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1. 发明授权

US4115195A Rabies vaccine preparation 失效
标题翻译：狂犬疫苗制剂
公开(公告)号：US4115195A
公开(公告)日：1978-09-19
申请号：US786766
申请日：1977-04-12
申请人： Rudolph Barth , Oskar Jaeger
发明人： Rudolph Barth , Oskar Jaeger
IPC分类号： C12N7/00 , A61K39/00 , A61K39/205 , C12K7/00 , A61K39/28 , C12K5/00
CPC分类号： A61K39/205 , A61K39/12 , A61K2039/5252 , C12N2760/20134 , Y10S435/948
摘要： A rabies vaccine is prepared by adaptation of the rabies virus to chick-embryo fibroplast cell cultures in progressing dilutions of from 10.sup.-1 to 10.sup.-5 for the inoculation of the cell culture passages and for multiplication in dilutions of from 10.sup.-2 to 10.sup.-5 for inoculation of the growth cultures.
摘要翻译：狂犬病疫苗通过将狂犬病病毒适应于雏鸡胚胎纤维增生细胞培养物进行稀释10-1至10-5，用于接种细胞培养物通道并以10-2至10倍的稀释倍数制备狂犬病疫苗 -5用于接种生长培养物。

2. 发明授权

US4040904A Novel rabies virus vaccine and processes 失效
标题翻译：新型狂犬病毒疫苗和流程
公开(公告)号：US4040904A
公开(公告)日：1977-08-09
申请号：US597654
申请日：1975-07-21
申请人： Eban A. Slater
发明人： Eban A. Slater
IPC分类号： C12N7/00 , A61K39/205 , C12K7/00 , A61K39/28
CPC分类号： A61K39/205 , A61K39/12 , A61K2039/5254 , A61K2039/552 , C12N2760/20134 , Y10S435/948
摘要： There is presented herein a novel rabies virus vaccine which has been developed from a known strain and a process for the preparation of the vaccine. One outstanding advantage of the novel strain is the direct correlation of its cytopathic effect on tissue culture cell monolayers and its titre.
摘要翻译：本文提供了一种新型的狂犬病病毒疫苗，其已经从已知的菌株和制备疫苗的方法开发。新菌株的一个突出优点是其细胞病变效应对组织培养细胞单层及其滴度的直接相关性。

3. 发明授权

US4112068A Canine lung cell strain culture systems and processes for the cultivation of viruses and vaccines therefrom 失效
标题翻译：犬肺细胞株培养系统及其从中培养病毒和疫苗的过程
公开(公告)号：US4112068A
公开(公告)日：1978-09-05
申请号：US828369
申请日：1977-08-29
申请人： Victor J. Cabasso
发明人： Victor J. Cabasso
IPC分类号： A61K39/12 , A61K39/15 , A61K39/155 , A61K39/175 , A61K39/205 , A61K39/265 , C12N7/00 , A61K39/28 , C12K9/00
CPC分类号： A61K39/155 , A61K39/12 , A61K39/15 , A61K39/175 , A61K39/205 , A61K39/265 , C12N7/00 , A61K2039/5254 , A61K2039/552 , C12N2710/16751 , C12N2720/12151 , C12N2760/18051 , C12N2760/18651 , C12N2760/20151
摘要： A finite cell strain is derived from canine fetal lung tissue, the cells of which are fibroblast-like, diploid, and are free of reverse transcriptase and C-type particles. With a nutrient medium the cells provide a cell culture system useful in the cultivation of a number of viruses from which vaccines may be prepared.
摘要翻译：有限的细胞株衍生自犬胎肺组织，其细胞是成纤维细胞样，二倍体，并且不含逆转录酶和C型颗粒。使用营养培养基，细胞提供可用于培养可以制备疫苗的许多病毒的细胞培养系统。

4. 发明授权

US4049794A Treatment of infections in animals 失效
标题翻译：治疗动物感染
公开(公告)号：US4049794A
公开(公告)日：1977-09-20
申请号：US664070
申请日：1976-03-05
申请人： Otto-Christian Straub
发明人： Otto-Christian Straub
IPC分类号： A61K35/12 , A61K35/76 , A61K35/766 , A61K31/00 , A61K45/02 , A61K39/28
CPC分类号： A61K35/76 , A61K35/766 , A61K2035/126 , C12N2710/16732 , Y10S514/889
摘要： There is disclosed novel non-antigenic attenuated viruses which non-specifically stimulate the natural defense mechanism of a host organism with a detectable non-specific induction of interferon; to methods for their production and to their use for the prophylaxis and treatment of viral and bacterial infections in human and veterinary medicine. The aforesaid term "non-antigenic attenuated virus" in this application means "an attenuated virus being incapable to cause an immunological cross-reaction with the original virus".
摘要翻译：公开了非特异性刺激宿主生物体的天然防御机制的新型非抗原性减毒病毒，其具有可检测的非特异性诱导的干扰素; 其生产方法及其用于预防和治疗人和兽医学中的病毒和细菌感染的方法。上述术语“非抗原性减毒病毒”是指“减毒病毒不能引起与原始病毒的免疫交叉反应”。

