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1. 发明授权

US06380366B1 Shark cartilage extract:process of making, methods of using and compositions thereof 失效
标题翻译：鲨鱼软骨提取物：制备方法，使用方法及其组合物
公开(公告)号：US06380366B1
公开(公告)日：2002-04-30
申请号：US09504065
申请日：2000-02-15
申请人： Éric Dupont , Paul Brazeau , Christina Juneau , Richard Béliveau
发明人： Éric Dupont , Paul Brazeau , Christina Juneau , Richard Béliveau
IPC分类号： A23J100
CPC分类号： A61Q17/00 , A61K8/987 , A61K35/60 , A61Q19/00 , A61Q19/08 , Y10S514/859 , Y10S514/863 , Y10S530/857
摘要： The present invention relates to cartilage extracts and to a method of producing the same. Shark cartilage extracts having anti-angiogenic, anti-tumor, anti-inflammatory and anti-collagenolytic activities have been obtained by an improved process. The process comprises the steps of obtaining a crude cartilage extract in an aqueous solution, this crude extract being fractionated to recover molecules of a molecular weight less than about 500 kDa. Some of the biologically active components of the extract are prepared by further fractionation. The cartilage extract can be used for treating diseases or conditions having etiological components selected from the group consisting of tumor proliferation, angiogenesis, inflammation, metalloprotease activity and collagenolysis. Several cosmetic applications based on the capacity of the liquid extract to improve skin conditions are also disclosed. A simple and efficient process for the preparation of cartilage extracts is also disclosed.
摘要翻译：本发明涉及软骨提取物及其制造方法。已经通过改进的方法获得具有抗血管生成，抗肿瘤，抗炎和抗胶原活化的鲨鱼软骨提取物。该方法包括以下步骤：在水溶液中获得粗的软骨提取物，将该粗提取物分馏以回收分子量小于约500kDa的分子。提取物的一些生物活性组分通过进一步分级制备。软骨提取物可用于治疗具有选自肿瘤增殖，血管生成，炎症，金属蛋白酶活性和胶原分解的病因的疾病或病症。还公开了基于液体提取物改善皮肤状况的能力的几种化妆品应用。还公开了用于制备软骨提取物的简单有效的方法。

2. 发明授权

US06635285B2 Shark cartilage extract: process of making, methods of using, and compositions thereof 失效
公开(公告)号：US06635285B2
公开(公告)日：2003-10-21
申请号：US10068950
申请日：2002-02-07
申请人： Éric Dupont , Paul Brazeau , Christina Juneau , Daniel H. Maes , Kenneth Marenus , Richard Béliveau
发明人： Éric Dupont , Paul Brazeau , Christina Juneau , Daniel H. Maes , Kenneth Marenus , Richard Béliveau
IPC分类号： A61K3534
CPC分类号： A61Q17/00 , A61K8/987 , A61K35/60 , A61Q19/00 , A61Q19/08 , Y10S514/859 , Y10S514/863 , Y10S530/857
摘要： The present invention relates to cartilage extracts and to a method of producing the same. Shark cartilage extracts having anti-angiogenic, anti-tumor, anti-inflammatory and anti-collagenolytic activities have been obtained by an improved process. The process comprises the steps of obtaining a crude cartilage extract in an aqueous solution, this crude extract being fractionated to recover molecules of a molecular weight less than about 500 kDa. Some of the biologically active components of the extract are prepared by further fractionation. The cartilage extract can be used for treating diseases or conditions having etiological components selected from the group consisting of tumor proliferation, angiogenesis, inflammation, metalloprotease activity and collagenolysis. Several cosmetic applications based on the capacity of the liquid extract to improve skin conditions are also disclosed. A simple and efficient process for the preparation of cartilage extracts is also disclosed.

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