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1. 发明申请

US20200278143A1 EVAPORATOR ASSEMBLY FOR A VERTICAL FLOW TYPE ICE MAKING MACHINE 审中-公开
公开(公告)号：US20200278143A1
公开(公告)日：2020-09-03
申请号：US16646276
申请日：2018-11-27
申请人： Ram Prakash SHARMA , Vinay SHARMA
发明人： Ram Prakash SHARMA , Vinay SHARMA
IPC分类号： F25C1/12
摘要： The present disclosure discloses, an evaporator assembly for a vertical flow type ice-making machine. The assembly comprising a plurality of tubes for circulating a refrigerant, and a plurality of conductive protrusions thermally coupled to and extending the plurality of tubes. Each of the plurality of conductive protrusions defines an ice-making region. The assembly also includes a non-conductive plate arranged adjacent to the plurality of tubes. The non-conductive plate is defined with a provision to accommodate the plurality of conductive protrusions which exchanges heat with the refrigerant flowing through the plurality of tubes and forms the ice layer by layer, and shape of at least one surface of the ice is defined by the non-conductive plate. The configuration of the assembly produces ice in the form of individual ice-cubes of a specific shape and size, and thereby improves the efficiency of the machine and ice-making process.

2. 发明授权

US06214864B1 Formulation of dihydroartemisinin for the control of wide spectrum of malaria 有权
标题翻译：制备二氢青蒿素用于控制广谱疟疾
公开(公告)号：US06214864B1
公开(公告)日：2001-04-10
申请号：US09264352
申请日：1999-03-05
申请人： Dharam Chand Jain , Rajendra Singh Bhakuni , Ram Prakash Sharma , Sushil Kumar , Guru Prakash Dutta
发明人： Dharam Chand Jain , Rajendra Singh Bhakuni , Ram Prakash Sharma , Sushil Kumar , Guru Prakash Dutta
IPC分类号： A61K31335
CPC分类号： A61K9/0095 , A61K9/0019 , A61K9/0031 , A61K31/366 , A61K47/44 , Y02A50/411 , Y10S514/895
摘要： The present invention relates to a synergistic formulation useful for the control of wide spectrum of malarial infections, which comprises a pharmaceutically effective amount of dihydroartemisinin and a vegetable oil.
摘要翻译：本发明涉及可用于控制广谱疟疾感染的协同制剂，其包含药学上有效量的二氢青蒿素和植物油。

3. 发明授权

US5955084A Process for the simultaneous production of artemisnin and essential oil from the plant artemisia annua 失效
标题翻译：从青蒿中同时生产青蒿素和精油的方法
公开(公告)号：US5955084A
公开(公告)日：1999-09-21
申请号：US944865
申请日：1997-10-06
申请人： Dharam Chand Jain , Sudeep Tandon , Rajendra Singh Bhakuni , Mohammed Shafique Siddique , Atul Prakash Kahol , Ram Prakash Sharma , Sushil Kumar , Asish Kumar Bhattacharya
发明人： Dharam Chand Jain , Sudeep Tandon , Rajendra Singh Bhakuni , Mohammed Shafique Siddique , Atul Prakash Kahol , Ram Prakash Sharma , Sushil Kumar , Asish Kumar Bhattacharya
IPC分类号： A61K36/00 , A61K36/282 , C07C51/48 , C07C57/26 , C07D493/18 , C07D493/20 , C11B5/00 , C11B9/02 , C11B13/00 , A61K35/78
CPC分类号： A61K36/282
摘要： This invention relates to a novel process for the dual production of essential oil and artemisinin from the plant Artemisia annua, said process comprising extracting the plant with hexane, partitioning the hexane extract between hexane and acetonitrile, hydrodistillation of hexane residue and Marc to yield essential oil, further fractionation of acetonitrile solvent between hexane-benzene mixture to remove artemisinic acid, chromatographing of the acetonitrile phase to produce substantially pure artemisinin, the artemisinic acid is reduced to obtain dihydro artemisinic acid which is then oxidised in a single step to form artemisinin.
摘要翻译：本发明涉及一种用于从植物青蒿双重生产精油和青蒿素的新方法，所述方法包括用己烷萃取植物，在己烷和乙腈之间分配己烷提取物，将己烷残渣和马克加热蒸馏得到精油乙腈溶剂进一步分离己烷 - 苯混合物以去除青蒿酸，色谱分离乙腈相以产生基本上纯的青蒿素，将青蒿酸还原得到二氢青蒿酸，然后在一步中氧化形成青蒿素。