5. 发明授权

US4206014A Process for removing detergents from virus-antigen suspensions 失效
标题翻译：从病毒 - 抗原悬浮液中去除洗涤剂的方法
公开(公告)号：US4206014A
公开(公告)日：1980-06-03
申请号：US958512
申请日：1978-11-07
申请人： Edgar Reichert , Mirko Majer
发明人： Edgar Reichert , Mirko Majer
IPC分类号： C12N7/00 , A61K39/12 , A61K39/145 , A61K39/205 , C12N7/06 , A61K39/18 , A61K39/28
CPC分类号： C12N7/00 , A61K39/12 , A61K39/145 , A61K39/205 , C12N2760/16134 , C12N2760/16151 , C12N2760/16234 , C12N2760/16251 , C12N2760/18834 , C12N2760/18851 , C12N2760/20134 , C12N2760/20151 , Y10S435/961 , Y10S530/826
摘要： A method for isolating a detergent-free virus-antigen from a suspension of said virus-antigen containing detergent, which method comprises precipitating said virus-antigen by adding a polyethylene glycol to said suspension and then isolating the detergent-free virus-antigen precipitate by sedimentation, said detergent remaining in said suspension.
摘要翻译：一种从所述含有病毒抗原的洗涤剂的悬浮液中分离无去污剂的病毒抗原的方法，该方法包括通过向所述悬浮液中加入聚乙二醇使所述病毒抗原沉淀，然后通过所述洗涤剂沉淀在所述悬浮液中。

6. 发明授权

US4014991A Oral rabies immunization of carnivores 失效
标题翻译：食肉动物的口服狂犬病免疫
公开(公告)号：US4014991A
公开(公告)日：1977-03-29
申请号：US651810
申请日：1976-01-23
申请人： George M. Baer , William G. Winkler
发明人： George M. Baer , William G. Winkler
IPC分类号： A61K39/205 , A61K39/28
CPC分类号： A61K39/205 , A61K39/12 , A61K9/0056 , A61K2039/5254 , A61K2039/542 , A61K2039/552 , C12N2760/20134
摘要： A vaccine and method of protecting wild carnivores and especially foxes from rabies virus which comprises setting out and orally administering an immunizing dose of an attenuated liquid antirabies vaccine, said vaccine being enclosed in a bite-permeable hydrophobic plastic container or sheath and said container being surrounded by an acceptable meat bait for the carnivore such as cured sausage. An elongated shape for both the container and bait is preferred. Acceptable vaccines for utilization include ERA/BHK-21 and PRI virus and a plastic elongated polyethylene tube is preferred for the container holding the attenuated vaccine. An effective amount of a temperature stabilizer for the vaccine may be added for operating temperatures of 27.degree..sup.+C. and these temperature stabilizers are selected from purified casein hydrolysates. The present method operates by bite penetration of the plastic container so that the vaccine is transferred to the buccal mucosa of the carnivore and the present method is effective in the treatment of wild carnivores, especially foxes.
摘要翻译：保护野生食肉动物，特别是狂犬病毒的狐狸的疫苗和方法，其包括设置和口服施用免疫剂量的减毒液体抗狂犬病疫苗，所述疫苗被包封在可渗透的疏水性塑料容器或鞘中，所述容器被包围通过可食用的肉类诱饵，如食用肉食，如硫化香肠。优选用于容器和诱饵的细长形状。可接受的使用疫苗包括ERA / BHK-21和PRI病毒，并且塑料细长聚乙烯管优选用于容纳减毒疫苗的容器。可以在27℃的操作温度下加入有效量的疫苗温度稳定剂。这些温度稳定剂选自纯化的酪蛋白水解产物。本方法通过塑料容器的咬入渗透进行操作，使得疫苗转移到食肉动物的颊粘膜上，本方法在野生食肉动物，特别是狐狸的治疗中是有效的。

7. 发明授权

US3973000A Process for purified rabies vaccine 失效
标题翻译：纯化狂犬病疫苗的方法
公开(公告)号：US3973000A
公开(公告)日：1976-08-03
申请号：US597054
申请日：1975-07-18
申请人： John F. Lavender
发明人： John F. Lavender
IPC分类号： A61K39/205 , A61K39/28
CPC分类号： A61K39/205 , A61K39/12 , A61K2039/5252 , C12N2760/20134
摘要： An improved purified rabies vaccine is produced by high-centrifugal force centrifugation of the crude egg-embryo-derived vaccine, redispersion of the separated solids, centrifugation of that dispersion at low centrifugal force, and collecting the supernatant.
摘要翻译：通过粗制胚胎衍生的疫苗的高离心力离心，分离的固体的再分散，低离心力下离心该分散体并收集上清液，制备改进的纯化狂犬病疫苗。

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