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1. 发明授权

US4782164A Process for synthesizing active esters of carboxylic acids 失效
标题翻译：合成羧酸活性酯的方法
公开(公告)号：US4782164A
公开(公告)日：1988-11-01
申请号：US801081
申请日：1985-11-22
申请人： Gerard Barcelo , Bertrand Castro , Mahmoud Jaouadi , Jean Martinez , Jean-Pierre Senet , Gerard Sennyey
发明人： Gerard Barcelo , Bertrand Castro , Mahmoud Jaouadi , Jean Martinez , Jean-Pierre Senet , Gerard Sennyey
IPC分类号： C07B41/10 , C07B41/00 , C07B51/00 , C07C67/00 , C07C68/02 , C07C68/06 , C07C69/96 , C07C205/43 , C07C239/00 , C07C239/22 , C07C271/22 , C07D207/40 , C07D207/404 , C07D207/46 , C07D209/48 , C07D249/18 , C07D295/10 , C07D295/22 , C07D409/12 , C07K1/10 , C07K5/078 , C07K5/097 , C07D209/32 , C07D409/06
CPC分类号： C07D409/12 , C07C201/12 , C07C271/22 , C07C68/02 , C07D207/404 , C07D207/46 , C07D249/18 , C07K1/10 , C07K5/0823 , C07C2101/08
摘要： The invention relates to a new process for preparing active esters or carboxylic acids, which consists in reacting a carboxylic acid, in the presence of an agent for binding hydrohalic acid, with a carbonate of formula: ##STR1## in which R.sup.1 denotes either a radical of formula ##STR2## in which R.sup.3 and R.sup.4, which may be identical or different, are not hydrogen atoms and denote organic radicals which may be substituted or unsubstituted and saturated or unsaturated, and may be or may not be bound to a polymer, and which can be joined together to form a hetero-cyclic system with the nitrogen atom,or a substituted or unsubstituted aryl radical which may or may not be bound to a polymer,R.sup.2 denotes a hydrogen atom, an aliphatic or cycloaliphatic radical which may be substituted or unsubstituted and saturated or unsaturated, or a substituted or unsubstituted aromatic radical,and X denotes a halogen atom.This process is especially useful for the synthesis of active esters of N-protected amino acids. The invention also relates to the new carbonates described above and the method of producing them, which consists in reacting an alpha-halogenated chloroformate of formula:R.sup.2 --CHX--O--COClwith an alcohol of formula R.sup.1 OH in an inert solvent medium of the presence of an organic or inorganic base.
摘要翻译：本发明涉及一种制备活性酯或羧酸的新方法，其中包括使羧酸在用于结合氢卤酸的试剂存在下与下式的碳酸酯反应：其中R 1表示基团其中可以相同或不同的R 3和R 4不是氢原子并且表示可以是取代或未取代的和饱和或不饱和的有机基团，并且可以是或可以不与聚合物结合，并且其可以连接在一起以形成具有氮原子的杂环系统，或可以或不结合到聚合物的取代或未取代的芳基，R2表示氢原子，可以被取代的脂族或脂环族基团或未取代的，饱和的或不饱和的，或取代或未取代的芳基，X表示卤素原子。该方法对于合成N-保护的氨基酸的活性酯特别有用。本发明还涉及上述新的碳酸酯及其制备方法，该方法包括使式R 2 -CHO-O-COCl的α-卤代氯甲酸酯与式R 1 OH的醇在惰性溶剂介质中反应，的有机或无机碱。

2. 发明授权

US4806286A Process for the preparation of acid chlorides by phosgenation of acids, and catalysts for this process 失效
标题翻译：通过酸的光气化制备酰氯的方法和该方法的催化剂
公开(公告)号：US4806286A
公开(公告)日：1989-02-21
申请号：US888208
申请日：1986-07-23
申请人： Jean-Pierre Senet , Patricia Gauthier , Thierry Malfroot , Patrick Wolf
发明人： Jean-Pierre Senet , Patricia Gauthier , Thierry Malfroot , Patrick Wolf
IPC分类号： B01J31/00 , B01J31/02 , C07B31/00 , C07B41/10 , C07B61/00 , C07C51/00 , C07C51/60 , C07C53/38 , C07C57/64 , C07C63/00 , C07C67/00
CPC分类号： C07C51/60
摘要： The invention relates to a new process for the preparation of carboxylic acid chlorides by phosgenation of the corresponding carboxylic acid in the presence of a catalyst.This process is characterized in that the said catalyst is chosen from the compounds represented by the formulae ##STR1## in which R.sub.1 to R.sub.6, which are identical of different, denote: aliphatic, alicyclic, araliphatic or aromatic radicals,or form, in pairs, with the nitrogen atom to which they are attached or with the N-C-N group, a 5- or 6-membered heterocyclic ring.The process applies to most carboxylic acids.The acid chlorides obtained are known and used to produce radical polymerization initiators or pesticides.
摘要翻译：本发明涉及在催化剂存在下通过相应羧酸的光气化制备羧酸氯化物的新方法。该方法的特征在于所述催化剂选自由下式表示的化合物：其中不同的相同的R 1至R 6表示：脂族，脂环族，芳脂族或芳族基团或与其所连接的氮原子或NCN基团成对形成5-或6-元杂环。该过程适用于大多数羧酸。获得的酰氯是已知的并且用于产生自由基聚合引发剂或杀虫剂。

