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1. 发明授权

US06355793B1 Organometallic zeolite 失效
标题翻译：有机金属沸石
公开(公告)号：US06355793B1
公开(公告)日：2002-03-12
申请号：US09342304
申请日：1999-06-29
申请人： Kuan-Jiuh Lin
发明人： Kuan-Jiuh Lin
IPC分类号： C07B4700
CPC分类号： C07D487/22
摘要： The invention relates to an organometallic zeolite which is formed of a multiplicity of units, each of which is of the formula (X.M)m, wherein M is a metal ion selected from the group consisting of Ni2+, Sn2+, Mg2+, Ca2+, Fe2+, Co2+, Mn2+, and Ru2+; X is a porphine which coordinates to a metal ion to form an (X.M) and is substituted with at least two linking groups and optionally with one or more non-linking groups; and m is an integer ranging from 4 to 12. Each linking group is an oxygen-, nitrogen-, or sulfur-containing moiety, and each of the non-linking groups, independently, is aryl, heteroaryl, aralkyl, or heteroaralkyl, optionally substituted with alkyl, alkoxy, hydroxyl, hydroxylalkyl, carboxyl, halo, haloalkyl, amino, aminoalkyl, mercapto, mercaptoalkyl, alkylcarbonyloxy, alkyloxycarbonyl, alkylcarbonyl, alkylcarbonylamino, aminocarbonyl, alkylsulfonylamino, aminosulfonyl, dihydroxyboryl, sulfo, or alkylsulfonyl. The organometallic zeolite can be used as molecular sieves, sorbents, or ion exchange materials.
摘要翻译：本发明涉及由多个单元形成的有机金属沸石，每个单元具有式（XM）m，其中M是选自Ni2 +，Sn2 +，Mg2 +，Ca2 +，Fe2 +， Co2 +，Mn2 +和Ru2 +; X是卟吩，其与金属离子配位以形成（X.M），并被至少两个连接基团任选地与一个或多个非连接基团取代; m是4至12的整数。每个连接基团是含氧，氮或硫的部分，并且每个非连接基团独立地是芳基，杂芳基，芳烷基或杂芳烷基，任选地巯基，巯基烷基，烷基羰基氧基，烷氧基羰基，烷基羰基，烷基羰基氨基，氨基羰基，烷基磺酰基氨基，氨基磺酰基，二羟基硼烷基，磺基或烷基磺酰基。有机金属沸石可用作分子筛，吸附剂或离子交换材料。

2. 发明授权

US06207821B1 Long-wavelength electromagnetic radiation and photoprotective tumor localizing agents for diagnosis 有权
标题翻译：长波电磁辐射和光保护肿瘤定位剂进行诊断
公开(公告)号：US06207821B1
公开(公告)日：2001-03-27
申请号：US09495837
申请日：2000-02-01
申请人： John Devens Gust, Jr. , Ana L. Moore , Thomas A. Moore , William H. Ralston
发明人： John Devens Gust, Jr. , Ana L. Moore , Thomas A. Moore , William H. Ralston
IPC分类号： C07B4700
CPC分类号： A61K49/0052 , A61K41/0071 , A61K49/0021 , A61K49/0036 , C07D487/22
摘要： A process of pathology or target tissue identification comprising administering an imaging material to a pathology or target tissue bearing mammalian host and irradiating the mammalian host with electromagnetic radiation having a wavelength between about 600 and 1100 nm, and especially in the region of 700 nm and longer wavelengths, whereupon the imaging material, which has been preferentially taken up by the pathology or target tissue, emits light and permits precise identification of the location, size and/or shape of the pathology or target tissue.
摘要翻译：一种病理学或靶组织鉴定过程，其包括向具有哺乳动物宿主的病理学或靶组织施用成像材料，并用波长在约600和1100nm之间，特别是在700nm和更长的区域的电磁辐射照射哺乳动物宿主因此已被病理学或靶组织优先摄取的成像材料发光并允许精确识别病理学或靶组织的位置，大小和/或形状。

