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1. 发明授权

US06242564B1 Treatment of tropical spastic paresis with peptide T 失效
标题翻译：用T肽治疗热带痉挛性麻痹
公开(公告)号：US06242564B1
公开(公告)日：2001-06-05
申请号：US07898691
申请日：1992-06-15
申请人： Candace B. Pert , Michael R. Ruff
发明人： Candace B. Pert , Michael R. Ruff
IPC分类号： A61K3702
CPC分类号： C07K14/005 , A61K38/162 , A61K39/00 , C07K14/70514 , C07K16/1063 , C12N2740/16122
摘要： Intranasal therapy using short peptides of the formula (I): Ra-Ser-Thr-Thr-Thr-Asn-Tyr-Rb (I) where Ra represents an amino terminal residue Ala-, D-Ala or Cys-Ala- and Rb represents a carboxy terminal residue -Thr, -Thr-amide, -Thr-Cys or -Thr-Cys-amide, or a derivative thereof, or a peptide of formula (II): R1-R2-R3-R4-R5 (II) where R1 is an amino terminal residue XR6 or R6 wherein R6 is Thr-, Ser-, Asn-, Leu-, Ile-, Arg- or Glu- and X is Cys, R2 is Thr, Ser or Asp, R3 is Thr, Ser, Asn, Arg, Gln, Lys or Trp, R4 is Tyr and R5 is a carboxy terminal residue which is R7X or R7 wherein R7 may be any amino acid and X is Cys, or an ester or amide derivative thereof, or a physiologically acceptable salt of (I) or (II) is disclosed. Such peptides bind to T4 receptors and are useful for intranasal administration in preventing viral infectivity in mammals by viruses which bind to the T4 receptors. These peptides are believed to act as competitive blocking agents.
摘要翻译：使用式（I）的短肽的鼻内治疗：其中Ra表示氨基末端残基Ala-，D-Ala或Cys-Ala-和Rb表示羧基末端残基-Thr，-Thr-amide，-Thr-Cys或 -Thr-Cys-酰胺或其衍生物或式（II）的肽：其中R 1是氨基末端残基XR 6或R 6，其中R 6是Thr-，Ser-，Asn-，Leu-，Ile-，Arg- 或Glu-和X是Cys，R2是Thr，Ser或Asp，R3是Thr，Ser，Asn，Arg，Gln，Lys或Trp，R4是Tyr，R5是R7X或R7的羧基末端残基，其中R7可以是任何氨基酸和X是Cys，或其酯或酰胺衍生物，或（I）或（II）的生理学上可接受的盐。这些肽与T4受体结合，并且可用于通过结合T4受体的病毒预防哺乳动物的病毒感染性进行鼻内给药。据信这些肽作为竞争性阻断剂。

2. 发明授权

US4371463A Enzyme-resistant opiate pentapeptides 失效
标题翻译：耐酶阿片五肽
公开(公告)号：US4371463A
公开(公告)日：1983-02-01
申请号：US769686
申请日：1977-02-17
申请人： Candace B. Pert , Jaw-Kang Chang
发明人： Candace B. Pert , Jaw-Kang Chang
IPC分类号： A61K38/00 , C07K14/70 , C07C103/52 , A61K37/00
CPC分类号： C07K14/702 , A61K38/00 , Y10S514/809
摘要： Pentapeptides having the formulaH-L-Tyr-A-Gly-L-Phe-B-Rwherein A is a D-amino acid residue, Sar or L-Pro, B is L-Met of L-Leu, and R is NH.sub.2 or OH. These pentapeptides are synthetic analogues of the naturally-occurring Met-and Leu-enkephalins and possess opiate activity which is resistant to destruction by body enzymes.
摘要翻译：具有式H-L-Tyr-A-Gly-L-Phe-B-R的五肽，其中A是D-氨基酸残基，Sar或L-Pro，B是L-Leu的L-Met，R是NH 2或OH。这些五肽是天然存在的Met-和Leu-脑啡肽的合成类似物，并且具有耐人体酶破坏的阿片剂活性。

