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1. 发明授权

US06706021B2 Heteroaryl aminoguanidines and alkoxyguanidines and their use as protease inhibitors 有权
标题翻译：杂芳基氨基胍和烷氧基胍及其作为蛋白酶抑制剂的用途
公开(公告)号：US06706021B2
公开(公告)日：2004-03-16
申请号：US10400073
申请日：2003-03-27
申请人： Tianbao Lu , Bruce E. Tomczuk , Thomas P. Markotan , Colleen Siedem
发明人： Tianbao Lu , Bruce E. Tomczuk , Thomas P. Markotan , Colleen Siedem
IPC分类号： A61M514
CPC分类号： C07D213/74 , C07D213/75 , C07D401/12 , C07D409/12 , C07K5/06139
摘要： Aminoguanidine and alkoxyguanidine compounds are described, including compounds of the Formula VII: wherein X is O or NR9 and Het, R1, R7, R8, R12-R15, Ra, Rb, Rc, Z, and n are set forth in the specification, as well as hydrates, solvates or pharmaceutically acceptable salts thereof, that inhibit proteolytic enzymes such as thrombin. Also described are methods for preparing such compounds. The compounds of the invention are potent inhibitors of proteases, especially trypsin-like serine proteases, such as chymotrypsin, trypsin, thrombin, plasmin and factor Xa. Certain of the compounds exhibit antithrombotic activity via direct, selective inhibition of thrombin. The invention includes a composition for inhibiting loss of blood platelets, inhibiting formation of blood platelet aggregates, inhibiting formation of fibrin, inhibiting thrombus formation, and inhibiting embolus formation in a mammal, comprising a compound of the invention in a pharmaceutically acceptable carrier. Other uses of compounds of the invention are as anticoagulants either embedded in or physically linked to materials used in the manufacture of devices used in blood collection, blood circulation, and blood storage, such as catheters, blood dialysis machines, blood collection syringes and tubes, blood lines and stents. Additionally, the compounds can be detectably labeled and employed for in vivo imaging of thrombi.
摘要翻译：描述了氨基胍和烷氧基胍化合物，包括式VII的化合物：其中X是O或NR 9，Het，R 1，R 7，R 8，R 12 -R 15， R a，R b，R c，Z和n在说明书中列出，以及抑制蛋白水解酶如凝血酶的水合物，溶剂合物或其药学上可接受的盐。还描述了制备这些化合物的方法。本发明的化合物是蛋白酶的有效抑制剂，特别是胰蛋白酶样丝氨酸蛋白酶，如胰凝乳蛋白酶，胰蛋白酶，凝血酶，纤溶酶和因子Xa。某些化合物通过直接，选择性抑制凝血酶表现出抗血栓形成活性。本发明包括用于抑制血小板损失，抑制血小板聚集体形成，抑制纤维蛋白形成，抑制血栓形成和抑制哺乳动物栓塞形成的组合物，其包含本发明化合物在药学上可接受的载体中。本发明化合物的其它用途是作为凝血剂或者物理上连接于用于血液收集，血液循环和血液储存（例如导管，血液透析机，采血注射器和管）中使用的装置的制造中使用的材料的抗凝剂，血线和支架。另外，化合物可以被可检测地标记并用于血栓的体内成像。

