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1. 发明授权

US4224341A 5-Substituted indan-2 carboxylic acid and functional derivatives 失效
标题翻译： 5-取代的茚满-2-羧酸和官能衍生物
公开(公告)号：US4224341A
公开(公告)日：1980-09-23
申请号：US860466
申请日：1977-12-14
申请人： Michel Bayssat , Francis Sautel , Jean-Claude Depin , Annie Betbeder Matibet
发明人： Michel Bayssat , Francis Sautel , Jean-Claude Depin , Annie Betbeder Matibet
IPC分类号： C07C49/784 , C07D213/50 , C07D213/80 , C07D307/46 , C07D307/54 , C07D333/22 , C07D333/24 , C07D333/28 , C07C65/20 , A61K31/19 , A61K31/215 , C07C69/95
CPC分类号： C07D213/80 , C07C205/55 , C07C45/004 , C07C45/46 , C07C45/63 , C07D213/50 , C07D307/46 , C07D307/54 , C07D333/22 , C07D333/24 , C07D333/28
摘要： 5-Substituted indan-2-carboxylic acids and functional derivatives thereof having inflammation-reducing properties have the general formula ##STR1## in which R is a phenyl, phenyl-lower alkenyl, phenyl-lower alkyl, phenyl substituted by at least one of the halogens, lower alkyl, lower alkoxy, acetamido, amino, lower dialkylamino, nitro, phenyl, lower alkylsulfonyl, lower dialkylaminosulfonyl and sulfamido, cyclohexyl, furyl, lower alkylfuryl, thienyl, halothienyl, lower alkylthienyl, or pyridyl group and R' is a hydroxyl, lower alkoxy, lower dialkylaminoalkoxy, cinnamoylamido lower alkoxy, 2-hydroxyethylamino, amino or lower dialkylaminoalkyl amino group. Besides the esters and amides, the functional derivatives of the acids include the pharmacologically acceptable salts of the above compounds. The compounds are also of low toxicity, have analgesic activity and exert an antipyretic effect.
摘要翻译： 5-取代的茚满-2-羧酸及其具有炎症降低性质的功能衍生物具有通式“IMAGE”，其中R是苯基，苯基 - 低级烯基，苯基 - 低级烷基，被至少一个卤素，低级烷基，低级烷氧基，乙酰氨基，氨基，低级二烷基氨基，硝基，苯基，低级烷基磺酰基，低级二烷基氨基磺酰基和磺酰氨基，环己基，呋喃基，低级烷基呋喃基，噻吩基，卤代噻吩基，低级烷基噻吩基或吡啶基，R' 低级烷氧基，低级二烷基氨基烷氧基，肉桂酰氨基低级烷氧基，2-羟基乙基氨基，氨基或低级二烷基氨基烷基氨基。除了酯和酰胺之外，酸的官能衍生物包括上述化合物的药理学上可接受的盐。该化合物也具有低毒性，具有镇痛作用，并具有解热作用。

