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1. 发明授权

US06267968B1 MDP derivatives and conjugates having haematipoietic function stimulating activity, and compositions containing same 失效
标题翻译：具有造血功能刺激活性的MDP衍生物和缀合物以及含有它们的组合物
公开(公告)号：US06267968B1
公开(公告)日：2001-07-31
申请号：US09302145
申请日：1999-04-29
申请人： Georges Bahr , Pierre Lefrancier , Louis Chedid
发明人： Georges Bahr , Pierre Lefrancier , Louis Chedid
IPC分类号： A61K3702
CPC分类号： A61K9/0019 , A61K38/00 , A61K47/183 , C07K9/005
摘要： Pharmaceutical compositions containing Muramyl dipeptide derivatives and conjugates or Muramyl dipeptide derivatives and conjugates combined with nucleoside derivatives which induce hematopoietic stem cell stimulation and mobilization into the circulating blood system. Methods to induce hematopoietic stem stimulation and mobilization, as well as methods to decrease myelotoxic effects using these pharmaceutical compositions.
摘要翻译：含有Muramyl二肽衍生物和缀合物或Muramyl二肽衍生物和缀合物与核苷衍生物结合的药物组合物，其诱导造血干细胞刺激和动员进入循环血液系统。诱导造血干细胞刺激和动员的方法，以及使用这些药物组合物降低骨髓毒性作用的方法。

2. 发明授权

US06403555B1 Depsipeptide and congeners thereof for use as immunosuppressants 有权
标题翻译：其作为免疫抑制剂的前列腺素及其同系物
公开(公告)号：US06403555B1
公开(公告)日：2002-06-11
申请号：US09732183
申请日：2000-12-06
申请人： Søren Skov
发明人： Søren Skov
IPC分类号： A61K3702
CPC分类号： C07K11/02 , A61K38/00 , C07K5/101 , C07K7/56
摘要： Depsipeptides and congeners thereof are disclosed having the following structure: wherein m, n, p, q, X, R1, R2 and R3 are as defined herein. These compounds, including FR901228, have activity as, for example, immunosuppressants, as well as for the prevention or treatment of patients suffering or at risk of suffering from inflammatory, autoimmune or immune system-related diseases including graft-versus-host disease and enhancement of graft/tissue survival following transplant. Also provided are methods for inhibiting lymphocyte activation, proliferation, and/or suppression of IL-2 secretion.
摘要翻译：公开了具有以下结构的脱肽及其同系物：其中m，n，p，q，X，R 1，R 2和R 3如本文所定义。这些化合物，包括FR901228，具有例如免疫抑制剂的活性，以及用于预防或治疗患有或有遭受炎症，自身免疫或免疫系统相关疾病（包括移植物抗宿主病和增强）的风险的患者移植后的移植物/组织存活。还提供了抑制淋巴细胞活化，增殖和/或抑制IL-2分泌的方法。

3. 发明授权

US06194384B1 Long-acting galenical formulation for GRF peptides 失效
标题翻译： GRF肽的长效盖仑制剂
公开(公告)号：US06194384B1
公开(公告)日：2001-02-27
申请号：US09135738
申请日：1998-08-18
申请人： Paul Brazeau , Denis Gravel
发明人： Paul Brazeau , Denis Gravel
IPC分类号： A61K3702
CPC分类号： A61K9/0024 , A61K38/25 , Y10S514/955 , Y10S514/96
摘要： The present invention relates to a long-acting galenical formulation of GRF peptides, GRF and/or analogs thereof which comprises about 1 to about 100 mg of a GRF peptide, fragment or analog thereof pressed from about 1 to about 100 kg/mm2 in a tablet for parenteral administration, whereby these GRF peptides are released as the tablet is eroded.
摘要翻译：本发明涉及GRF肽，GRF和/或其类似物的长效盖仑制剂，其包含约1至约100mg在约1至约100kg / mm 2的约1至约100kg / mm 2的压制的GRF肽，其片段或类似物用于肠胃外给药的片剂，由此当片剂被侵蚀时，这些GRF肽被释放。