3. 发明授权

US5534495A Treatment of non-HIV neuropathic pain syndromes 失效
标题翻译：治疗非HIV神经性疼痛综合征
公开(公告)号：US5534495A
公开(公告)日：1996-07-09
申请号：US385443
申请日：1995-02-08
申请人： Candace B. Pert , Michael R. Ruff
发明人： Candace B. Pert , Michael R. Ruff
IPC分类号： A61K38/00 , A61K38/16 , C07K14/16
CPC分类号： C07K14/005 , A61K38/162 , C12N2740/16122
摘要： The present invention relates to methods of treating diabetic and other non-HIV related neuropathic pain. The methods involve administration of an effective amount of defined linear peptides to patients. The peptides can be administered for example, as a powder or a solution obtained by dissolving a powder in a pharmaceutically acceptable solvent. Intranasal or sublingual administration of the defined peptides is the most preferred treatment.
摘要翻译：本发明涉及治疗糖尿病和其他非HIV相关神经性疼痛的方法。所述方法涉及向患者施用有效量的定义的线性肽。肽可以例如作为粉末或通过将粉末溶解在药学上可接受的溶剂中获得的溶液来施用。定义的肽的鼻内或舌下施用是最优选的治疗。

4. 发明授权

US5567682A Method of treating Alzheimer's disease 失效
标题翻译：治疗阿尔茨海默病的方法
公开(公告)号：US5567682A
公开(公告)日：1996-10-22
申请号：US346334
申请日：1994-11-29
申请人： Candace B. Pert
发明人： Candace B. Pert
IPC分类号： A61K38/08 , A61K38/16 , A61K38/07
CPC分类号： A61K38/162 , A61K38/08
摘要： The present invention relates to a method of treating the symptoms of Alzheimer's disease by the intranasal administration of a therapeutically effective amount of specific short chain peptides, in particular peptide T, to patients. Intranasal administration of the defined short chain peptides promotes neuronal survival for reducing or halting the progressive neuronal degeneration which occurs in Alzheimer's disease.
摘要翻译：本发明涉及通过鼻内给予患者治疗有效量的特定短链肽，特别是肽T来治疗阿尔茨海默病症状的方法。定义的短链肽的鼻内给药促进神经元存活以减少或停止在阿尔茨海默病中发生的进行性神经元变性。

5. 发明授权

US5446026A Potent non-opiate analgesic 失效
标题翻译：有效的非阿片类镇痛药
公开(公告)号：US5446026A
公开(公告)日：1995-08-29
申请号：US19830
申请日：1993-02-19
申请人： Michael R. Ruff , Joanna M. Hill , Lawrence D. Kwart , Candace B. Pert
发明人： Michael R. Ruff , Joanna M. Hill , Lawrence D. Kwart , Candace B. Pert
IPC分类号： A61K38/00 , C07K14/585 , C07K7/06 , C07K9/00
CPC分类号： C07K14/585 , A61K38/00
摘要： The present invention is directed to Cholic, Chenodeoxycholic and deoxycholic acid derivatives of a peptide having the sequence: Pro-Arg-Thr-Asn-Thr-Gly-Ser-Gly-Thr-Pro-amide and use thereof in inducing analgesia.
摘要翻译：本发明涉及具有序列Pro-Arg-Thr-Asn-Thr-Gly-Ser-Gly-Thr-Pro-amide的肽的Cholic，脱氧胆酸和脱氧胆酸衍生物及其在诱导镇痛中的用途。

