, hydroxy group, halogen, trifluoromethyl N INTEGER FROM 0 TO 3 R4 lower aliphatic hydrocarbon radical for example: 3-CARBOXY-4-HYDROXY-6-(MORPHOLINOSULFAMYL)-QUINOLINE. Use: anti-inflammatory agents.

8. 发明授权

US3624075A Dibenzazepine acetic acid derivatives 失效
标题翻译：二苯甲酸乙酸衍生物
公开(公告)号：US3624075A
公开(公告)日：1971-11-30
申请号：US3624075D
申请日：1969-02-24
申请人： GEIGY CHEM CORP
发明人： FITZI KONRAD , SALLMANN ALFRED
IPC分类号： A01D76/00 , A01D80/02 , A01D87/00 , A61K8/00 , A61K8/49 , A61K31/55 , A61Q17/04 , C07D223/22 , G01M3/02 , C07D41/08 , C07D87/38 , C07D87/46
CPC分类号： C07D223/22 , A61K31/55 , G01M3/02 , Y10S514/818 , Y10S514/825 , Y10S514/87
摘要： Derivatives of 10,11-dihydro-5H-dibenz(b,f)azepine-acetic acids and salts thereof with a base are prepared by various methods; the compounds have anti-inflammatory, analgesic and antipyretic activity and absorb irritating rays of ultraviolet light; they are the active ingredients of pharmaceutical compositions and are useful for treating inflammatory diseases; an illustrative embodiment is 5-methyl-10,11-dihydro-5H-dibenz(b,f)azepine-3acetic acid.

9. 发明授权

US3622576A 2-tertiaryamino or pyridyl alkyl-4,6 diphenyl-3 pyridazones 失效
标题翻译： 2-季戊四醇或吡啶基亚苄基-4,6-二苯基-3吡啶酮
公开(公告)号：US3622576A
公开(公告)日：1971-11-23
申请号：US3622576D
申请日：1968-05-06
申请人： SEPERIC
发明人： BAETZ JACQUES
IPC分类号： C07D403/06 , C07D87/46
CPC分类号： C07D403/06
摘要： The new diphenyl-pyridazones are 4,6-di-(phenyl or substituted phenyl)-pyridaz-3-ones substituted at 2-position by a dialkylaminoalkyl group or an alkyl group substituted with a heterocycle containing a nitrogen atom. They are useful as psychotropic and analgesic drugs.

10. 发明授权

US3622574A N-(morpholino alkyl)-benzo{8 b{9 thiophene-2-carboxamides 失效
标题翻译： N-（MORPHOLINO ALKYL）-BENZO {8 B {9 THIOPHENE-2-CARBOXAMIDES
公开(公告)号：US3622574A
公开(公告)日：1971-11-23
申请号：US3622574D
申请日：1969-05-23
申请人： AMERICAN CYANAMID CO
发明人： WRIGHT WILLIAM BLYTHE JR , BRABANDER HERBERT JOSEPH
IPC分类号： C07D333/70 , C07D413/12 , C07D87/46
CPC分类号： C07D333/70
摘要： The preparation of N-(morpholinoalkyl)benzo( b)thiophene-2carboxamides from benzo(b)thiophene-2-carboxamides by reaction with an alkylenediamine, is described. The compounds are also prepared by other methods such as from benzo(b)thiophene-2carbonyl chlorides by reaction with an alkylenediamine. The products are useful as depressants and antidepressants.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式