4. 发明授权

US06468972B1 Method to promote, stimulate and/or delay hair loss by a brady kinin antagonist 失效
标题翻译：促进，刺激和/或延缓脱发激素拮抗剂的方法
公开(公告)号：US06468972B1
公开(公告)日：2002-10-22
申请号：US08981279
申请日：1998-02-11
申请人： Francis Pruche , Albert Duranton , Nathalie Boyera , Brigitte Gautier
发明人： Francis Pruche , Albert Duranton , Nathalie Boyera , Brigitte Gautier
IPC分类号： A61K3702
CPC分类号： A61K38/043 , A61K8/64 , A61Q7/00 , Y10S514/88
摘要： The present invention is directed to a method to promote, stimulate and/or delay hair loss by administering an effective amount of at least one bradykinin antagonists to promote, stimulate and/or delay hair loss to an individual in need thereof.
摘要翻译：本发明涉及通过施用有效量的至少一种缓激肽拮抗剂促进，刺激和/或延缓脱发的方法，以促进，/或延缓脱发需要的个体。

5. 发明授权

US06291428B1 Peptides which promote bone-forming cell attraction and adhesion 失效
标题翻译：促进骨形成细胞吸引和粘附的肽
公开(公告)号：US06291428B1
公开(公告)日：2001-09-18
申请号：US09467423
申请日：1999-12-20
申请人： William B. Macaulay , Elizabeth Merrifield , Adele Boskey
发明人： William B. Macaulay , Elizabeth Merrifield , Adele Boskey
IPC分类号： A61K3702
CPC分类号： C07K14/78 , A61K38/00 , Y10S514/955 , Y10S514/96
摘要： Peptides are provided with the properties of enhancing the migration and adhesion of bone-forming cells to a substrate, useful for promoting bone mineralization and osseointegration in the healing of, for example, orthopedic surgical procedures.
摘要翻译：肽具有增强骨形成细胞向底物的迁移和粘附的性质，其可用于促进骨矿化和骨整合在例如矫形外科手术的愈合中。

6. 发明授权

US06780848B2 Use of GPE to protect glial cells or non-dopaminergic cells from death from neural injury or disease 失效
标题翻译：使用GPE来保护神经损伤或疾病的神经胶质细胞或非多巴胺能细胞免于死亡
公开(公告)号：US06780848B2
公开(公告)日：2004-08-24
申请号：US09910461
申请日：2001-07-20
申请人： Peter D. Gluckman , Christopher E. Williams
发明人： Peter D. Gluckman , Christopher E. Williams
IPC分类号： A61K3702
CPC分类号： A61K38/30 , A61K38/05 , A61K38/06
摘要： The tripeptide glycine-proline-glutamine (GPE) may be administered before, or usually after, injury to reduce damage to the central nervous system. GPE appears useful for neuronal rescue particularly but not exclusively within the hippocampus. Advantages of GPE include: (a) that it crosses the blood-brain barrier, so is effective by injected peripheral administration, (b) it is unlikely to challenge the immune system, (c) it is cheap, and (d) its therapeutic ratio is high. GPE may also be infused into the CSF. It may be administered prior to parturition or elective brain or cardiac surgery. Transdermal routes may be useful for chronic neural disorders. The CNS of mammals (including foetal mammals) after trauma including hypoxic/ischaemic experimental insults showed reduced damage under GPE protection as measured by histological assessment of cell damage or death and regional shrinkage.
摘要翻译：三肽甘氨酸 - 脯氨酸 - 谷氨酰胺（GPE）可以在损伤之前或通常在损伤后施用以减少对中枢神经系统的损伤。 GPE似乎对神经元的拯救有用，特别是但不限于海马内。 GPE的优点包括：（a）它穿过血脑屏障，因此通过注射的外周给药是有效的，（b）不可能挑战免疫系统，（c）它是便宜的，和（d）其治疗比例高。 GPE也可以输入CSF。它可以在分娩或选择性脑或心脏手术之前进行。透皮途径可用于慢性神经障碍。包括缺氧/缺血性实验性损伤在内的哺乳动物（包括胎儿哺乳动物）的CNS显示，在通过细胞损伤或死亡和区域收缩的组织学评估测量的GPE保护下减少的损伤。

