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1. 发明授权

US3862189A Aralkyl-substituted purines and pyrimidines as antianginal bronchodilator agents 失效
标题翻译： ARALKYL取代的脯氨酸和嘌呤类作为抗原递质剂
公开(公告)号：US3862189A
公开(公告)日：1975-01-21
申请号：US38829073
申请日：1973-08-14
申请人： WARNER LAMBERT CO
发明人： SCHWENDER CHARLES F
IPC分类号： C07D239/48 , C07D473/00 , C07D57/38
CPC分类号： C07D473/00 , C07D239/48 , Y10S514/826
摘要： The present invention relates to compounds of formula I:

wherein R1 is hydroxy, methoxy, mercapto, hydrazino, substituted hydrazino, chloro, amino, alkylamino, dialkylamino, hydroxyalkylamino, aralkylamino or substituted aralkylamino and R2 is phenylalkyl having 1 to 3 carbon atoms in the alkyl moiety and at least two alkoxy, alkyl, halogen, hydroxy, nitro, amino, substituted amino, aminomethyl, acylamino, carboxy, carboxyalkyl or hydroxymethyl groups in the benzene ring or naphthylalkyl, tetrahydronaphthylalkyl, quinolylalkyl, tetrahydroquinolylalkyl or isoquinolylalkyl, each having 1 to 3 carbon atoms in the alkyl moiety and pharmaceutically acceptable acid addition salts thereof. These compounds are useful as antianginal or bronchial dilator agents.
摘要翻译：本发明涉及式I化合物：

2. 发明授权

US3567705A N-(delta-(6-purinylthio)valeryl)amino acids and peptides 失效
标题翻译： N-（DELTA-（6-嘌呤基）缬氨酸）氨基酸和肽
公开(公告)号：US3567705A
公开(公告)日：1971-03-02
申请号：US3567705D
申请日：1967-06-26
申请人： SPOFA VEREINIGTE PHARMA WERKE
发明人： CERNY ANTONIN , SEMONSKY MIROSLAV , JELINEK VACLAV
IPC分类号： C07D473/38 , A61K27/00 , C07C103/52 , C07D57/38
CPC分类号： C07D473/38
摘要： A COMPOUND OF THE GENERAL FORMULA:

PURIN-4-YL-S-(CH2)4-CO-NH-(CH2)N-CH(-Y)-CO-R

WHEREIN:

N IS AN INTEGER FROM 0 TO 5; R IS A MEMBER SELECTED FROM THE GROUP CONSISTING OF: (A) ALKOXY HAVING A STRAIGHT OR BRANCHED CHAIN OF 1 TO 8 CARBON ATOMS; (B) HYDROXY; (C) A RESIDUE OF A PEPTIDICALLY ATTACHED AMINO ACID; (D) A RESIDUE OF A DIPEPTIDE; THE SAID AMINO-ACID AND DIPEPTIDE RESIDUES BEING IN THE FORM OF THEIR FREE CARBOXY ACID; (E) A RESIDUE AS AT (C) AND (D) WHEREIN THE CARBOXY GROUP IS ESTERIFIED WITH AN ALCOHOL, HAVING A STRAIGHT OR BRANCHED CHAIN OF 1 TO 7 CARBON ATOMS; Y IS A MEMBER SELECTED FROM THE GROUP CONSISTING OF: HYDROGEN; ALKYL HAVING A STRAIGHT OR BRANCHED CARBON CHAIN OF 1 TO 5 ATOMS; PHENYL; 3-INDOLYL; -CH2OH, -CH2SH, -(CH2)SCH3 AND -(CH2)MCOR1 M IN THE LAST MEMBER BEING AN INTEGER FROM 1 TO 3 AND R1 BEING ALKOXY HAVING A STRAIGHT OR BRANCHED CHAIN OF 1 TO 8 CARBON ATOMS. AN EXAMPLE IS N-($-(6-PURINYLTHIO)VALERYL)GLYCINE ETHYL ESTER.

THE COMPOUNDS HAVE SHOWN AN ANTINEOPLASTIC EFFECT IN CERTAIN SPECIFIC TRANSPLANTABLE MICE TUMORS. THEY ARE DISTINGUISHED BY THEIR HIGH AFFINITY TO A PARTICULAR ORGAN OR TO THE TISSUE OF A PARTICULAR ORGAN AND THEIR ACUTE AND CHRONICAL TOXICITY IS LOW.

