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1. 发明申请

US20110269692A1 ALPHA-FETOPROTEIN PEPTIDES AND USES THEREOF 审中-公开
标题翻译： ALPHA-FETOPROTEIN PEPTIDES及其用途
公开(公告)号：US20110269692A1
公开(公告)日：2011-11-03
申请号：US13108923
申请日：2011-05-16
申请人： Thomas T. Andersen , James A. Bennett , Herbert I. Jacobson , Fassil B. Mesfin
发明人： Thomas T. Andersen , James A. Bennett , Herbert I. Jacobson , Fassil B. Mesfin
IPC分类号： A61K38/08 , A61K38/12 , A61P35/00
CPC分类号： A61K38/1709 , A61K31/138 , A61K38/12 , A61K45/06 , A61K49/0002 , C07K14/4715 , C07K2319/00 , G01N33/57415 , A61K2300/00
摘要： Therapeutic compounds which are cell proliferation modulators, preferably inhibitors. These modulators contain amino acid structures that are arranged as a hydrophilic analog of an alpha-fetoprotein. The modulator may be a peptide itself, e.g., an octapeptide like that of SEQ ID NO: 5; a peptidomimetic; or may be in the form of a pharmaceutically acceptable scaffold, such as a polycyclic hydrocarbon to which is attached the necessary amino acid structures for biological and/or chemical activity. The modulators of the invention are distinguished in one aspect over previous compounds in that they are orally active, and therefore do not have to be injected into the patient. The compositions and methods are useful for reducing estrogen-dependent and estrogen-independent growth of cells, and treating or preventing cancer, such as breast cancer, brain cancer, head-and-neck cancer, thyroid cancer, lung cancer, colon cancer, ovarian cancer, prostate cancer, cervical cancer, and skin cancer. The treatment or prevention methods can include the use of tamoxifen therapy in combination with the peptide therapy.
摘要翻译：作为细胞增殖调节剂的治疗化合物，优选抑制剂。这些调节剂含有排列成甲胎蛋白的亲水类似物的氨基酸结构。调节剂可以是肽本身，例如像SEQ ID NO：5那样的八肽; 一个拟人的或者可以是药学上可接受的支架的形式，例如连接有用于生物和/或化学活性的必需氨基酸结构的多环烃。本发明的调节剂在一个方面与先前化合物的区别在于它们是口服活性的，因此不必将其注入患者体内。组合物和方法可用于减少细胞的雌激素依赖性和雌激素非依赖性生长，以及治疗或预防癌症，如乳腺癌，脑癌，头颈癌，甲状腺癌，肺癌，结肠癌，卵巢癌癌症，前列腺癌，子宫颈癌和皮肤癌。治疗或预防方法可以包括与肽疗法组合使用他莫昔芬治疗。

2. 发明授权

US06818741B2 Alpha-fetoprotein peptides and uses therof 有权
标题翻译：甲胎蛋白肽，并使用
公开(公告)号：US06818741B2
公开(公告)日：2004-11-16
申请号：US09872623
申请日：2001-06-02
申请人： Thomas T. Andersen , James A. Bennett , Herbert I. Jacobson , Fassil B. Mesfin
发明人： Thomas T. Andersen , James A. Bennett , Herbert I. Jacobson , Fassil B. Mesfin
IPC分类号： A61K3800
CPC分类号： C07K14/4715 , A61K38/00 , G01N33/57415
摘要： The subject invention addresses the need for methods of treatment and prevention of breast cancer, and other cancers, by providing a peptide of eight to twenty amino acids in length which comprises a hydrophilic analog of an alpha-fetoprotein peptide having SEQ ID NO: 6: EMTPVNPG. The peptides may be linear, but are preferably cyclic. The peptides may be provided as dimers or other multimers. A composition comprising the peptide, an antibody that specifically binds to the peptide, a method of reducing estrogen-stimulated growth of cells using the peptide, as well as a method of treating or preventing cancer, such as breast cancer, are also provided. The treatment or prevention method can include the use of tamoxifen therapy in combination with the peptide therapy.
摘要翻译：本发明解决了通过提供长度为8至20个氨基酸的肽来治疗和预防乳腺癌和其它癌症的方法的需要，其包含具有SEQ ID NO：6的甲胎蛋白肽的亲水类似物： EMTPVNPG。肽可以是线性的，但优选是环状的。肽可以作为二聚体或其他多聚体提供。还提供了包含肽，特异性结合肽的抗体，使用肽减少细胞的雌激素刺激生长的方法的组合物，以及治疗或预防癌症如乳腺癌的方法。治疗或预防方法可以包括与肽疗法组合使用他莫昔芬治疗。

