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1. 发明授权

US06579523B1 Transplants for myocardial scars 有权
公开(公告)号：US06579523B1
公开(公告)日：2003-06-17
申请号：US09634304
申请日：2000-08-08
申请人： Donald A. G. Mickle , Ren-Ke Li , Richard D. Weisel
发明人： Donald A. G. Mickle , Ren-Ke Li , Richard D. Weisel
IPC分类号： A61K3534
CPC分类号： C12N5/0657 , A61K35/12 , A61K35/34 , A61K38/00 , A61K48/00 , C12N5/0656 , C12N5/0661 , C12N5/069 , C12N5/0691 , C12N2500/44 , C12N2501/70 , C12N2502/28 , C12N2509/00 , C12N2510/00
摘要： A method is provided for forming a graft in heart tissue which comprises the transplantation of cells chosen from cardiomyocytes, fibroblasts, smooth muscle cells, endothelial cells and skeletal myoblasts. The grafts are especially useful in treating scar tissue on the heart.

2. 发明授权

US06790461B2 Hyaluronic acid gel, method of its production and medical material containing it 有权
标题翻译：透明质酸凝胶，其生产方法和含有它的医用材料
公开(公告)号：US06790461B2
公开(公告)日：2004-09-14
申请号：US10047091
申请日：2002-01-17
申请人： Yoshiaki Miyata , Akio Okamoto , Masatoshi Kawata , Kazuhiro Oshima , Masamichi Hashimoto , Kazuhiko Arai
发明人： Yoshiaki Miyata , Akio Okamoto , Masatoshi Kawata , Kazuhiro Oshima , Masamichi Hashimoto , Kazuhiko Arai
IPC分类号： A61K3534
CPC分类号： C08L5/08 , A61L15/28 , A61L27/20 , A61L31/042 , C08B37/0072 , Y10S514/944
摘要： A gel made of hyaluronic acid alone which is hardly soluble in a neutral aqueous solution and which keeps its shape for at least one day in a neutral aqueous solution at 25° C.
摘要翻译：由透明质酸单独制成的凝胶，其几乎不溶于中性水溶液，并且在25℃的中性水溶液中保持至少一天的形状。

3. 发明授权

US06638538B1 Hyaluronic acid gel composition, process for producing the same, and medical material containing the same 失效
标题翻译：透明质酸凝胶组合物，其制造方法以及含有该透明质酸凝胶组合物的医用材料
公开(公告)号：US06638538B1
公开(公告)日：2003-10-28
申请号：US09913718
申请日：2001-09-27
申请人： Masamichi Hashimoto , Toshihiko Umeda , Kazuhiko Arai , Yoshiaki Miyata , Osamu Yamamoto , Yasukazu Himeda
发明人： Masamichi Hashimoto , Toshihiko Umeda , Kazuhiko Arai , Yoshiaki Miyata , Osamu Yamamoto , Yasukazu Himeda
IPC分类号： A61K3534
CPC分类号： A61L31/042 , A61L26/0023 , A61L26/008 , A61L27/20 , A61L27/52 , C08B37/0072 , C08L1/286 , C08L5/08 , C08L29/04 , C08L1/26 , C08L2666/02
摘要： A hyaluronic acid gel composition comprising hyaluronic acid and a polymer, which is substantially unmodified with a chemical cross-linking agent or a chemical modifying agent and which has a percentage dissolution of hyaluronic acid of 50% or lower in 12 hours in a neutral aqueous solution of 37° C.
摘要翻译：一种透明质酸凝胶组合物，其包含透明质酸和聚合物，其基本上用化学交联剂或化学改性剂未改性，并且在中性水溶液中在12小时内透明质酸溶解百分率为50％或更低的37℃

4. 发明授权

US06635285B2 Shark cartilage extract: process of making, methods of using, and compositions thereof 失效
公开(公告)号：US06635285B2
公开(公告)日：2003-10-21
申请号：US10068950
申请日：2002-02-07
申请人： Éric Dupont , Paul Brazeau , Christina Juneau , Daniel H. Maes , Kenneth Marenus , Richard Béliveau
发明人： Éric Dupont , Paul Brazeau , Christina Juneau , Daniel H. Maes , Kenneth Marenus , Richard Béliveau
IPC分类号： A61K3534
CPC分类号： A61Q17/00 , A61K8/987 , A61K35/60 , A61Q19/00 , A61Q19/08 , Y10S514/859 , Y10S514/863 , Y10S530/857
摘要： The present invention relates to cartilage extracts and to a method of producing the same. Shark cartilage extracts having anti-angiogenic, anti-tumor, anti-inflammatory and anti-collagenolytic activities have been obtained by an improved process. The process comprises the steps of obtaining a crude cartilage extract in an aqueous solution, this crude extract being fractionated to recover molecules of a molecular weight less than about 500 kDa. Some of the biologically active components of the extract are prepared by further fractionation. The cartilage extract can be used for treating diseases or conditions having etiological components selected from the group consisting of tumor proliferation, angiogenesis, inflammation, metalloprotease activity and collagenolysis. Several cosmetic applications based on the capacity of the liquid extract to improve skin conditions are also disclosed. A simple and efficient process for the preparation of cartilage extracts is also disclosed.