4. 发明申请

US20210108847A1 ICE-MACHINE ROTATABLE ASSEMBLY AND HOUSING, AN ICE-MACHINE ROTATABLE ASSEMBLY, AN ICE-MACHINE, AND ASSOCIATED METHODS 有权
公开(公告)号：US20210108847A1
公开(公告)日：2021-04-15
申请号：US16463035
申请日：2018-02-28
申请人： Ram Prakash SHARMA , Vinay SHARMA
发明人： Ram Prakash SHARMA , Vinay SHARMA
IPC分类号： F25C5/20 , F25C1/12
摘要： An ice-machine rotatable assembly and housing, comprising a first side wall defining a first elongate slot extending from an edge of the first side wall, and the rotatable assembly comprising: a rotatable member configured to move liquid toward an ice former mounted with respect to the housing. The rotatable member including a first connecting part towards a first end of the rotatable member; and a first slide plate having a rail and a first side panel extending along a length of the rail of the first slide plate. The rail of the first slide plate being configured to be at least partially received by the first elongate slot, wherein: the first connecting part of the rotatable member is moveable along the elongate slot to position the rotatable member in the installed position. The first slide plate is mountable with its rail at least partially received by the first elongate slot.

5. 发明申请

US20080242836A1 Convergent Solid Phase Peptide Synthesis By Reaction Of Two Fragments Bound To Solid Support 审中-公开
标题翻译：通过与固体支持物结合的两个片段反应的收敛固相肽合成
公开(公告)号：US20080242836A1
公开(公告)日：2008-10-02
申请号：US11886180
申请日：2006-03-13
申请人： Ram Prakash Sharma
发明人： Ram Prakash Sharma
IPC分类号： C07K14/00 , C07K1/00 , C07K7/06
CPC分类号： C07K14/43572 , C07K1/04 , C07K1/042 , C07K5/06078 , C07K5/0812 , C07K5/1016 , C07K5/1019 , C07K7/06 , C07K17/00
摘要： A process for preparing a peptide or protein by solid phase synthesis comprising combining a sequence including one or more amino acids obtainable by C-N synthesis linked to a first resin, with an amino acid sequence including one or more amino acid obtainable by N-C synthesis linked to a second resin so as to create a native peptide link between unprotected N and unprotected C terminals of said amino acid sequences, and optionally releasing the resulting peptide from one or more of the linked resins so as to combine with further N-C or C-N sequences or to release the desired peptide or protein sequence.
摘要翻译：通过固相合成制备肽或蛋白质的方法，包括将包含一个或多个可通过CN合成获得的氨基酸的序列与包含一个或多个可通过NC合成获得的氨基酸的氨基酸序列组合的序列与第一树脂以在所述氨基酸序列的未保护的N和未保护的C末端之间产生天然肽连接，并且任选地从一个或多个所述连接的树脂中释放得到的肽，以便与另外的NC或CN序列结合或释放所需的肽或蛋白质序列。

