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1. 发明授权

US06184367B2 Process for the production of 4-aryl-2 butanols from Taxus wallichiana 有权
标题翻译：从Taxus wallichiana生产4-芳基-2丁醇的方法
公开(公告)号：US06184367B2
公开(公告)日：2001-02-06
申请号：US09358113
申请日：1999-07-21
申请人： Sunil Kumar Chattopadhyay , Ram Prakash Sharma , Sushil Kumar
发明人： Sunil Kumar Chattopadhyay , Ram Prakash Sharma , Sushil Kumar
IPC分类号： C07C3982
CPC分类号： C07H15/18 , C07C37/004 , C07H1/08 , C07C39/11
摘要： The present invention provides a process for the production of two molecules of 4-aryl-2 butanols having the general formula 1 given below: Wherein R═H or glucose from the leaves of Taxus wallichiana, which comprises: (a) defatting air dried, pulverized leaves with aliphatic hydrocarbon solvents, (b) extracting the defatted leaves with chlorinated solvents and polar solvent successively at room temperature, (b) concentrating the chlorinated solvent soluble faction to a residue and treating the residue with aqueous solution of alkali and extracting with chlorinated solvents, (d) acidifying the alkali layer with mineral acid and extracting with ethyl acetate and concentrating the ethyl acetate phase to give compound of formula 1 where R═H, (e) concentrating the polar solvent fraction from step (b) to a residue and treating the residue with aqueous solution of alkali and extracting with chlorinated solvent, and (f) acidifying the alkali phase with mineral acid and extracting with ethyl acetate and concentrating the ethyl acetate to give compound of formula 1 where R=glucose.
摘要翻译：本发明提供了一种生产具有下列通式1的两分子的4-芳基-2丁醇的方法：其中R = H或来自红豆杉叶的葡萄糖，其包括：（a）将空气干燥脱脂，用脂肪族烃溶剂粉碎叶片，（b）在室温下连续用氯化溶剂和极性溶剂萃取脱脂叶，（b）将氯化溶剂可溶部分浓缩至残留物，用碱水溶液处理残留物，用氯化物萃取溶剂，（d）用无机酸酸化碱层并用乙酸乙酯萃取并浓缩乙酸乙酯相，得到其中R = H的式1化合物，（e）将步骤（b）的极性溶剂级分浓缩至残余物并用碱水溶液处理残留物，用氯化溶剂萃取，（f）用无机酸酸化碱相，用乙酸乙酯萃取并浓缩乙酸乙酯，得到其中R =葡萄糖的式1化合物。

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