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1. 发明授权

US06274160B1 Methods of use of histamine H2 agonists in treating dry eye 失效
标题翻译：使用组胺H2激动剂治疗干眼症的方法
公开(公告)号：US06274160B1
公开(公告)日：2001-08-14
申请号：US09529837
申请日：2000-04-19
申请人： Steven T. Miller , Daniel A. Gamache , John M. Yanni
发明人： Steven T. Miller , Daniel A. Gamache , John M. Yanni
IPC分类号： A61K906
CPC分类号： A61K31/425 , A61K31/17 , A61K31/4178 , Y10S514/887 , Y10S514/944
摘要： A topical ophthalmic composition for the treatment of dry eye in humans, comprising one or more histamine H2 agonists, is disclosed.
摘要翻译：公开了一种用于治疗人类干眼症的局部用眼用组合物，其包含一种或多种组胺H2激动剂。

2. 发明授权

US06723349B1 Polyoxometalate materials, metal-containing materials, and methods of use thereof 失效
标题翻译：多金属氧酸盐材料，含金属材料及其使用方法
公开(公告)号：US06723349B1
公开(公告)日：2004-04-20
申请号：US09689231
申请日：2000-10-11
申请人： Craig L. Hill , Ling Xu , Jeffrey T. Rhule , Eric A. Boring
发明人： Craig L. Hill , Ling Xu , Jeffrey T. Rhule , Eric A. Boring
IPC分类号： A61K906
CPC分类号： A62D3/30 , A61K31/01 , A61K31/14 , A61K33/24 , A61K33/26 , A61K33/32 , A61K33/34 , A61K33/36 , A61K33/42 , A62D3/38 , A62D5/00 , A62D2101/02 , A62D2101/22 , A62D2101/24 , A62D2101/26 , A62D2101/28 , A62D2101/47 , C07F9/005 , Y02A50/395 , Y10S424/13 , Y10S514/823 , Y10S514/844 , Y10S514/845 , Y10S514/848 , Y10S514/862 , Y10S514/887 , Y10S514/937 , Y10S514/944 , Y10S514/969 , Y10S514/974
摘要： The invention relates to a polyoxometalate topical composition for removing a contaminant from an environment, comprising a topical carrier and at least one polyoxometalate, with the proviso that the polyoxometalate is not H5PV2Mo10O40; K5Si(H2O)MnIIIW11O39; K4Si(H2O)MnIVW11O39; or K5CoIIIW12O40. The invention further relates to a method for removing a contaminant from an environment, comprising contacting the polyoxometalate topical composition of the present invention with the environment containing the contaminant for a sufficient time to remove the contaminant from the environment. The invention further relates to a modified polyoxometalate, wherein the modified polyoxometalate comprises the admixture of (1) a polyoxometalate and (2) a cerium compound, a silver compound, a gold compound, a platinum compound, or a combination thereof. The invention further relates to a method for removing a contaminant from an environment, comprising contacting a modified material with the environment containing the contaminant for a sufficient time to remove the contaminant from the environment, wherein the modified material comprises (1) a material and (2) a metal compound comprising a transition metal compound, an actinide compound, a lanthanide compound, or a combination thereof, wherein the metal compound is not a polyoxometalate. The invention further relates to an article comprising the modified material of the present invention.
摘要翻译：本发明涉及用于从环境中除去污染物的多金属氧酸盐局部组合物，其包含局部载体和至少一种多金属氧酸盐，条件是多金属氧酸盐不是H5PV2Mo10O40; K5Si（H2O）Mn W11O39; K4Si（H2O）MnⅣW11O39; 或K5Co W12O40。本发明还涉及一种从环境中去除污染物的方法，包括将本发明的多金属氧酸盐局部组合物与含有污染物的环境接触足够的时间以从环境中除去污染物。本发明还涉及改性多金属氧酸盐，其中改性多金属氧酸盐包括（1）多金属氧酸盐和（2）铈化合物，银化合物，金化合物，铂化合物或其组合的混合物。本发明还涉及从环境中去除污染物的方法，包括使改性材料与含有污染物的环境接触足够的时间以从环境中除去污染物，其中改性材料包括（1）材料和（ 2）包含过渡金属化合物，锕系化合物，镧系元素化合物或其组合的金属化合物，其中所述金属化合物不是多金属氧酸盐。本发明还涉及包含本发明的改性材料的制品。

3. 发明授权

US06468553B1 Formula and preparation method of an improved ointment for treating burns and scalds 有权
标题翻译：用于治疗烧伤和烫伤的改进软膏的配方和制备方法
公开(公告)号：US06468553B1
公开(公告)日：2002-10-22
申请号：US09631813
申请日：2000-08-03
申请人： Ce-Shing Sheu , Yi-Ching Wu , Jun-Hung Kuo
发明人： Ce-Shing Sheu , Yi-Ching Wu , Jun-Hung Kuo
IPC分类号： A61K906
CPC分类号： A61K9/0014 , A61K36/232 , A61K36/30 , A61K47/06 , A61K47/24 , A61K47/44 , Y10S514/887 , A61K2300/00
摘要： The invention discloses an extract containing puccoon and Chinese angelica, and a formula and preparation method of an ointment containing the extract. The extract is used for treating burns and scalds and is characterized by superior shelf-life. The puccoon and Chinese angelica are extracted with an organic solvent having a polarity of between 0.35 and 0.95, which are then filtrated, concentrated and mixed with a physiologically acceptable carrier or excipient.
摘要翻译：本发明公开了含有葫芦和当归的提取物，以及含有提取物的软膏的配方及制备方法。提取物用于治疗烧伤和烫伤，其特征在于优良的保质期。用极性为0.35〜0.95的有机溶剂提取葫芦和当归，然后将其过滤，浓缩并与生理学上可接受的载体或赋形剂混合。