6. 发明授权

US5276016A Small peptides which inhibit binding to T-4 receptors and act as immunogens 失效
标题翻译：抑制与T-4受体结合并作为免疫原的小肽
公开(公告)号：US5276016A
公开(公告)日：1994-01-04
申请号：US568616
申请日：1990-08-16
申请人： Candace B. Pert , Michael R. Ruff , William L. Farrar
发明人： Candace B. Pert , Michael R. Ruff , William L. Farrar
IPC分类号： A61K38/00 , A61K39/00 , C07K14/16 , C07K14/73 , C07K16/10 , A61K37/02 , C07K7/06
CPC分类号： C07K14/005 , C07K14/70514 , C07K16/1063 , A61K38/00 , A61K39/00 , C12N2740/16122 , Y10S514/885
摘要： Short peptide of the formula:R.sup.a -Ser-Thr-Thr-Thr-Asn-Tyr-R.sup.b (I)where R.sup.a represents an amino terminal residue Ala- or D-Ala and R.sup.b represents a carboxy terminal residue -Thr or -Thr amide or a derivative thereof with an additional Cys- residue at one or both of the amino and carboxy terminals, or a peptide of formula (II):R.sup.1 -R.sup.2 -R.sup.3 -R.sup.4 -R.sup.5 (II)whereR.sup.1 is an amino terminal residue Thr-, Ser-, Asn-,Leu-,Ile-,Arg- or Glu-R.sup.2 is Thr, Ser or AspR.sup.3 is Thr, Ser, Asn, Arg, Gln, Lys or TrpR.sup.4 is Tyr andR.sup.5 is a carboxy terminal amino group or a derivative thereof with a corresponding D- amino acid as the amino terminal residue, and/or a corresponding amide derivative at the carboxy terminal residue and/or additionally a Cys- residue at one or both of the amino and carboxy terminals,or a physiologically acceptable salt thereof.Such peptides bind to T4 receptors are useful in preventing viral infectivity by viruses which bind to the T4 receptors. These peptides are believed to act as competitive blocking agents.
摘要翻译：下式的短肽：Ra-Ser-Thr-Thr-Thr-Asn-Tyr-Rb（I）其中Ra表示氨基末端残基Ala-或D-Ala，Rb表示羧基末端残基-Thr或-Thr酰胺或其衍生物在氨基和羧基末端的一个或两个上具有另外的Cys-残基，或式（II）的肽：R 1 -R 2 -R 3 -R 4 -R 5（II）其中R 1是氨基末端残基Thr - ，Ser-，Asn-，Leu-，Ile-，Arg-或Glu-R2是Thr，Ser或Asp R3是Thr，Ser，Asn，Arg，Gln，Lys或Trp R4是Tyr，R5是羧基末端氨基或其衍生物与相应的D-氨基酸作为氨基末端残基，和/或羧基末端残基处的相应酰胺衍生物和/或另外在氨基和羧基末端的一个或两个上的Cys-残基，或其生理上可接受的盐。与T4受体结合的这些肽可用于通过结合T4受体的病毒来预防病毒感染性。据信这些肽作为竞争性阻断剂。

7. 发明授权

US4073885A Anodynin, an endogenous opiate analgesic from human blood, and process for recovering same 失效
标题翻译： Anodynin，人血液中的内源性鸦片止痛药，以及回收该药物的方法
公开(公告)号：US4073885A
公开(公告)日：1978-02-14
申请号：US722207
申请日：1976-09-10
申请人： Candace B. Pert , Agu Pert , John F. Tallman
发明人： Candace B. Pert , Agu Pert , John F. Tallman
IPC分类号： A61K38/00 , C07K14/70 , A61K35/14 , A61K37/00
CPC分类号： C07K14/70 , A61K38/00 , Y10S530/83
摘要： A method of recovering a hormone from human blood plasma which has morphine agonist properties which comprises heating said plasma, extracting into butanol to recover anodynin, and purifying said anodynin by centrifuging and ion exchange column separation. Anodynin has a molecular weight of about 600.
摘要翻译：从具有吗啡激动剂性质的人血浆中回收激素的方法，包括加热所述血浆，提取到丁醇中以回收anodynin，并通过离心和离子交换柱分离来纯化所述异烟肼。蒽醌的分子量约为600。