3. 发明授权

US3517006A Process for the purification of 6-halogenopurine 失效
标题翻译： 6-卤代嘌呤的纯化方法
公开(公告)号：US3517006A
公开(公告)日：1970-06-23
申请号：US3517006D
申请日：1966-01-19
申请人： KYOWA HAKKO KOGYO KK
发明人： FUJIMOTO YASUO , NARUSE MASAO
IPC分类号： A61K31/52 , C07D473/00 , C07D473/40 , C07D57/38
CPC分类号： A61K31/52 , C07D473/00 , C07D473/40

4. 发明授权

US3857842A Process for preparing purine compounds by reaction of a carbonitrile with formic acid 失效
标题翻译：通过与形成酸反应的碳酸酯制备磷化合物的方法
公开(公告)号：US3857842A
公开(公告)日：1974-12-31
申请号：US20576471
申请日：1971-12-07
申请人： SAGAMI CHEM RES
发明人： ASAI N
IPC分类号： C07D473/00 , C07D473/18 , C07D473/26 , C07D473/34 , C07D57/38
CPC分类号： C07D473/34 , C07D473/00 , C07D473/18 , C07D473/26
摘要： An improved process for preparing purine compounds of the formula

WHEREIN X is selected from the group consisting of an amino and a hydroxy group, and Y is selected from the group consisting of an amino and a hydroxy group and hydrogen, which are useful as precursors for the synthesis of organic compounds, as well as a process for preparing a carboxyamide of the formula

USEFUL AS AN INTERMEDIATE FOR THE SYNTHESIS OF THE ABOVE PURINE COMPOUNDS ARE
摘要翻译：制备式WHEREIN X的嘌呤化合物的改进方法是选自氨基和羟基，Y选自氨基和羟基和氢，其可用作有机化合物的合成，以及制备下式的羧酰胺的方法有用的合成上述化合物的中间体被公开。这些方法从具有下式的4（5） - 氨基咪唑-5（4） - 腈开始

5. 发明授权

US3825541A (+-)-9-(beta-(3-alpha-amino-2alpha-hydroxy)cyclopentyl)-6-substituted-purines and derivatives thereof 失效
标题翻译：（±）-9-（BETA-（3-ALPHA-AMINO-2ALPHA-羟基）环戊基）-6-取代的脯氨酸及其衍生物
公开(公告)号：US3825541A
公开(公告)日：1974-07-23
申请号：US22089072
申请日：1972-01-26
申请人： UNIV MINNESOTA
发明人： VINCE R
IPC分类号： C07D317/72 , C07D473/00 , C07D57/38
CPC分类号： C07D317/72 , C07D473/00
摘要： A NEW CLASS OF CHEMICAL COMPOUNDS, ($)-9-(B(3AAMINO-2A-HYDROXY)CYCLOPENTYL) - 6 - SUBSTITUTED - PURINES HAVING THE GENERAL FORMULA:

6-R,9-(2-(HO-),3-X-CYCLOPENTYL)-9H-PURINE

WHEREIN R IS A SUBSTITUENT SELECTED FROM THE GROUP CONSISTING OF HYDROXYL, MERCAPTO, METHYL MERCAPTO, HALOGEN (CHLORINE, BROMINE, FLUORINE AND IODINE) AND SUBSTITUTED AMONO:

R''-N(-R")-

WHEREIN R'' AND R'''' MAY BE THE SAME OR DIFFERENT SUBSTITUENTS AND ARE SELECTED FROM THE GROUP CONSISTING OF HYDROGEN, METHYL, ETHYL, PROPYL AND PHENYL; X IS AN AMINO RADICALOR AMINO ACID; AND ACID SALT DERIVATIVES OF THE SAME, SUCH AS ACETIC, HYDROCHLORIC, SULFURIC, ETC.; AND THE METHOD OF PREPARATION THEREOF. THE INTERMEDIATE ($)-9(B-(3A-AMINO - 2A - HYDROXY)CYCLOPENTYL) - 6 - DIMETHYLAMINOPURINE, OR ANY OF ITS CORRESPONDING 6-SUBSTITUTED DERIVATIVES, LEADS TO THE PREPARATION OF TWO DIASTERIOISOMERS WHEN CONDENSED WITH THE APPROPRIATELY BLOCKED LAMINO ACID. THE SEPARATION OF THESE DIASTERIOISOMERS RESULTS IN THE ISOLATION OF ANTIMICROBIAL AND ANTITUMOR AGENTS.

