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1. 发明授权

US4161611A Process for the production of 2-methoxy-3,6-dichlorobenzoic acid 失效
标题翻译： 2-甲氧基-3,6-二氯苯甲酸的制备方法
公开(公告)号：US4161611A
公开(公告)日：1979-07-17
申请号：US868091
申请日：1978-01-09
申请人： Dong-Whee Kim
发明人： Dong-Whee Kim
IPC分类号： C07C51/367 , C07C65/08
CPC分类号： C07C51/367
摘要： This invention discloses a process for the production of 2-methoxy-3,6-dichlorobenzoic acid which comprises reacting 2-amino-3,6-dichlorobenzoic acid with nitrous acid to form the corresponding diazonium salt, hydrolyzing the diazonium salt to form 2-hydroxy-3,6-dichlorobenzoic acid and methylating said hydroxy acid.
摘要翻译：本发明公开了一种2-甲氧基-3,6-二氯苯甲酸的制备方法，该方法包括使2-氨基-3,6-二氯苯甲酸与亚硝酸反应形成相应的重氮盐，水解重氮盐形成2- 羟基-3,6-二氯苯甲酸并甲基化所述羟基酸。

2. 发明授权

US3957852A Diphenyl ether compounds 失效
标题翻译：二苯醚化合物
公开(公告)号：US3957852A
公开(公告)日：1976-05-18
申请号：US537003
申请日：1974-12-27
申请人： Kanichi Fujikawa , Isao Yokomichi , Nobuyuki Sakashita , Kazuyuki Maeda , Takahiro Haga
发明人： Kanichi Fujikawa , Isao Yokomichi , Nobuyuki Sakashita , Kazuyuki Maeda , Takahiro Haga
IPC分类号： A01N37/40 , C07C65/24 , C07C69/92 , C07C65/08
CPC分类号： A01N37/40 , C07C65/24 , C07C69/92
摘要： A diphenyl ether compound, such as 2,4'-dichloro-4-trifluoromethyl-3'-carbomethoxydiphenyl ether, which has herbicidal properties and is effective for controlling weeds using soil and/or foliage application and herbicidal compositions containing the same.

3. 发明授权

US3865854A Process of preparation of alkyl tridecatrienoates and intermediates 失效
标题翻译：烷基十三碳烯酸酯和中间体的制备方法
公开(公告)号：US3865854A
公开(公告)日：1975-02-11
申请号：US28643972
申请日：1972-09-05
申请人： ROUSSEL UCLAF
发明人： HAINAUT DANIEL , TOROMANOFF EDMOND , DEMOUTE JEAN-PIERRE
IPC分类号： C07C69/587 , C07C20060101 , C07C67/00 , C07C67/30 , C07C69/00 , C07C69/52 , C07D20060101 , C07D335/02 , C07C65/08
CPC分类号： C07C51/097 , Y10S424/12
摘要： A process for the production of alkyl 3,11-dimethyl-7-ethyl2,6,10-tridecatrienoates starting from the S-oxide of 4-methyl5,6-dihydro-2H-thiapyran, 1-oxa-6-thia-spiro/2,5/octane and alkyl 3-methyl-4-halo-2-butenoate and the novel intermediates. The alkyl 3,11-dimethyl-7-ethyl-2,6,10-tridecatrienoates are intermediates in the synthesis of the juvenile hormone.
摘要翻译：一种从4-甲基-5,6-二氢-2H-噻唑烷的1-氧化物，1-氧杂-6-S的氧化物制备3,11-二甲基-7-乙基-2,6,10-十三碳三烯酸烷基酯的方法噻吩/ 2,5 /辛烷和3-甲基-4-卤代-2-丁烯酸烷基酯和新的中间体。 3,11-二甲基-7-乙基-2,6,10-十三碳三烯酸烷基酯是少年激素合成中的中间体。

4. 发明授权

US4126636A Process of producing the magnesium salt of p-chlorophenoxyisobutyric acid 失效
标题翻译：生产对氯苯氧基酸镁盐的方法
公开(公告)号：US4126636A
公开(公告)日：1978-11-21
申请号：US841835
申请日：1977-10-13
申请人： Franz Stuckler
发明人： Franz Stuckler
IPC分类号： C07C51/41 , C07C65/08
CPC分类号： C07C51/412
摘要： P-chlorophenoxyisobutyric acid is dissolved in an aqueous solution of a surplus of ammonia. The resulting solution is reacted with an aqueous solution of a magnesium salt, which latter solution contains a large surplus of ammonium ions and gaseous ammonia.