2. 发明授权

US4173708A Purification of 4,4'-benzophenonedicarboxylic acid 失效
标题翻译： 4,4'-二苯甲酮二羧酸的纯化
公开(公告)号：US4173708A
公开(公告)日：1979-11-06
申请号：US846758
申请日：1977-10-31
申请人： Louis R. Palmer , James T. Karo
发明人： Louis R. Palmer , James T. Karo
IPC分类号： C07C51/487 , C07C65/20
CPC分类号： C07C51/487
摘要： A process is described for purifying 4,4'-benzophenonedicarboxylic acid, useful in preparing thermoplastic polyesters yielding molded articles having high impact strength, wherein the acid contains aromatic monocarboxylic acid genetic impurity, which comprises the steps of(a) mixing the impure 4,4-benzophenonedicarboxylic acid with aqueous ammonium hydroxide solution, containing about 28 weight percent or less of ammonia in a weight ratio of solution to acid of about 5:1 to 100:1, thereby forming a solution of the diammonium salt of the aromatic dicarboxylic acid;(b) mixing the resultant solution with an inert water-soluble organic liquid which is a non-solvent for the diammonium salt, in a weight ratio of organic liquid to solution not greater than about 20:1, thereby precipitating the diammonium salt of the acid;(c) separating the diammonium salt from the solution; and(d) recovering the aromatic dicarboxylic acid from the diammonium salt.
摘要翻译：一种方法是在制备热塑性聚酯得到具有高冲击强度的模塑制品，其中所述酸含有芳香族一元羧酸杂质遗传，其包括以下步骤：用于纯化4,4'-二苯甲酮二羧酸所描述的，有用的（a）混合不纯4， 4-二苯甲酮二羧酸与氢氧化铵水溶液混合，含有约28重量％或更少的氨，其酸与酸的重量比为约5:1至100:1，从而形成芳族二羧酸的二铵盐 ; （b）用惰性的水溶性有机液体，它是一种非溶剂的二铵盐将所得溶液混合，在有机液体的的重量比为溶液不大于约20：1，由此沉淀的二铵盐酸; （c）从溶液中分离二铵盐; 和（d）从二铵盐中回收芳族二羧酸。

3. 发明授权

US4087458A Process for preparation of 2-(amylbenzoyl)benzoic acid 失效
标题翻译： 2-（戊基苯甲酰基）苯甲酸的制备方法
公开(公告)号：US4087458A
公开(公告)日：1978-05-02
申请号：US794620
申请日：1977-05-06
申请人： Fumitoshi Emori , Yasuhisa Iwasaki , Takao Yoshimura
发明人： Fumitoshi Emori , Yasuhisa Iwasaki , Takao Yoshimura
IPC分类号： C07C51/373 , C07C65/20
CPC分类号： C07C51/373
摘要： This invention relates to an improvement in the process for preparation of 2-(amylbenzoyl)benzoic acid containing a high percentage of 2-(t-amylbenzoyl)benzoic acid. More particularly it relates to a process for preparation of 2-(amylbenozyl)benzoic acid wherein said 2-(amylbenzoyl)benzoic acid is prepared by reacting t-amylbenzene with phthalic anhydride in the presence of Lewis acid, characterized by that 2-(amylbenzoyl)benzoic acid containing a high percentage of 2-(t-amylbenzoyl)benzoic acid is produced by suppressing the undesirable isomerization reaction of the amyl radical by applying one of the means selected from the group consisting of the means of introducing an inert gas into the reaction system and the means of reducing the pressure of the reaction system. 2-(Amylbenzoyl)benzoic acid is a compound useful as the starting material of preparation of 2-amylanthraquinone which is an effective organic catalyst in the manufacture of hydrogen peroxide.
摘要翻译：本发明涉及含有高百分比的2-（叔戊基苯甲酰基）苯甲酸的2-（戊基苯甲酰基）苯甲酸的制备方法的改进。更具体地说，涉及制备2-（戊基苯甲酰基）苯甲酸的方法，其中所述2-（戊基苯甲酰基）苯甲酸通过在路易斯酸存在下使叔戊基苯与邻苯二甲酸酐反应来制备，其特征在于2-（戊基苯甲酰基））苯甲酸，其含有高百分比的2-（叔戊基苯甲酰基）苯甲酸是通过将选自由惰性气体引入惰性气体的方法中选择的一种方法抑制到所需的戊基自由基的不期望的异构化反应反应体系和降低反应体系压力的手段。 2-（戊基苯甲酰基）苯甲酸是可用作制备过氧化氢的有效有机催化剂的2-戊基蒽醌的起始原料的化合物。