3. 发明授权

US07132400B2 Alpha-fetoprotein peptides and uses thereof 有权
标题翻译：甲胎蛋白肽及其用途
公开(公告)号：US07132400B2
公开(公告)日：2006-11-07
申请号：US10990877
申请日：2004-11-16
申请人： Thomas T. Andersen , James A. Bennett , Herbert I. Jacobson , Fassil B. Mesfin
发明人： Thomas T. Andersen , James A. Bennett , Herbert I. Jacobson , Fassil B. Mesfin
IPC分类号： A61K38/00
CPC分类号： A61K31/138 , A61K38/08 , A61K38/10 , A61K2300/00
摘要： The subject invention addresses the need for methods of treatment and prevention of breast cancer, and other cancers, by providing a peptide of eight to twenty amino acids in length which comprises a hydrophilic analog of an alpha-fetoprotein peptide having SEQ ID NO:6: EMTPVNPG. The peptides may be linear, but are preferably cyclic. The peptides may be provided as dimers or other multimers. A composition comprising the peptide, an antibody that specifically binds to the peptide, a method of reducing estrogen-stimulated growth of cells using the peptide, as well as a method of treating or preventing cancer, such as breast cancer, are also provided. The treatment or prevention method can include the use of tamoxifen therapy in combination with the peptide therapy.
摘要翻译：本发明解决了通过提供长度为8至20个氨基酸的肽来治疗和预防乳腺癌和其它癌症的方法的需要，其包含具有SEQ ID NO：6的甲胎蛋白肽的亲水类似物： EMTPVNPG。肽可以是线性的，但优选是环状的。肽可以作为二聚体或其他多聚体提供。还提供了包含肽，特异性结合肽的抗体，使用肽减少细胞的雌激素刺激生长的方法的组合物，以及治疗或预防癌症如乳腺癌的方法。治疗或预防方法可以包括与肽疗法组合使用他莫昔芬治疗。

4. 发明授权

US07122522B2 Alpha-fetoprotein peptides and uses thereof 有权
标题翻译：甲胎蛋白肽及其用途
公开(公告)号：US07122522B2
公开(公告)日：2006-10-17
申请号：US10300530
申请日：2002-11-20
申请人： Thomas T. Andersen , James A. Bennett , Herbert I. Jacobson , Fassil B. Mesfin
发明人： Thomas T. Andersen , James A. Bennett , Herbert I. Jacobson , Fassil B. Mesfin
IPC分类号： A61K38/00
CPC分类号： A61K49/0002 , A61K38/1709 , C07K14/4715 , C07K2319/00 , G01N33/57415
摘要： Therapeutic compounds which are cell proliferation modulators, preferably inhibitors. These modulators contain amino acid structures that are arranged as a hydrophilic analog of an alpha-fetoprotein. The modulator may be a peptide itself, e.g., an octapeptide like that of SEQ ID NO: 5; a peptidomimetic; or may be in the form of a pharmaceutically acceptable scaffold, such as a polycyclic hydrocarbon to which is attached the necessary amino acid structures for biological and/or chemical activity. The modulators of the invention are distinguished in one aspect over previous compounds in that they are orally active, and therefore do not have to be injected into the patient. The compositions and methods are useful for reducing estrogen-stimulated growth of cells, and treating or preventing cancer, such as breast cancer. The treatment or prevention methods can include the use of tamoxifen therapy in combination with the peptide therapy.
摘要翻译：作为细胞增殖调节剂的治疗化合物，优选抑制剂。这些调节剂含有排列成甲胎蛋白的亲水类似物的氨基酸结构。调节剂可以是肽本身，例如像SEQ ID NO：5那样的八肽; 一个拟人的或者可以是药学上可接受的支架的形式，例如连接有用于生物和/或化学活性的必需氨基酸结构的多环烃。本发明的调节剂在一个方面与先前化合物的区别在于它们是口服活性的，因此不必将其注入患者体内。组合物和方法可用于减少雌激素刺激的细胞生长，以及治疗或预防癌症，例如乳腺癌。治疗或预防方法可以包括与肽疗法组合使用他莫昔芬治疗。