6. 发明授权

US3471472A N6-substituted adenosine derivatives 失效
标题翻译： N6-取代的腺苷衍生物
公开(公告)号：US3471472A
公开(公告)日：1969-10-07
申请号：US3471472D
申请日：1967-08-08
申请人： BOEHRINGER & SOEHNE GMBH
发明人： THIEL MAX , WINTER WERNER , STACH KURT , SCHAUMANN WOLFGANG , DIETMANN KARL
IPC分类号： A61K31/70 , C07H19/16 , A61K27/00 , C07D57/38
CPC分类号： C07H19/16 , A61K31/70

7. 发明授权

US3813394A Purine derivatives having hypocholesterolemic activity 失效
标题翻译：具有高脂肪活性的嘌呤衍生物
公开(公告)号：US3813394A
公开(公告)日：1974-05-28
申请号：US2236170
申请日：1970-03-24
申请人： FUJISAWA PHARMACEUTICAL CO
发明人： SAITO Y , HASHIMOTO M , TENSHO A , KAMIYA T , SEKI H
IPC分类号： C07D473/00 , C07D57/38
CPC分类号： C07D473/00
摘要： PURINE DERIVATIIVES OF THE FORMULA:

1-(R5-CO-R4-),2-R3,4,5-(-C(-R1)=A-C(-R2)=N-)IMIDAZOLE

WHEREIN A IS N OR N$O, R1 IS HYDROGEN, HALOGEN, HYDORYXL, MERCAPTO, LOWER ALKOXY, AR(LOWER)ALKOXY, LOWER AKYTHIO, AMINO, LLLOWER ALKYLAMINO, DI(LOWER)ALKYLAMINO, AR(LOWER)ALKYLAMINO, ACYLAMINO, HYDROXYAMINO, LOWER AKOXYAMINO, AR(LOWER) ALKOXYAMINO OR ARYLOXYAMINO, R2 AND R3 ARE EACH HYDROGEN, HALOGEN, HYDOXYL, MERCAPTO, AMINO, LOWER ALKYL, ARYL, LOWER ALKOXY, AR(LOWER)ALKOXY OR LOWER ALKYLTHIO, R4 IS LOWER ALKYLENE SUBSTITUTED WITH ONE OR MORE HYDROXYIS (BUT NO HYDROXYL GROUP BEING PRESENT AT THE CARBON ATOM ADJACENT TO THE RING NITROGEN ATOM) WHICH MAY BE PROTECTED WITH ACYL, LOWER OR HIGHER ALKOXY, A AR(LOWER)AKYL OR, WHEN A PAIR OF HYDROXYLS EXIST ON THE ALKYLENE GROUP, WHICH LOWER ALKYLIDENE OR AR(LOWER)ALKYLIDENE AND R5 IS HYDROXYL, LOWER OR HIGHER ALKOXY, AMINO, LOWER ALKYLAMINO OR DI(LOWER)ALKYLAMINO, AND THEIR SALTS, WHICH EXIBIT MAKED HYPOCHOLESTEROLEMIC ACTIVITY WHICH EXTREMELY LOW TOXICITY.

8. 发明授权

US3457263A Purine compounds 失效
标题翻译：嘌呤化合物
公开(公告)号：US3457263A
公开(公告)日：1969-07-22
申请号：US3457263D
申请日：1967-12-29
申请人： EN NOM COLLECTIF SCIENCE UNION
发明人： REGNIER GILBERT , CANEVARI ROGER , DOUAREC JEAN-CLAUDE LE , LAUBIE MICHEL
IPC分类号： C07D473/32 , A61K17/00 , C07D57/38
CPC分类号： C07D473/32

9. 发明授权

US3437661A Process of producing purine derivatives 失效
标题翻译：生产嘌呤衍生物的方法
公开(公告)号：US3437661A
公开(公告)日：1969-04-08
申请号：US42593765
申请日：1965-01-15
申请人： KYOWA HAKKO KOGYO KK
发明人： FUJIMOTO YASUO , TERANISHI MASAYUKI
IPC分类号： C07D473/00 , C07D473/04 , C07D473/18 , C07D473/22 , C07D473/30 , C07D57/38 , C07C113/00
CPC分类号： C07D473/00 , C07D473/04 , C07D473/18 , C07D473/22 , C07D473/30

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