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1. 发明授权

US07220402B1 Alpha-fetoprotein peptides and uses for imaging 有权
标题翻译：甲胎蛋白肽和成像用途
公开(公告)号：US07220402B1
公开(公告)日：2007-05-22
申请号：US10300531
申请日：2002-11-20
申请人： Thomas T. Andersen , James A. Bennett , Herbert I. Jacobson , Fassil B. Mesfin
发明人： Thomas T. Andersen , James A. Bennett , Herbert I. Jacobson , Fassil B. Mesfin
IPC分类号： A61K5/055
CPC分类号： A61K49/0002 , A61K38/00 , C07K14/4715 , C07K2319/00 , G01N33/57415
摘要： The invention provides diagnostic procedures wherein the presence or absence of a cell-proliferating disorder, e.g., a breast cancer, may be determined. The imaging agents of the invention include alpha-fetoprotein hydrophilic analogs which have been determined to target cancers, e.g., breast cancer, and are also anti-cell proliferating in nature. These modulators contain amino acid structures which are arranged as a hydrophilic analog of an alpha-fetoprotein. The modulator may be a peptide; a peptidomimetic; or may be in the form of a pharmaceutically acceptable scaffold, such as a polycyclic hydrocarbon to which is attached the necessary amino acid structures. The imaging agents of the invention further comprise an imaging moiety that allows for the imaging of the area targeted by the imaging agent.
摘要翻译：本发明提供诊断方法，其中可以确定细胞增殖性病症（例如乳腺癌）的存在或不存在。本发明的成像剂包括已被确定为靶向癌症（例如乳腺癌）的甲胎蛋白亲水类似物，并且在本质上也是抗细胞增殖。这些调节剂含有排列成甲胎蛋白的亲水类似物的氨基酸结构。调节剂可以是肽; 一个拟人的或者可以是药学上可接受的支架的形式，例如连接有必需的氨基酸结构的多环烃。本发明的成像剂还包括成像部分，其允许对由成像剂靶向的区域进行成像。

2. 发明授权

US6015545A Manganese containing magnetic resonance contrast agent 失效
标题翻译：锰含磁共振造影剂
公开(公告)号：US6015545A
公开(公告)日：2000-01-18
申请号：US677051
申请日：1996-07-09
申请人： Henrik S. Thomsen
发明人： Henrik S. Thomsen
IPC分类号： A61K49/00 , A61K49/06 , A61K49/10 , A61K49/18 , A61K5/055
CPC分类号： A61K49/10 , A61K49/06 , A61K49/18 , Y10S514/836
摘要： A composition for use as a contrast medium being particularly suitable for imaging of the stomach, liver, bile duct and gall bladder, said composition comprising as an active ingredient a physiologically acceptable manganese compound and an uptake promoter, wherein the uptake promoter comprises a physiologically acceptable reducing compound containing a physiologically acceptable amino acid or a salt thereof, and/or vitamin D.
摘要翻译：用作造影剂的组合物特别适用于胃，肝，胆管和胆囊的成像，所述组合物包含生理上可接受的锰化合物和摄取促进剂作为活性成分，其中摄取促进剂包含生理上可接受的还原化合物，其含有生理上可接受的氨基酸或其盐，和/或维生素D.

3. 发明授权

US07897140B2 Multi DTPA conjugated tetrapyrollic compounds for phototherapeutic contrast agents 有权
标题翻译：用于光疗治疗造影剂的多DTPA共轭四氢化合物
公开(公告)号：US07897140B2
公开(公告)日：2011-03-01
申请号：US11479524
申请日：2006-06-30
申请人： Ravindra K. Pandey , Lalit Goswami , Joseph Spernyak , Peter Kanter , Richard Mazurchuk
发明人： Ravindra K. Pandey , Lalit Goswami , Joseph Spernyak , Peter Kanter , Richard Mazurchuk
IPC分类号： A61K5/055
CPC分类号： C07D487/22 , A61K41/0071 , A61K41/0076 , A61K49/124
摘要： Novel tetrapyrollic water soluble photosensitizing and imaging compounds and the methods of treating and imaging hyperproliferative tissue, e.g. tumors and hypervacularized tissue such as found in macular degeneration. Broadly, the compounds are tetrapyrollic photosensitizer compounds where the tetrapyrollic compound is a chlorin, bacteriochlorin, porphyrin, pyropheophorbide, purpurinimide, or bacteriopurpurinimide having 3 to 6 —CH2CONHphenylCH2CH(N(CH2COOH)2))(CH2N(CH2COOH)(CH2CH2N(CH2COOH)2)) groups or esters thereof or complexes thereof with gadolinium(III).
摘要翻译：新型四级水溶性光敏剂和成像化合物以及治疗和成像过度增生组织的方法，例如，肿瘤和高血压组织，如发现于黄斑变性。广泛地说，这些化合物是四级光敏剂化合物，其中四溴化合物是二氢卟酚，细菌二氢卟酚，卟啉，焦脱镁叶绿素，嘌呤酰亚胺或具有3至6个-CH 2 CONH苯基CH 2 CH（N（CH 2 COOH）2））（CH 2 CO 2）（CH 2 CH 2 N（CH 2 COOH） 2））或其酯或其与钆（III）的络合物。

