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    • 3. 发明授权
    • Method for preparing small sized benzoyl peroxide crystals
    • 制备小型过氧化苯甲酰晶体的方法
    • US4401835A
    • 1983-08-30
    • US303229
    • 1981-09-17
    • Arthur Tarasov
    • Arthur Tarasov
    • A61K31/19A61K8/30A61K8/33C07C67/00C07C407/00C07C409/32C07C409/34C07C409/36C07C179/06
    • C07C409/34C07C407/00C07C407/003C07B2200/13
    • A method for the preparation of benzoyl peroxide in crystalline form, which crystals may range in size below 10 microns, comprises forming a first solution of the benzoyl peroxide in a precipitate promoting material, adding the first solution to a second solution comprising an aqueous solution of a dispersant, to precipitate the benzoyl peroxide in the desired crystalline form, and finally recovering the crystalline benzoyl peroxide from the first and second solutions. The precipitate promoting material may be selected from sulfur-containing aliphatic ethers, long-chain aliphatic and araliphatic ethers, ethylene oxide derivatives, and mixtures thereof. The dispersant may be selected from cellulosic derivatives, anionic surfactants, nonionic surfactants, colloidal inorganic materials, and mixtures thereof. The present method may be performed at room temperature and is therefore safe and energy conservative. The resulting benzoyl peroxide crystals are of desirably reduced size, and are particularly well suited for incorporation into commercial cosmetic and pharmaceutical preparations.
    • 制备结晶形式的过氧化苯甲酰的方法,该晶体的尺寸范围可以在10微米以下,包括在沉淀促进材料中形成过氧化苯甲酰的第一溶液,将第一溶液加入到第二溶液中,所述第二溶液包含 分散剂,以期望的结晶形式沉淀过氧化苯甲酰,最后从第一和第二溶液中回收结晶的过氧化苯甲酰。 沉淀促进材料可以选自含硫脂族醚,长链脂族醚和芳脂族醚,环氧乙烷衍生物及其混合物。 分散剂可以选自纤维素衍生物,阴离子表面活性剂,非离子表面活性剂,胶体无机材料及其混合物。 本方法可以在室温下进行,因此是安全和节能的。 所得到的过氧化苯甲酰晶体理想地减小尺寸,并且特别适合于掺入商业化妆品和药物制剂中。