6. 发明授权

US5856532A Process for the production of taxol 失效
标题翻译：紫杉醇生产工艺
公开(公告)号：US5856532A
公开(公告)日：1999-01-05
申请号：US909810
申请日：1997-08-12
申请人： Sunil Kumar Chattopadhyay , Ram Prakash Sharma , Sushil Kumar , Kunnath Padmanabhan Madhusudanan
发明人： Sunil Kumar Chattopadhyay , Ram Prakash Sharma , Sushil Kumar , Kunnath Padmanabhan Madhusudanan
IPC分类号： A61K31/335 , A61K31/337 , A61K36/18 , A61P35/00 , C07C13/26 , C07D305/14
CPC分类号： C07D305/14
摘要： A process has been developed for production of taxols A, B, C with high yields from 7-xylosyl-10-deacetyl taxol A (taxol analogue A or, xyloside A), 7-xylosyl-10-deacetyl-taxol B (taxol analogue B or xyloside B), 7-xylosyl-10-deacetyl--taxol C (taxol analogue C or xyloside C), which comprises (i) isolating the taxol analogues A, B, C form the stembark of Taxus wallichiana by an improved process devoiding of solvent partitioning step, (ii) treating the isolated taxol analogues A, B, C with periodates in an acid free polar solvent medium to cleave the diol into dialdehyde at ambient temperature, (iii) reducing the dialdehyde solution with borohydride in a polar solvent--acetic acid medium at 0.degree.-40.degree. C. into an acetal, (iv) acidifying the resultant acetal with a mixture of mineral acid-polar solvent at 0.degree.-40.degree. C. into intermediate product 10-deacetyl taxols A, B, C, (V) reacting 10-deacetyl taxols A or B or C with a silane in presence of a base at 20.degree.-40.degree. C. to protect 2', 7-hydroxyl groups, of 10-deacetyl taxols A, B, C (vi) acetylating the 10-hydroxyl group in situ with an acetylating agent at 10.degree.-40.degree. C., (vii) deprotecting the 2', 7-hydroxyl groups with a mixture of mineral acid-polar solvent at 0.degree.-10.degree. C. (viii) isolating taxols A or B or C by chromatography over silica.
摘要翻译：已经开发了用于从7-木糖基-10-脱乙酰紫杉醇A（紫杉醇类似物A或木糖苷A），7-木糖基-10-脱乙酰基紫杉醇B（紫杉醇类似物）的高收率生产紫杉醇A，B，C的方法 B或木糖苷B），7-木糖基-10-脱乙酰基紫杉醇C（紫杉醇类似物C或木糖苷C），其包括（i）通过改进的方法脱除紫杉醇类似物A，B，C形成紫杉属的溶剂分配步骤，（ii）在酸性极性溶剂介质中用高碘酸盐处理分离的紫杉酚类似物A，B，C，以在环境温度下将二醇切割成二醛，（iii）用极性溶剂中的硼氢化物还原二醛溶液 - 乙酸培养基在0°-40℃进入缩醛，（iv）在0-40℃下用无机酸 - 极性溶剂的混合物将所得缩醛酸化成中间产物10-脱乙酰基紫杉醇A，B C，（Ⅴ）在20℃-40℃下，使10-脱乙酰基的紫杉醇A或B或C与硅烷反应，保护2' ，10-脱乙酰基紫杉醇A，B，C（vi）的7-羟基，（vi）在10°-40℃用乙酰化剂原位乙酰化10-羟基，（vii）使2'，7- 羟基与无机酸极性溶剂的混合物在0-10℃下进行。（viii）通过硅胶色谱分离紫杉醇A或B或C。

7. 发明公开

US20230400239A1 A MECHANISM FOR REMOVABLY ASSEMBLING PLURALITY OFCOMPONENTS IN EVAPORATOR OF AN ICE MAKING MACHINE 审中-公开
公开(公告)号：US20230400239A1
公开(公告)日：2023-12-14
申请号：US18249874
申请日：2021-06-03
申请人： RAM PRAKASH SHARMA , VINAY SHARMA
发明人： RAM PRAKASH SHARMA , VINAY SHARMA
IPC分类号： F25C1/12 , F28D1/047
CPC分类号： F25C1/12 , F28D1/0477
摘要： An evaporator assembly for an ice making machine is disclosed. The evaporator assembly includes a first metal plate and a second metal plate accommodating a refrigerant tube. The first and second metal plates are defined with a plurality of projections (1x and 2x) extending from a first major surface. The plurality of projections (1x and 2x) defines a slot. The slots defined in the second major surface of first and second metal plates comprise a first connector and a second connector, respectively. At least one of the first metal plate and the second metal plate is movable relative to the other such that the first connector and second connector engage with each other secure the first metal plate and the second metal palate.

