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1. 发明授权

US5792860A Substituted phthalocyanides with sulfonyl substituted with amino or carboxyl groups 失效
标题翻译：具有被氨基或羧基取代的磺酰基的取代的酞菁
公开(公告)号：US5792860A
公开(公告)日：1998-08-11
申请号：US700405
申请日：1996-09-25
申请人： Neil Bruce McKeown , Kevin Edward Treacher , Guy James Clarkson
发明人： Neil Bruce McKeown , Kevin Edward Treacher , Guy James Clarkson
IPC分类号： B41M5/26 , C07D487/22 , C09B47/067 , C09B47/08 , C09B47/18 , C09B67/22 , C09K19/34 , C09K19/38 , C09K19/40 , C09K19/60 , G02F1/13 , G11B7/248 , C07D478/22 , C09B47/00
CPC分类号： C07D487/22 , C09B47/0675 , C09B67/0035 , C09K19/3488 , C09K19/3861 , C09K19/40 , C09K19/406 , G11B7/248 , C09K2019/0429
摘要： Phthalocyanines of formula (I) are described, wherein M is a metal atom, metal compound or silicon or a compound of silicon or is 2H; R.sub.1 -R.sub.25 may be the same or different, provided that at least one of R.sub.1 -R.sub.25 has the Formula (II), wherein Y groups are independently H, C.sub.1-3 alkyl, halogen or CN; k=0 or 1; l=1-10; m=0 or 1; n=1-10; p=1-10; q=1-20; r=0 or 1; X may be H, Me, etc . . . Compounds of the above formulae are useful in a broad range of applications, including electrooptical devices, and for use in optical recording media. ##STR1##
摘要翻译： PCT No.PCT / GB95 / 00647 Sec。 371日期1996年9月25日 102（e）1996年9月25日PCT PCT 1995年3月23日PCT公布。第WO95 / 26381号公报日期：1995年10月5日描述了式（I）的酞菁，其中M是金属原子，金属化合物或硅或硅化合物或2H; R1-R25可以相同或不同，条件是R 1 -R 25中的至少一个具有式（II），其中Y基团独立地为H，C 1-3烷基，卤素或CN; k = 0或1; l = 1-10; m = 0或1; n = 1-10; p = 1-10; q = 1-20; r = 0或1; X可以是H，Me等。。。上述式的化合物可用于广泛的应用，包括电光装置，并用于光学记录介质。

2. 发明授权

US06054449A Compounds and method for PDT of intimal hyperplasia and other diseases 失效
标题翻译： PDT内膜增生等疾病的化合物和方法
公开(公告)号：US06054449A
公开(公告)日：2000-04-25
申请号：US801829
申请日：1997-02-14
申请人： Byron Robinson , Alan R. Morgan , Hugh L. Narciso, Jr.
发明人： Byron Robinson , Alan R. Morgan , Hugh L. Narciso, Jr.
IPC分类号： A61K31/366 , A61K31/407 , A61K31/409 , A61K31/4375 , A61K41/00 , A61P9/10 , A61P17/06 , A61P27/06 , A61P35/00 , C07D487/22 , C07D493/04 , C07D519/00 , A61K31/41 , C09B47/00 , C07D478/22
CPC分类号： C07D493/04 , A61K41/0066 , A61K41/0071
摘要： A broad class of photosensitive compounds having enhanced in vivo target tissue selectivity and versatility in photodynamic therapy. Many furocoumarin compounds, such as psoralens, exhibit cytostatic activity when photoactivated but exhibit little in vivo specificity for selectively accumulating in any particular target tissue such as atheromatous plaques. Reactive Oxygen Producing Photosensitizers ("ROPPs") are photoactivatable compounds having an affinity for hyperproliferating cells (such as atheromatous plaque cells), which when photoactivated, produce cytotoxic reaction products. The photoactivity of a ROPP, such as a porphyrin, may be reduced by metalating the porphyrin while the selective affinity of the metalized ROPP for hyperproliferating tissue remains substantially unchanged. By linking a furocoumarin compound to a ROPP to form a F-ROPP, the cytostatic properties of the furocoumarin portion of the F-ROPP can be exploited while the selective affinity of the ROPP portion of the compound for hyperproliferating cells such as atheromatous plaque provides enhanced tissue selectivity without cytotoxicity. In vivo, certain F-ROPPs may be forced to selectively accumulate in a target tissue by illuminating only the target tissue with light having a wavelength operable for photoactivating the F portion of the F-ROPP thereby causing the F-ROPP to either form a monoadduct with or crosslink the cellular DNA in the target tissue. Light of a second wavelength can then be delivered to the target tissue to photoactivate the ROPP portion causing further interference with cellular activity.
摘要翻译：广泛的光敏化合物具有增强的体内靶组织选择性和光动力疗法的多功能性。许多呋喃香豆素化合物，如补骨脂素，当光活化时表现出细胞抑制活性，但是在任何特定靶组织如动脉粥样硬化斑块中选择性积累，但体内特异性较小。活性氧生产光敏剂（“ROPP”）是具有对过度增殖细胞（如动脉粥样硬化斑块细胞）的亲和力的光活化化合物，其在光活化时产生细胞毒性反应产物。可以通过金属化卟啉来减少ROPP如卟啉的光活性，同时金属化ROPP对过度增殖组织的选择性亲和性基本上保持不变。通过将呋喃香豆素化合物与ROPP连接以形成F-ROPP，可以利用F-ROPP的呋喃香豆素部分的细胞生长抑制性能，而化合物的ROPP部分对过度增殖细胞如动脉粥样硬化斑块的选择性亲和力提高组织选择性没有细胞毒性。在体内，某些F-ROPP可能被迫通过用具有可激活F-ROPP的F部分的光波长的光照射目标组织而选择性地累积在靶组织中，从而使F-ROPP形成单加合物与目标组织中的细胞DNA交联或交联。然后可以将第二波长的光递送到目标组织以激活ROPP部分，导致进一步干扰细胞活性。