5. 发明授权

US06537587B1 Compositions containing muscle-derived active agents 失效
标题翻译：含有肌肉衍生活性成分的组合物
公开(公告)号：US06537587B1
公开(公告)日：2003-03-25
申请号：US09700745
申请日：2001-08-28
申请人： Pnina Fishman
发明人： Pnina Fishman
IPC分类号： A61K3534
CPC分类号： A61K35/34
摘要： The present invention relates to a composition of matter having the following characteristics: (i) it is derived from muscle tissue; (ii) it filters through a filler with a maximal molecular weight cut-off of about 10,000 Dalton, preferably less than 3,000 Daltons; and (iii) it has a biological effect of inhibiting proliferation of tumor cells and stimulation of proliferation of leukocytes and neutrophils; and to a method for preparing said composition of matter. Furthermore, the invention relates to pharmaceutical and neutraceutical preparations comprising the composition of matter disclosed herein. According to one embodiment, the pharmaceutical preparation is intended for treating or preventing cancer. The pharmaceutical preparations according to yet a further embodiment may be used for increasing the efficacy of a cytotoxic drug towards target cells, the target cells, being, for example, cancer cells. The pharmaceutical preparations may be administered parentally, however, are preferably administered orally.
摘要翻译：本发明涉及具有以下特征的物质组合物：（i）其衍生自肌肉组织; （ii）它通过具有约10,000道尔顿，优选小于3,000道尔顿的最大分子量截止值的填料过滤; （iii）具有抑制肿瘤细胞增殖和刺激白细胞和嗜中性粒细胞增殖的生物学作用; 以及制备所述物质组合物的方法。此外，本发明涉及包含本文公开的物质组合物的药物和营养制剂。根据一个实施方案，药物制剂用于治疗或预防癌症。根据另一个实施方案的药物制剂可用于增加细胞毒性药物对靶细胞，靶细胞，例如癌细胞的功效。药物制剂可以是亲本施用的，但优选口服给药。

6. 发明授权

US06503540B1 Cloning and characterization of bves, a novel gene expressed in heart and uses thereof 失效
标题翻译： bves的克隆和表征，一种在心脏中表达的新基因及其用途
公开(公告)号：US06503540B1
公开(公告)日：2003-01-07
申请号：US09535909
申请日：2000-03-24
申请人： David E. Reese , David M. Bader
发明人： David E. Reese , David M. Bader
IPC分类号： A61K3534
CPC分类号： C07K14/47 , A61K38/00
摘要： The present invention is directed to cloning and characterization of bves (blood vessel/epicardial substance), a cDNA expressed in developing and adult heart and skeletal muscle cells in chick, mouse and human. Also provided are applications of Bves as a marker for cardiovascular or skeletal muscle diseases.
摘要翻译：本发明涉及克隆和表征bves（血管/心外膜物质），在小鸡，小鼠和人类的发育和成年心脏和骨骼肌细胞中表达的cDNA。还提供了Bves作为心血管或骨骼肌疾病标记物的应用。

7. 发明授权

US06387413B1 Hyaluronic acid gel, a method of its production and medical material containing it 有权
标题翻译：透明质酸凝胶，其生产方法和含有它的医用材料
公开(公告)号：US06387413B1
公开(公告)日：2002-05-14
申请号：US09463993
申请日：2000-06-26
申请人： Yoshiaki Miyata , Akio Okamoto , Masatoshi Kawata , Kazuhiro Oshima , Masamichi Hashimoto , Kazuhiko Arai , Tomio Sawada
发明人： Yoshiaki Miyata , Akio Okamoto , Masatoshi Kawata , Kazuhiro Oshima , Masamichi Hashimoto , Kazuhiko Arai , Tomio Sawada
IPC分类号： A61K3534
CPC分类号： C08L5/08 , A61L15/28 , A61L27/20 , A61L31/042 , C08B37/0072 , Y10S514/944
摘要： A gel made of hyaluronic acid alone which is hardly soluble in a neutral aqueous solution and which keeps its shape for at least one day in a neutral aqueous solution at 25° C.
摘要翻译：由透明质酸单独制成的凝胶，其几乎不溶于中性水溶液，并且在25℃的中性水溶液中保持至少一天的形状。