8. 发明授权

US5739109A Method of treating neuroinflammatory degenerative diseases 失效
标题翻译：治疗神经炎症性退行性疾病的方法
公开(公告)号：US5739109A
公开(公告)日：1998-04-14
申请号：US608434
申请日：1996-02-28
申请人： Jeffrey E. Galpin , Dennis A. Casciato , Michael A. Davis , Saul M. Levin , MerriBeth Adams , Candace B. Pert , Michael R. Ruff , Gary Globe
发明人： Jeffrey E. Galpin , Dennis A. Casciato , Michael A. Davis , Saul M. Levin , MerriBeth Adams , Candace B. Pert , Michael R. Ruff , Gary Globe
IPC分类号： A61K38/08 , A61K38/16 , A61K38/07
CPC分类号： A61K38/08 , A61K38/162
摘要： The present invention relates to a method of treating neuroinflammatory degenerative diseases which are cytokine mediated. The method involves administration of an effective amount of Peptide T or a related Peptide to diminish, halt or reverse the patient's loss of function due to neuroinflammation.
摘要翻译：本发明涉及治疗神经炎症性退行性疾病的方法，其是细胞因子介导的。该方法包括施用有效量的肽T或相关肽以减少，停止或逆转患者由于神经炎症引起的功能丧失。

9. 发明授权

US07390788B2 Peptide pharmaceutical compositions 失效
标题翻译：肽药物组合物
公开(公告)号：US07390788B2
公开(公告)日：2008-06-24
申请号：US11474049
申请日：2006-06-23
申请人： Candace B. Pert , Michael R. Ruff
发明人： Candace B. Pert , Michael R. Ruff
IPC分类号： A61K38/00 , A61K38/08 , C07K7/00
CPC分类号： A61K38/162 , A61K9/0019 , A61K9/0043 , A61K9/19 , A61K38/2278 , A61K47/26
摘要： The present invention relates to alkylglycoside-containing compositions and methods for increasing the stability, reducing the aggregation and immunogenicity, increasing the biological activity, and reducing or preventing fibrillar formation of a peptide, polypeptide, or variant thereof, for example insulin and Peptide T or analog thereof.
摘要翻译：本发明涉及含有烷基糖苷的组合物和增加其多肽，多肽或其变体（例如胰岛素和肽T）的稳定性，降低聚集和免疫原性，增加生物学活性以及减少或预防纤维状形成的方法，其类似物。

10. 发明授权

US5529983A Use of small peptides in the treatment of psoriasis 失效
标题翻译：使用小肽治疗牛皮癣
公开(公告)号：US5529983A
公开(公告)日：1996-06-25
申请号：US480104
申请日：1995-06-07
申请人： Candace B. Pert , Michael R. Ruff , Lennart Wetterberg
发明人： Candace B. Pert , Michael R. Ruff , Lennart Wetterberg
IPC分类号： A61K38/00 , C07K14/16 , C07K14/73 , C07K16/10 , A61K38/08 , C07K7/06
CPC分类号： C07K14/005 , C07K14/70514 , C07K16/1063 , A61K38/00 , C12N2740/16122 , Y10S514/863
摘要： The treatment of human patients suffering from Acquired Immune Deficiency Syndrome (AIDS) with therapeutic amounts of certain small peptides which specifically utilizes peptide T (Ala-Ser-Thr-Thr-Thr-Asn-Tyr-Thr), vasoactive intestinal polypeptide (VIP), or a core pentapeptide selected from a peptide of the following formula:Thr-X-Y-Tyr-ThrwhereX and Y=any amino acid.gamma.=preferably AspThr.sub.1 may be repalced by D-AlaA preferred regimen for utilization of peptide T, a preferred peptide treating agent, is 1 mg twice daily for one week followed by 2 mg twice daily for three weeks, constituting an initial dosage regimen which may be repeated. This regimen has resulted in substantial increase in total white cell count assay, thus combatting the deleterious effect of the AIDS virus.
摘要翻译：用治疗量的特异性利用肽T（Ala-Ser-Thr-Thr-Thr-Thr-Asn-Tyr-Thr）的某些小肽，血管活性肠肽（VIP）等治疗患有获得性免疫缺陷综合征（AIDS）的人类患者，，或选自下式的肽的核心五肽：Thr-XY-Tyr-Thr，其中X和Y =任何氨基酸γ=优选Asp Thr1可以被D-Ala重新补充用于肽T的优选方案，优选的肽处理剂为1mg，每天两次，持续一周，随后2mg，每日两次，持续三周，构成可重复的初始给药方案。这种方案导致白细胞总计数测定的显着增加，从而抵抗艾滋病病毒的有害影响。

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