4. 发明授权

US06692762B2 Process for the preparation of materials with a high content of long chain polyunsaturated fatty acids 有权
标题翻译：具有高含量长链多不饱和脂肪酸的材料的制备方法
公开(公告)号：US06692762B2
公开(公告)日：2004-02-17
申请号：US09500475
申请日：2000-02-09
申请人： Frederick William Cain , Stephen Raymond Moore , Gerald Patrick McNeill , Olga Cornelia Zwemmer
发明人： Frederick William Cain , Stephen Raymond Moore , Gerald Patrick McNeill , Olga Cornelia Zwemmer
IPC分类号： A61K906
CPC分类号： C12P7/6427 , A23D9/00 , A23L33/115 , C12P7/6436 , C12P7/6472 , C12P7/6481 , C12P7/649 , Y02E50/13 , Y10S426/807
摘要： Compositions comprising glycerides containing conjugated linoleic acid moieties. These glycerides are prepared by an enzymatic conversion process which is selective to provide specific isomers, advantageously the cis9, trans11 and trans10, cis12 linoleic acid isomers or vice versa. The compositions may be blended with complementary fats and may be used in foods, food supplements and pharmaceutical compositions.
摘要翻译：包含含有共轭亚油酸部分的甘油酯的组合物。这些甘油酯通过酶转化方法制备，其可选择性地提供特异性异构体，有利地是顺式9，反式11和反式10，顺式12亚油酸异构体，反之亦然。组合物可以与互补脂肪混合并且可以用于食品，食品添加剂和药物组合物中。

5. 发明授权

US06558688B2 Ocular tissue regeneration inducer 失效
标题翻译：眼组织再生诱导剂
公开(公告)号：US06558688B2
公开(公告)日：2003-05-06
申请号：US09768625
申请日：2001-01-25
申请人： Mototsugu Saishin , Mitsuo Tsukamoto , Takashi Makabe , Yoshimi Kakimaru , Takumi Fujitani , Tatsuhiko Higaki
发明人： Mototsugu Saishin , Mitsuo Tsukamoto , Takashi Makabe , Yoshimi Kakimaru , Takumi Fujitani , Tatsuhiko Higaki
IPC分类号： A61K906
CPC分类号： A61K31/79 , A61K31/765 , A61K31/785 , A61K31/787
摘要： The invention relates to an ocular tissue regeneration inducer which comprises, as an active ingredient, a hydrophilic polymer mainly composed of alkylene glycol units or vinyl monomeric units having a nondissociating hydrophilic group. The composition can induce the regeneration of ocular tissues such as the cornea, the crystalline lens, and the vitreous body.
摘要翻译：本发明涉及一种眼组织再生诱导剂，其包含主要由具有非离解性亲水基团的亚烷基二醇单元或乙烯基单体单元构成的亲水性聚合物作为活性成分。组合物可以诱导眼组织如角膜，晶状体和玻璃体的再生。

6. 发明授权

US06287601B1 Topical nitric oxide donor compositions 失效
标题翻译：局部一氧化氮供体组成
公开(公告)号：US06287601B1
公开(公告)日：2001-09-11
申请号：US09333974
申请日：1999-06-16
申请人： Meri Charmyne Russell
发明人： Meri Charmyne Russell
IPC分类号： A61K906
CPC分类号： A61K47/24 , A61K9/0014 , A61K9/0017 , A61K31/195 , A61K31/21 , A61K31/295 , A61K31/405 , A61K45/06 , A61K47/10 , A61K47/14 , Y10S514/946 , Y10S514/947 , A61K31/19 , A61K31/00 , A61K2300/00
摘要： Compositions and methods of the topical treatment of equine laminitis are disclosed. In particular, combinations of a fast acting nitric oxide (NO) donor, a sustained acting NO donor and an NSAID mixed in a lipid-based carrier are described. The application of such combinations to the affected areas, e.g., the hoofs and surrounding tissues, of an equine afflicted with laminitis provides relief from the debilitating effects of this painful, often life-threatening condition.
摘要翻译：公开了局部治疗马蒂炎炎症的组合物和方法。特别地，描述了快速作用的一氧化氮（NO）供体，持续作用的NO供体和在脂质载体中混合的NSAID的组合。将这种组合应用于患有椎板炎的马的受影响区域，例如蹄和周围组织，可以缓解这种痛苦的，通常危及生命的疾病的衰弱作用。

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