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1. 发明授权

US06313351B1 Process for producing alicyclic monoketones and process for producing alicyclic diketones 有权
标题翻译：生产脂环族单酮的方法和生产脂环族二酮的方法
公开(公告)号：US06313351B1
公开(公告)日：2001-11-06
申请号：US09389079
申请日：1999-09-02
申请人： Norimoto Kiya , Shinsaku Kawasaki , Kenji Ekawa , Kenji Sugiyama , Toyokazu Kitaura
发明人： Norimoto Kiya , Shinsaku Kawasaki , Kenji Ekawa , Kenji Sugiyama , Toyokazu Kitaura
IPC分类号： C07C4562
CPC分类号： C07C45/00 , B01J23/58 , C07C49/417 , C07C49/517 , C07C49/747 , C07C49/753 , C07C315/04 , C07C2601/14 , C07C317/22
摘要： The process for producing alicyclic monoketones (hydroxyphenylcyclohexanone derivatives) according to the present invention comprises hydrogenating substituted bisphenols such as bisphenol A in a solvent in the presence of a palladium/alkali metal catalyst in which palladium and an alkali metal are both supported on a carrier to obtain alicyclic monoketones such as 2-(4-oxocyclohexyl)-2-(4-hydroxyphenyl)propane. The process for producing alicyclic diketones according to the present invention comprises hydrogenating substituted bisphenols such as bisphenol A in a solvent in the presence of a palladium/alkali metal catalyst in which palladium and an alkali metal are both supported on a carrier to obtain alicyclic diketones such as 2,2-bis(4-oxocyclohexyl)propane and 4,4′-bicyclohexanone. The other process for producing alicyclic monoketones according to the present invention comprises hydrogenating biphenols such as bis(4-hydroxyphenyl) in an organic solvent in the presence of a palladium catalyst in which 10 to 30% by weight of palladium is supported on a carrier to obtain alicyclic monoketones such as 4(4′-hydroxyphenyl)cyclohexanone. According to the present invention, alicyclic monoketones or alicyclic diketones can be obtained with high selectivity and in high yields through simple steps, because the process includes only one reaction step to hydrogenate substituted bisphenols under relatively mild conditions.
摘要翻译：本发明的脂环式单酮类（羟基苯基环己酮衍生物）的制造方法包括在钯/碱金属催化剂的存在下，在载体上负载钯/碱金属催化剂的情况下，在溶剂中，氢化取代的双酚，例如双酚A，得到2-（4-氧代环己基）-2-（4-羟基苯基）丙烷等脂环族单酮。根据本发明的制备脂环族二酮的方法包括在钯/碱金属催化剂的存在下在溶剂中将取代的双酚如双酚A氢化，其中钯和碱金属都负载在载体上，以获得脂环族二酮作为2,2-双（4-氧代环己基）丙烷和4,4'-二环己酮。根据本发明的其它生产脂环族单酮的方法包括在钯催化剂存在下，在有机溶剂中，将双酚如双（4-羟基苯基）氢化，其中载体上载有10〜30重量％的钯，得到脂环族单酮如4（4'-羟基苯基）环己酮。根据本发明，可以通过简单的步骤以高选择性和高产率获得脂环族单酮或脂环族二酮，因为该方法仅包括在相对温和的条件下氢化取代的双酚的一个反应步骤。

2. 发明授权

US06215028B1 Process for the preparation of cyclohexanones 失效
标题翻译：制备环己酮的方法
公开(公告)号：US06215028B1
公开(公告)日：2001-04-10
申请号：US09184080
申请日：1998-11-02
申请人： Bernd Oster , Peter Mackert , Detlef Pauluth , Markus Wydra
发明人： Bernd Oster , Peter Mackert , Detlef Pauluth , Markus Wydra
IPC分类号： C07C4562
CPC分类号： C07C45/006 , C07B63/02 , C07C67/313 , C07C49/417 , C07C49/403 , C07C49/657 , C07C69/757
摘要： The invention relates to a process for the preparation of cyclohexanones from the corresponding phenols by partial hydrogenation, characterized in that the reaction mixture obtained by means of the hydrogenation is treated with sulfonating agents before the isolation of the cyclohexanone.
摘要翻译：本发明涉及通过部分氢化从相应的酚制备环己酮的方法，其特征在于通过氢化获得的反应混合物在分离环己酮之前用磺化剂处理。