3. 发明授权

US4301186A Ammonium salts of .alpha.-ketocarboxylic acids 失效
标题翻译： α-酮羧酸的铵盐
公开(公告)号：US4301186A
公开(公告)日：1981-11-17
申请号：US53009
申请日：1979-06-28
申请人： Wolfram Mayer , Hans Rudolph , Eckhard De Cleur , Manfred Schonfelder
发明人： Wolfram Mayer , Hans Rudolph , Eckhard De Cleur , Manfred Schonfelder
IPC分类号： C07D333/24 , C07B31/00 , C07B41/10 , C07C51/00 , C07C59/76 , C07C59/84 , C07C59/88 , C07C59/90 , C07C65/38 , C07C67/00 , C07C201/00 , C07C205/56 , C07C231/00 , C07C235/76 , C07C235/78 , C07C235/84 , C07C253/00 , C07C255/23 , C07C255/41 , C07C313/00 , C07C323/62 , C07D487/08 , C09D163/00 , C09D175/00 , B05D3/06
CPC分类号： C07D487/08 , C07C59/84 , C07C59/88 , C07C59/90
摘要： This invention relates to new ammonium salts of .alpha.-ketocarboxylic acids, to their use for the production of amines in situ by photochemical decomposition and to photochemically hardenable coating compositions containing these ammonium salts.
摘要翻译：本发明涉及α-酮羧酸的新型铵盐，其用于通过光化学分解原位生产胺和用于含有这些铵盐的光化学硬化涂料组合物。

4. 发明授权

US5670685A Process for preparing carboxylates of polyoxyalkylene siloxanes 失效
标题翻译：制备聚氧化烯硅氧烷的羧酸盐的方法
公开(公告)号：US5670685A
公开(公告)日：1997-09-23
申请号：US471809
申请日：1995-06-06
申请人： Parfait J. M. Likibi , Robert V. Casciani , Gregory L. McCraw
发明人： Parfait J. M. Likibi , Robert V. Casciani , Gregory L. McCraw
IPC分类号： C07C69/708 , A61K8/44 , A61K8/58 , A61K8/73 , A61K8/894 , A61K8/897 , A61Q19/00 , C07B41/10 , C07B43/04 , C07C51/27 , C07C217/08 , C07C231/12 , C07C235/08 , C07F7/08 , C07F9/00 , C07F9/24 , C07H15/04 , C08B37/00 , C08G65/22 , C08G65/32 , C08G65/321 , C08G65/323 , C08G65/324 , C08G65/333 , C08G65/336 , C08G65/48 , C08G77/14 , C08G77/38 , C08G77/42 , C08G77/46 , C08G85/00 , C11D1/06 , C11D1/10 , C11D3/22 , C11D3/36 , C11D3/37
CPC分类号： C11D3/3738 , A61K8/44 , A61K8/585 , A61K8/608 , A61K8/73 , A61K8/86 , A61K8/894 , A61Q19/00 , C07H15/04 , C08B37/00 , C08G65/321 , C08G65/323 , C08G65/324 , C08G65/333 , C08G65/33396 , C08G65/336 , C08G77/38 , C08G77/46 , C11D1/06 , C11D1/10 , C11D3/225 , C11D3/364 , C11D3/3742
摘要： A process for preparing carboxylates of polyoxyalkylene siloxanes and -amines, alkylpolyoxyalkylenes, polyoxyalkylene block polymers, alkylamidepolyoxyalkylenes and alkylpolyglucosides comprising subjecting a primary hydroxyl group-containing polyoxyalkylene compound or alkylpolyglucoside to mild oxidiation. The invention also relates to the novel polyoxyalkylene amine and alkylamidepolyoxyalkylene carboxylates prepared by the process.
摘要翻译：一种制备聚氧化烯硅氧烷和胺的羧酸盐的方法，烷基聚氧化烯，聚氧化烯嵌段聚合物，烷基酰胺聚氧化烯和烷基聚葡糖苷，包括使含有伯羟基的聚氧化烯化合物或烷基聚葡糖苷进行温和的氧化。本发明还涉及通过该方法制备的新型聚氧化烯胺和烷基酰胺聚氧化烯羧酸盐。