7. 发明授权

US06548479B1 Therapeutic uses of depsipeptides and congeners thereof 有权
标题翻译：去磷脂肽及其同源物的治疗用途
公开(公告)号：US06548479B1
公开(公告)日：2003-04-15
申请号：US10115576
申请日：2002-04-02
申请人： Søren Skov
发明人： Søren Skov
IPC分类号： A61K3702
CPC分类号： C07K11/02 , A61K38/00 , C07K5/101 , C07K7/56
摘要： Depsipeptides and congeners thereof are disclosed having the following structure: wherein m, n, p, q, X, R1, R2 and R3 are as defined herein. These compounds, including FR901228, have activity as, for example, immunosuppressants, as well as for the prevention or treatment of patients suffering or at risk of suffering from inflammatory, autoimmune or immune system-related diseases including graft-versus-host disease and enhancement of graft/tissue survival following transplant. Also provided are methods for inhibiting lymphocyte activation, proliferation, and/or suppression of IL-2 secretion.
摘要翻译：公开了具有以下结构的脱肽及其同系物：其中m，n，p，q，X，R 1，R 2和R 3如本文所定义。这些化合物，包括FR901228，具有例如免疫抑制剂的活性，以及用于预防或治疗患有或有遭受炎症，自身免疫或免疫系统相关疾病（包括移植物抗宿主病和增强）的风险的患者移植后的移植物/组织存活。还提供了抑制淋巴细胞活化，增殖和/或抑制IL-2分泌的方法。

8. 发明授权

US06387881B1 Inhibitors and substrates of thrombin 失效
标题翻译：凝血酶抑制剂和底物
公开(公告)号：US06387881B1
公开(公告)日：2002-05-14
申请号：US09205349
申请日：1998-12-03
申请人： Vijay Vir Kakkar , John Joseph Deadman , Goran Karl Claeson , Leifeng Cheng , Naoyashi Chino , Said Mohamed Anwar Elgendy , Michael Finbarr Scully
发明人： Vijay Vir Kakkar , John Joseph Deadman , Goran Karl Claeson , Leifeng Cheng , Naoyashi Chino , Said Mohamed Anwar Elgendy , Michael Finbarr Scully
IPC分类号： A61K3702
CPC分类号： C07K5/0812 , C07K5/06191 , C07K7/02
摘要： Peptides which act as inhibitors or substrates of thrombin are provided. The peptides of the invention have the general structural formula:
摘要翻译：提供充当抑制剂或凝血酶底物的肽。本发明的肽具有以下通式：

9. 发明授权

US06242564B1 Treatment of tropical spastic paresis with peptide T 失效
标题翻译：用T肽治疗热带痉挛性麻痹
公开(公告)号：US06242564B1
公开(公告)日：2001-06-05
申请号：US07898691
申请日：1992-06-15
申请人： Candace B. Pert , Michael R. Ruff
发明人： Candace B. Pert , Michael R. Ruff
IPC分类号： A61K3702
CPC分类号： C07K14/005 , A61K38/162 , A61K39/00 , C07K14/70514 , C07K16/1063 , C12N2740/16122
摘要： Intranasal therapy using short peptides of the formula (I): Ra-Ser-Thr-Thr-Thr-Asn-Tyr-Rb (I) where Ra represents an amino terminal residue Ala-, D-Ala or Cys-Ala- and Rb represents a carboxy terminal residue -Thr, -Thr-amide, -Thr-Cys or -Thr-Cys-amide, or a derivative thereof, or a peptide of formula (II): R1-R2-R3-R4-R5 (II) where R1 is an amino terminal residue XR6 or R6 wherein R6 is Thr-, Ser-, Asn-, Leu-, Ile-, Arg- or Glu- and X is Cys, R2 is Thr, Ser or Asp, R3 is Thr, Ser, Asn, Arg, Gln, Lys or Trp, R4 is Tyr and R5 is a carboxy terminal residue which is R7X or R7 wherein R7 may be any amino acid and X is Cys, or an ester or amide derivative thereof, or a physiologically acceptable salt of (I) or (II) is disclosed. Such peptides bind to T4 receptors and are useful for intranasal administration in preventing viral infectivity in mammals by viruses which bind to the T4 receptors. These peptides are believed to act as competitive blocking agents.
摘要翻译：使用式（I）的短肽的鼻内治疗：其中Ra表示氨基末端残基Ala-，D-Ala或Cys-Ala-和Rb表示羧基末端残基-Thr，-Thr-amide，-Thr-Cys或 -Thr-Cys-酰胺或其衍生物或式（II）的肽：其中R 1是氨基末端残基XR 6或R 6，其中R 6是Thr-，Ser-，Asn-，Leu-，Ile-，Arg- 或Glu-和X是Cys，R2是Thr，Ser或Asp，R3是Thr，Ser，Asn，Arg，Gln，Lys或Trp，R4是Tyr，R5是R7X或R7的羧基末端残基，其中R7可以是任何氨基酸和X是Cys，或其酯或酰胺衍生物，或（I）或（II）的生理学上可接受的盐。这些肽与T4受体结合，并且可用于通过结合T4受体的病毒预防哺乳动物的病毒感染性进行鼻内给药。据信这些肽作为竞争性阻断剂。

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