4. 发明授权

US3888905A Prostaglandin intermediates and optically active isomers thereof 失效
标题翻译： PROSTAGLANDIN中间体和光学活性异构体
公开(公告)号：US3888905A
公开(公告)日：1975-06-10
申请号：US18750871
申请日：1971-10-07
申请人： SEARLE & CO
发明人： MIYANO MASATERU
IPC分类号： C07C45/28 , C07C59/90 , C07C405/00 , C07D295/185 , C07C65/02 , C07C65/20 , C07C69/76
CPC分类号： C07D295/185 , C07C45/28 , C07C59/90 , C07C405/00 , C07C405/0041 , C07C49/258
摘要： The condensation of dimethyl 3-oxoundecane-1,11-dioate with styrylglyoxal affords 14-phenyl-9,12-dioxo-11-hydroxytetradec-13enoic acid, which is cyclized to afford 3-hydroxy-5-oxo-2styrylcyclopent-1-eneheptanoic acid. Hydroxylation of the styryl double bond affords the corresponding 2-( Alpha , Beta dihydroxyphenethyl) derivative. Resolution of the racemic 2styryl-3-hydroxy-compounds with either (-) or (+)-0methylmandelyl chloride yields the optically active isomers which are separated chroma topographically. The instant compounds are useful as anti-microbial, anti-fungal and hypotensive agents, as prostaglandin (PGE2) antagonists and also as intermediates to prostanoic acid derivatives and their optically active isomers which exhibit anti-microbial, pepsin-inhibitory, hypotensive and smooth muscle-contracting properties.

5. 发明授权

US3828093A Benzoylphenylacetic acids and related compounds 失效
标题翻译：苯甲酰基苯甲酸及相关化合物
公开(公告)号：US3828093A
公开(公告)日：1974-08-06
申请号：US74743568
申请日：1968-07-25
申请人： ALLEN & HANBURYS LTD
发明人： BAYS D , FOSTER R
IPC分类号： C07C69/738 , A61K31/185 , A61K31/19 , A61K31/195 , A61K31/215 , A61P25/04 , A61P29/00 , C07C45/46 , C07C45/63 , C07C45/75 , C07C49/782 , C07C49/784 , C07C49/813 , C07C51/00 , C07C59/76 , C07C59/84 , C07C59/86 , C07C59/88 , C07C59/90 , C07C65/34 , C07C67/00 , C07C69/72 , C07C201/00 , C07C205/56 , C07C229/42 , C07C233/12 , C07D295/16 , C07D295/185 , C07D295/194 , C07C65/20 , C07C69/76
CPC分类号： C07D295/185 , C07C45/46 , C07C45/63 , C07C59/84 , C07C59/86 , C07C59/88 , C07C59/90 , C07C65/34 , C07C255/00 , C07D295/194 , C07C49/784 , C07C49/813
摘要： NOVEL PHENYLACETIC DERIVATIVES ARE PROVIDED OF THE GENERAL FORMULA