5. 发明授权

US07943577B2 Alpha-fetoprotein peptides and uses thereof 有权
标题翻译：甲胎蛋白肽及其用途
公开(公告)号：US07943577B2
公开(公告)日：2011-05-17
申请号：US11582629
申请日：2006-10-17
申请人： Thomas T. Andersen , James A. Bennett , Herbert I. Jacobson , Fassil B. Mesfin
发明人： Thomas T. Andersen , James A. Bennett , Herbert I. Jacobson , Fassil B. Mesfin
IPC分类号： A61K38/00
CPC分类号： A61K38/1709 , A61K31/138 , A61K38/12 , A61K45/06 , A61K49/0002 , C07K14/4715 , C07K2319/00 , G01N33/57415 , A61K2300/00
摘要： Therapeutic compounds which are cell proliferation modulators, preferably inhibitors. These modulators contain amino acid structures that are arranged as a hydrophilic analog of an alpha-fetoprotein. The modulator may be a peptide itself, e.g., an octapeptide like that of SEQ ID NO: 5; a peptidomimetic; or may be in the form of a pharmaceutically acceptable scaffold, such as a polycyclic hydrocarbon to which is attached the necessary amino acid structures for biological and/or chemical activity. The modulators of the invention are distinguished in one aspect over previous compounds in that they are orally active, and therefore do not have to be injected into the patient. The compositions and methods are useful for reducing estrogen-dependent and estrogen-independent growth of cells, and treating or preventing cancer, such as breast cancer, brain cancer, head-and-neck cancer, thyroid cancer, lung cancer, colon cancer, ovarian cancer, prostate cancer, cervical cancer, and skin cancer. The treatment or prevention methods can include the use of tamoxifen therapy in combination with the peptide therapy.
摘要翻译：作为细胞增殖调节剂的治疗化合物，优选抑制剂。这些调节剂含有排列成甲胎蛋白的亲水类似物的氨基酸结构。调节剂可以是肽本身，例如像SEQ ID NO：5那样的八肽; 一个拟人的或者可以是药学上可接受的支架的形式，例如连接有用于生物和/或化学活性的必需氨基酸结构的多环烃。本发明的调节剂在一个方面与先前化合物的区别在于它们是口服活性的，因此不必将其注入患者体内。组合物和方法可用于减少细胞的雌激素依赖性和雌激素非依赖性生长，以及治疗或预防癌症，如乳腺癌，脑癌，头颈癌，甲状腺癌，肺癌，结肠癌，卵巢癌癌症，前列腺癌，子宫颈癌和皮肤癌。治疗或预防方法可以包括与肽疗法组合使用他莫昔芬治疗。

6. 发明申请

US20100249040A1 Alpha-fetoprotein peptides and uses thereof 有权
标题翻译：甲胎蛋白肽及其用途
公开(公告)号：US20100249040A1
公开(公告)日：2010-09-30
申请号：US11582629
申请日：2006-10-17
申请人： Thomas T. Andersen , James A. Bennett , Herbert I. Jacobson , Fassil B. Mesfin
发明人： Thomas T. Andersen , James A. Bennett , Herbert I. Jacobson , Fassil B. Mesfin
IPC分类号： A61K38/08 , A61P35/00
CPC分类号： A61K38/1709 , A61K31/138 , A61K38/12 , A61K45/06 , A61K49/0002 , C07K14/4715 , C07K2319/00 , G01N33/57415 , A61K2300/00
摘要： Therapeutic compounds which are cell proliferation modulators, preferably inhibitors. These modulators contain amino acid structures that are arranged as a hydrophilic analog of an alpha-fetoprotein. The modulator may be a peptide itself, e.g., an octapeptide like that of SEQ ID NO: 5; a peptidomimetic; or may be in the form of a pharmaceutically acceptable scaffold, such as a polycyclic hydrocarbon to which is attached the necessary amino acid structures for biological and/or chemical activity. The modulators of the invention are distinguished in one aspect over previous compounds in that they are orally active, and therefore do not have to be injected into the patient. The compositions and methods are useful for reducing estrogen-dependent and estrogen-independent growth of cells, and treating or preventing cancer, such as breast cancer, brain cancer, head-and-neck cancer, thyroid cancer, lung cancer, colon cancer, ovarian cancer, prostate cancer, cervical cancer, and skin cancer. The treatment or prevention methods can include the use of tamoxifen therapy in combination with the peptide therapy.
摘要翻译：作为细胞增殖调节剂的治疗化合物，优选抑制剂。这些调节剂含有排列成甲胎蛋白的亲水类似物的氨基酸结构。调节剂可以是肽本身，例如像SEQ ID NO：5那样的八肽; 一个拟人的或者可以是药学上可接受的支架的形式，例如连接有用于生物和/或化学活性的必需氨基酸结构的多环烃。本发明的调节剂在一个方面与先前化合物的区别在于它们是口服活性的，因此不必将其注入患者体内。组合物和方法可用于减少细胞的雌激素依赖性和雌激素非依赖性生长，以及治疗或预防癌症，如乳腺癌，脑癌，头颈癌，甲状腺癌，肺癌，结肠癌，卵巢癌癌症，前列腺癌，子宫颈癌和皮肤癌。治疗或预防方法可以包括与肽疗法组合使用他莫昔芬治疗。