8. 发明申请

US20090099307A1 Inverse solid phase peptide synthesis with additional capping step 审中-公开
标题翻译：具有附加封端步骤的反相固相肽合成
公开(公告)号：US20090099307A1
公开(公告)日：2009-04-16
申请号：US11886184
申请日：2006-03-13
申请人： Ram Prakash Sharma
发明人： Ram Prakash Sharma
IPC分类号： C07K1/04
CPC分类号： C07K1/04
摘要： A process for preparing a peptide by solid phase synthesis in the N to C direction comprising a capping step after an amide bond formation step to prevent or reduce deletion artefacts.
摘要翻译：在N至C方向上通过固相合成制备肽的方法，包括酰胺键形成步骤之后的封端步骤以防止或减少缺失伪影。

9. 发明授权

US06620599B1 Process for the production of a biologically active phenolic compound(+) catechin 失效
标题翻译：用于生产生物活性酚类化合物（+）儿茶素的方法
公开(公告)号：US06620599B1
公开(公告)日：2003-09-16
申请号：US09535806
申请日：2000-03-28
申请人： Sunil Kumar Chattopadhyay , Suchitra Banerjee , Shipra Agarwal , Manish Kulshrestha , Ram Prakash Sharma , Vijay Kumar Mehta , Sushil Kumar
发明人： Sunil Kumar Chattopadhyay , Suchitra Banerjee , Shipra Agarwal , Manish Kulshrestha , Ram Prakash Sharma , Vijay Kumar Mehta , Sushil Kumar
IPC分类号： C12P1702
CPC分类号： C12P17/06 , C12N5/0025 , C12N5/04
摘要： The invention provides a process for the production of a biologically active phenolic compound (+) catechin from Taxus wallichiana tissue cultures, said process comprising the steps of (a) inoculating the of explants on a culture medium supplemented with combinations of auxins and cytokinins, (b) incubating the cultures under continuous light or dark conditions for 4-6 weeks for callus initiation followed by subculturing at 4-6 weeks intervals, (c) extracting the fresh pulverized calli with polar solvents at room temperature; (d) evaporating the solvent to obtain a residue; and (e) treating the residue with a chlorinated solvent and isolating (+) catechin compound by filtration.
摘要翻译：本发明提供从紫杉属组织培养物生产生物活性酚类化合物（+）儿茶素的方法，所述方法包括以下步骤：（a）将外植体接种在补充有生长素和细胞分裂素的组合的培养基上（ b）在连续的光照或黑暗条件下培养培养物4-6周，用于愈伤组织起始，然后以4-6周间隔传代培养，（c）在室温下用极性溶剂萃取新鲜粉碎的愈伤组织; （d）蒸发溶剂得到残余物; 和（e）用氯化溶剂处理残余物并通过过滤分离（+）儿茶素化合物。

10. 发明授权

US06362219B1 Process for the preparation of a formulation of dihydroartemisinin for the control of wide spectrum of malaria 有权
标题翻译：用于制备二氢青蒿素制剂用于控制疟疾广泛的方法
公开(公告)号：US06362219B1
公开(公告)日：2002-03-26
申请号：US09704485
申请日：2000-11-02
申请人： Dharam Chand Jain , Rajendra Singh Bhakuni , Ram Prakash Sharma , Sushil Kumar , Guru Prakash Dutta
发明人： Dharam Chand Jain , Rajendra Singh Bhakuni , Ram Prakash Sharma , Sushil Kumar , Guru Prakash Dutta
IPC分类号： A61K31335
CPC分类号： A61K9/0095 , A61K9/0019 , A61K9/0031 , A61K31/366 , A61K47/44 , Y02A50/411 , Y10S514/895
摘要： The present invention relates to a synergistic formulation useful for the control of wide spectrum of malarial infections, which comprises a pharmaceutically effective amount of dihydroartemisinin and a vegetable oil.
摘要翻译：本发明涉及可用于控制广谱疟疾感染的协同制剂，其包含药学上有效量的二氢青蒿素和植物油。

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