5. 发明授权

US5334756A Carboxylate of certain polyoxyalkylene amines 失效
标题翻译：某些聚氧化烯胺的羧酸酯
公开(公告)号：US5334756A
公开(公告)日：1994-08-02
申请号：US675220
申请日：1991-03-26
申请人： Parfait J. M. Likibi , Robert V. Casciani , Gregory L. McCraw
发明人： Parfait J. M. Likibi , Robert V. Casciani , Gregory L. McCraw
IPC分类号： C07C69/708 , A61K8/44 , A61K8/58 , A61K8/73 , A61K8/894 , A61K8/897 , A61Q19/00 , C07B41/10 , C07B43/04 , C07C51/27 , C07C217/08 , C07C231/12 , C07C235/08 , C07F7/08 , C07F9/00 , C07F9/24 , C07H15/04 , C08B37/00 , C08G65/22 , C08G65/32 , C08G65/321 , C08G65/323 , C08G65/324 , C08G65/333 , C08G65/336 , C08G65/48 , C08G77/14 , C08G77/38 , C08G77/42 , C08G77/46 , C08G85/00 , C11D1/06 , C11D1/10 , C11D3/22 , C11D3/36 , C11D3/37 , C07C229/00
CPC分类号： C11D3/3738 , A61K8/44 , A61K8/585 , A61K8/608 , A61K8/73 , A61K8/86 , A61K8/894 , A61Q19/00 , C07H15/04 , C08B37/00 , C08G65/321 , C08G65/323 , C08G65/324 , C08G65/333 , C08G65/33396 , C08G65/336 , C08G77/38 , C08G77/46 , C11D1/06 , C11D1/10 , C11D3/225 , C11D3/364 , C11D3/3742
摘要： A process for preparing carboxylates of polyoxyalkylene siloxanes and -amines, alkylpolyoxyalkylenes, polyoxyalkylene block polymers, alkylamidepolyoxyalkylenes and alkylpolyglucosides comprising subjecting a primary hydroxyl group-containing polyoxyalkylene compound or alkylpolyglucoside to mild oxidiation. The invention also relates to the novel polyoxyalkylene amine and alkylamidepolyoxyalkylene carboxylates prepared by the process.
摘要翻译：一种制备聚氧化烯硅氧烷和胺的羧酸盐的方法，烷基聚氧化烯，聚氧化烯嵌段聚合物，烷基酰胺聚氧化烯和烷基聚葡糖苷，包括使含有伯羟基的聚氧化烯化合物或烷基聚葡糖苷进行温和的氧化。本发明还涉及通过该方法制备的新型聚氧化烯胺和烷基酰胺聚氧化烯羧酸盐。

6. 发明授权

US4435575A Process for preparing carboxylated organic compounds 失效
标题翻译：制备羧基有机化合物的方法
公开(公告)号：US4435575A
公开(公告)日：1984-03-06
申请号：US279090
申请日：1981-06-30
申请人： Gianfranco Cainelli , Marco Foa' , Achille U. Ronchi , Andrea Gardano
发明人： Gianfranco Cainelli , Marco Foa' , Achille U. Ronchi , Andrea Gardano
IPC分类号： C07C69/614 , B01J31/00 , B01J31/20 , C07B31/00 , C07B41/08 , C07B41/10 , C07B41/12 , C07B61/00 , C07C51/00 , C07C51/10 , C07C57/32 , C07C67/00 , C07C67/36 , C07C69/38 , C07D307/54
CPC分类号： C07C51/10 , C07D307/54
摘要： A process is herein described for preparing carboxylated organic compounds (acids, esters, alkaline salts) of formula ##STR1## wherein R is a hydrocarbyl group having up to 11 carbon atoms (an aliphatic, alicyclic, aryl- or heteroarylalkyl group), also substituted, in its turn, by groups inert under the reaction conditions (alkyl, aryl, etheric, thioetheric, halogen, nitrile, ester, amide, ketonic groups), and R' is a hydrogen atom or an alkyl C.sub.1 -C.sub.8 group, by reaction of carbon monoxide with the corresponding hydrocarbyl halides, having the halogen bound to a non-tertiary carbon atom, in the presence of catalysts which are salts of cobalt hydrocarbonyl, or precursors thereof, in a hydro-alcoholic or alcoholic solvent and in the presence of bases.The process is characterized in that the catalytic system composed by the salt of cobalt hydrocarbonyl is supported on an anion exchange resin. The process permits to operate also continuously, in any case allowing an easy recovery, recycle and regeneration of the catalysts.The products obtained, i.e. carboxylic acids, esters and alkaline salts thereof, are utilized as intermediates for organic syntheses particularly for fine chemistry (phytopharmaceuticals, pharmaceuticals, etc.).
摘要翻译：本文描述了制备式（IMAGE）的羧化有机化合物（酸，酯，碱性盐）的方法，其中R是具有至多11个碳原子的烃基（脂族，脂环族，芳基或杂芳基烷基），也被取代（烷基，芳基，醚基，硫醚，卤素，腈，酯，酰胺，酮基）为惰性的基团，R'为氢原子或C1-C8烷基，通过反应的一氧化碳与相应的烃基卤化物，其卤素与非叔碳原子结合，在催化剂存在下，在氢醇或醇溶剂中存在钴烃基或其前体的催化剂存在下，基地该方法的特征在于将由烃基烃基组成的催化体系负载在阴离子交换树脂上。该方法允许连续操作，在任何情况下允许催化剂的容易回收，再循环和再生。获得的产物，即羧酸，其酯和碱金属盐被用作有机合成的中间体，特别用于精细化学（植物药物，药物等）。