(R4-CO-C(-R1)(-R2)-),(R3-CO-),X,Y,Z-BENZENE

IN WHICH R1, R2, R3 AND R4 ARE AS DEFINED HEREIN, SPECIFICALLY WHEREIN R1 AND R2 WHICH MAY BE THE SAME OR DIFFERENT, REPRESENT A HYDROGEN ATOM OR AN ALKYL RADICAL CONTAINING 1-6 CARBON ATOMS, WHICH MAY BE SUBSTITUTED BY AN ARYL GROUP, R3 REPRESENTS A CYCLOALKYL RADICAL ONTAINING FROM 3-9 CARBON ATOMS OR AN ARYL RADICAL WHICH MAY BE SUBSTITUTED BY 1 OR MORE HALOGEN ATOMS OR AN ALKYL, NITRO, HYDROXY, ALKOXY, PHENYL OR TRIFLUOROMETHYL GROUP, OR BY A GROUP -NR3R6 IN WHICH R5 AND R6 WHICH MAY BE THE SAME OR DIFFERENT, REPRESENT A HYDROGEN ATOM OR AN ALKYL RADICAL CONTAINING FROM 1-6 CARBON ATOMS, R4 IS A HYDROXY, ARYALOXY OR LOWER ALKOXY GROUP CONTAINING 1-6 CARBON ATOMS, WHICH MAY BE SUBSTITUTED BY AN ARYL RADICAL OR AN AMINE GROUP -NR4R6 OR R4 MAY BE -NR3R6 IN WHICH R7 AND R8, WHICH MAY BE THE SAME OR DIFFERENT, REPRESENT A HYDROGEN ATOM OR AN HYDROXY GROUP AND AN ALKYL GROUP CONTAINING 1-6 CARBON ATOMS OR AN ARYLALKYL OR ARYL GROUP, OR R7 AND R8 TOGETHER MAY PROVISOS, THAT (A) WHEN R1, R2 X,Y AND Z ARE HYDROGEN, FORM A HETEROCYCLIC RING WHICH MAY CONTAIN ADDITIONAL REPRESENT A HYDROGEN OR HALOGEN ATOM, A LAYER ALKYL, HYDROXY, LOWER ALKOXY OR AMINO GROUP WITH THE FOLLOWING PROVISOS, THAT (A) WHEN R1 R2, X, Y AND Z ARE HYDROGEN, R3 IS PHENYL AND R4 IS HYDROXYL THEN THE GROUP R3CO MUST BE META ORENTED TO THE GROUP-CR1R2CIR4; (B) WHEN R3CO IS PARA ORENTED TO THE GROUP CR1R2COR4, R4, R2, X, Y AND Z ARE HYDROGEN AND R3 IS PHENYL, THEN R4 MAY NOT BE A HYDROXY, METHOXY OR PRIMARY AMINO GROUP AND (C) WHEN Z IS A METHOXY GROUP IN THE 2-POSITION TO THE GROUP -CR1R2COR4 AND X, Y, R1 AND R2 ARE HYDROGEN AND R2 IS PHENYL THEN THE GROUP R3COMAY NOT BE IN THE 5-POSITION, AND PHARMACEUTICALLY ACCEPTABLE SALTS THEREFO. THESE HAVE ANTI-INFLAMMATORY OR ANALGETIC ACTIVITY. THE INVENTION ALSO PROVIDES A PROCESS FOR THE PRODUCTION OF THESE COMPOUNDS FROM A KETONE OF THE STRUCTURE: (R3-CO-),R9,X,Y,Z-BENZENE IT ALSO PROVIDES PHARMACEUTICAL COMPOSITIONS INCLUDING PHENYLACETIC DERIVATIVES,

6. 发明授权

US3819694A 6-(2-(3-hydroxyalkyl)-3,5-disubstituted-phenyl)hexanoic acids and salts thereof 失效
标题翻译： 6-（2-（3-羟基乙基）-3,5-取代苯基）十六烷酸及其盐
公开(公告)号：US3819694A
公开(公告)日：1974-06-25
申请号：US20116171
申请日：1971-11-22
申请人： SANDOZ AG
发明人： GALANTAY E
IPC分类号： C07C45/30 , C07C45/72 , C07C47/575 , C07C49/255 , C07C65/20 , C07C65/02
CPC分类号： C07C49/255 , C07C45/30 , C07C45/72 , C07C47/575 , Y10S514/826 , Y10S514/958 , Y10S514/96
摘要： THE INVENTION DISCLOSES COMPOUNDS OF THE FORMULA:

1-(Q-(CH2)5-),2-(HO-C(-R0)(-R'')-CH2-CH2-),3,5-DI(R-O-)-

BENZENE

IN WHICH Q IS -CH2OH OR -COOR''''; R* IS STRAIGHT CHAIN LOWER ALKYL (C4-C6; R'' IS HYDROGEN OR ALKYL; AND R'''' IS HYDROGEN OR A CATION FORMING PHARMACEUTICALLY ACCEPTABLE SALT, E.G., 6,- (2 - (3 - HYDROXYOCTYL) - 3,5 - DIMETHOXYPHENYL)HEXANOIC ACID AND ITS SODIUM SALT, SAID COMPOUNDS BEING USEFUL AS PHARMACEUTICAL AGENTS, E.G., AS BRONCHODILATORS. THE ABOVE FINAL PRODUCTS WHERE R'' IS HYDROGEN MAY BE PREPARED BY CATALYTIC HYDROGENATION OF A CORRESPONDING 1-(2'',4'' - DISUBUTITUTED6''W-SUBSTITUTED-HEXYL - 1'' - PHENYL!-1-OLEFIN-3-ONE, BY REDUCTION OF NOVEL INTERMEDIATES WHICH ARE 6-(3,5 - DISUBSTITUTED - 2 - (2-ALKANOYLETHYL)PHENYL)HEXANOIC ACID AND HEXANOLS WHICH MAY BE OBTAINED FROM THE ABOVE-MENTIONED CATALYTIC HYDROGENATION AND, WHERE R'' IS ALKYL, BY REACTION OF THE LAST NAMED HEXANOIC ACID AND HEXANOLS WITH A GRIGNARD REAGENT, SAID NOVEL INTERMEDIATES BEING SIMILARLY USEFUL AS PHARMACEUTICAL AGENTS.

7. 发明授权

US3732267A 14-phenyl-9,12-dioxo-11-hydroxytetradec-13-enoic acid and salt thereof 失效
标题翻译： 14-PHENYL-9,12-DIOXO-11-HYDROXYTETRADEC-13-全酸及其盐
公开(公告)号：US3732267A
公开(公告)日：1973-05-08
申请号：US3732267D
申请日：1971-10-07
申请人： SEARLE & CO
发明人： MIYANO M
IPC分类号： C07C59/90 , C07C405/00 , C07C65/20 , C08H17/36
CPC分类号： C07C59/90 , C07C405/00
摘要： THE CONDENSATION OF DIMETHYL 3-OXOUNDECANE-1,11DIOATE WITH STYRYGLYOXAL AFFORDS 14-PHENYL-9,12-DIOXO11-HYDROXYTETRADEC-13-ENOIC ACID. THE INSTANT COMPOUNDS ARE USEFUL AS INTERMEDIATES TO PROSTANOIC ACID DERIVATIVES WHICH EXHIBIT ANTI-MICROBIAL, PEPSIN-INHIBITORY, HYPOTENSIVE AND SMOOTH MUSCLE-CONTRACTING PROPERTIES.

8. 发明授权

US3641127A (3-benzoylphenyl) alkanoic acids 失效
标题翻译：（3-BENZOYLPHENYL）ALKANOIC ACIDS
公开(公告)号：US3641127A
公开(公告)日：1972-02-08
申请号：US70037568
申请日：1968-01-25
申请人： RHONE POULENC SA
发明人： FARGE DANIEL , MESSER MAYER NAOUM , MOUTONNIER CLAUDE
IPC分类号： C07C57/32 , A61K31/19 , C07C45/63 , C07C51/08 , C07C57/30 , C07C59/185 , C07C59/84 , C07C59/90 , C07D307/82 , C07C65/20 , C07C149/40
CPC分类号： C07D307/82 , C07C45/63 , C07C57/30 , C07C59/84 , C07C59/90 , C07C255/00 , C07C323/00 , Y10S514/96 , C07C49/84 , C07C49/813
摘要： (3-BENZOYLPHENYL) ALKANOIC ACIDS OF THE FORMULA:

1-(HOOC-CH(-R)-),2-R2,3-((4-R1-PHENYL)-CO-)BENZENE

WHEREIN R REPRESENTS A HYDROGEN ATOM OR AN ALKYL GROUP CONTAINING 1 TO 4 CARBON ATOMS, R1 REPRESENTS A HYDROGEN ATOM OR AN ALKYLTHIO GROUP CONTAINING 1 TO 4 CARBON ATOMS, AND R2 REPRESENTS A HYDROGEN ATOM OR A HYDROXY OR METHOXY GROUP, AND SALTS THEREOF, FOR EXAMPLE 3BENZOYLPHENYLACETIC ACID, HAVE BEEN FOUND TO POSSESS PHARMACODYNAMIC PROPERTIES AND ARE ESPECIALLY USEFUL AS ANTI-INFLAMMATION AGENTS.