3. 发明授权

US06369277B1 Selective liquid-phase hydrogenation of &agr;,&bgr;-unsaturated carbonyl compounds 失效
标题翻译： α，β-不饱和羰基化合物的选择性液相氢化
公开(公告)号：US06369277B1
公开(公告)日：2002-04-09
申请号：US09645583
申请日：2000-08-25
申请人： Franz Josef Broecker , Gerd Kaibel , Werner Aquila , Hartwig Fuchs , Guenter Wegner , Manfred Stroezel
发明人： Franz Josef Broecker , Gerd Kaibel , Werner Aquila , Hartwig Fuchs , Guenter Wegner , Manfred Stroezel
IPC分类号： C07C4562
CPC分类号： C07C45/62 , B01J8/20 , B01J8/22 , B01J19/2465 , B01J19/2495 , B01J2219/00103 , B01J2219/0011 , B01J2219/32 , C07C47/21
摘要： An &agr;,&bgr;-unsaturated carbonyl compound of formula (I) where R1 is saturated C1-40-hydrocarbyl or a substituted or unsubstituted aromatic radical containing moiety, and R2, R3 and R4, independently of one another, are hydrogen or a C1- to C4-alkyl group, is selectively hydrogenated in the liquid phase to a saturated carbonyl compound of formula (II) with hydrogen in the presence of a pulverulent palladium and/or rhodium catalyst and in the presence of an organic base, by conducting the hydrogenation in a packed bubble column reactor in which product is recycled and hydrogen gas is recirculated.
摘要翻译：其中R 1为饱和C 1-40烃基或取代或未取代的含芳基部分的式（I）的α，β-不饱和羰基化合物，R 2，R 3和R 4彼此独立地为氢或C1- 通过氢气在粉状钯和/或铑催化剂存在下，在有机碱的存在下，在液相中选择性地氢化成式（II）的饱和羰基化合物，通过进行氢化在包装泡罩塔反应器中，其中产物被再循环并且氢气被再循环。

4. 发明授权

US06284928B1 Process for preparing intermediates useful in the synthesis of vitamin D compounds 失效
标题翻译：制备可用于合成维生素D化合物的中间体的方法
公开(公告)号：US06284928B1
公开(公告)日：2001-09-04
申请号：US09501359
申请日：2000-02-10
申请人： Andrzej Robert Daniewski
发明人： Andrzej Robert Daniewski
IPC分类号： C07C4562
CPC分类号： C07C45/62 , C07C45/63 , C07C49/443 , C07C49/477
摘要： The invention relates to an improved process for preparing [(3aR,4S,7aS)4-bromooctahydro-7a-methyl-1H-indene-1,5-dione]. (S)-(+)-2,3,7,7a-tetrahydro-7a-methyl-1H-indene-1,5(6H)-dione is reduced by reaction with diisobutylaluminum hydride and hexamethylphosphoric triaminde in the presence of a catalyst of the formula R—Cu, wherein R is and R1, R2 and R3 are each, independently, selected from the group consisting of C1-7 alkyl, phenyl, phenyl substituted by at least one C1-4 alkyl group, benzyl, or benzyl substituted by at at least one C1-4 alkyl group to form a reductate. The reductate is then treated with a bromine-containing electrophile to yield (3aR,4S,7aS)4-bromooctahydro-7a-methyl-1H-indene-1,5-dione.
摘要翻译：本发明涉及制备[（3aR，4S，7aS）4-溴八氢-7a-甲基-1H-茚-1,5-二酮]的改进方法。（S） - （+） - 2,3,7,7a-四氢-7a-甲基-1H-茚-1H（6H） - 二酮在催化剂存在下与二异丁基氢化铝和六甲基磷酸三的式R-Cu，其中R是和R 1，R 2和R 3各自独立地选自C 1-7烷基，苯基，被至少一个C 1-4烷基取代的苯基，苄基或苄基取代的在至少一个C 1-4烷基上形成还原物。然后用含溴亲电子试剂处理还原物，得到（3aR，4S，7aS）4-溴八氢-7a-甲基-1H-茚-1,5-二酮。

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