2. 发明授权

US06497699B1 Hybrid neuroprosthesis for the treatment of brain disorders 失效
标题翻译：混合神经假体用于治疗脑部疾病
公开(公告)号：US06497699B1
公开(公告)日：2002-12-24
申请号：US09634172
申请日：2000-08-09
申请人： Nandor Ludvig , Lorant Kovacs
发明人： Nandor Ludvig , Lorant Kovacs
IPC分类号： A61M514
CPC分类号： A61M5/14276 , A61M5/1723 , A61N1/0529 , A61N1/0531 , A61N1/08 , Y10S977/903
摘要： A miniature apparatus for the treatment of brain disorders is provided which is a combination of electronic and pharmacological devices placed and powered entirely within the human body. The apparatus is based on the dual, electrical—molecular, nature of intercellular communication in the brain. The hybrid neuroprosthesis monitors the electrical activity of a dysfunctioning brain area, analyzes the incoming electrical signals, and delivers drug molecules into the dysfunctioning area to correct its function. The apparatus delivers drugs into the brain in such a way that the timing and duration of the drug deliveries are determined by the brain's own electrical activity. The hybrid neuroprosthesis includes (a) an electrophysiological recording electrode implanted in a dysfunctioning brain site, (b) a miniature electrical signal conditioner to amplify, filter and digitize the incoming electrophysiological signals, (c) a cannula or catheter implanted in the dysfunctioning brain site, (d) a miniature, refillable pump for driving drug solutions through the cannula or catheter, (e) a microcontroller which analyzes on-line the digitized electrophysiological signals and either activates or inactivates the pump on the basis of the analyzed electrophysiological data, (f) a miniature radiotelemetry system which provides data transfer between the apparatus and the outside world, and (g) a rechargeable power supply to power the components of the apparatus. The recording electrode can be complemented with a neurochemical sensor to transmit not only electrophysiological but also neurochemical information from the dysfunctioning brain area to the microcontroller. The components of the apparatus are encapsulated in medical grade silicon.
摘要翻译：提供了用于治疗脑部疾病的微型装置，其是放置并完全在人体内供电的电子和药理学装置的组合。该装置基于大脑中细胞间通讯的双重电分子性质。混合神经假体监测功能障碍的大脑区域的电活动，分析进入的电信号，并将药物分子输送到功能障碍区域以校正其功能。该装置以药物递送的时间和持续时间由大脑自身的电活动决定的方式将药物输送到大脑中。混合神经假体包括（a）植入功能障碍的脑部位的电生理记录电极，（b）微型电信号调节器，用于放大，滤波和数字化进入的电生理信号，（c）植入功能障碍性脑部位的插管或导管（d）用于通过插管或导管驱动药物溶液的微型可重新填充的泵，（e）在线分析数字化电生理信号并且基于所分析的电生理数据激活或停用泵的微控制器（ f）提供设备和外界之间的数据传输的微型无线电测距系统，以及（g）用于为设备的组件提供动力的可再充电电源。记录电极可以用神经化学传感器补充，不仅将电生理学而且将神经化学信息从功能障碍的大脑区域传递到微控制器。该装置的组件被封装在医用级硅中。

3. 发明授权

US06416499B2 Medical fluid flow control valve 失效
标题翻译：医用流体流量控制阀
公开(公告)号：US06416499B2
公开(公告)日：2002-07-09
申请号：US09126335
申请日：1998-07-30
申请人： Ram H. Paul, Jr.
发明人： Ram H. Paul, Jr.
IPC分类号： A61M514
CPC分类号： A61M39/0606 , A61M39/0613 , A61M2039/062 , A61M2039/0633 , A61M2039/064 , A61M2039/0653 , A61M2039/066
摘要： A valve (10) useful as a fluid flow check valve or as a self-sealing, penetrable, hemostatic valve for sealing a catheter introducer (12) includes a seal (26) which is highly resistant to tearing and leakage, yet is capable of accepting repeated penetrations by devices of a wide variety of diameters. The seal (26) is disk-shaped and is composed of a thermoplastic styrenic elastomer, such as a styrene-ethylene/butylene-styrene block copolymer, of very low durometer (a hardness of no more than about 30 Shore A). The seal (26) is preferably contained in a valve body (40) and is disposed between a valve seat (48) in the valve body (40) and a cap (56) connected to the valve body (40) and becomes deflected upon assembly of the valve. The seal (26) includes at least one perforation (34) closed by such deflection. This deflection also provides the seal (26) with a proximal or upstream concave surface (30), and this deflection along with the clamping of the periphery of the seal by and between the cap and the valve seat, makes it highly resistant to inversion during repeated removals and manipulations of interventional devices passing through the valve (10). The valve (10) of the present invention is particularly advantageous in that it seals the introducer (12) with a high degree of effectiveness when no interventional device lies across its seal (26), and in that it offers a high resistance to tearing when penetrated by devices of large diameter.
摘要翻译：用作流体流动止回阀或用作密封导管引入器（12）的自密封，可穿透的止血阀的阀（10）包括密封件（26），其高度抵抗撕裂和渗漏，但是能够接受由各种直径的装置重复的穿透。密封件（26）是圆盘形的，并且由诸如苯乙烯 - 乙烯/丁烯 - 苯乙烯嵌段共聚物的热塑性苯乙烯弹性体组成，其硬度非常低（硬度不超过约30肖氏A）。密封件26优选地包含在阀体40中并且设置在阀体40内的阀座48和与阀体40连接的盖56之间，组装阀门。密封件（26）包括由这种偏转关闭的至少一个穿孔（34）。该偏转还使密封件（26）具有近端或上游凹形表面（30），并且这种偏转以及由帽盖和阀座之间以及在阀座之间夹紧密封件的周边使得其在通过阀（10）的介入装置的重复移除和操作。本发明的阀（10）特别有利的是，当没有介入装置位于其密封件（26）上时，它以高效率的方式密封导引器（12），并且因为它提供了高的撕裂能力穿透大直径的装置。