7. 发明授权

US3709934A Method of making carboxylic acid anhydrides 失效
标题翻译：制备羧酸类抗坏血酸的方法
公开(公告)号：US3709934A
公开(公告)日：1973-01-09
申请号：US3709934D
申请日：1970-02-27
申请人： ROEHM & HAAS GMBH
发明人： GRUBER W , KLEINE DOEPKE W , QUIS P , SCHROEDER G
IPC分类号： C07C53/00 , B01J21/00 , B01J23/00 , B01J31/00 , C07B31/00 , C07B41/10 , C07B61/00 , C07C51/00 , C07C51/56 , C07C57/04 , C07C63/00 , C07C67/00
CPC分类号： C07C51/56
摘要： METHOD OF MAKING CARBOXYLIC ACID ANHYDRIDES BY REACTING DICYAN AND A CARBOXYLIC ACID.

8. 发明授权

US5847117A Reagent and catalytic process useful for cleaving a protected functional group 失效
标题翻译：用于切割受保护的官能团的试剂和催化方法
公开(公告)号：US5847117A
公开(公告)日：1998-12-08
申请号：US107903
申请日：1993-08-18
申请人： Jean-Marie Bernard , Errol Blart , Jean-Pierre Genet , Monique Savignac , Sandrine Lemaire-Audoire
发明人： Jean-Marie Bernard , Errol Blart , Jean-Pierre Genet , Monique Savignac , Sandrine Lemaire-Audoire
IPC分类号： B01J31/28 , B01J31/18 , B01J31/24 , C01B21/16 , C07B41/02 , C07B41/08 , C07B43/04 , C07B51/00 , C07B61/00 , C07C27/02 , C07C29/09 , C07C29/147 , C07C33/02 , C07C33/025 , C07C33/14 , C07C33/22 , C07C35/12 , C07C41/26 , C07C51/09 , C07C57/32 , C07C67/31 , C07C209/62 , C07C211/27 , C07C211/52 , C07C213/02 , C07C215/30 , C07C227/18 , C07C227/20 , C07C229/36 , C07C241/02 , C07C245/14 , C07D20060101 , C07D207/16 , C07D209/12 , C07D211/62 , C07D295/023 , C07D295/20 , C07D501/04 , C07F7/18 , C07F15/00 , C07H1/00 , C07H9/04 , C07H13/12 , C07H15/18 , C07H19/01 , C07K1/00 , C07K1/02 , C07K1/06 , C07K1/113 , C07K1/12 , C07K5/08 , C09K3/00 , C07B41/10
CPC分类号： C07F15/0066 , B01J31/18 , B01J31/24 , B01J31/2404 , C07H15/18 , C07H19/01 , C07K1/061 , C07K1/12 , B01J2231/40 , B01J2531/80 , B01J2531/824 , B01J2531/828 , B01J31/28
摘要： The subject matter of the present invention relates to a reagent and a process useful for cleaving a functional group protected by an alkoxycarbonyl group during an organic synthesis. This reagent comprises: a) an aqueous phase; b) a catalyst comprising at least one group VIII element in the periodic table of elements and at least one water-soluble ligand, wherein the group VIII element in the periodic table is maintained in the aqueous phase by the formation of a complex with at least one water-soluble ligand; and c) a nucleophilic compound soluble in the aqueous phase; and optionally d) an organic phase.
摘要翻译：本发明的主题涉及在有机合成中用于切割被烷氧基羰基保护的官能团的试剂和方法。该试剂包括：a）水相; b）包含元素周期表中至少一个VIII族元素和至少一种水溶性配体的催化剂，其中周期表中的VIII族元素通过至少形成络合物而保持在水相中一种水溶性配体; 和c）可溶于水相的亲核化合物; 和任选地d）有机相。