3. 发明授权

US5675001A Heteroatom-functionalized porphyrazines and multimetallic complexes and polymers derived therefrom 失效
标题翻译：杂原子官能化的四氮杂卟啉和多金属络合物及其衍生的聚合物
公开(公告)号：US5675001A
公开(公告)日：1997-10-07
申请号：US403302
申请日：1995-03-14
申请人： Brian M. Hoffman , Anthony G. M. Barrett
发明人： Brian M. Hoffman , Anthony G. M. Barrett
IPC分类号： C07D487/22 , C07D491/22 , C07D495/22 , C07D497/22 , C07D498/22 , C07F1/00 , C07F1/08 , C07F3/00 , C07F5/00 , C07F5/06 , C07F7/22 , C07F7/24 , C07F7/30 , C07F9/6561 , C07F9/6564 , C07F15/00 , C07F15/04 , C07D478/22 , C09B47/00 , C09B62/00
CPC分类号： C07D487/22 , C07D491/22 , C07D497/22 , C07D498/22 , C07F9/6561
摘要： Porphyrazine compounds having moieties substituted at the eight peripheral .beta.-pyrrole positions are disclosed. The porphyrazine compounds have the general structural formula: ##STR1## wherein M is H.sub.2 or a metal capable of complexing with the pyrrole nitrogen atoms, and A, B, C and D are independently selected from the group consisting of a thio moiety, an amino moiety, an oxo moiety, a phospho moiety, a seleno moiety, a telluro moiety and a non-coordinating moiety, like a hydrocarbon moiety, with the proviso that not all of A, B, C and D are a thio moiety and that not all of A, B, C, and D are a hydrocarbon moiety. The porphyrazine compounds, depending on the identity of A, B, C and D, are capable of complexing one to four metal ions to the periphery of the porphyrazine to form a multimetallic porphyrazine. Multimetallic porphyrazine compounds can be linked by the peripherally-complexed metal ions to form a linear, i.e., ribbon, polymer or a two-dimension, i.e., sheet polymer. The porphyrazine compounds, and the multimetallic complexes and polymers derived therefrom, are useful in, or as, magnet materials, molecular metal conductors, pharmaceuticals, imaging agents, and dyes.
摘要翻译：公开了在八个外围β-吡咯位置取代部分的四氮杂卟啉化合物。四氮杂卟啉化合物具有以下通式结构式：其中M为H 2或能与吡咯氮原子络合的金属，A，B，C和D独立地选自硫基部分，氨基部分，氧代部分，磷酸部分，硒部分，尾流部分和非配位部分，如烃部分，条件是不是全部A，B，C和D都是硫基部分，而不是全部所有A，B，C和D都是烃部分。取决于A，B，C和D的同一性，四氮杂卟啉化合物能够将1-4个金属离子络合到四氮杂卟啉的周围以形成多金属四氮杂卟啉。多金属四氮杂卟啉化合物可以通过周边配合的金属离子连接以形成线性，即带状聚合物或二维即片状聚合物。四氮杂卟啉化合物及其衍生的多金属络合物和聚合物可用于或作为磁体材料，分子金属导体，药物，成像剂和染料。

4. 发明授权

US5837865A Phosphorescent dendritic macromolecular compounds for imaging tissue oxygen 失效
标题翻译：用于成像组织氧的磷光树枝状大分子化合物
公开(公告)号：US5837865A
公开(公告)日：1998-11-17
申请号：US767158
申请日：1996-12-16
申请人： Sergei A. Vinogradov , David F. Wilson
发明人： Sergei A. Vinogradov , David F. Wilson
IPC分类号： A61B10/00 , A61B5/00 , A61K41/00 , C07D487/22 , C07H15/26 , G01N21/64 , G01N31/22 , C07D478/22
CPC分类号： C07D487/22 , A61B5/0059 , A61B5/14556 , A61B5/1459 , A61B5/6833 , A61B5/6848 , A61K41/0071 , C07H15/26 , G01N21/64 , G01N21/6408 , G01N21/6458 , G01N31/225 , A61B2562/146 , G01N21/6456
摘要： This invention relates to phosphorescent probes effective for oxygen measurement in human or animal tissue comprising a porphyrin chromophore capable of releasing absorbed energy as phosphorescent light and a dendrimer, wherein said porphyrin chromophore comprises the core of the dendrimer.
摘要翻译：本发明涉及在人或动物组织中对氧测量有效的磷光探针，其包括能够释放作为磷光光的吸收能量的卟啉发色团和其中所述卟啉发色团包含树状聚合物的核心。

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