4. 发明授权

US06805685B2 In-line IV drug delivery pack with controllable dilution 失效
公开(公告)号：US06805685B2
公开(公告)日：2004-10-19
申请号：US10712747
申请日：2003-11-12
申请人： Michael A. Taylor
发明人： Michael A. Taylor
IPC分类号： A61M514
CPC分类号： A61M5/1409
摘要： An in-line drug delivery pack that connects in-line with an intravenous (IV) line and allows for the mixing of diluent with a drug reagent to be delivered to the patient. An internal drug bed bypass mechanism is tailored to apportion diluent flow between the bypass and the drug bed. The apportionment is selected to achieve a solution concentration suitable for IV administration as the dried reagent is dissolved. Thus, both dissolution and precisely tailored dilution are performed in the same simple device.

5. 发明授权

US06685670B2 Apparatus and method for preventing free flow in an infusion line 有权
标题翻译：用于防止输注管线中的自由流动的装置和方法
公开(公告)号：US06685670B2
公开(公告)日：2004-02-03
申请号：US10122116
申请日：2002-04-12
申请人： Scott Miles , Kent F. Beck , James Malmstrom
发明人： Scott Miles , Kent F. Beck , James Malmstrom
IPC分类号： A61M514
CPC分类号： A61M5/16813 , A61M5/14 , A61M5/142 , A61M5/14228 , A61M5/14232 , A61M39/22 , A61M39/24 , A61M39/281 , A61M39/287 , A61M2039/242 , A61M2039/2426 , A61M2039/2473 , A61M2039/248 , A61M2039/2486 , A61M2205/12 , Y10T137/87917
摘要： An apparatus and method for preventing free flow through an infusion set utilizes an occluder disposed within the infusion set to selectively prevent flow therethrough. The occluder may be responsive to a pressure differential within the infusion set or may respond to compression of the infusion set. When a pair of occluders are used in sequence, an in-line pump may be formed.
摘要翻译：用于防止自由流动通过输液器的装置和方法利用设置在输注器内的阻塞器来选择性地防止流过其中。封堵器可以响应于输注组件内的压力差，或者可以对输注装置的压缩作出响应。当依次使用一对闭塞器时，可以形成直列泵。