3. 发明授权

US06482943B1 Quinones as disease therapies 失效
标题翻译：醌类作为疾病治疗
公开(公告)号：US06482943B1
公开(公告)日：2002-11-19
申请号：US09562980
申请日：2000-04-27
申请人： Andrei V. Blokhin , Benjamin Frydman , Laurence J. Marton , Karen M. Neder , Jerry Shunneng Sun
发明人： Andrei V. Blokhin , Benjamin Frydman , Laurence J. Marton , Karen M. Neder , Jerry Shunneng Sun
IPC分类号： C07B4700
CPC分类号： C07D295/185 , A61K38/00 , A61K47/65 , C07C45/00 , C07C45/46 , C07C46/00 , C07C50/32 , C07C67/343 , C07C69/708 , C07C69/96 , C07C229/22 , C07C233/31 , C07C237/22 , C07C255/54 , C07C305/20 , C07D207/34 , C07D219/10 , C07D235/18 , C07D307/79 , C07D307/92 , C07D311/92 , C07D317/70 , C07D493/04 , C07F9/12 , C07F9/65517 , C07F9/65522 , C07K5/1013 , C07K7/06 , C07C47/575 , C07C69/734
摘要： Novel quinones are provided, as well as compositions comprising these novel quinones. Methods of using the novel quinones in treatment of various indications including cancer are also provided.
摘要翻译：提供了新的醌，以及包含这些新型醌的组合物。还提供了使用该类醌来治疗各种适应症（包括癌症）的方法。

4. 发明授权

US06262257B1 Calixpyrroles, calixpyridinopyrroles and calixpyridines 失效
标题翻译：杯状吡咯，杯吡啶并吡咯和卡吡啶
公开(公告)号：US06262257B1
公开(公告)日：2001-07-17
申请号：US08833379
申请日：1997-04-04
申请人： Philip A. Gale , Jonathan L. Sessler , John W. Genge , Vladimír A. Král , Andrei Andrievsky , Vincent Lynch , Petra I. Sansom , William E. Allen , Christopher T. Brown , Andreas Gebauer
发明人： Philip A. Gale , Jonathan L. Sessler , John W. Genge , Vladimír A. Král , Andrei Andrievsky , Vincent Lynch , Petra I. Sansom , William E. Allen , Christopher T. Brown , Andreas Gebauer
IPC分类号： C07B4700
CPC分类号： G01N30/482 , B01J45/00 , B01J2220/54 , C07D487/22 , C07D495/22 , C07D498/22 , C07F17/02 , G01N30/02 , G01N30/88 , G01N2030/484 , G01N2030/8818 , G01N2030/8836 , G21F9/06 , G21F9/12 , B01D15/26
摘要： The present invention provides calixpyrrole, calixpyridinopyrrole, and calixpyridine macrocycles, having 4, 5, 6, 7, or 8 heterocyclic rings, as well as syntheses, derivatives, conjugates, multimers, and solid supports thereof. Such macrocycles have proved to be effective and selective ion- and neutral molecule-binding agents forming supramolecular ensembles, and ion- and neutral molecule-separation agents. The macrocycles are fully meso-non-hydrogen-substituted porphyrinogens, a few molecules of which were previously known but not recognized as possessing anion- or molecule-binding properties. The binding mode is noncovalent, primarily that of hydrogen-bonding, thereby providing a new mode for liquid chromatography, that of Hydrogen Bonding Liquid Chromatography. Further useful applications of the macrocycles provided herein include environmental remediation by removal of undesired ions or neutral molecules, and removal of phosphate for kidney dialysis.
摘要翻译：本发明提供具有4,5,6,7或8个杂环的杯状吡咯，杯状吡啶并吡咯和杯状吡啶大环，以及其合成，衍生物，缀合物，多聚体和固体支持物。已经证明这种大环化合物是有效和选择性的离子和中性分子结合剂形成超分子集合，以及离子和中性分子分离剂。大环是完全中和非氢取代的卟啉原子，其中几个分子先前已知但不被认为具有阴离子或分子结合性质。结合模式是非共价键，主要是氢键合，因此提供了液相色谱法，氢键合液相色谱法的新模式。本文提供的大环的进一步有用的应用包括通过去除不需要的离子或中性分子进行环境修复，以及除去用于肾透析的磷酸盐。

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