9. 发明授权

US5668261A Process for preparing carboxylates of alkylpolyglucosides 失效
标题翻译：制备烷基聚葡萄糖苷羧酸盐的方法
公开(公告)号：US5668261A
公开(公告)日：1997-09-16
申请号：US612146
申请日：1996-03-07
申请人： Parfait J. M. Likibi , Robert V. Casciani , Gregory L. McCraw
发明人： Parfait J. M. Likibi , Robert V. Casciani , Gregory L. McCraw
IPC分类号： C07C69/708 , A61K8/44 , A61K8/58 , A61K8/73 , A61K8/894 , A61K8/897 , A61Q19/00 , C07B41/10 , C07B43/04 , C07C51/27 , C07C217/08 , C07C231/12 , C07C235/08 , C07F7/08 , C07F9/00 , C07F9/24 , C07H15/04 , C08B37/00 , C08G65/22 , C08G65/32 , C08G65/321 , C08G65/323 , C08G65/324 , C08G65/333 , C08G65/336 , C08G65/48 , C08G77/14 , C08G77/38 , C08G77/42 , C08G77/46 , C08G85/00 , C11D1/06 , C11D1/10 , C11D3/22 , C11D3/36 , C11D3/37 , C07H15/00
CPC分类号： C11D3/3738 , A61K8/44 , A61K8/585 , A61K8/608 , A61K8/73 , A61K8/86 , A61K8/894 , A61Q19/00 , C07H15/04 , C08B37/00 , C08G65/321 , C08G65/323 , C08G65/324 , C08G65/333 , C08G65/33396 , C08G65/336 , C08G77/38 , C08G77/46 , C11D1/06 , C11D1/10 , C11D3/225 , C11D3/364 , C11D3/3742
摘要： A process for preparing carboxylates of polyoxyalkylene siloxanes and -amines, alkylpolyoxyalkylenes, polyoxyalkylene block polymers, alkylamidepolyoxyalkylenes and alkylpolyglucosides comprising subjecting a primary hydroxyl group-containing polyoxyalkylene compound or alkylpolyglucoside to mild oxidiation. The invention also relates to the novel polyoxyalkylene amine and alkylamidepolyoxyalkylene carboxylates prepared by the process.
摘要翻译：一种制备聚氧化烯硅氧烷和胺的羧酸盐的方法，烷基聚氧化烯，聚氧化烯嵌段聚合物，烷基酰胺聚氧化烯和烷基聚葡糖苷，包括使含有伯羟基的聚氧化烯化合物或烷基聚葡糖苷进行温和的氧化。本发明还涉及通过该方法制备的新型聚氧化烯胺和烷基酰胺聚氧化烯羧酸盐。

10. 发明授权

US5493054A Process for the synthesis of acid halides and reactants useful for its implementation 失效
标题翻译：用于合成可用于其实施的酰卤和反应物的方法
公开(公告)号：US5493054A
公开(公告)日：1996-02-20
申请号：US313402
申请日：1994-09-27
申请人： Gerard Forat , Laurent Gilbert
发明人： Gerard Forat , Laurent Gilbert
IPC分类号： B01J27/128 , C07B41/10 , C07B61/00 , C07C51/60 , C07C53/38 , C07C63/10 , C07C51/58
CPC分类号： C07C51/60
摘要： The subject of the present invention is a new catalytic system and a process for the synthesis of acid halides, especially from haloforms. This process for halogenating by means of a haloform is characterized by the use of a metal chloride, advantageously trivalent, as a catalyst, the solubility of which in the reaction mixture is at least equal to one millimole, preferably 1/100 mole per liter, and the metal chloride also being at least half, advantageously two-thirds and preferably three-quarters in the dissolved state.
摘要翻译：本发明的主题是新的催化体系和用于合成酰卤的方法，特别是卤代。通过卤代甲醛卤化的该方法的特征在于使用有利地为三价的金属氯化物作为催化剂，其在反应混合物中的溶解度至少等于1毫摩尔，优选1/100摩尔/升，并且金属氯化物在溶解状态下也至少为一半，有利地为三分之二，优选为四分之三。

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