6. 发明授权

US06673052B2 Nonreturn warning device for an intravenous drip infusion 失效
标题翻译：用于静脉滴注的止回警告装置
公开(公告)号：US06673052B2
公开(公告)日：2004-01-06
申请号：US10075383
申请日：2002-02-15
申请人： Hai-Su Huang
发明人： Hai-Su Huang
IPC分类号： A61M514
CPC分类号： A61M5/40 , A61M5/1411 , A61M5/1684 , A61M5/1685 , A61M2205/18
摘要： The present invention relates to a nonreturn warning device for an intravenous drip infusion which includes a top member and a bottom member both of which forms an accommodation which has an inlet pipe and an outlet pipe at the top and bottom thereof. The outlet pipe includes a flange around which a recess is provided. A conic valve with a middle hole is arranged onto the flange. A float with a cylindrical stopper is received in the accommodation formed after connection of the top member and the bottom member. The middle section of the float contains a magnetic element, and a warning device is fitted beside the top member. Besides, a magnetic reed switch is installed in the warning device. As the float sinks with the fluid surface in the accommodation, the magnetic element approaches the magnetic reed switch and the magnetic force of the float will activate a buzzer for giving out a warning sound which is transmitted through a headphone jack or a radio transmitter to the nurses' call station. Moreover, the cylindrical stopper is inserted through the middle hole of the conic valve when the float sinks with the fluid surface in the accommodation. And the outlet pipe can be sealed at the end of the intravenous drip in order for nurses to replace an I.V. container. Furthermore, the nonreturn warning device for an intravenous drip infusion is repeatedly usable.
摘要翻译：本发明涉及一种用于静脉滴注的不返回警告装置，其包括顶部构件和底部构件，两者都构成在其顶部和底部具有入口管和出口管的容纳物。出口管包括一个凸缘，在该凸缘周围设有凹部。法兰上设有一个带中间孔的锥形阀。具有圆柱形止动器的浮子被容纳在顶部构件和底部构件连接之后形成的容置中。浮子的中间部分包含磁性元件，并在顶部构件旁边安装警告装置。此外，警报装置中安装有磁簧开关。当浮子与容纳物中的流体表面一起陷入时，磁性元件接近磁簧开关，并且浮子的磁力将激活蜂鸣器以发出通过耳机插孔或无线电发射器传输的警告声音到护士通话站。此外，当浮子与容器中的流体表面一起沉入时，圆柱形止动件插入锥形阀的中间孔中。并且出口管可以在静脉滴注结束时密封，以便护士更换I.V. 容器。此外，可以重复使用用于静脉滴注的非返回警告装置。

7. 发明授权

US06595950B1 Apparatus and method for preventing free flow in an infusion line 有权
公开(公告)号：US06595950B1
公开(公告)日：2003-07-22
申请号：US09569332
申请日：2000-05-11
申请人： Scott Miles , Kent F. Beck , James Malmstrom
发明人： Scott Miles , Kent F. Beck , James Malmstrom
IPC分类号： A61M514
CPC分类号： A61M5/16813 , A61M5/14 , A61M5/142 , A61M5/14228 , A61M5/14232 , A61M39/22 , A61M39/24 , A61M39/281 , A61M39/287 , A61M2039/242 , A61M2039/2426 , A61M2039/2473 , A61M2039/248 , A61M2039/2486 , A61M2205/12 , Y10T137/87917
摘要： An apparatus and method for preventing free flow through an infusion set utilizes an occluder disposed within the infusion set to selectively prevent flow therethrough. The occluder may be responsive to a pressure differential within the infusion set or may respond to compression of the infusion set. When a pair of occluders are used in sequence, an in-line pump may be formed.