4. 发明授权

US07186399B2 Methods for targeted drug delivery 失效
标题翻译：靶向药物递送方法
公开(公告)号：US07186399B2
公开(公告)日：2007-03-06
申请号：US10302369
申请日：2002-11-22
申请人： Gregory M. Lanza , Samuel A. Wickline
发明人： Gregory M. Lanza , Samuel A. Wickline
IPC分类号： A61K5/055
CPC分类号： A61K51/1217 , A61K49/18 , A61K49/1812 , G01N33/586
摘要： A method for ligand-based binding of lipid encapsulated particles to molecular epitopes on a surface in vivo or in vitro comprises sequentially administering (a) a site specific ligand activated with a biotin activating agent; (b) an avidin activating agent; and (c) lipid encapsulated particles activated with a biotin activating agent, whereby the ligand is conjugated to the particles through an avidin-biotin interaction and the resulting conjugate is bound to the molecular epitopes on such surface. The conjugate is effective for imaging by x-ray, ultrasound, magnetic resonance or positron emission tomography. Compositions for use in ultrasonic imaging of natural or synthetic surfaces and for enhancing the acoustic reflectivity thereof are also disclosed.
摘要翻译：在体内或体外，脂质包封的颗粒与表面上的分子表位的基于配体的结合的方法包括顺序施用（a）用生物素活化剂活化的位点特异性配体; （b）抗生物素蛋白活化剂; 和（c）用生物素活化剂活化的脂质包封的颗粒，由此配体通过抗生物素蛋白 - 生物素相互作用与颗粒缀合，并且所得到的缀合物结合到这种表面上的分子表位。该共轭物通过X射线，超声，磁共振或正电子发射断层扫描成像是有效的。还公开了用于天然或合成表面的超声成像和增强其声反射率的组合物。

5. 发明授权

US6004529A Chelating agents 失效
标题翻译：螯合剂
公开(公告)号：US6004529A
公开(公告)日：1999-12-21
申请号：US833995
申请日：1997-04-11
申请人： Shi-Bao Yu , Jasbir Singh
发明人： Shi-Bao Yu , Jasbir Singh
IPC分类号： C07D233/14 , A61K49/00 , A61K49/04 , A61K49/08 , A61K51/00 , A61K51/04 , A61P35/00 , C07C323/59 , C07C323/60 , C07D213/52 , C07D213/53 , C09K3/00 , C07C319/00 , C07D213/04 , A61K5/055
CPC分类号： A61K49/103 , A61K49/04 , A61K51/0478
摘要： The invention provides a complexant compound of formula IR.sup.3 S (CR.sup.1.sub.2).sub.n N(R.sup.2).sub.i (CR.sup.1.sub.2).sub.n X(CR.sup.1.sub.2).sub.n N(R.sup.2).sub.i (CR.sup.1.sub.2).sub.n SR.sup.3(I)(wherein each n, which may be the same or different, is an integer 2, 3 or 4 (preferably 2); each i, which may be the same or different, represents 0 or 1; each R.sup.3, which may be the same or different, is H or a thiol protecting group, preferably a protecting group; X is O, S, N, NR.sup.4 or a substituted phosphorus (eg. oxo substituted phosphorus), preferably S or N; each R.sup.4, which may be the same or different, is hydrogen or an optionally substituted organic group; each R.sup.1, which may be the same or different, is hydrogen or an optionally substituted organic group, or a moiety CR.sup.1.sub.2 may represents a carbonyl group or two, three or four R.sup.1 s on two different carbons together with those carbons and any intervening atoms may represent an optionally substituted saturated or unsaturated homocyclic or heterocyclic ring; and preferably, at least one CR.sup.1.sub.2 moiety is other than CH.sub.2 or CH(CH.sub.3)) or a salt or complex thereof, wherein optionally at least one of the R.sup.1, R.sup.2, R.sup.3 and R.sup.4 moieties is coupled directly or indirectly to a vector moiety.
摘要翻译：本发明提供式IR3S（CR12）nN（R2）i（CR12）nX（CR12）nN（R2）i（CR12）nSR3（I）的络合物，其中每个n可以相同或不同，整数2,3或4（优选2）;每个i可以相同或不同，表示0或1;每个R 3可以相同或不同，是H或硫醇保护基，优选保护基基团; X是O，S，N，NR 4或取代的磷（例如氧代取代的磷），优选S或N;每个可以相同或不同的R 4是氢或任选取代的有机基团;每个R 1 可以相同或不同的是氢或任选取代的有机基团，或者部分CR 12可以表示羰基或两个不同碳上的两个，三个或四个R 1与那些碳原子一起并且任何中间原子可以代表任选地取代的饱和或不饱和的杂环或杂环;并且优选地，至少一个CR 12部分不是CH 2或CH（CH 3））或其盐或其复合物，其中任选地，R 1，R 2，R 3和R 4部分中的至少一个直接或间接连接到载体部分。

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