9. 发明授权

US3585234A Process for producing 4-phenyl-3-oxo-butane-1 carboxylic acid esters 失效
标题翻译：生产4-苯基-3-氧代丁烷-1-羧酸酯的方法
公开(公告)号：US3585234A
公开(公告)日：1971-06-15
申请号：US3585234D
申请日：1967-10-09
申请人： SUMITOMO CHEMICAL CO
发明人： YOSHIOKA HIROSUKE , ITAYA NOBUSHIGE , MATSUMOTO YUTAKA
IPC分类号： C07C51/08 , C07C67/00 , C07C65/20 , C07C69/94
CPC分类号： C07C51/08 , C07C59/205
摘要： A PROCESS FOR PRODUCING 4-PHENYL-3-OXO-BUTANE-1-CARBOXYLIC ACID ESTERS COMPRISING REACTING A 4-PHENYL-4CYANO-3-OXO-BUTANE-1-CARBOXYLATE WITH ORTHOPHOSPHORIC ACID OR AQUEOUS ORTHOPHOSPHORIC ACID, THEREBY HYDROLYZING AND REMOVING THE CYANO GROUP OF SAID ESTER PRIOR TO HYDROLYSIS OF THE ESTER PORTION THEREOF. THE REACTION PROGRESSES SMOOTHLY AND QUICKLY, AND EVEN WHEN MORE OR LESS AMOUNT OF FREE CARBOXYLIC ACID IS BY-PRODUCED, THE FREE ACID CAN BE CONVERTED INTO THE DESIRED ESTER BY ADDING THE CORRESPONDING ALCOHOL TO THE REACTION SYSTEM. IN THE CASE OF CYANO-CARBOXYLIC ACID ALSO, THE REACTION PROCEEDS SMOOTHLY AND THEREFORE ACCORDING TO THE PRESENT PROCESS, THE DESIRED ESTER CAN BE PRODUCED ALSO FROM THIS STARTING MATERIAL BY ADDING THE CORRESPONDING ALCOHOL TO THE REACTION SYSTEM.

10. 发明授权

US3557291A Octalone carbodylic acids and their derivatives 失效
标题翻译： OCTALONE CARBODYLIC ACIDS及其衍生物
公开(公告)号：US3557291A
公开(公告)日：1971-01-19
申请号：US3557291D
申请日：1968-06-28
申请人： MEAD JOHNSON & CO
发明人： WEBER ABRAHAM , FROSSARD JACQUES JEAN
IPC分类号： C07C45/74 , C07C49/683 , C07C49/697 , C07C49/747 , C07C49/753 , C07C65/20
CPC分类号： C07C49/747 , C07C45/74 , C07C49/683 , C07C49/697 , C07C49/753 , Y10S514/937 , Y10S514/96
摘要： 1. A PHARMACEUTICAL COMPOSITION IN DOSAGE UNIT FORM COMPRISING A PHARMACEUTICAL CARRIER AND FROM 50 TO 500 MG. OF A COMPOUND HAVING THE FORMULA

3,3-DI(CH3-),6-R,7-Y,8-X-1,2,3,4,5,6,7,8-OCTAHYDRO-

NAPHTHALEN-1-ONE

WHEREIN R IS PHENYL OR PHENYL BEARING FROM ONE TO TWO SUBSTITUENTS SELECTED FROM ALKOXY HAVING UP TO FOUR CARBON ATOMS, HALOGEN AND HUDROXYL AND WHEREIN ONE OF X AND Y IS CARBOXYL AND THE OTHER IS THE GROUP

-CO-N(-R1)-R2

IN WHICH R1 AND R2 ARE HYDROGEN OR LOWER ALKYL HAVING UP TO FOUR CARBON ATOMS.

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