8. 发明授权

US06391001B1 Intravenous line flushing device 失效
标题翻译：静脉注射冲洗装置
公开(公告)号：US06391001B1
公开(公告)日：2002-05-21
申请号：US09666927
申请日：2000-09-21
申请人： Jolie Graham , Joyce R. Varhola
发明人： Jolie Graham , Joyce R. Varhola
IPC分类号： A61M514
CPC分类号： A61M5/1486 , A61M5/165 , A61M5/36 , A61M2005/1403 , Y10S128/12
摘要： An intravenous line flushing device for preventing clotting of blood by the addition of saline solution to an intravenous line. The intravenous line flushing device includes a sleeve having an inner panel and an outer panel. Each of the panels has a top edge and a bottom edge. The top edge of the inner panel is integrally coupled to the top edge of the outer panel, and the bottom edge of the inner panel is integrally coupled to the bottom edge of the outer panel such that a space is defined between the inner and outer panels. The inner and outer panels are substantially air impermeable. A generally sealed container is positioned in the space between the inner and outer panels. A first agent is disposed in the space. A second agent is disposed in the container. Breaking the container mixes the first and second agents such that a gas is produced, which inflates the sleeve. A primary tube has a first end and a second end. The first end is adapted to removably fluidly engage a pouch. A secondary tube has a first end and a second end. The first end is fluidly coupled to the primary tube and positioned generally between the first and second ends of the primary tube. The second end of the secondary tube comprises a primary infusion port. The pouch contains a solution. The pouch is placed in the sleeve such that inflation of the sleeve forces the solution into the primary tube.
摘要翻译：一种静脉内管线冲洗装置，用于通过向静脉内管线中加入盐水溶液来防止血液凝结。静脉管线冲洗装置包括具有内板和外板的套筒。每个面板具有顶部边缘和底部边缘。内板的顶边一体地联接到外板的顶部边缘，并且内板的底边一体地联接到外板的底边缘，使得在内板和外板之间限定一个空间。内外板基本上是不透气的。通常密封的容器位于内板和外板之间的空间中。第一代理人被安置在该空间中。将第二药剂置于容器中。打破容器混合第一和第二试剂，使得产生气体，使气囊膨胀。主管具有第一端和第二端。第一端适于可移除地流体地接合袋。次级管具有第一端和第二端。第一端流体耦合到主管并且大致位于主管的第一和第二端之间。第二管的第二端包括一个主要输液口。袋包含一个解决方案。将袋放置在套筒中，使得套筒的膨胀迫使溶液进入主管。

9. 发明授权

US06699225B2 Mixing/charging port for medical treatment 失效
标题翻译：混合/充电口用于医疗
公开(公告)号：US06699225B2
公开(公告)日：2004-03-02
申请号：US09963834
申请日：2001-09-25
申请人： Ryoji Fujii
发明人： Ryoji Fujii
IPC分类号： A61M514
CPC分类号： A61M39/045 , Y10S604/905
摘要： A mixing/charging port for medical treatment capable of cleanly wiping out a residual liquid, residual blood, or the like. The mixing/charging port includes a disk-like valve having an insertion hole at the center, a seating for supporting a lower part of the periphery of the valve, and a cover for restraining the valve. A fitting hole defined by an inner edge portion of the cover works as an anchor for anchoring an insertion member to the mixing/charging port, the thickness of the center of the valve is larger than the thickness of the periphery of the valve, and the thickness of the edge portion of the cover provided with the fitting hole substantially corresponds to the difference between the thickness of the center of the valve and the thickness of the periphery of the valve.
摘要翻译：用于医疗处理的混合/充气口，其能够清洁残留的液体，残余血液等。混合/充气口包括在中心具有插入孔的盘状阀，用于支撑阀的周边下部的阀座和用于限制阀的盖。由盖的内缘部分限定的装配孔用作将插入构件固定到混合/充气口的锚固件，阀的中心厚度大于阀的周边的厚度，并且设置有装配孔的盖的边缘部的厚度基本上对应于阀的中心的厚度和阀的周边的厚度之间的差。

10. 发明授权

US06676632B2 In-line IV drug delivery pack with controllable dilution 失效
公开(公告)号：US06676632B2
公开(公告)日：2004-01-13
申请号：US10358443
申请日：2003-02-03
申请人： Michael A. Taylor
发明人： Michael A. Taylor
IPC分类号： A61M514
CPC分类号： A61M5/1409
摘要： An in-line drug delivery pack that connects in-line with an intravenous (IV) line and allows for the mixing of diluent with a drug reagent to be delivered to the patient. An internal drug bed bypass mechanism is tailored to apportion diluent flow between the bypass and the drug bed. The apportionment is selected to achieve a solution concentration suitable for IV administration as the dried reagent is dissolved. Thus, both dissolution and precisely tailored dilution are performed in the same simple device.

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