5. 发明授权

US4093648A Therapeutically active benzoic acid derivatives and a process for preparing them 失效
标题翻译：治疗活性苯甲酸衍生物及其制备方法
公开(公告)号：US4093648A
公开(公告)日：1978-06-06
申请号：US697154
申请日：1976-06-17
申请人： Enrico Sianesi , Giuseppe Bonola , Ivo Setnikar , Maria Jose Magistretti
发明人： Enrico Sianesi , Giuseppe Bonola , Ivo Setnikar , Maria Jose Magistretti
IPC分类号： A61K31/165 , A61K31/19 , A61P37/08 , C07C65/40 , C07C67/00 , C07C217/22 , C07C231/00 , C07C231/02 , C07C231/12 , C07C233/12 , C07C235/84 , C07C65/08 , A01N9/24
CPC分类号： C07C65/40 , C07C233/12
摘要： Therapeutically active 2- and 3-substituted benzoic acid derivatives having the general formula ##STR1## wherein X is OH, NH.sub.2 or an anilino group having the phenyl ring unsubstituted or substituted by chlorine or by a 4-ethoxy group; or ##STR2## wherein X is NH.sub.2 or an anilino group having the phenyl ring unsubstituted or substituted by chlorine or by a 4-ethoxy group; pharmacologically acceptable mineral or organic acid addition salts including quaternary ammonium salts of those compounds having a basic nitrogen atom and alkaline or alkaline earth metal salts of those compounds wherein X is OH.Compounds of the formula wherein X is amino or anilino are prepared by reacting 3-propionylsalicyclic acid or a functional derivative thereof with ammonia or an amine in an anhydrous solvent. Compounds of the formula wherein X is OH are prepared by etherifying the ethylester of 3-propionylsalicyclic acid with diethylaminoethylchloride in the presence of an acid binding agent in a ketonic solvent and thereafter hydrolyzing the ester group with a mineral acid or an alkaline earth metal hydroxide.
摘要翻译：具有通式“IMAGE”的治疗活性2-和3-取代的苯甲酸衍生物，其中X是OH，NH 2或苯基环未取代或被氯取代或被4-乙氧基取代的苯胺基; 或其中X是NH 2或苯基环未被取代或被氯取代的苯胺基或4-乙氧基; 药理学上可接受的矿物或有机酸加成盐，包括具有碱性氮原子的那些化合物的季铵盐和其中X是OH的那些化合物的碱金属或碱土金属盐。

6. 发明授权

US4075241A 2-(Aryl)-3-(dimethylamino)butyl-3,4,5-trimethoxybenzoates 失效
标题翻译： 2-（芳基）-3-（二甲基氨基）丁基-3,4,5-三甲氧基苯甲酸酯
公开(公告)号：US4075241A
公开(公告)日：1978-02-21
申请号：US251025
申请日：1972-05-08
申请人： Elvio Bellasio , Franco Cristiani
发明人： Elvio Bellasio , Franco Cristiani
IPC分类号： C07C227/06 , C07C65/08
CPC分类号： C07C227/06 , Y10S514/929
摘要： The compounds 2-Aryl-3-amino-1-butanol derivatives of the formula ##STR1## wherein R represents hydrogen or acyl; R.sup.1 and R.sup.2 each independently represents hydrogen, phenyl lower alkyl, or lower alkoxy substituted phenyl lower alkyl, or both R.sup.1 and R.sup.2 are lower alkyl; and their pharmaceutically acceptable acid salts.The compounds are crystalline solids or liquids which, having two asymmetry centers, can be obtained in their stereoisomeric forms as racemic mixtures or in their optically active forms. The compounds have cardiovascular activity as coronary dilators.The compounds can be prepared by reacting an .alpha.-arylcrotonate with ammonia or with an amine followed by hydrogenation of the carbalkoxy group to give the corresponding butanol. The butanols are acylated in usual ways to give the compounds of formula (I) wherein R represents an acyl group.
摘要翻译：下式化合物2-芳基-3-氨基-1-丁醇衍生物其中R代表氢或酰基; R 1和R 2各自独立地表示氢，苯基低级烷基或低级烷氧基取代的苯基低级烷基，或者R 1和R 2均为低级烷基; 及其药学上可接受的酸式盐。

7. 发明授权

US3923885A Polyfluoroalkoxy-substituted aromatic carboxylic acids 失效
标题翻译：多氟烷氧基取代的芳族羧酸
公开(公告)号：US3923885A
公开(公告)日：1975-12-02
申请号：US34923773
申请日：1973-04-09
申请人： RIKER LABORATORIES INC
发明人： MENDEL ARTHUR
IPC分类号： C07C243/38 , C07C65/08 , C07C63/02 , C07C65/14
CPC分类号： C07C243/38
摘要： Acyl halides, esters, amides, hydrazides and salts as well as the acid form derived from aromatic acids substituted by polyfluoroalkoxy groups. These compounds are valuable as synthetic intermediates in the preparation of physiologically active compounds.
摘要翻译：酰卤，酯，酰胺，酰肼和盐以及衍生自被多氟烷氧基取代的芳族酸的酸形式。这些化合物在制备生理活性化合物中作为合成中间体是有价值的。

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