8. 发明授权

US06517872B1 FGFR3 as a marker for mesenchymal skeletal progenitor cells 失效
公开(公告)号：US06517872B1
公开(公告)日：2003-02-11
申请号：US08981031
申请日：1998-06-12
申请人： Avner Yayon , Zvi Nevo
发明人： Avner Yayon , Zvi Nevo
IPC分类号： A61K3534
CPC分类号： G01N33/6887 , G01N33/56966 , G01N33/74 , G01N2333/9121
摘要： The present invention concerns fibroblast growth factor receptor 3 (FGFR3) as a novel marker for mesenchymal skeletal progenitor cells. By utilizing this novel marker it was possible both to identify and locate mesenchymal skeletal progenitor cells in a tissue, as well as to obtain a substantially pure culture of such cells. The pure culture of the mesenchymal skeletal progenitor cells may be used, optionally after various manipulations ex vivo, as an active ingredient in pharmaceutical compositions or implants for the purpose of bone and/or cartilage repair. FGFR3 may also be used as a marker for the identification and the localization of cartilage- and bone-derived tumors. Agents capable of binding to FGFR3 may also be used for targeting cytotoxic agents to cartilage- and bone-derived tumors.

9. 发明授权

US06379709B1 Angiogenesis inhibitors and activators from shark cartilage 失效
标题翻译：血管生成抑制剂和鲨鱼软骨激活剂
公开(公告)号：US06379709B1
公开(公告)日：2002-04-30
申请号：US09367727
申请日：1999-12-10
申请人： George Charles Slim , Paul Frank Davis , Yi He , Bei Xu
发明人： George Charles Slim , Paul Frank Davis , Yi He , Bei Xu
IPC分类号： A61K3534
CPC分类号： A61K35/60
摘要： A process for obtaining an angiogenesis inhibitor and an angiogenesis activator from shark cartilage comprising, as the key step, the aqueous extraction of dried shark cartilage. The angiogenesis inhibitor obtained is more potent than shark cartilage not subjected to the extraction step. The angiogenesis inhibitor is particularly useful for the prevention or treatment of cancer. The angiogenesis activator is particularly useful for stimulating wound healing.
摘要翻译：从鲨鱼软骨获得血管生成抑制剂和血管生成活化剂的方法，其中包括作为关键步骤的干鲨鱼软骨的水提取物。获得的血管生成抑制剂比未进行提取步骤的鲨鱼软骨更有效。血管生成抑制剂特别可用于预防或治疗癌症。血管生成激活剂特别可用于刺激伤口愈合。

10. 发明授权

US06368614B2 Biological material, method of preparing such materials 失效
标题翻译：生物材料，这种材料的制备方法
公开(公告)号：US06368614B2
公开(公告)日：2002-04-09
申请号：US09745446
申请日：2000-12-26
申请人： Svyatoslav Nikolayevich Fedorov , Sergei Nikolayevich Bagrov , Yevgeny Viktorovich Larionov
发明人： Svyatoslav Nikolayevich Fedorov , Sergei Nikolayevich Bagrov , Yevgeny Viktorovich Larionov
IPC分类号： A61K3534
CPC分类号： A61K35/34
摘要： A biological material is prepared for use in ophthalmology by steps of providing animal pericardium, subjecting the animal pericardium to multiple steps of freezing and thawing in a salt solution and incubating the animal pericardium in a solution of ammonia and ethyl alcohol. The multiple steps of freezing and thawing are conducted in a mixture of about 0.9% sodium chloride solution and distilled water in about 1:1 proportions of sodium chloride solution to distilled water. The incubating step is conducted in a mixture of 1% ammonia solution and 1% ethyl alcohol solution in about 1:1 proportions of ammonia solution to ethyl alcohol solution over a period of 48 to 72 hours.
摘要翻译：制备用于眼科的生物材料，其步骤为提供动物心包，使动物心包在盐溶液中进行多次冷冻和解冻步骤，并将动物心包在氨水和乙醇溶液中孵育。冷冻和解冻的多个步骤在约0.9％氯化钠溶液和蒸馏水的混合物中以约1:1比例的氯化钠溶液与蒸馏水进行。在48〜72小时内，以1:1比例的氨水溶液与乙醇溶液在1％氨水溶液和1％乙醇溶液的混合物中进行孵育步骤。

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