7. 发明申请

US20090043073A1 Alpha-fetoprotein peptides and uses for imaging 审中-公开
标题翻译：甲胎蛋白肽和成像用途
公开(公告)号：US20090043073A1
公开(公告)日：2009-02-12
申请号：US11805068
申请日：2007-05-21
申请人： Thomas T. Andersen , James A. Bennett , Herbert I. Jacobson , Fassil B. Mesfin
发明人： Thomas T. Andersen , James A. Bennett , Herbert I. Jacobson , Fassil B. Mesfin
IPC分类号： C07K14/00 , C07K7/06 , C07K7/08
CPC分类号： A61K49/0002 , A61K38/00 , C07K14/4715 , C07K2319/00 , G01N33/57415
摘要： The invention provides diagnostic procedures wherein the presence or absence of a cell-proliferating disorder, e.g., a breast cancer, may be determined. The imaging agents of the invention include alpha-fetoprotein hydrophilic analogs which have been determined to target cancers, e.g., breast cancer, and are also anti-cell proliferating in nature. These modulators contain amino acid structures which are arranged as a hydrophilic analog of an alpha-fetoprotein. The modulator may be a peptide; a peptidomimetic; or may be in the form of a pharmaceutically acceptable scaffold, such as a polycyclic hydrocarbon to which is attached the necessary amino acid structures. The imaging agents of the invention further comprise an imaging moiety that allows for the imaging of the area targeted by the imaging agent.
摘要翻译：本发明提供诊断方法，其中可以确定细胞增殖性病症（例如乳腺癌）的存在或不存在。本发明的成像剂包括已被确定为靶向癌症（例如乳腺癌）的甲胎蛋白亲水类似物，并且在本质上也是抗细胞增殖。这些调节剂含有排列成甲胎蛋白的亲水类似物的氨基酸结构。调节剂可以是肽; 一个拟人的或者可以是药学上可接受的支架的形式，例如连接有必需的氨基酸结构的多环烃。本发明的成像剂还包括成像部分，其允许对由成像剂靶向的区域进行成像。

8. 发明授权

US07220402B1 Alpha-fetoprotein peptides and uses for imaging 有权
标题翻译：甲胎蛋白肽和成像用途
公开(公告)号：US07220402B1
公开(公告)日：2007-05-22
申请号：US10300531
申请日：2002-11-20
申请人： Thomas T. Andersen , James A. Bennett , Herbert I. Jacobson , Fassil B. Mesfin
发明人： Thomas T. Andersen , James A. Bennett , Herbert I. Jacobson , Fassil B. Mesfin
IPC分类号： A61K5/055
CPC分类号： A61K49/0002 , A61K38/00 , C07K14/4715 , C07K2319/00 , G01N33/57415
摘要： The invention provides diagnostic procedures wherein the presence or absence of a cell-proliferating disorder, e.g., a breast cancer, may be determined. The imaging agents of the invention include alpha-fetoprotein hydrophilic analogs which have been determined to target cancers, e.g., breast cancer, and are also anti-cell proliferating in nature. These modulators contain amino acid structures which are arranged as a hydrophilic analog of an alpha-fetoprotein. The modulator may be a peptide; a peptidomimetic; or may be in the form of a pharmaceutically acceptable scaffold, such as a polycyclic hydrocarbon to which is attached the necessary amino acid structures. The imaging agents of the invention further comprise an imaging moiety that allows for the imaging of the area targeted by the imaging agent.
摘要翻译：本发明提供诊断方法，其中可以确定细胞增殖性病症（例如乳腺癌）的存在或不存在。本发明的成像剂包括已被确定为靶向癌症（例如乳腺癌）的甲胎蛋白亲水类似物，并且在本质上也是抗细胞增殖。这些调节剂含有排列成甲胎蛋白的亲水类似物的氨基酸结构。调节剂可以是肽; 一个拟人的或者可以是药学上可接受的支架的形式，例如连接有必需的氨基酸结构的多环烃。本发明的成像剂还包括成像部分，其允许对由成像剂靶向的区域进行成像。

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